Abstract
Berberine-containing plants have been used for more than 2000 years in traditional folk medicine for therapeutic treatment. Berberine alkaloids are widely distributed in plants of the families Berberidaceae, Ranunclaceae, Menispermaceae and Rutaceae. Coptis species (Ranunclaceae) and Phellodendron amurense (Rutaceae), typical berberine-containing plants, have been frequently used as a folk antidysenteric in Japan and East Asia, effective by its berberine alkaloids. Another berberine-containing plant, Berberis aristata (Berberidaceae) was used for cholera and other bacterial diarrhoea. The protoberberine alkaloids and their derivatives show at least four types of biological activity: antimicrobial, uterine, anti-inflammatory, and antileukemic and antineoplastic. (Kondo 1976; Otsuka et al. 1981). Protoberberines and their derivatives as potential anticancer agents have been reviewed (Suffness and Coroell 1985) and their chemistry has also been reviewed (Kondo 1976). The cultivation of the rhizome of Coptis species is very slow, and takes 5–6 years to use as the raw material and as a source of berberine. The price of Coptis rhizome is at present very high (20 000 yen/kg, 1983 in Japan), almost the same as that of Panax ginseng.
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References
Chadha YR (ed) (1976) Wealth of India raw materials, vol 10. CSIR, New Delhi.
Fujita E, Tomimatsu T (1956) Studies on the alkaloids of Thalictrum thunbergii DC. I. A quaternary base in the root. Chem Pharm Bull 4:489–491.
Fujita E, Tomimatsu T (1959) Studies on the alkaloids of Thalictrum thunbergii DC. III. On the structure of takatonine, quaternary base of “Takato gusa”. Yakugaku Zasshi 79:1082–1086.
Furuya T, Syōno K, Ikuta A (1972) Isolation of berberine from callus tissue of Coptis japonica. Phytochemistry 11:175.
Furuya T, Yoshikawa T, Kiyohara H (1983) Alkaloid production cultured cells of Dioscoreophyllum cumminii. Phytochemistry 22:1671–1673.
Hinz H, Zenk MH (1981) Production of protoberberine alkaloids by cell suspension cultures of Berberis species. Naturwissenschaften 68:620–621.
Ikuta A, Itokawa H (1980) Accumulation of berberine and the related alkaloids in callus tissue of Thalictrum thunbergii. Planta Med 39:283.
Ikuta A, Itokawa H (1982a) Berberine and other protoberberine alkaloids in callus tissue of Thalictrum minus. Phytochemistry 21:1419–1421.
Ikuta A, Itokawa H (1982b) Studies on the alkaloids from tissue culture of Nandina domestica. In: Fujiwara A (ed) Plant tissue culture 1982. Maruzen, Tokyo, pp 315–316.
Ikuta A, Syōno K, Furuya T (1975) Alkaloids in plants regenerated from Coptis callus cultures. Phytochemistry 14:1209–1210.
Kondo Y (1976) Organic and biological aspects of berberine alkaloids. Heterocycles 4:197–219.
Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15:473–497.
Nakagawa K, Konagai A, Fukui H, Tabata M (1984) Release and crystallization of berberine in the liquid medium of Thalictrum minus cell suspension cultures. Plant Cell Rep 3:254–257.
Otsuka H, Fujimura H, Sawada T, Goto M (1981) Studies on anti-inflammatory agents II. Anti-inflammatory constituents from rhizome of Coptis japonica Makino. Yakugaku Zasshi 101:883–890.
Reinhard E (1967) Probleme der Produktion von Arzneistoffen durch pflanzliche „Gewebe-Kulturen”. Dtsch Apotheker Z 107:1201–1207.
Satake Y, Ohwi J, Kitamura S, Watari S, Tominari T (eds) (1983) Wild flowers of Japan. Heibonsha, Tokyo.
Sato F, Yamada Y (1984) High berberine producing cultures of Coptis japonica cells. Phytochemistry 23:281–285.
Shamma M, Dudock BS (1965) Thalictrum Alkaloids II. Thalidastine. Tetrahedron Lett 3825-3828.
Shamma M, Greenberg M, Dudock BS (1965) Thalictrum alkaloids 1 Thalifenderine and Thalifendine. Tetrahedron Lett 3595-3598.
Suffness M, Coroell GA (1985) Antitumor alkaloids. In: Bross A (ed) The Alkaloids. Chemistry and Pharmacology XXV. Academic Press, London New York, pp 189–198.
Syōno K, Furuya T (1972) The differentiation of Coptis plants in vitro from callus cultures. Experientia 28:236.
Tomimatsu T (1967) The alkaloids of Thalictrum plants (II). Tokushima Daigaku Yakugaku Kenkyu Nempo 16:40–63.
Tomimatsu T (1976) The alkaloids of Thalictrum plants. III. Syoyakugaku Zasshi 30:1–17.
Tomimatsu T, Matsui M, Uji A, Kanda Y (1962) Studies on the alkaloids of Thalictrum thunbergii DC XII. Difference of quaternary bases by the growth district of plants. Yakugaku Zasshi 82:1560–1563.
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© 1988 Springer-Verlag Berlin Heidelberg
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Ikuta, A., Itokawa, H. (1988). Berberine: Production Through Plant (Thalictrum spp.) Cell Cultures. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants I. Biotechnology in Agriculture and Forestry, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73026-9_15
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DOI: https://doi.org/10.1007/978-3-642-73026-9_15
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