Serological Studies of Patients with Multiple Sclerosis, controls, and Patients with Other Neurological Diseases: Antibodies to HTLV-I, HTLV-II, HIV, and STLV-III
Retroviruses have been associated with neurological disease in man. Recently, Kaprowski et al.  reported that outbreaks of mutliple sclerosis (MS) in Key West, Florida, and in Sweden seem to be associated with increased antibody for human retroviruses. In addition, homology studies under nonstringent conditions using CSF cells derived from MS patients reacted with human T-cell leukemia virus (HTLV)-I antigen. During the past 10 years more than ten different possible agents have been suggested as causes of MS . These agents include a number of recognized viruses such as measles, canine distemper, scrapie agent, coronaviruses, and agents of unclear classification such as the MSAA (multiple sclerosis associated agent), bone marrow agent, and chimpanzee agent. We report here our studies of retrovirus antibody in a large number of sera and CSF collected from MS patients, matched controls, and patients with other neurological diseases (OND) prior to AIDS becoming a serious disease.
KeywordsMultiple Sclerosis Optic Neuritis Optical Density Reading Hairy Cell Leukemia Scrapie Agent
Unable to display preview. Download preview PDF.
- 2.Sever JL, Madden DL (1979) Viruses that do not cause multiple sclerosis. In: Boese A (ed). Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system. First International Symposium of Hertie Foundation in Frankfurt/Main, 414–424Google Scholar
- 3.Gessain A, Bavia F, Vernant JC et al. (1985) Antibodies to human ? lymphotropic virus type 1 in patients with tropical spastic parapresis. Lancet ii: 407–10Google Scholar
- 6.Ho DD, Rota TR, Schooby RT, Kaplen JC, Allan JD, Gropman JE, Resnick L, Felsentein D, Andrews CA, Hinsch MS. Isolation of HTLV-III from cerebrospinal fluid and nerve tissue of patients with neurological syndromes related to the acquired immunodeficiency syndrome. J Engl J Med 313:1493–1497Google Scholar