New Perspectives in Resuscitation and Prevention of Multiple Organ System Failure

  • U. Kreimeier
  • K. Messmer


As result of improved primary care, fewer patients suffering from trauma, multiple injuries, or forms of shock will succumb within the first hours except those presenting with lethal injuries to the vital organs. One-half of the deaths among trauma victims occur within 1 h after injury and are due to rapid hemorrhage or CNS trauma [26]. As a consequence of vigorous and rapid resuscitation and volume substitution many trauma patients survive the initial critical hours and appear to be in a stable reconvalescent condition. With time, however, dysfunction of one or several of their organs becomes apparent and they are prone to die from the primary complications of trauma in sepsis and multiple organ failure [2, 6, 9]. Deterioration of organ function sequentially involves the lung, liver, and cardiovascular system, followed by blood, central nervous system, kidneys, and gastrointestinal tract [10].


Mean Arterial Pressure Pulmonary Capillary Wedge Pressure Hypertonic Saline Regional Blood Flow Hypertonic Solution 
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© Springer Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • U. Kreimeier
  • K. Messmer

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