Indium-111 Platelet-Scintigraphy in Stroke Patients

  • C. Kessler


In 1976 Thakur et al. [47] succeeded in labelling human platelets with an indium-111 8-hydroxychinoline complex (oxine). In the beginning, 111In-labelled platelets were used in hematologic disorders to estimate the platelet life span and the site of platelet destruction, e.g., in Werlhof’s disease [22, 34]. Since 111In is a gamma-emitting isotope, the recording of gamma-camera images became possible, thereby making visible the incorporation of radiolabeled platelets in thrombus formations.


Stroke Patient Atrial Thrombus Left Ventricular Thrombus Ventricular Thrombus Transient Ischemic Attack 
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  1. 1.
    Aas KA, Gardner FH (1958) Survival of blood platelets labeled with chromium. J Clin Invest 37: 1257–1268PubMedCrossRefGoogle Scholar
  2. 2.
    Bridgers SL, Strauss E, Smith EO, Reed D, Ezekowitz MD (1986) Demonstration of superior sagittal sinus thrombosis by Indium-111-platelet-scintigraphy. Arch Neurol 43: 1079–1081PubMedGoogle Scholar
  3. 3.
    Bousser MG, Chiras J, Bories I, Castaigne P (1985) Cerebral venous thrombosis: a review of 38 cases. Stoke 16: 199–214Google Scholar
  4. 4.
    Caplan LR, Hier DB, D’Cruz JD (1983) Cerebral embolism in the Michael Reese stroke registry. Stroke 14: 530–536PubMedCrossRefGoogle Scholar
  5. 5.
    Clarke-Pearson DL, Coleman RE, Siegel R, Synan JS, Petry N (1985) Indium-111 platelet imaging for the detection of deep venous thrombosis and pulmonary embolism in patients without symptoms after surgery. Surgery 98: 98–104PubMedGoogle Scholar
  6. 6.
    Cunnigham DA, Kumar B, Siegel BA, Gilula LA, Totty WG, Welch MJ (1984) Aspirin inhibition of platelet deposition at angioplasty sites: demonstration by platelet scintigraphy. Radiology 151: 487–490Google Scholar
  7. 7.
    Danpure HJ, Osman S, Brady F (1982) The labelling of blood cells in plasma with 111-In- tropolone. Br J Radiol 55: 247–249PubMedCrossRefGoogle Scholar
  8. 8.
    Davis HH, Heaton WA, Siegel BA, Mathias CJ, Joist JH, Sherman LA, Welch MJ (1978) Scintigraphic detection of atherosclerotic lesions and venous thrombi in man by Indium-111-labelled autologous platelets. Lancet 1: 1185–1187PubMedCrossRefGoogle Scholar
  9. 9.
    DeMaria AN, Bommer W, Neumann A, Grehl T, Weinart L, Nardo S, Amstertam EA, Mason TD (1979) Left ventricular thrombi identified by cross-sectional echocardiography. Ann Intern Med 90: 14–18PubMedGoogle Scholar
  10. 10.
    Dewanjee MK, Fuster V, Kaye MP, Josa M (1978) Imaging platelet deposition with Indium-Ill-labeled platelets in coronary artery bypass grafts in dogs. Mayo Clin Proc 53: 327–331PubMedGoogle Scholar
  11. 11.
    Dewanjee MK, Rao SA, Didisheim P (1981) Indium-111-tropolone, a new high affinity platelet label. Preparation and evaluation of labeling parameters. J Nucl Med 22: 981–988Google Scholar
  12. 12.
    Dewanjee MK, Solis E, Lenker J, Tidwell C, Mackey S, Didisheim P, Kaye MP (1986) Quantification of platelet and fibrinogen-fibrin deposition on components of tissue valves ( Ionescu-Shiley) in calves. Trans Am Soc Artif Intern Organs 32: 591–596Google Scholar
  13. 13.
    Ericus MS, Chandler WF, Ford JW, Swanson DP, Burke JC (1984) Effect of different aspirin doses on arterial thrombosis after canine carotid endarterectomy: a scanning electron microscope and Indium-111-labelled platelet study. Neurosurgery 14: 198–203CrossRefGoogle Scholar
  14. 14.
    Ezekowitz MD, Cox AC, Smith EO, Taylor FB (1981) Failure of aspirin to prevent incorporation of indium-Ill platelets into cardiac thrombi in man. Lancet 2:440 - 443Google Scholar
  15. 15.
    Ezekowitz MD, Burrow RD, Heath PW, Streitz T, Smith EO, Parker DE (1983) Diagnostic accuracy of Indium-111-platelet scintigraphy identifying left ventricular thrombi. Am J Cardiol 51: 1712–1716PubMedCrossRefGoogle Scholar
  16. 16.
    Fitscha P, Kaliman J, Sinzinger H (1985) Gamma-camera imaging after autologous platelet labeling with 11-In-oxine sulfate: a key for assessing the efficacy of prostacyclin treatment in active atherosclerosis? In: Schror (ed) Prostacyclins and other eicosanoids in the cardiovascular system. Karger, Basel, pp 252–357 (Proc 2nd Int Symp, Nurnberg Furth 1984 )Google Scholar
  17. 17.
    Goldman M, Hall C, Dykes J, Hawker J, McCollum CM (1983) Does 111-Indium-platelet deposition predict patency in prosthetic arterial grafts. Br J Surg 70: 635–638PubMedCrossRefGoogle Scholar
  18. 18.
    Goldman M, Leung JO, Aukland A, Hawker RJ, Drolc Z, McCollum CM (1983) 111-Indium platelet imaging, Doppler spectral analysis and angiography compared in patients with transient cerebral ischemia. Stroke 14: 752–759Google Scholar
  19. 19.
    Grimley RP, Rafigi E, Hawker RJ, Drolez A (1981) Imaging of Indium-111-labeled platelets: a new method for the diagnosis of deep vein thrombosis. Br J Surg 68: 714–716PubMedCrossRefGoogle Scholar
  20. 20.
    Henningsen H, Kessler C, Reuther R, Bihl H, Allenberg J, Antalics I, Nemetschek H (1985) In- dium-111-platelet-scintigraphy for detection of carotid artery atherosclerosis. In: Nestel JB (ed) Proceedings of the poster communications. 7th international symposium on atherosclerosis, MelbourneGoogle Scholar
  21. 21.
    Henningsen H, Kessler C, Reuther R (1986) Dual isotope scintigraphy of the carotid arteries. In: Balas P (ed) Progress in angiology. Minerva Medica, Turin, pp 95–98Google Scholar
  22. 22.
    Heyns du Pont, Loetter MG, Badenhorst PN, de Kock F, Pieters H, Herbst C, van Reenen OR, Kotze H, Minaar PC (1982) Kinetics and sites of destruction of 111-Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study. Am J Hematol 12: 167–171Google Scholar
  23. 23.
    Isaka Y, Kimura K, Yoneda S, Kusnucki M, Etani H, Osamu U, Tsuda Y, Abe H (1984) Platelet accumulation in carotid atherosclerosic lesions: Semiquantitative analysis with Indium-Ill platelet and Technetium-99m human serum albumin. J Nucl Med 25: 556–563PubMedGoogle Scholar
  24. 24.
    Kessler C, Kniffert T, Botch H (1980) Der Nutzen der Plattchenszintigraphie zur Aufklarung in- trakranieller vaskularer Prozesse. Akt Neurol 7: 27–29CrossRefGoogle Scholar
  25. 25.
    Kessler C, Trabant R (1982) Thrombozytensuzintgigraphyie mit Indium-111. Arch Psychiat Nervenkr 231: 449–457PubMedCrossRefGoogle Scholar
  26. 26.
    Kessler C, Reuther R, Berentelg J, Kimmig B (1983) The clinical use of platelet scintigraphy with 111-In-oxine. J Neurol 229: 255–261PubMedCrossRefGoogle Scholar
  27. 27.
    Kessler C, Reuther R, Kimmig B, Pietzsch T (1984) Dual isotope scintigraphy in stroke patients. Neuroradiology 26: 113–117PubMedCrossRefGoogle Scholar
  28. 28.
    Kessler C, Kniffert T, Reuther R, Kimmig B, zum Winkel K (1984) Die Szintigraphie mit 111-In markierten Blutplattchen. Dtsch Med Wochenschr 109: 1853–1859PubMedCrossRefGoogle Scholar
  29. 29.
    Kessler C, Henningsen H, Bihl H (1986) Interobserver reproducibility of Indium-111 platelet carotid scintigraphy and its correlation to computerized analysis. In: Reisner T, Binder H, Deisenhammer E (eds) Advances in neuroimaging. Second international congress for clinical neuroimaging Vienna. Verlag der Wiener Medizinischen Akademie, Vienna, pp 110–114Google Scholar
  30. 30.
    Kessler C, Henningsen H, Reuther R, Kimmig B (1987) Identification of cardiac thrombi in stroke patients with Indium-111 platelet scintigraphy. Stroke (in press)Google Scholar
  31. 31.
    Klonizakis J, Peters AM, Fitzpatrick ML, Kensett MJ, Lewis SM, Lavender JP (1980) Radionuclide distribution following injection of Indium-111-labelled platelets. Br J Haematol 46: 595–602PubMedCrossRefGoogle Scholar
  32. 32.
    Loewinger R, Berman M (1968) A scheme for absorbed-dose calculation for biologically-distributed radionuclides. J Nucl Med (Suppl) l: 9–14Google Scholar
  33. 33.
    Panel of diagnostic application on radioisotopes in haematology, international committee for standardization in haematology (1977): recommended methods for radioisotop platelet survival studies. Blood 50:1137–1144Google Scholar
  34. 34.
    Peters AM, Klonizakis I, Lavender JP, Lewis SM (1980) Use of 111-Indium-labeled platelets to measure spleen function. Br J Haemat 46: 587–589CrossRefGoogle Scholar
  35. 35.
    Peters AM, Lavender JP (1981) Imaging vascular lesions with Indium-111-labeled platelets. Circulation 64: 1297–1298PubMedGoogle Scholar
  36. 36.
    Powers WJ, Siegel BA, Davis HH, Mathias CJ, Clark HB, Welch MJ (1982) Indium-111-platelet scintigraphy in cerebrovascular disease. Neurology 32: 938–943PubMedGoogle Scholar
  37. 37.
    Powers WJ, Hopkins KT, Welch MJ (1984) Validation of the dua radiotracer method for quantitative In-Ill platelet scintigraphy. Thromb Res 34: 135–145PubMedCrossRefGoogle Scholar
  38. 38.
    Ramirez-Lassepas M, Cipolle RJ, Bjork RI, Kowitz J, Snyder BD, Weber JC, Stein SD (1987) Can embolic stroke be diagnosed on the basis of neurologic clinical criteria? Arch Neurol 44: 87–89PubMedGoogle Scholar
  39. 39.
    Randell J, Wilding RJ (1980) Acute arterial thrombosis in rabbits: reducted platelet accumulation after treatment with dazoxiben hydrochloride. Br J Clin Pharmacol 15: 495–499Google Scholar
  40. 40.
    Riba LA, Thakur ML, Gottschalk A, Andrile VT, Zaret BL (1979) Imaging experimental infective endocarditis with Indium-111-labeled blood cellular components. Circulation 59: 336–343PubMedGoogle Scholar
  41. 41.
    Ritchie JL, Stratton JR, Thiele B, Hamilton GW, Warrick LN, Huang TW, Harker LA (1981) Indium-111 platelet imaging for detection of platelet deposition in abdominal aneurysms and prosthetic grafts. Am J Cardiol 47: 882–889PubMedCrossRefGoogle Scholar
  42. 42.
    Scheffel U, Tsan M, Mclntryre PA (1979) Labeling of human platelets with lll-In-8- hydroxquinoline. J Nucl Med 20: 524–528PubMedGoogle Scholar
  43. 43.
    Sinn H, Silvester DJ (1979) Simplified cell labelling with Indium-111 acetylacetone. Br J Radiol 52: 758–761PubMedCrossRefGoogle Scholar
  44. 44.
    Sinzinger H, Fitscha P (1983) Radioisotope technique for diagnosis of atherosclerosis. Giorn Arteriosclerosi 2: 31–38Google Scholar
  45. 45.
    Stratton JR, Ritchie JL, Hamilton GW, Hammermeister KE, Harker LA (1981) Left ventricular thrombi: in vivo detection by Indium-111 platelet imaging and two dimensional echocardiography. Am J Cardiol 47: 874–881PubMedCrossRefGoogle Scholar
  46. 46.
    Stratton JR, Ritchie JL (1986) Reduction of indium-111 platelet deposition on Dacron vascular grafts in humans by aspirin plus dipyridamole. Circulation 73: 325–330PubMedCrossRefGoogle Scholar
  47. 47.
    Thakur ML, Welch MJ, Joist JH, Coleman RE (1976) Indium-111-labeled platelets: studies on preparation and evaluation of in vitro and in vivo functions. Thromb Res 9: 345–357PubMedCrossRefGoogle Scholar
  48. 48.
    Vallabhajosula S, Machac J, Goldsmith SJ, Lipszyc H, Badimon L, Rand J, Fuster V (1986) Indium-111 platelet kinetics in normal human subjects: tropolone versus oxine methods. J Nucl Med 27: 1669–1874PubMedGoogle Scholar
  49. 49.
    Webber MM, Chang D, Baffkin D, Verma A (1979) In-111-labeled platelets or iodinated fibrinogen for the detection of deep venous thrombosis. J Nucl Med 20: 459–460PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • C. Kessler
    • 1
  1. 1.Department of NeurologyKrankenhaus MerheimKöln 91Germany

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