Abstract
Because of the large number of compounds described as photosensitizing in man, it very soon became necessary to develop a test in animals in order to verify the effects observed in man. This test would then be used to predict the possible occurrence of this type of side-effect when introducing a new chemical therapeutic compound.
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References
Chalmers RJG, Skrinivas V, Benett DH, Muston HL (1982) The incidence of photosensitivity and pigmentation induced by the anti-arrhythmic drug amiodarone. Br J Dermatol 107 [Suppl 22]:32–33
Daymond TJ, Diffey BL (1983) Narrow band photosensitivity in patients taking benoxaprofen. Br J Clin Pharmacol 15:139
Ferguson J, Addo HA, McGill PE, Woodcook KR, Johnson BE, Frain BW (1982) A study of benoxaprofen induced photosensitivity. Br J Dermatol 107 [Suppl 22]:429–441
Girard J, Unkovic J, Delahayes J, Lafille C (1979) Etude expérimentale de la phototoxicité de l’essence de bergamote. Corrélations entre l’homme et le cobaye. Dermatologica 158:229–243
Giudici P, Maguire HC Jr (1985) Experimental systemic photoallergy. J Invest Dermatol 84:355
Harber LC (1981) Current status of mammalian and human models for predicting drug photosensitivity. J Invest Dermatol 77:65–70
Harber LC, Baer RL (1972) Pathogenic mechanisms of drug-induced photosensitivity. J Invest Dermatol 58:327–342
Harber LC, Harris H, Baer RL (1966) Photoallergic contact dermatitis. Due to halogenated salicylanilides and related compounds. Arch Dermatol 94:255–262
Harber LC, Targovnik SE, Baer RL (1967) Contact photosensitivity patterns to halogenated salicylanilides in man and guinea pigs. Arch Dermatol 96:646–656
Jordan WP (1982) The guinea pig as a model for predicting photoallergic contact dermatitis. Contact Dermatitis 8:109–116
Kochevar IE, Hoover KW, Gawienowski M (1984) Benoxaprofen photosensitization of cell membrane disruption. J Invest Dermatol 82:214–218
Ljunggren B (1977) Phenothiazine phototoxicity: tonic chlorpromazine photoproducts. J Invest Dermatol 69:383–386
Maguire HC, Kaidbey K (1982) Experimental photoallergic contact dermatitis: a mouse model. J Invest Dermatol 79:147–152
Marzulli FN, Maibach HI (1970) Perfume phototoxicity. J Soc Cosmet Chem 21:695–715
Pathak MA, Fitzpatrick TB (1959) Bioassay of natural and synthetic furocoumarins (psoralens). J Invest Dermatol 32:509–518
Takigawa M, Miyachi Y (1982) Mechanisms of contact photosensitivity in mice: I. T cell regulation of contact photosensitivity to tetrachloro-salicylanilide under the genetic restrictions of the major histocompatibility complex. J Invest Dermatol 78:105–115
Unkovic J, Richer G, Girard J (1981) Action of UVA with psoralens on skin; is it a sunburn? Study on animal model. In: Cohn J, Forlot P, Gruper C, Meibeck M, Urbach F (eds) Psoralens in cosmetics and dermatology. Pergamon, Oxford, pp 357–358
Unkovic J, Mazué G, Girard J (1983) Prévision des accidents de produits photodynamisants chez l’homme à l’aide d’un modèle expérimental animal. Sci Tech Anim Lab 8:149–160
Unkovic J, Combes M, Mazué G, Roncucci R (1984) Human amiodarone photosensitivity: a predictive study in animal. Poster presented to the American Academy of Dermatology, 43rd annual meeting, Washington DC
Unkovic J, Combes M, Tosi L, Mazué G (1985) Photosensibilisation par l’amiodarone: étude prédictive chez le cobaye. Ann Dermatol Venereol 112:196
Unkovic J, Combes, M, Mazué G, Girard J (1986) Etude du pouvoir photosensibilisant chez l’animal. Les Nouvelles Dermatologiques 5 [Suppl 3]:199–203
Zachary CB, Storey G, Holt D, Slater D, McDonald DM (1983) The nature of amiodarone photosensitivity and pigmentation. Br J Dermatol 109:35–36
Zaynoun ST, Johnson BE, Frain-Bell W (1977) A study of oil of bergamot and its importance as a phototoxic agent. Characterization and quantification of the photoactive component. Br J Dermatol 96:475–482
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© 1988 Springer-Verlag
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Unkovic, J., Barbier, A., Combes, M., Vic, P. (1988). Human Drug Photosensitivity: Predictive Studies in Guinea Pigs. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_3
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DOI: https://doi.org/10.1007/978-3-642-73113-6_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18512-3
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