Discovery of the Fallopian Tubes and Subsequent Historical Landmarks



In the context of the reproductive system, the names of Fallopius and de Graaf are widely known to students working in this now distinctive field of physiology. However, it is historians rather than physiologists who are perhaps best placed to appreciate the remarkable good fortune of Fallopius (Gabriele Fallopio 1523–1562) in the sphere of medical discovery. Almost a contemporary of Andreas Vesalius at Padua, he was at first a pupil of this distinguished anatomist and yet it was to be the name of Fallopius — and not that of his master — which would lend itself to quite specialised portions of the female genital tract. How did this situation arise? The history of earlier endeavours appears in part to be one of misinterpretation coupled with a too-willing acceptance of the dogma handed down the ages. Instead of reviewing this saga in detail, a task which itself could lead to the writing of a weighty volume, only a few highlights and personalities are touched upon in the following pages. The objective has been to pave the way for the more substantial contents of subsequent chapters.


Fallopian Tube Oestrous Cycle Acta Obstet Gynecol Distinguished Anatomist Seminal Duct 
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  1. Andersen DH (1927a) Lymphatics of the Fallopian tube of the sow. Contrib Embryol Carneg Instn 19:135–148Google Scholar
  2. Andersen DH (1927b) The rate of passage of the mammalian ovum through various portions of the Fallopian tube. Am J Physiol 82:557–569Google Scholar
  3. Andersen DH (1928) Comparative anatomy of the tubo-uterine junction. Histology and physiology in the sow. Am J Anat 42:255–305CrossRefGoogle Scholar
  4. von Baer KE (1827) De ovi mammalium et hominis genesi. LeipzigGoogle Scholar
  5. Barry M (1843) Spermatozoa observed within the mammiferous ovum. Phil Trans Roy Soc B 133:33CrossRefGoogle Scholar
  6. Bischoff TLW (1842) Entwicklungsgeschichte des Kanincheneies. BraunschweigGoogle Scholar
  7. Bischoff TLW (1854) Entwicklungsgeschichte des Rehes. GießenGoogle Scholar
  8. Blundell J (1819) Experiments on a few controverted points respecting the physiology of generation. Med Chir Soc Trans 10:245–272Google Scholar
  9. Bodemer CW (1969) History of the mammalian oviduct. In: Hafez ESE, Blandau RJ (eds) The mammalian oviduct. University of Chicago Press, Chicago, pp 3–26Google Scholar
  10. Borland RM, Biggers JD, Lechene CP, Taymor ML (1980) Elemental composition of fluid in the human Fallopian tube. J Reprod Fertil 58:479–482PubMedCrossRefGoogle Scholar
  11. Brenner R (1969a) The biology of oviductal cilia. In: Hafez ESE, Blandau RJ (eds) The mammalian oviduct. University of Chicago Press, Chicago, pp 203–229Google Scholar
  12. Brenner R (1969b) Renewal of oviduct cilia during the menstrual cycle in the Rhesus monkey. Fertil Steril 20:599–611Google Scholar
  13. Brundin J (1964) The distribution of noradrenaline and adrenaline in the Fallopian tube of the rabbit. Acta Physiol Scand 62:156–159PubMedCrossRefGoogle Scholar
  14. Corner GW (1921) Abnormalities of the mammalian embryo occurring before implantation. Contrib Embryol Carneg Instn 13:61–66Google Scholar
  15. Corner GW (1923) Cyclic variation in uterine and tubal contraction waves. Am J Anat 32:345–351CrossRefGoogle Scholar
  16. Coutinho EM, Maia H (1971) The contractile response of the human uterus, Fallopian tubes and ovary to prostaglandins in vivo. Fertil Steril 22:539–543PubMedGoogle Scholar
  17. Cruickshank W (1797) Experiments in which, on the third day after impregnation, the ova of rabbits were found in the Fallopian tubes; and on the fourth day after impregnation in the uterus itself; with the first appearance of the foetus. Phil Trans Roy Soc 87:197–214CrossRefGoogle Scholar
  18. De Graaf R (1672) De mulierum organis generationi inservientibus. LeydenGoogle Scholar
  19. Estes WL Jr (1924) Ovarian implantation. Surg Gynecol Obstet 38:394–398Google Scholar
  20. Estes WL Jr, Heitmeyer PL (1934) Pregnancy following ovarian implantation. Am J Surg 24:563–580CrossRefGoogle Scholar
  21. Fallopius G (1561) Observationes anatomicae. VeniceGoogle Scholar
  22. Gomel V (1980) Microsurgical reversal of female sterilization: a reappraisal. Fertil Steril 33:587–597PubMedGoogle Scholar
  23. Green-Armytage VB (1959) Recent advances in the surgery of infertility. J Obstet Gynaecol Brit Emp 66:32–39CrossRefGoogle Scholar
  24. Greenwald GS (1961) A study of the transport of ova through the rabbit oviduct. Fertil Steril 12:80–95PubMedGoogle Scholar
  25. Greep RO (ed) (1973) Handbook of physiology. Section 7 Endocrinology II. Female Reproductive System Part II. American Physiological Society, Washington DCGoogle Scholar
  26. Hafez ESE, Blandau RJ (eds) (1969) The mammalian oviduct. University of Chicago Press, ChicagoGoogle Scholar
  27. Hamner CE, Williams WL (1965) Composition of rabbit oviduct secretions. Fertil Steril 16:170–176PubMedGoogle Scholar
  28. Harper MJK (1961) The mechanisms involved in the movement of newly ovulated eggs through the ampulla of the rabbit Fallopian tube. J Reprod Fertil 2:522–524Google Scholar
  29. Harper MJK, Pauerstein CJ, Adams CE, Coutinho EM, Croxatto HB, Paton DM (1976) Symposium on ovum transport and fertility regulation. Scriptor, CopenhagenGoogle Scholar
  30. Harvey W (1651) Exercitationes de generatione animalium. LondonGoogle Scholar
  31. Herrlinger R, Feiner E (1964) Why did Vesalius not discover the Fallopian tubes? Med Hist 8:335–341PubMedGoogle Scholar
  32. Heuser CH (1927) A study of the implantation of the ovum of the pig. Contrib Embryol Carneg Instn 19:229–243Google Scholar
  33. Heuser CH, Streeter GL (1929) Early stages in the development of pig embryos. Contrib Embryol Carneg Instn 20:1–30Google Scholar
  34. Holst PJ, Cox RI, Braden AWH (1970) The distribution of noradrenaline in the sheep oviduct. Aust J Exp Biol Med Sci 48:563–565PubMedCrossRefGoogle Scholar
  35. Horton EW, Main IHM, Thompson CJ (1965) Effects of prostaglandins on the oviduct, studied in rabbits and ewes. J Physiol 180:514–528PubMedGoogle Scholar
  36. Hunter RHF (1977) Function and malfunction of the Fallopian tubes in relation to gametes, embryos and hormones. Europ J Obstet Gynecol Reprod Biol 7:267–283CrossRefGoogle Scholar
  37. Hunter RHF (1982) Anatomy and physiology of the Fallopian tube. In: Chamberlain G, Winston R (eds) Tubal infertility: diagnosis and treatment. Blackwell Sci Publ, Oxford, pp 1–29Google Scholar
  38. Johnson AD, Foley CW (eds) (1974) The oviduct and its functions. Academic Press, New York Lams H (1913) Étude de l’oeuf de cobaye aux premiers stades de l’embryogenèse. Arch Biol Paris 28:229–323Google Scholar
  39. Leese HJ (1983) Studies on the movement of glucose, pyruvate and lactate into the ampulla and isthmus of the rabbit oviduct. Q JI Exp Physiol 68:89–96Google Scholar
  40. Leese HJ, Gray SM (1985) Vascular perfusion: a novel means of studying oviduct function. Am J Physiol 248:E624–E632PubMedGoogle Scholar
  41. Mastroianni L Jr, Shah U, Abdul-Karim R (1961) Prolonged volumetric collection of oviduct fluid ih Rhesus monkey. Fertil Steril 12:417–424Google Scholar
  42. Morton H, Hegh V, Clunie GJA (1976) Studies of the rosette inhibition test in pregnant mice: evidence of immunosuppression. Proc R Soc B 193:413–419CrossRefGoogle Scholar
  43. Nancarrow CD, Wallace ALC, Grewal AS (1981) The early pregnancy factor of sheep and cattle. J Reprod Fertil Suppl 30:191–199PubMedGoogle Scholar
  44. Nilsson O, Reinius S (1969) Light and electron microscopic structure of the oviduct. In: Hafez ESE, Blandau RJ (eds) The mammalian oviduct. University of Chicago Press, Chicago, pp 57–83Google Scholar
  45. O’Neill C (1985) Thrombocytopenia is an initial maternal response to fertilisation in mice. J Reprod Fertil 73:559–566PubMedCrossRefGoogle Scholar
  46. O’Neill C, Pike IL, Porter RN, Gidley-Baird A, Sinosich MJ, Saunders DM (1985) Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. Annls NY Acad Sci 442:429–439CrossRefGoogle Scholar
  47. Palmer R (1960) Salpingostomy — a critical study of 396 personal cases operated upon without polythene tubing. Proc R Soc Med 53:357–359PubMedGoogle Scholar
  48. Patek E (1974) The epithelium of the human Fallopian tube. Acta Obstet Gynecol Scand 53 Suppl 31:1–28CrossRefGoogle Scholar
  49. Pauerstein CJ (1975) Clinical implications of oviductal physiology and biochemistry. Gynecol Invest 6:253–264PubMedCrossRefGoogle Scholar
  50. Pauerstein CJ (1978) From Fallopius to fantasy. Fertil Steril 30:133–140PubMedGoogle Scholar
  51. Perkins JL, Goode L, Wilder WA, Henson DB (1965) Collection of secretions from the oviduct and uterus of the ewe. J Anim Sci 24:383–387PubMedGoogle Scholar
  52. Pinner O (1880) Über den Übertritt des Eies aus dem Ovarium in die Elbe beim Säugetier. Arch Physiol 241Google Scholar
  53. Roblero L, Biggers JD, Lechene CP (1976) Electron probe analysis of the elemental microenvironment of oviducal mouse embryos. J Reprod Fertil 46:431–434PubMedCrossRefGoogle Scholar
  54. Rubin IC (1920) The nonoperative determination of patency of Fallopian tubes. J Am Med Assn 75:661–666Google Scholar
  55. Rubin IC (1947) Intra-tubal insufflation. CV Mosby, St Louis MissouriGoogle Scholar
  56. Rumery RE, Eddy EM (1974) Scanning electron microscopy of the fimbriae and ampullae of rabbit oviducts. Anat Rec 178:83–102PubMedCrossRefGoogle Scholar
  57. Seckinger DL (1923) Spontaneous contractions of the Fallopian tube of the domestic pig with reference to the oestrous cycle. Bull Johns Hopkins Hosp 34:236–239Google Scholar
  58. Seckinger DL, Snyder FF (1926) Cyclic changes in the spontaneous contractions of the human Fallopian tube. Bull Johns Hopkins Hosp 39:371–378Google Scholar
  59. Sjöberg N-O (1967) The adrenergic transmitter of the female reproductive tract: distribution and functional changes. Acta Physiol Scand Suppl 305:1–32PubMedGoogle Scholar
  60. Snyder FF (1923) Changes in the Fallopian tube. during the ovulation cycle and early pregnancy. Bull Johns Hopkins Hosp 34:121–125Google Scholar
  61. Snyder FF (1924) Changes in the human oviduct during the menstrual cycle and pregnancy. Bull Johns Hopkins Hosp 35:141–146Google Scholar
  62. Sobotta J (1895) Die Befruchtung und Furchung des Eies der Maus. Arch Mikr Anat 45:15–93CrossRefGoogle Scholar
  63. Spilman CH, Harper MJK (1973) Effect of prostaglandins on oviduct motility in estrous rabbits. Biol Reprod 9:36–45PubMedGoogle Scholar
  64. Stalheim OHV, Gallagher JE, Deyoe BL (1975) Scanning electron microscopy of the bovine, equine, porcine and caprine uterine tube (oviduct). Am J Vet Res 36:1069–1075PubMedGoogle Scholar
  65. Temkin O (1956) Soranus’ gynecology. Hopkins, BaltimoreGoogle Scholar
  66. Thibault C (1972) Physiology and physiopathology of the Fallopian tube. Int J Fertil 17:1–13PubMedGoogle Scholar
  67. Thiry L (1862) Über das Vorkommen eines Flimmerepithelium auf dem Bauchfell des weiblichen Frosches. Göttinger Nachrichten 171Google Scholar
  68. Van Beneden E (1875) La maturation de l’oeuf, la fécondation et les premières phases du développement embryonnaire des mammifères d’après des recherches faites chez le lapin. Bull Acad Belg Cl Sci 40:686–689Google Scholar
  69. Van Horne J (1668) Suarum circa partes generationis in utroque sexu observationum prodromus. LeydenGoogle Scholar
  70. Vesalius A (1543) De humani corporis fabrica. BaselGoogle Scholar
  71. Westman A (1926) A contribution to the question of the transit of the ovum from the ovary to the uterus in rabbits. Acta Obstet Gynecol Scand Suppl 5:1–104CrossRefGoogle Scholar
  72. Winston RML (1980) Microsurgery of the Fallopian tube: from fantasy to reality. Fertil Steril 34:521–530PubMedGoogle Scholar
  73. Wintenberger-Torres S (1961) Mouvements des trompes et progression des oeufs chez la brebis. Ann Biol Anim Biochim Biophys 1:121–133CrossRefGoogle Scholar
  74. Wislocki GB, Guttmacher AF (1924) Spontaneous peristalsis of the excised whole uterus and Fallopian tubes of the sow with reference to the ovulation cycle. Bull Johns Hopkins Hosp 35:246–252Google Scholar
  75. Woodruff JD, Pauerstein CJ (1969) The Fallopian tube: structure, function, pathology and management. Williams and Wilkins, BaltimoreGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  1. 1.Faculty of ScienceUniversity of EdinburghEdinburghScotland, Great Britain

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