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Loco-Regional Drug Delivery in Cancer Treatment, with Special Reference to Isolation Perfusion

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Book cover Drug Delivery in Cancer Treatment

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

The idea of loco-regional treatment arises from the lack of selectivity of the available chemotherapeutic agents. For most tumours the amount of drug that can be given without unacceptable effects (toxicity) on the normal tissues is not enough. The second idea is that more drug is more effective on tumour response. This is not necessarily always the case in all tumour-drug combinations. The third idea stems from the fact that malignant tumours are different in their metastasizing behaviour. Some tumours metastasize widely through the body in an early stage; others have hardly any metastasizing tendency. The ideal indication for regional therapies therefore remains limited to tumours that have for a prolonged period only a regional spread. Deviation from this concept makes only sense for tumours in a systemically inaccessible location or for palliation.

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Authors and Affiliations

  1. The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands

    S. P. Israëls

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  1. S. P. Israëls
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Editors and Affiliations

  1. Department of Surgery, Regional Hospital, S-701 85, Örebro, Sweden

    Lennart Domellöf (Head) (Head)

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© 1987 Springer-Verlag Berlin Heidelberg

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Israëls, S.P. (1987). Loco-Regional Drug Delivery in Cancer Treatment, with Special Reference to Isolation Perfusion. In: Domellöf, L. (eds) Drug Delivery in Cancer Treatment. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73077-1_6

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  • DOI: https://doi.org/10.1007/978-3-642-73077-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73079-5

  • Online ISBN: 978-3-642-73077-1

  • eBook Packages: Springer Book Archive

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