Structure-Activity Relationships for Hepatic Peroxisome Proliferation
Many compounds have been shown to produce liver enlargement and hepatic peroxisome proliferation in rodents (Cohen and Grasso 1981; Reddy and Lalwani 1983). Organelle proliferation is accompanied by large increases in certain enzyme activities, particularly in the peroxisomal fatty acid β-oxidation cycle, which is normally measured as cyanide-insensitive palmitoyl-CoA oxidation (Lazarow and DeDuve 1976). Certain peroxisome proliferators have been shown to increase the incidence of liver tumours in rats and/or in mice and it has been suggested that tumour formation is, in some manner, related to organelle proliferation (Reddy and Lalwani 1983; Reddy et al. 1986).
KeywordsPeroxisome Proliferation Phthalate Ester Clofibric Acid Phthalate Monoester Methylpropionic Acid
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