Genetics in Multiple Sclerosis — with Special Emphasis on Twin Studies

  • A. Heltberg
Conference paper


The etiology of multiple sclerosis (MS) is largely unknown. Genetic as well as environmental factors are probably involved, and therefore it seems relevant to include genetic aspects in this symposium. An increased risk for the disease in relatives to MS patients has been demonstrated in several studies. However, the prevalence in relatives is well below 25%, which is the lowest value predicted by ordinary Mendelian inheritance — so a simple Mendelian mode of inheritance is ruled out. The discovery of an association of MS with the genetic HLA system suggests the importance of genetic factors for the development of MS. This association suggests that MS may occur only in persons with a susceptible genotype.


Multiple Sclerosis Twin Pair Twin Study Concordance Rate Multiple Sclerosis Case 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. Heltberg
    • 1
  1. 1.Department of NeurologyRoskilde AmtssygehusRoskildeDenmark

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