Structure-Activity Relationships for Hepatic Peroxisome Proliferation

  • B. G. Lake
  • D. F. V. Lewis
  • T. J. B. Gray
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)


Many compounds have been shown to produce liver enlargement and hepatic peroxisome proliferation in rodents (Cohen and Grasso 1981; Reddy and Lalwani 1983). Organelle proliferation is accompanied by large increases in certain enzyme activities, particularly in the peroxisomal fatty acid β-oxidation cycle, which is normally measured as cyanide-insensitive palmitoyl-CoA oxidation (Lazarow and DeDuve 1976). Certain peroxisome proliferators have been shown to increase the incidence of liver tumours in rats and/or in mice and it has been suggested that tumour formation is, in some manner, related to organelle proliferation (Reddy and Lalwani 1983; Reddy et al. 1986).


Peroxisome Proliferation Phthalate Ester Clofibric Acid Phthalate Monoester Methylpropionic Acid 
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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • B. G. Lake
    • 1
  • D. F. V. Lewis
    • 2
  • T. J. B. Gray
    • 1
  1. 1.The British Industrial Biological Research Association (BIBRA)Carshalton, SurreyUK
  2. 2.Department of BiochemistryUniversity of SurreyGuildford, SurreyUK

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