Geliperm Treatment of Skin Graft Donor Sites and Other Wounds in Animals and Human Subjects
It was over 20 years ago that investigators found that a moist environment enhances epithelialization of partial thickness excision wounds [1, 2]. Despite this finding, the moist treatment of wounds, such as skin graft donor sites, is still not widespread. Much of the difficulty is due to the fact that the occlusive [3–5] and semi-occlusive [6–9] films used to provide a moist environment result in undesirable fluid accumulation under the film. This condition may potentiate infection, as it generally leads to leakage of fluid from the wound site, contaminating surrounding areas. In addition, as the film is lifted from the surface of the skin by the accumulating fluid, bacteria can be given access to the wound site. New hydrogel materials [10–18] can provide a moist environment while absorbing some of the excess fluid exudate and, therefore, can be beneficial for the treatment of skin wounds.
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