What are the indications of pirenzepine?

  • C. Maffioli
Conference paper


At the parietal gastric cells where hydrochloric acid is secreted there are cholinergic receptors, particularly muscarinic receptors. Pirenzepine is a pyridobenzodiazepine which blocks the Ml muscarinic receptors of the gastric wall exerting a selective anti- muscarinic action. This produces an inhibition of acid gastric secretion which is greater and more prolonged than with traditional anticholinergics. It is this action against acid secretion that has led to pirenzepine being proposed for the treatment of gastroesophageal reflux as it combats the noxious effect of the acidity of the reflux fluid.


Gastroesophageal Reflux Muscarinic Receptor Acid Gastric Secretion Parietal Gastric Cell Noxious Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. Maffioli
    • 1
  1. 1.ReimsFrance

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