Nephrotoxicity of Antitumoral Agents
The new concept of cancer as a systemic disease has led to the use of adjuvant chemotherapy. Indeed, in many cancers, asymptomatic metastatic dissemination occurs in early stages of the disease and the aim of early adjuvant chemotherapy is to prevent poor subsequent evolution. The rapid development of chemotherapy has led to the common use of more than 50 drugs, many of them in association. Side-effects of these antitumoral agents are numerous. Physicians were first preoccupied with the digestive and myelodepressive effects and little attention was paid to drug-induced nephrotoxicity. Only few and recent data on the nephrotoxicity of antitumoral agents will be discussed here. The reader may consult reviews on this subject recently published (Fillastre et al. 1987; Raymond 1984; Weiss and Poster 1982).
KeywordsAcute Renal Failure Hemolytic Uremic Syndrome Antitumoral Agent Antineoplastic Drug Renal Tubular Acidosis
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