Reduction of Cisplatin Nephrotoxicity by Selenium: Does Metallothionein Play a Role?

  • G. S. Baldew
  • K. J. Volkers
  • C. J. A. Van den Hamer
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)

Abstract

Cisplatin is an important antineoplastic drug widely used against several tumors, especially those of the testis and ovaries (Prestayko et al. 1980). The dose-limiting side-effect of cisplatin chemotherapy is its nephrotoxicity, mainly consisting of degeneration of proximal tubules (Walker and Gale 1981); the mechanism of this nephrotoxicity is still unknown. Many attempts have been made to reduce cisplatin-induced nephrotoxicity. An interesting approach in this respect is the use of selenium. Selenium has been shown to prevent cadmium toxicity in animals (Parizek et al. 1974) and a protective effect of selenium against cisplatin lethality in mice has been described (Berry et al. 1984). It is not known how selenium exerts its protective effect against cisplatin.

Keywords

Zinc Toxicity Mercury Urea Platinum 

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References

  1. Bakka A, Endresen L, Johnsen ABS, Edminson PD, Rugstad HE (1981) Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein. Toxicol Appl Pharmacol 61: 215–226PubMedCrossRefGoogle Scholar
  2. Baldew GS, Van den Hamer CJA, de Goeij JJM, McVie JG (1987) Selenium-induced protection against cis-diamminedichloroplatinum (II) nephrotoxicity in mice and rats. (Manuscript in preparation)Google Scholar
  3. Berry JP, Pauwells C, Tlouzeau S, Lespinats G (1984) Effect of selenium in combination with cis-diamminedichloroplatinum (II) in the treatment of murine fibrosarcoma. Cancer Res 44:2864–2868PubMedGoogle Scholar
  4. Dunn MA, Blalock TL, Cousins RJ (1987) Minireview metallothionein. Proc Soc Exp Biol Med 185:107–119PubMedGoogle Scholar
  5. Hoeschele JD, Butler TA, Roberts JA (1982) Analysis and refinement of the microscale synthesis of the 195mPt-labeled antitumor drug, cis-dichlorodiammineplatinum (II), cis-DDP. Radiochim Acta 31:27–36Google Scholar
  6. Parizek J, Kalouskova J, Baliky A, Benes J, Pavlik L (1974) Interaction of selenium with mercury, cadmium and other toxic metals. In: Hoekstra WC, Suttie JW, Ganther HE, Mertz W (eds) Trace element metabolism in animals, vol. 2. University Park Press, Baltimore, pp 119–132Google Scholar
  7. Prestayko AW, Crooke ST, Carter SK (eds) (1980) Cisplatin: current status and new developments. Academic, New YorkGoogle Scholar
  8. Prins HW, van den Hammer CJA (1981) Comparative studies of copper metabolism in liver and kidney of normal and mutated brindled mice — with special emphasis on metallothionein. Comp Biochem Physiol [C]70:255–260CrossRefGoogle Scholar
  9. Walker EM, Gale GR (1981) Methods of reduction of cisplatin nephrotocitiy. Ann Clin Lab Sci 11:397–410PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • G. S. Baldew
    • 1
  • K. J. Volkers
    • 1
  • C. J. A. Van den Hamer
    • 1
  1. 1.Department of RadiochemistryInterfaculty Reactor InstituteDelftThe Netherlands

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