Abstract
The new concept of cancer as a systemic disease has led to the use of adjuvant chemotherapy. Indeed, in many cancers, asymptomatic metastatic dissemination occurs in early stages of the disease and the aim of early adjuvant chemotherapy is to prevent poor subsequent evolution. The rapid development of chemotherapy has led to the common use of more than 50 drugs, many of them in association. Side-effects of these antitumoral agents are numerous. Physicians were first preoccupied with the digestive and myelodepressive effects and little attention was paid to drug-induced nephrotoxicity. Only few and recent data on the nephrotoxicity of antitumoral agents will be discussed here. The reader may consult reviews on this subject recently published (Fillastre et al. 1987; Raymond 1984; Weiss and Poster 1982).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Campbell AB, Kaiman SM, Jacobs C (1983) Plasma platinum levels: relationship to cisplatin dose and nephrotoxicity. Cancer Treat Resp 67:169–174
Cattell V (1985) Mitomycin-induced hemolytic uremic kidney. Am J Pathol 121:88–95
Daley-Yates PT, Mc Brien DCH (1982) The inhibition of renal ATPase by cisplatin and some biotransformation products. Chem Biol Interact 40:325–333
Dobyan DC, Levi J, Jacobs C, Kosek J, Weiner MW (1980) Mechanism of cis-plastinum nephrotoxicity. II. Morphologic observations. J Pharmacol Exp Ther 213:551–556
Favre R, Pignon T, Lena N, Cano JP, Carcassonne Y (1983) Maîtrise de la toxicité du methotrexate à forte dose par la surveillance pharmacocinétique. Nouv Presse Med 12:2400–2403
Fulastre JP, Viotte G, Morin JP, Moulin B (1987) Néphrotoxicité des agents antitumoraux. In: Crosnier J, Funck-Brentano JL, Bach JF, Grünfeld JP (eds) Actualités néphrologiques de l’hôpital Necker, vol 1. Flammarion, Paris, pp 161–200
Goldstein RS, Mayor GH (1983) The nephrotoxicity of cisplatin. Life Sci 32:685–688
Gordon JA, Gattone VH (1986) Mitochondrial alterations in cisplatin induced acute renal failure. Am J Physiol 250:F991–F998
Levi J, Jacobs C, Mc Tigue M, Weiner MM (1978) Effects of cis-diamminedichloroplatinum on renal sulfhydryl groups. Kidney Int 14:728
Nechay BR, Neldon SL (1984) Characteristics of inhibitions of human renal adenosine triphosphatases by cisplatin and chloroplatinic acid. Cancer Treat Resp 68:1135–1141
Offerman JJG, Meijer S, Sleijfer DTH, Mulder NH, Donker AJM, Schraffordt-Koops H, Van der Hem GK (1984) Acute effects of cw-diamminedichloroplatinum (CDDP) on renal function. Cancer Chemother Pharmacol 12:36–38
Raymond JR (1984) Nephrotoxicities of antineoplastic and immunosuppressive agents. In Current problems in cancer Vol 8, Year Book Med Publ Chicago, pp 5–24
Remuzzi G, Imberti L, Rossini M, Morelli C, Carminad C, Cattaneo GM, Bertani T (1985) Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. J Clin Invest 75:94–101
Ryckelynck JPH, Heron JF, Juret P, Schneider P, Herlin P, De Ranieri E, Hardouin A, Peny J, Le Talaer JY (1984) Toxicité rénale du 9-hydroxy-2-methylellipticinium. Néphrologie 5:59–63
Simmons CF, Humes HD (1979) Inhibitory effects of cis-diamminedichloroplatinum (cis P) on renal cortical mitochondrial respiration: a primary pathogenic event in cis-P-nephrotoxicity. Kidney Int 16:862
Thyss A, Milano G, Kubar J, Namer M, Schneider M (1986) Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen. Lancet i:256–258
Viotte G, Lahouel M, Ducastelle T, Morin JP, Fillastre JP (1988) CCNU-Adriamycin association induces earlier and more severe nephropathy in rats. Arch Toxicol 61:282–291
Weiss RB, Poster DS (1982) The renal toxicity of cancer chemotherapeutic agents. Cancer Treat Rev 9:37–52
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag
About this paper
Cite this paper
Fillastre, J.P., Raguenez-Viotte, G., Moulin, B. (1988). Nephrotoxicity of Antitumoral Agents. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-73113-6_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18512-3
Online ISBN: 978-3-642-73113-6
eBook Packages: Springer Book Archive