What are the indications of pirenzepine?

  • C. Maffioli
Conference paper

Abstract

At the parietal gastric cells where hydrochloric acid is secreted there are cholinergic receptors, particularly muscarinic receptors. Pirenzepine is a pyridobenzodiazepine which blocks the Ml muscarinic receptors of the gastric wall exerting a selective anti- muscarinic action. This produces an inhibition of acid gastric secretion which is greater and more prolonged than with traditional anticholinergics. It is this action against acid secretion that has led to pirenzepine being proposed for the treatment of gastroesophageal reflux as it combats the noxious effect of the acidity of the reflux fluid.

Keywords

Placebo Acidity Cimetidine Ranitidine Esophagitis 

References

  1. 1.
    Cecconello I, Zilberstein B, Pinotti M, Pollara WM, Pugliese V, Nasi A, Pinotti HW (1986) Treatment of reflux œsophagitis with pirenzepin. Symposium 8ème Congrès Mondial de Gastroentérologie. Sao PauloGoogle Scholar
  2. 2.
    Denis P, Galmiche JP, Gibon JF, Colin R, Pasquis P, Lefrancois R (1982) Effet du pirenzepin sur la motricité œsophagienne chez l’aduhe sain. Gastroenterol Clin Biol 6: 27–31PubMedGoogle Scholar
  3. 3.
    Evreux M, Jacquet N (1984) La pirenzepine dans le traitement de l’œsophagite. Rev Fr Gastroenterol 20 (204): 18–21Google Scholar
  4. 4.
    Gouerou H (1986) Etude multicentrique pirenzepine versus cimetidine dans le traitement du reflux gastro-œsophagien. Rapport d’expertise cliniqueGoogle Scholar
  5. 5.
    Kohek PH, Rehak PH, Friehs GB (1984) Effet de la pirenzepine sur le sphincter inférieur de l’œsophage. Medwelt 35: 943–945Google Scholar
  6. 6.
    Minaire Y (1985) Etude de l’effet de la pirenzepine chez des patients porteurs d’une hypotonie du sphincter inférieur de l’œsophage. Rapport de pharmacologie cliniqueGoogle Scholar
  7. 7.
    Niemela S, Lehtola J, Krekela I, Jaaskelainen T, Martikamen J, Sarna S, Sarelin H (1986) Pirenzepin in the treatment of reflux œsophagitis: a placebo-controlled double-bhnd study. Symposium. 8ème Congrès Mondial de Gastroentérologie. Sao PauloGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. Maffioli
    • 1
  1. 1.ReimsFrance

Personalised recommendations