Calcium Binding to Troponin C and the Regulation of Muscle Contraction: a Comparative Approach

Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Muscle contraction consists of the cyclic attachment and detachment of the heads of myosin in the thick filament to actin in the thin filament. The attachment is followed by a change in the angle of myosin-actin attachment, so that the thick and thin filaments slide past each other and contractile force is generated. The energy for this process is supplied by ATP and is released by the interaction of actin with myosin, which activates the ATPase activity of myosin. The regulation of the actin-myosin-ATP interaction has been studied by analyzing the actin-activated myosin ATPase activity, which is the in vitro correlate of muscle contraction (Taylor 1979; Adelstein and Eisenberg 1980).


Calcium Binding Thin Filament Myosin Head Rabbit Skeletal Muscle Fast Skeletal Muscle 
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© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • W. Wnuk
    • 1
  1. 1.Division de Gastroentérologie et NutritionHôpital Cantonal UniversitaireGenevaSwitzerland

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