Abstract
Furocoumarins are currently used, in association with UVA irradiation, in the therapy for skin diseases such as psoriasis and vitiligo, although they can also yield side-effects like skin phototoxicity, genotoxicity, and increased tumor incidence. Furocoumarins’ phototoxicity is mainly attributed to their ability to form DNA cross-links under UVA irradiation (Vedaldi et al. 1983). Both bi-functional furocoumarins (able to form cross-links with two strands of DNA) and monofunctional furocoumarins (which form DNA monoadducts only) are able to photogenerate active forms of oxygen and/or oxyradicals, which are involved both in mutagenesis and in carcinogenesis (Vedaldi et al. 1983).
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© 1988 Springer-Verlag
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Bianchi, L., Bianchi, A., Pizzala, R., Dall’ Acqua, F., Santamaria, L. (1988). Photomutagenic Effect Induced by 4,4′,6-Trimethylangelicin in Salmonella typhimurium TA 102 and Saccharomyces cerevisiae D7. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_10
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DOI: https://doi.org/10.1007/978-3-642-73113-6_10
Publisher Name: Springer, Berlin, Heidelberg
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