What is the underlying mechanism of the toxicity of biliary acids?
Various animal experimental studies have been performed to understand the intimate mechanism of the toxicity of the bile acids (BA) towards both the gastric and the esophageal mucosa. Their toxicity could be associated with their ability to solubilize the lipids of the cell membrane. In the concentrations usually observed in man, the dihydrozyl BA increase retrodiffusion of the H+ ions in significantly greater fashion than the trohydroxyl BA in the gastric mucosa of the dog, whether ischemic or nonischemic. As the dihydroxyl BA are more lipophile, it has been suggested that they produce more extensive membranous solubilization .
KeywordsCholesterol Toxicity Trypsin Lecithin Esophagitis