Can Omeprazole allow healing of certain ulcerated esophagitis?

  • J. Dent
  • G. Vantrappen
  • J. P. Isal
Conference paper


The potential of omeprazole for the therapy of peptic esophagitis has been investigated in three separate studies conducted within Australia. The minimum criterion for enrolment of patients in these studies was erosive peptic esophagitis. This was graded in severity according to the extent and appearances of ulceration in the distal 5 cm of the esophageal mucosa as follows: grade 2, less than 10% ulceration: grade 3, from 10 to 50% ulceration, and grade 4 more than 50% ulceration, or a deep chronic appearing ulcer, regardless of the area of ulceration. The first study performed was an open therapy pilot study on eight patients who were treated with omeprazole 30 mg daily for 8 weeks. Prior to this, simultaneous 3 hour post prandial recordings of esophageal motility and esophageal and gastric pH were made. These measurements were repeated during the 7th week of therapy with omeprazole. Macroscopic ulceration had healed in 7 of 8 patients after 8 weeks therapy. The esophageal pH recordings made during therapy showed abolition of all episodes of exposure of the esophagus to a pH of less than 4. This effect was dependent upon the very effective antisecretory action of omeprazole, since gastric pH was also maintained above 4. The motihty recordings showed no detectable effect of omeprazole on patterns of lower esophageal sphincter and esophageal body motor function. In particular, the frequency of gastro-esophageal reflux episodes, as determined by manometric indices of reflux, was unchanged by omeprazole therapy.


Lower Esophageal Sphincter Reflux Esophagitis Esophageal Mucosa Omeprazole Therapy Ranitidine Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Blum AL, Riecken EO, Dammann HG (1986) Comparison of omeprazole and ranitidine in the treatment of reflux esophagitis. N Engl J Med 314:716PubMedGoogle Scholar
  2. 2.
    Khnkenberg-Knol EC, Jansen JBMJ, Festen HPM (1987) Double-bhnd multicentre study comparison of omeprazole and ranitidine in treatment of reflux esophagitis. Lancet 1:349–351CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. Dent
    • 1
  • G. Vantrappen
    • 2
  • J. P. Isal
    • 3
  1. 1.AdelaideAustralia
  2. 2.LeuvenBelgium
  3. 3.ParisFrance

Personalised recommendations