Structure-Activity Relationships for Hepatic Peroxisome Proliferation
Many compounds have been shown to produce liver enlargement and hepatic peroxisome proliferation in rodents (Cohen and Grasso 1981; Reddy and Lalwani 1983). Organelle proliferation is accompanied by large increases in certain enzyme activities, particularly in the peroxisomal fatty acid β-oxidation cycle, which is normally measured as cyanide-insensitive palmitoyl-CoA oxidation (Lazarow and DeDuve 1976). Certain peroxisome proliferators have been shown to increase the incidence of liver tumours in rats and/or in mice and it has been suggested that tumour formation is, in some manner, related to organelle proliferation (Reddy and Lalwani 1983; Reddy et al. 1986).
KeywordsCatalase Diester Phenoxy Octyl Hexyl
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- Lück H (1963) Catalase. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 885–888.Google Scholar
- Reddy JK, Reddy MK, Usman MI, Lalwani ND, Rao MS (1986) Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug. Environ Health Perspect 65:317–327.PubMedGoogle Scholar
- Rhodes C, Soames T, Stonard MD, Simpson MG, Vernall AJ, Elcombe CR (1984) The absence of testicular atrophy and in vivo and in vitro effects on hepatocyte morphology and peroxisomal enzyme activities in male rats following the administration of several alkanols. Toxicol Lett 21:103–109.PubMedCrossRefGoogle Scholar