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Long-Term Hyperbaric Oxygen in Chronic Progressive Multiple Sclerosis: A Placebo-Controlled Double-Blind Randomized Study with Evoked Potential Evaluation

  • S. Barbieri
  • C. Pirovano
  • G. Cislaghi
  • G. Albonico
  • G. Oriani
  • C. Mariani
Conference paper

Abstract

The immunosuppressive action of hyperbaric oxygen (HBOX) has been proved by experimental studies in allergic encephalomyelitis [1] and other pathologies. Since 1970, clinical studies, most of them uncontrolled and nonblind, have been set up to evaluate the possible efficacy of HBOX in patients with multiple sclerosis (MS). The results have been controversial: some trials reported a positive action of HBOX [2] while others have not shown any clinical improvement [3].

Keywords

Multiple Sclerosis Hyperbaric Oxygen Sphincteric Function Cerebellar Function Multiple Sclerosis Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Warren J, Sacksteder MR, Thuning CA (1978) Oxygen immunosuppression: modification of experimental allergic encephalomyelitis in rodents. J Immunol 121:315–320PubMedGoogle Scholar
  2. 2.
    Fischer BH, Marks M, Reich F (1983) Hyperbaric oxygen treatment of multiple sclerosis. A randomized, placebo-controlled, double-blind study. J Engl J Med 308:181–186Google Scholar
  3. 3.
    Barnes MP, Bates D, Cartlidge NEF, French JM, Shaw DA (1985) Hyperbaric oxygen and multiple sclerosis: short-term results of a placebo-controlled, double-blind trial. Lancet i: 297–300Google Scholar
  4. 4.
    Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW (1983) New diagnosis criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–231PubMedCrossRefGoogle Scholar
  5. 5.
    Kurtzke JF (1984) The evaluation of disability in mutliple sclerosis: In: Scheinberg L, Raine CS (eds) M.S.: experimental and clinical aspects. Ann NY Acad Sci 436Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • S. Barbieri
    • 1
  • C. Pirovano
    • 1
  • G. Cislaghi
    • 1
  • G. Albonico
    • 1
  • G. Oriani
    • 1
  • C. Mariani
    • 1
  1. 1.Istituto di Clinica Neurologica Université di MilanoMilanoItaly

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