Abstract
Paeonia is said to be named after the Greek God Paeon. Hutchinson (1973) reported that the Paeoniaceae was considered histologically as an independent family of the dicotyledons by Worsdell in 1908, and the position of classification is intermediate between Magnoliaceae and Helleboraceae, Paeonia being rather closer to the Helleboraceae. The Paeonia genus is distributed in Spain, North Africa to Siberia, South to Central Europe and North and South America. In Japan (Pharmacopoeia Japonica, undecima, ed. by Niphonkoteishokyokai 1986), the root of Paeonia is used as a herbal medicine or “Shakuyaku”, as also the roots of the herb Paeonia lactiflora Pallas (P. albiflora Pallas var. trichocarpa Bunge = P. albiflora Pallas form. hortensis Makino) and related plants. The cortex of the woody Paeonia moutan Smis. (= P. suffruticosa Andrews) is called “Botan” (Moutan Bark, Moutan Cortex). The origin of these plants is in China. Some plants are cultivated in Nara and Hokkaido in Japan, but most crude drugs are imported from China and Korea. Plants of P japonica (Makino) Miyabe et Takeda, and P. obovata Maxim. are found as natives, but are never used as commercial resources.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aimi N, Inaba M, Watanabe M, Shibata S (1969) Chemical studies on the oriental plant drug III. Paeoniflorin, A glucoside of Chinese paeony root. Tetrahedron 25:1825–1838.
Akada Y, Kawano S, Tanase Y (1979) High-speed liquid chromatographic analysis of drugs V. Rapid estimation of paeoniflorin in paeony root. Yakugaku Zasshi 99:858–861.
Akada Y, Kawano S, Tanase Y (1980a) High-speed liquid chromatographic analysis of drugs VIII. Determination of paeoniflorin in Moutan cortex. Yakugaku Zasshi 100:224–226.
Akada Y, Kawano S, Tanase Y (1980b) Basic studies on the separation analysis of paeoniflorin and benzoic acid in plasma and serum by high-performance liquid chromatography. Bunseki Kagaku 29:727–729.
Akada Y, Kawano S, Tanase Y (1980c) High-speed liquid chromatographic analysis of drugs XII. Determination of paeoniflorin in pharmaceutical preparations including paeony root. Yakugakku Zasshi 100:961–985.
Anderson LA, Keene T, Phillipson JD (1982) Alkaloid production by leaf organ, root organ, cell suspension cultures of Cinchona ledgeriana. Planta Med 46:25–29.
Arichi S, Kubo M, Matsuda H, Tani T, Tsunaga K, Yoshikawa M, Kitagawa I (1979) Studies on Moutan cortex III. On antiinflammatory activities, pt 1. Shoyakugaku Zasshi 33:178–184.
Asagawa N, Hattori T, Ueyama M, Shinoda A, Miyake Y (1979) Determination of paeoniflorin in paeony extract by high performance liquid chromatography. Yakugaku Zasshi 99:598–601.
Baba K, Maeda T, Hayashi E (1984) Antispasmodic and analgestric effect of Shakuyaku-Kanzo-Tho, a prescription of Shakuyaku (Paeoniae Radix) and Kanzoh (Glycyrrhizae Radix). J Med Pharm Soc Wakanyaku (I):54-55.
Chmielewska I, Jachymczyk W, Kaniuga Z, Lewak S, Paszewski A, Zadrozynska E (1962) The constituents of Paeonia lactiflora flowers I. Gallotannin. Roc Chem 36:1599–1605 [cf. CA 9086:59 (1963)].
Committee of Chinese pharmacopoeia (ed) (1977) Official pharmacopoeia of China, p 269.
Hara H, Willams LHJ (1979) 45 Paeoniaceae. An enumeration of the flowering plants of Nepal, vol 2. Natural history. Trustees of British Museum London, p 23.
Harada M (1969) Pharmacological studies on herb Paeony root IV. Analysis of therapeutic effects of paeony-and licorice-containing frequent prescriptions in Chinese medicine and comparison with effects of experimental pharmacological tests. Yakugaku Zasshi 89:899–908.
Harada M, Yamashita A (1969) Pharmacological studies on the root bark of Paeonia moutan I. Central effects of paeonol. Yakugaku Zasshi 89:1205–1211.
Harada M, Yamashita A, Aburada M (1972) Pharmacological studies on the root bark of Paeonia moutan II. Antiinflammatory effect, preventive effect on stress-induced gastric erosion, inhibitory effect on gastric juice serection and other effects of paeonol. Yakugaku Zasshi 92:750–756.
Hashimoto T, Yamada Y (1980) Scopolamine production in suspension cultures and redifferentiated roots of Hyoscyamus niger. Planta Med 47:195–199.
Hattori M, Yue-Zhong S, Shimizu M, Namba T (1985a) Metabolism of paeoniflorin and related compounds by human intestinal bacteria. Chem Pharm Bull 33:3838–3846.
Hattori M, Yue-Zhong S, Shimizu M, Namba T (1985b) Metabolism of albiflorin by human intestinal bacteria. J Med Pharm Soc Wakanyaku 2:398–404.
Hayashi K (1939) Studien über Anthocyane I. Isolierung des Paeonins aus den Blüten von Paeonia albiflora var. hortensis. Acta Phytochem 11:81–89.
Hayashi K (1980) Plant pigment, an introduction to research and experiments. Yokendo, Tokyo, pp 159–160, 301, 304, 442.
Hayashi T, Kurosawa S, Shimizu M, Morita N (1985) Studies on muscle relaxants in Paeonia Radix, effect of heat on stability of paeoniflorigenone. Shoyakugaku Zasshi 39:214–217.
Hirai A, Terano T, Hamazaki T, Tahara K, Saito H, Tamura Y, Kumagai A (1983) Studies on the antiaggregatory effects of Moutan cortex and paeonol. Proc Symp Wakanyaku 16:114–118.
Ho Liyi, Feng Ruizhi, Xiao Peigen (1980) The occurrence of paeoniflorin in the genus Paeonia. Acta Pharm Sin 15:429–433.
Huiying L, Shouzhen L, McCabe T, Clardy J (1984) A new monoterpene glucoside of Paeonia lactiflora. Planta Med 50:501–504.
Hutchinson J (1973) The families of flowering plants, 3rd edn. Clarendon, New York, pp 492–493.
Institute of pharmacy, Chinese ministry of sciences (ed) (1979) Chinese pharmacopoeia, vol 1. Peoples Hygienic Publ, pp 182-192.
Institute of plants, Chinese ministry of sciences (1972) Encyclopedia of higher plant in China, vol 1. Sci Publ, pp 651-654.
Ishidoya T (1941) Chinese Drogen. Pharmakol Inst Kaiserl Univ Keijo, Korea, pp 78–80, 410.
Kanaoka M, Yano S, Kato H, Nakanishi K, Yoshizaki M (1984) The studies for EIA on paeoniflorin of paeony root. J Med Pharm Soc Wakanyaku 1:42–43.
Kaneda M, Iitaka Y, Shibata S (1972) Chemical studies on the oriental plant drugs XXXIII. The absolute structures of paeoniflorin, albiflorin, oxypaeoniflorin and benzoylpaeoniflorin isolated from Chinese paeony root. Tetrahedron 28:4309–4317.
Kariyone T, Takahashi M, Takaishi K (1956a) Studies on glycosides VII. Components of Paeonia suffruticosa Andr. (1) Studies on glucosides VIII. Yakugaku Zasshi 76:917–919.
Kariyone T, Takahashi M, Takaishi K (1956b) Components of Paeonia suffruticosa Andr. (2). Yakugaku Zasshi 76:920–921.
Kasprzyk Z, Kochman K, Pass L (1963) The constituent of paeony flowers (Paeonia albiflora) petroleum ether extractives. Bull Acad Polon Ser, Sci Biol 10:457–461 [cf. CA, 10508, 58].
Kitagawa I, Yoshikawa M, Tsunaga K, Tani T (1979) Studies on Moutan cortex (II). On the chemical constituents. Shoyakugaku Zasshi 33:171–177.
Koeloen JK, Grass GG (1982) Partial purification and properties of tropine dehydrogenase from root cultures of Datura stramonium. Planta Med 44:227–230.
Konoshima M, Kano Y, Otsuka K, Ihara J (1973) Chemical evaluation on moutan cortex (mudanpiroot bark of Paeonia moutan Sim.). Shoyakugaku Zasshi 27:124–128.
Koso new medical institute (1978) Dictionary of Chinese medicine, vol A. Sci Tech Publ, Shanghai, pp 706–709.
Kubo M, Matsuda H, Izumi S, Tani T, Arichi S, Yoshikawa M, Kitagawa I (1982) Studies on moutan cortex (VI). Inhibitory effects on the intravascular coagulation, pt 1. Shoyakugaku Zasshi 36:70–77.
Li Yulong, Wu Deyu, Pan Shulong, Xu Shaoli, Wei Zhiming, Xu Zi-hong, Li Xiaojuan (1984) In vitro propagation of Paeonia suffruticosa. Kexue Tongbao 29:1975–1978.
Linsmaier EM, Skoog F (1965) Organic growth factor requirements of tobacco tissue cultures. Physiol Plant 18:100–127.
Maeda T, Shizuka K, Okabe T, Hayashi M (1982) Antispasmodic effect of Shakuyaku-Kanzo-Tho, a prespriction of Shakuyaku (Paeoniae Radix) and Kanzoh (Glycyrrhizae Radix). Proc Symp Wakanyaku 15:83–88.
McLean RC, Ivimey-Cook WR (1986) Text book of theoretical botany, vol 2. Longman, Western Printing, Bristol pp 1143–1627.
Mitsuma T, Itoh T, Bandoh M, Terasawa T, Imadaya A, Tosa T (1983) A haemotological study of the anti-blood stasis prescription (Ku-Oketsu-Zai) in the Chino-Japanese medicine effects on the blood viscosity. Proc Symp Wakanyuka 16:119–122.
Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15:473–497.
Nanking pharmaceutical institute (1959) Materials for medicine. Shoka, pp 326-333.
Niphonkoteishokyokai (ed) (1986) Pharmacopoeia Japonica editio undecima. Hirokawa, Tokyo, pp 1191–1192, 1376-1377.
Nishizawa M, Yamagishi T (1979) Chemical studies on Paeoniae Radix, pt 2. Determination of gallic acid in Paeoniae Radix. Doeikenshoho 29:5–7.
Nishizawa M, Yamagishi T, Horikoshi T, Homma N (1979) Chemical studies on Paeoniae radix, pt 1. Quantitative determination of glucosides in Paeoniae Radix. Shoyakugaku Zasshi 33:65–71.
Nishizawa M, Yamagishi T, Nonaka G, Nishioka I, Nagasawa T, Oura H (1983) Tannins and related compounds XII. Isolation and characterization of galloylglucoses from Paeoniae Radix and their effect on urea-nitrogen concentration in rat serum. Chem Pharm Bull 31:2593–2600.
Nishizawa M, Yamagishi T, Nonaka G, Nishioka I (1984) Quantitative determination of Gallotannin in Paeoniae Radix. Yakugaku Zasshi 104:1244–1250.
Nitsch JP, Nitsch C (1956) Auxin dependent growth of excised Helianthus tuberosus tissues. Am J Bot 43:839–851.
Ohta T, Mihashi S, Saheki Y, Wakabayashi K (1960) Bacteriostatic effect of Paeonol, the main component of Moutan radix on some bacteria causing Appendicitis. Shoyakugaku Zasshi 14:100–102.
Okugawa H, Moriyasu M, Kato A, Matsumoto K, Fujioka A, Hashimoto Y (1985) Evaluation of crude drugs by the combination of enfleurage and chromatography (I). Paeonol in Moutan cortex and Paeoniae Radix Shoyakugaku Zasshi 39:223–227.
Ono K, Harashima S (1981) Induction of haploid callus from isolated microspores of peony in vitro. Plant Cell Physiol 22:337–341.
Ono K, Tsukida T (1978) Haploid callus formation from anther cultures in a cultivar of Paeonia. Jpn J Genet 53:51–54.
Shibata S, Nakahara M (1963) Studies on the constituents of Japanese and Chinese paeony crude drugs VIII. Paeoniflorin, a glucoside of Chinese paeony root. Chem Pharm Bull 11:327–378.
Shibata S, Nakahara M, Aimi N (1963) Studies on the constituents of Japanese and Chinese crude drugs XI. Paeoniflorin, a glucoside of Chinese paeony root (2). Chem Pharm Bull 11:327–378.
Shibata S, Inaba M, Aimi N (1966) The occurrence of paeoniflorin in the plant of Paeonia spp. Shoyakugaku Zasshi 20:37–39.
Shibutani S, Nagasawa T, Oura H, Nonaka G, Nishioka I (1981) Effect of extract from Paeoniae Radix on urea-nitrogen concentration in rat serum I. Chem Pharm Bull 29:874–878.
Shimizu M, Hashimoto T, Ishikawa S, Kurosaki F, Morita N (1979) Analysis of constituents in crude drugs by high-speed liquid chromatography. I. Quantitative analysis of paeoniflorin in paeony roots. Yakugaku Zasshi 99:432–435.
Shimizu M, Hayashi T, Morita N, Kimura I, Kimura M (1981) Paeoniflorigenone, a new monoterpene from paeony roots. Tetrahedron Lett 22:3069–3070.
Shimizu M, Hayashi T, Morita N, Kiuchi F, Noguchi H, Iitaka Y, Sankawa U (1983) The structure of paeoniflorigenone, a new monoterpene isolated from Paeonia Radix. Chem Pharm Bull 31:755–783.
Stahl E, Cooper S (1969) Untersuchungen über Inhaltsstoffe von Paeonia-Arten. Arch Pharm 302:685–690.
Sunderland N, Dunwell JM (1974) Pathways in pollen embryogenesis. In: Street HE (ed) Tissue culture and plant science. Academic Press, London New York, pp 141–167.
Sunderland N, Dunwell JM (1977) Anther and pollen culture. In: Street HE (ed) Plant tissue and cell culture, 2nd edn. Blackwell, Oxford, pp 223–265.
Swain T (1963) Chemical plant taxonomy. Methylation pattern anthocyanines. Academic Press, London New York, pp 376–377.
Tabata M, Yamamoto H, Hiraoka N (1970) Alkaloid production in the tissue cultures of some solanaceous plants. Proc 2nd Int Congr Plant tissue cell culture, Strasburg, Fr, pp 389-402.
Tabata M, Yamamoto H, Hiraoka N, Marumoto Y, Konoshima M (1971) Regulation of nicotine production in tobacco tissue culture by plant growth regulators. Phytochemistry 10:723–729.
Tabata M, Yamamoto H, Hiraoka N, Konoshima M (1972) Organization and alkaloid production in tissue cultures of Scopolia parviflora. Phytochemistry 11:949–955.
Takagi K, Harada M (1969a) Pharmacological studies on herb paeony root. I. Central effects of paeoniflorin and combined effects with licorice component FM100. Yakugaku Zasshi 89:879–886.
Takagi K, Harada M (1969b) Pharmacological studies on herb paeony root. II. Antiinflammatory effect, inhibitory effect on gastric juice secretion, preventive effect on stress ulcer, antidiuretic effect of paeoniflorin and combined effects with licorice component FM100. Yakugaku Zasshi 89:887–892.
Takagi K, Harada M (1969c) Pharmacological studies on herb paeony root III. Effect of paeoniflorin on circulatory and respiratory system and isolated organs. Yakugaku Zasshi 89:893–898.
Tani T, Katsuki T, Kubo M, Arichi S, Kitagawa I (1980a) Studies on Moutan Cortex (IV). Distribution of paeonol in the root of Paeonia moutan from Nara prefecture. Shoyakugaku Zasshi 34:292–298.
Tani T, Katsuki T, Matsuda H, Kubo M, Arichi S, Yoshikawa M, Kitagawa I (1980b) Studies on Moutan Cortex (V). Distribution of monoterpene glucosides in the root of Paeonia moutan from Nara prefecture. Shoyakugaku Zasshi 34:299–305.
Tani T, Katsuki T, Kosoto H, Arichi A, Kubo M, Matsuda H, Kimura Y, Kitagawa I, Yoshikawa M (1981) Studies on Moutan cortex from various view point. Proc Symp Wakanyaku 14:86–92.
Thieme G (1938) Lehrbuch der biologischen Heilmittel von Gerhard Madaus (transi Yamagishi A, Nagasawa M (1978) Niphonkoigakushiryocenter, Tokyo, p 244).
Tutin TG, Heywood VH, Burges NA, Vatentine DH, Waleers SM, Wess DA (eds) (1964) Flora europea I. Univ Press, Cambridge, pp 234–244.
Wenzel DG, Haskell AR (1952) Pharmacological actions of Paeonia officinalis. J Am Pharm Assoc 41:162–194.
Yamagishi T, Kinoshita Y, Mori M (1976) Studies on the standardization of crude drugs produced in Hokkaido, pt XI. Chemical evaluation on Paeoniae Radix pt 1. Doeikenshopho 26:32–36.
Yamamoto H, Tomimori T (1981) Studies of the fundamental condition on growth and alkaloid formation of the callus cultures of Coptis japonica var. japonica (1). Shoyakugaku Zasshi 35:1–8.
Yamamoto H, Ishida M, Tomimori T (1981) Studies of the fundamental condition and growth and alkaloid formation of the callus cultures of Coptis japonica var. japonica (III). Effects of cloning and mutagents. Shoyakugaku Zasshi 35:15–21.
Yamamoto H, Kitayama A, Tomimori T (1982) Growth and paeoniflorin in Paeonia lactiflora callus cultures. In: Fujiwara A (ed) Plant tissue culture 1982. Maruzen, Tokyo, pp 351–352.
Yamamoto H, Kitayama A, Tomimori T (1985) Root differentiation and paeoniflorin production in Paeonia lactiflora callus cultures. Shoyakugaku Zasshi 39:185–189.
Yamamoto H, Chatani N, Watanabe K, Tomimori T (1986a) Effects of carbon sources on the growth and flavonoid formation of Scutellaria baicalensis stem callus cultures. Shoyakugaku Zasshi 40:19–25.
Yamamoto H, Chatani N, Watanabe K, Tomimori T (1986b) Effect of culture periods on the growth and flavonoid formation of Scutellaria baicalensis stem callus culture. Shoyakugaku Zasshi 40:26–32.
Yamamoto H, Chatani N, Watanabe K, Tomimori T (1986c) Effects of 5% maltose and plant growth regulators on the callus growth and flavonoid formation of some Scutellaria baicalensis stem callus lines. Shoyakugaku Zasshi 40:33–39.
Yoneda K, Ohta Y, Tsujimoto S (1975) Seed biology of medicinal plants. II. The studies on the germination of Paeonia albiflora Pallas by embryo culture (1). Shoyakugaku Zasshi 29:6–9.
Yoshizaki M, Tomimori T, Yoshioka N, Namba T (1977) Fundamental studies on the evaluation of the crude drugs. V. Quantitative analysis of constituents in crude drugs by rod-thin-layer chromatography with FID (2). Determination of paeoniflorin and albiflorin in paeony roots. Yakugaku Zasshi 97:916–921.
Zenkteler M, Misiura E, Pointka A (1975) Induction of androgenic embryoids in the vitro cultured anthers of several species. Experientia 3:289–291.
Zito SW, Staba EJ (1982) Thebaine from root cultures of Papayer bracteatum. Planta Med 45:53–54.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Yamamoto, H. (1988). Paeonia spp.: In Vitro Culture and the Production of Paeoniflorin. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants I. Biotechnology in Agriculture and Forestry, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73026-9_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-73026-9_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73028-3
Online ISBN: 978-3-642-73026-9
eBook Packages: Springer Book Archive