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Long-Term Hyperbaric Oxygen in Chronic Progressive Multiple Sclerosis: A Placebo-Controlled Double-Blind Randomized Study with Evoked Potential Evaluation

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Virology and Immunology in Multiple Sclerosis: Rationale for Therapy

Abstract

The immunosuppressive action of hyperbaric oxygen (HBOX) has been proved by experimental studies in allergic encephalomyelitis [1] and other pathologies. Since 1970, clinical studies, most of them uncontrolled and nonblind, have been set up to evaluate the possible efficacy of HBOX in patients with multiple sclerosis (MS). The results have been controversial: some trials reported a positive action of HBOX [2] while others have not shown any clinical improvement [3].

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References

  1. Warren J, Sacksteder MR, Thuning CA (1978) Oxygen immunosuppression: modification of experimental allergic encephalomyelitis in rodents. J Immunol 121:315–320

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© 1988 Springer-Verlag Berlin Heidelberg

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Barbieri, S., Pirovano, C., Cislaghi, G., Albonico, G., Oriani, G., Mariani, C. (1988). Long-Term Hyperbaric Oxygen in Chronic Progressive Multiple Sclerosis: A Placebo-Controlled Double-Blind Randomized Study with Evoked Potential Evaluation. In: Cazzullo, C.L., Caputo, D., Ghezzi, A., Zaffaroni, M. (eds) Virology and Immunology in Multiple Sclerosis: Rationale for Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73032-0_33

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  • DOI: https://doi.org/10.1007/978-3-642-73032-0_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73034-4

  • Online ISBN: 978-3-642-73032-0

  • eBook Packages: Springer Book Archive

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