Abstract
Zinc ethylenebisdithiocarbamate (ZINEB) and other dithiocarbamates are widely employed in agricultural practice as fungicides. These compounds display several biological effects (for references, see Borin et al. 1985), including goitrogenic effects in a variety of animal species (Guarda et al. 1985). Moreover, they may give rise to metabolic products such as ethylenebisisothiocyanate sulfide, ethylenethiourea (ETU), and carbon disulfide, which, in turn, possess a wide range of toxic actions (FAO 1981). Due to its extensive use, ZINEB is therefore a potential danger in the food chain and environment, both for man and for animals. Despite this, little is known about the chronic toxicity of ZINEB in cattle. Therefore a study was undertaken in Friesian calves to ascertain whether thyroid function may be affected by low levels of ZINEB and to investigate the possible sites of extrathyroidal effects.
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References
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© 1988 Springer-Verlag
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Soffietti, M.G. et al. (1988). Chronic Zinc Ethylenebisdithiocarbamate Toxicity in Calves: Effects on the Thyroid and Clinicopathological Findings. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_16
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DOI: https://doi.org/10.1007/978-3-642-73113-6_16
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