Abstract
At the parietal gastric cells where hydrochloric acid is secreted there are cholinergic receptors, particularly muscarinic receptors. Pirenzepine is a pyridobenzodiazepine which blocks the Ml muscarinic receptors of the gastric wall exerting a selective anti- muscarinic action. This produces an inhibition of acid gastric secretion which is greater and more prolonged than with traditional anticholinergics. It is this action against acid secretion that has led to pirenzepine being proposed for the treatment of gastroesophageal reflux as it combats the noxious effect of the acidity of the reflux fluid.
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© 1989 Springer-Verlag Berlin Heidelberg
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Maffioli, C. (1989). What are the indications of pirenzepine?. In: Giuli, R., McCallum, R.W. (eds) Benign Lesions of the Esophagus and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73055-9_77
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DOI: https://doi.org/10.1007/978-3-642-73055-9_77
Publisher Name: Springer, Berlin, Heidelberg
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