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Calcium Binding to Troponin C and the Regulation of Muscle Contraction: a Comparative Approach

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Calcium and Calcium Binding Proteins

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Muscle contraction consists of the cyclic attachment and detachment of the heads of myosin in the thick filament to actin in the thin filament. The attachment is followed by a change in the angle of myosin-actin attachment, so that the thick and thin filaments slide past each other and contractile force is generated. The energy for this process is supplied by ATP and is released by the interaction of actin with myosin, which activates the ATPase activity of myosin. The regulation of the actin-myosin-ATP interaction has been studied by analyzing the actin-activated myosin ATPase activity, which is the in vitro correlate of muscle contraction (Taylor 1979; Adelstein and Eisenberg 1980).

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  1. Division de Gastroentérologie et Nutrition, Hôpital Cantonal Universitaire, Geneva, Switzerland

    W. Wnuk

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  1. W. Wnuk
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  1. Laboratory of Muscle Biochemistry, Institute of Chemistry B6, University of Liège, Sart Tilman, 4000, Liège, Belgium

    Charles Gerday

  2. Institute of General Physiology, University of Messina, Via dei Verdi 85, 98100, Messina, Italy

    L. Bolis

  3. Laboratory of Animal Physiology, University of Liège, 22, quai Van Beneden, 4020, Liège, Belgium

    R. Gilles

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Wnuk, W. (1988). Calcium Binding to Troponin C and the Regulation of Muscle Contraction: a Comparative Approach. In: Gerday, C., Bolis, L., Gilles, R. (eds) Calcium and Calcium Binding Proteins. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73042-9_4

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