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Indium-111 Platelet-Scintigraphy in Stroke Patients

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Abstract

In 1976 Thakur et al. [47] succeeded in labelling human platelets with an indium-111 8-hydroxychinoline complex (oxine). In the beginning, 111In-labelled platelets were used in hematologic disorders to estimate the platelet life span and the site of platelet destruction, e.g., in Werlhof’s disease [22, 34]. Since 111In is a gamma-emitting isotope, the recording of gamma-camera images became possible, thereby making visible the incorporation of radiolabeled platelets in thrombus formations.

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References

  1. Aas KA, Gardner FH (1958) Survival of blood platelets labeled with chromium. J Clin Invest 37: 1257–1268

    Article  PubMed  CAS  Google Scholar 

  2. Bridgers SL, Strauss E, Smith EO, Reed D, Ezekowitz MD (1986) Demonstration of superior sagittal sinus thrombosis by Indium-111-platelet-scintigraphy. Arch Neurol 43: 1079–1081

    PubMed  CAS  Google Scholar 

  3. Bousser MG, Chiras J, Bories I, Castaigne P (1985) Cerebral venous thrombosis: a review of 38 cases. Stoke 16: 199–214

    CAS  Google Scholar 

  4. Caplan LR, Hier DB, D’Cruz JD (1983) Cerebral embolism in the Michael Reese stroke registry. Stroke 14: 530–536

    Article  PubMed  CAS  Google Scholar 

  5. Clarke-Pearson DL, Coleman RE, Siegel R, Synan JS, Petry N (1985) Indium-111 platelet imaging for the detection of deep venous thrombosis and pulmonary embolism in patients without symptoms after surgery. Surgery 98: 98–104

    PubMed  CAS  Google Scholar 

  6. Cunnigham DA, Kumar B, Siegel BA, Gilula LA, Totty WG, Welch MJ (1984) Aspirin inhibition of platelet deposition at angioplasty sites: demonstration by platelet scintigraphy. Radiology 151: 487–490

    Google Scholar 

  7. Danpure HJ, Osman S, Brady F (1982) The labelling of blood cells in plasma with 111-In- tropolone. Br J Radiol 55: 247–249

    Article  PubMed  CAS  Google Scholar 

  8. Davis HH, Heaton WA, Siegel BA, Mathias CJ, Joist JH, Sherman LA, Welch MJ (1978) Scintigraphic detection of atherosclerotic lesions and venous thrombi in man by Indium-111-labelled autologous platelets. Lancet 1: 1185–1187

    Article  PubMed  CAS  Google Scholar 

  9. DeMaria AN, Bommer W, Neumann A, Grehl T, Weinart L, Nardo S, Amstertam EA, Mason TD (1979) Left ventricular thrombi identified by cross-sectional echocardiography. Ann Intern Med 90: 14–18

    PubMed  CAS  Google Scholar 

  10. Dewanjee MK, Fuster V, Kaye MP, Josa M (1978) Imaging platelet deposition with Indium-Ill-labeled platelets in coronary artery bypass grafts in dogs. Mayo Clin Proc 53: 327–331

    PubMed  CAS  Google Scholar 

  11. Dewanjee MK, Rao SA, Didisheim P (1981) Indium-111-tropolone, a new high affinity platelet label. Preparation and evaluation of labeling parameters. J Nucl Med 22: 981–988

    Google Scholar 

  12. Dewanjee MK, Solis E, Lenker J, Tidwell C, Mackey S, Didisheim P, Kaye MP (1986) Quantification of platelet and fibrinogen-fibrin deposition on components of tissue valves ( Ionescu-Shiley) in calves. Trans Am Soc Artif Intern Organs 32: 591–596

    Google Scholar 

  13. Ericus MS, Chandler WF, Ford JW, Swanson DP, Burke JC (1984) Effect of different aspirin doses on arterial thrombosis after canine carotid endarterectomy: a scanning electron microscope and Indium-111-labelled platelet study. Neurosurgery 14: 198–203

    Article  Google Scholar 

  14. Ezekowitz MD, Cox AC, Smith EO, Taylor FB (1981) Failure of aspirin to prevent incorporation of indium-Ill platelets into cardiac thrombi in man. Lancet 2:440 - 443

    Google Scholar 

  15. Ezekowitz MD, Burrow RD, Heath PW, Streitz T, Smith EO, Parker DE (1983) Diagnostic accuracy of Indium-111-platelet scintigraphy identifying left ventricular thrombi. Am J Cardiol 51: 1712–1716

    Article  PubMed  CAS  Google Scholar 

  16. Fitscha P, Kaliman J, Sinzinger H (1985) Gamma-camera imaging after autologous platelet labeling with 11-In-oxine sulfate: a key for assessing the efficacy of prostacyclin treatment in active atherosclerosis? In: Schror (ed) Prostacyclins and other eicosanoids in the cardiovascular system. Karger, Basel, pp 252–357 (Proc 2nd Int Symp, Nurnberg Furth 1984 )

    Google Scholar 

  17. Goldman M, Hall C, Dykes J, Hawker J, McCollum CM (1983) Does 111-Indium-platelet deposition predict patency in prosthetic arterial grafts. Br J Surg 70: 635–638

    Article  PubMed  CAS  Google Scholar 

  18. Goldman M, Leung JO, Aukland A, Hawker RJ, Drolc Z, McCollum CM (1983) 111-Indium platelet imaging, Doppler spectral analysis and angiography compared in patients with transient cerebral ischemia. Stroke 14: 752–759

    Google Scholar 

  19. Grimley RP, Rafigi E, Hawker RJ, Drolez A (1981) Imaging of Indium-111-labeled platelets: a new method for the diagnosis of deep vein thrombosis. Br J Surg 68: 714–716

    Article  PubMed  CAS  Google Scholar 

  20. Henningsen H, Kessler C, Reuther R, Bihl H, Allenberg J, Antalics I, Nemetschek H (1985) In- dium-111-platelet-scintigraphy for detection of carotid artery atherosclerosis. In: Nestel JB (ed) Proceedings of the poster communications. 7th international symposium on atherosclerosis, Melbourne

    Google Scholar 

  21. Henningsen H, Kessler C, Reuther R (1986) Dual isotope scintigraphy of the carotid arteries. In: Balas P (ed) Progress in angiology. Minerva Medica, Turin, pp 95–98

    Google Scholar 

  22. Heyns du Pont, Loetter MG, Badenhorst PN, de Kock F, Pieters H, Herbst C, van Reenen OR, Kotze H, Minaar PC (1982) Kinetics and sites of destruction of 111-Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study. Am J Hematol 12: 167–171

    Google Scholar 

  23. Isaka Y, Kimura K, Yoneda S, Kusnucki M, Etani H, Osamu U, Tsuda Y, Abe H (1984) Platelet accumulation in carotid atherosclerosic lesions: Semiquantitative analysis with Indium-Ill platelet and Technetium-99m human serum albumin. J Nucl Med 25: 556–563

    PubMed  CAS  Google Scholar 

  24. Kessler C, Kniffert T, Botch H (1980) Der Nutzen der Plattchenszintigraphie zur Aufklarung in- trakranieller vaskularer Prozesse. Akt Neurol 7: 27–29

    Article  Google Scholar 

  25. Kessler C, Trabant R (1982) Thrombozytensuzintgigraphyie mit Indium-111. Arch Psychiat Nervenkr 231: 449–457

    Article  PubMed  CAS  Google Scholar 

  26. Kessler C, Reuther R, Berentelg J, Kimmig B (1983) The clinical use of platelet scintigraphy with 111-In-oxine. J Neurol 229: 255–261

    Article  PubMed  CAS  Google Scholar 

  27. Kessler C, Reuther R, Kimmig B, Pietzsch T (1984) Dual isotope scintigraphy in stroke patients. Neuroradiology 26: 113–117

    Article  PubMed  CAS  Google Scholar 

  28. Kessler C, Kniffert T, Reuther R, Kimmig B, zum Winkel K (1984) Die Szintigraphie mit 111-In markierten Blutplattchen. Dtsch Med Wochenschr 109: 1853–1859

    Article  PubMed  CAS  Google Scholar 

  29. Kessler C, Henningsen H, Bihl H (1986) Interobserver reproducibility of Indium-111 platelet carotid scintigraphy and its correlation to computerized analysis. In: Reisner T, Binder H, Deisenhammer E (eds) Advances in neuroimaging. Second international congress for clinical neuroimaging Vienna. Verlag der Wiener Medizinischen Akademie, Vienna, pp 110–114

    Google Scholar 

  30. Kessler C, Henningsen H, Reuther R, Kimmig B (1987) Identification of cardiac thrombi in stroke patients with Indium-111 platelet scintigraphy. Stroke (in press)

    Google Scholar 

  31. Klonizakis J, Peters AM, Fitzpatrick ML, Kensett MJ, Lewis SM, Lavender JP (1980) Radionuclide distribution following injection of Indium-111-labelled platelets. Br J Haematol 46: 595–602

    Article  PubMed  CAS  Google Scholar 

  32. Loewinger R, Berman M (1968) A scheme for absorbed-dose calculation for biologically-distributed radionuclides. J Nucl Med (Suppl) l: 9–14

    Google Scholar 

  33. Panel of diagnostic application on radioisotopes in haematology, international committee for standardization in haematology (1977): recommended methods for radioisotop platelet survival studies. Blood 50:1137–1144

    Google Scholar 

  34. Peters AM, Klonizakis I, Lavender JP, Lewis SM (1980) Use of 111-Indium-labeled platelets to measure spleen function. Br J Haemat 46: 587–589

    Article  CAS  Google Scholar 

  35. Peters AM, Lavender JP (1981) Imaging vascular lesions with Indium-111-labeled platelets. Circulation 64: 1297–1298

    PubMed  CAS  Google Scholar 

  36. Powers WJ, Siegel BA, Davis HH, Mathias CJ, Clark HB, Welch MJ (1982) Indium-111-platelet scintigraphy in cerebrovascular disease. Neurology 32: 938–943

    PubMed  CAS  Google Scholar 

  37. Powers WJ, Hopkins KT, Welch MJ (1984) Validation of the dua radiotracer method for quantitative In-Ill platelet scintigraphy. Thromb Res 34: 135–145

    Article  PubMed  CAS  Google Scholar 

  38. Ramirez-Lassepas M, Cipolle RJ, Bjork RI, Kowitz J, Snyder BD, Weber JC, Stein SD (1987) Can embolic stroke be diagnosed on the basis of neurologic clinical criteria? Arch Neurol 44: 87–89

    PubMed  CAS  Google Scholar 

  39. Randell J, Wilding RJ (1980) Acute arterial thrombosis in rabbits: reducted platelet accumulation after treatment with dazoxiben hydrochloride. Br J Clin Pharmacol 15: 495–499

    Google Scholar 

  40. Riba LA, Thakur ML, Gottschalk A, Andrile VT, Zaret BL (1979) Imaging experimental infective endocarditis with Indium-111-labeled blood cellular components. Circulation 59: 336–343

    PubMed  CAS  Google Scholar 

  41. Ritchie JL, Stratton JR, Thiele B, Hamilton GW, Warrick LN, Huang TW, Harker LA (1981) Indium-111 platelet imaging for detection of platelet deposition in abdominal aneurysms and prosthetic grafts. Am J Cardiol 47: 882–889

    Article  PubMed  CAS  Google Scholar 

  42. Scheffel U, Tsan M, Mclntryre PA (1979) Labeling of human platelets with lll-In-8- hydroxquinoline. J Nucl Med 20: 524–528

    PubMed  CAS  Google Scholar 

  43. Sinn H, Silvester DJ (1979) Simplified cell labelling with Indium-111 acetylacetone. Br J Radiol 52: 758–761

    Article  PubMed  CAS  Google Scholar 

  44. Sinzinger H, Fitscha P (1983) Radioisotope technique for diagnosis of atherosclerosis. Giorn Arteriosclerosi 2: 31–38

    Google Scholar 

  45. Stratton JR, Ritchie JL, Hamilton GW, Hammermeister KE, Harker LA (1981) Left ventricular thrombi: in vivo detection by Indium-111 platelet imaging and two dimensional echocardiography. Am J Cardiol 47: 874–881

    Article  PubMed  CAS  Google Scholar 

  46. Stratton JR, Ritchie JL (1986) Reduction of indium-111 platelet deposition on Dacron vascular grafts in humans by aspirin plus dipyridamole. Circulation 73: 325–330

    Article  PubMed  CAS  Google Scholar 

  47. Thakur ML, Welch MJ, Joist JH, Coleman RE (1976) Indium-111-labeled platelets: studies on preparation and evaluation of in vitro and in vivo functions. Thromb Res 9: 345–357

    Article  PubMed  CAS  Google Scholar 

  48. Vallabhajosula S, Machac J, Goldsmith SJ, Lipszyc H, Badimon L, Rand J, Fuster V (1986) Indium-111 platelet kinetics in normal human subjects: tropolone versus oxine methods. J Nucl Med 27: 1669–1874

    PubMed  CAS  Google Scholar 

  49. Webber MM, Chang D, Baffkin D, Verma A (1979) In-111-labeled platelets or iodinated fibrinogen for the detection of deep venous thrombosis. J Nucl Med 20: 459–460

    PubMed  CAS  Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Kessler, C. (1987). Indium-111 Platelet-Scintigraphy in Stroke Patients. In: Poeck, K., Ringelstein, E.B., Hacke, W. (eds) New Trends in Diagnosis and Management of Stroke. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72996-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-72996-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18369-3

  • Online ISBN: 978-3-642-72996-6

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