What is the underlying mechanism of the toxicity of biliary acids?

  • A. Papazian
Conference paper


Various animal experimental studies have been performed to understand the intimate mechanism of the toxicity of the bile acids (BA) towards both the gastric and the esophageal mucosa. Their toxicity could be associated with their ability to solubilize the lipids of the cell membrane. In the concentrations usually observed in man, the dihydrozyl BA increase retrodiffusion of the H+ ions in significantly greater fashion than the trohydroxyl BA in the gastric mucosa of the dog, whether ischemic or nonischemic. As the dihydroxyl BA are more lipophile, it has been suggested that they produce more extensive membranous solubilization [1].


Bile Acid Bile Salt Esophageal Mucosa Bile Acid Increase Gastric Mucosal Barrier 
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  1. 1.
    Ritchie WP Jr, Felger TS (1981) Differing ulcerogenic potential of dihydroxy and trihydroxy bile acids in canine gastric mucosa. Surgery 89:342–347PubMedGoogle Scholar
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    Duane WC, Wiegand DM (1980) Mechanism by which bile salts disrupt the gastric mucosal barrier in the dog. I Clin Invest 66:1044–1049CrossRefGoogle Scholar
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    Salo JA, Lehto VP, Kivilaakso E (1983) Morphological alterations in experimental esophagitis Light microscopic and scanning and transmission electron microscopic study. Dig Dis Sci 28:440–448PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. Papazian
    • 1
  1. 1.AmiensFrance

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