The Functional Significance of Regulatory Gene Variation: The α-Amylase Gene-Enzyme System of Drosophila melanogaster

  • A. J. Klarenberg


One of the main topics in population and evolutionary genetics has been the question whether electrophoretic variants, encoded by a single structural gene and involved in the same biochemical reaction, are selectively neutral (Nei and Koehn 1983). Only for a very few enzyme loci have selective differences between enzyme variants been established; α-amylase in the fruitfly, Drosophila melanogaster, is among the best characterized (Scharloo 1984). The significance of regulatory variation has only been recently recognized (Maclntyre 1982; Wilson 1985).


Regulatory Gene Variation Electrophoretic Variant Posterior Midgut Anterior Midgut Linkage Disequi 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abraham I, Doane WW (1978) Genetic localization of tissue-specific expression of amylase structural genes in Drosophila melanogaster. Proc Natl Acad Sci USA 75:4446–4450PubMedCrossRefGoogle Scholar
  2. Bahn E (1967) Crossing over in the chromosomal region determining amylase isozymes in Drosophila melanogaster. Hereditas 58:1–12PubMedCrossRefGoogle Scholar
  3. Boer PH, Hickey DA (1986) The alpha-amylase gene in Drosophila melanogaster: nucleotide sequence, gene structure and expression motifs. Nucl Acids Res 21:8399–8411CrossRefGoogle Scholar
  4. De Jong G, Scharloo W (1976) Environmental determination of selective significance or neutrality of amylase variants in Drosophila melanogaster. Genetics 84:77–94PubMedGoogle Scholar
  5. Hoorn AJW, Scharloo W (1980) Functional significance of amylase polymorphism in Drosophila melanogaster. III. Ontogeny of amylase and some α-glucosidases. Biochem Genet 18:51–63PubMedCrossRefGoogle Scholar
  6. Klarenberg AJ (1986) Genetic variation in regulation of a-amylase expression in Drosophila melanogaster. Thesis, Rijksuniv UtrechtGoogle Scholar
  7. Klarenberg AJ, Scharloo W (1986) Nonrandom association between structural Amy and regulatory map variants in Drosophila melanogaster. Genetics 114:875–884PubMedGoogle Scholar
  8. Klarenberg AJ, Sikkema K, Scharloo W (1986a) Functional significance of regulatory map and structural Amy variants in Drosophila melanogaster. Heredity (in press)Google Scholar
  9. Klarenberg AJ, Visser AJS, Willemse MFM, Scharloo W (1986b) Genetic localization and action of regulatory genes and elements for tissue-specific expression of a-amylase in Drosophila melanogaster. Genetics 114:1131–1145PubMedGoogle Scholar
  10. Levy JN, Gemmill RM, Doane WW (1985) Molecular cloning of the a-amylase genes from Drosophila melanogaster. II. Clone organization and verification. Genetics 110:313–324PubMedGoogle Scholar
  11. Lewontin RC (1974) The genetic basis of evolutionary change. Columbia Univ Press, New York LondonGoogle Scholar
  12. Maclntyre RJ (1982) Regulatory genes and adaptation: past, present and future. Evol Biol 15: 247–285Google Scholar
  13. Nei M, Koehn RK (1983) Evolution of genes and proteins. Sinauer, Sunderland, MassGoogle Scholar
  14. Scharloo W (1984) Genetics of adaptive reactions. In: Wöhrmann K, Loeschcke V (eds) Population biology and evolution. Springer, Berlin Heidelberg New York, pp 5–15CrossRefGoogle Scholar
  15. Wilson AC (1985) The molecular basis of evolution. Sci Am 253:148–157CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. J. Klarenberg
    • 1
  1. 1.Vakgroep Populatie- en EvolutiebiologieRijksuniversiteit UtrechtUtrechtThe Netherlands

Personalised recommendations