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Evaluation Criteria in Comparative Clinical Trials in Advanced Breast Cancer: A Proposal for Improvement

  • Chapter
Endocrine Therapy of Breast Cancer

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

Clinical trials in metastatic breast cancer and other presently incurable diseases may have three basically different aims:

  1. a)

    The development of new drugs or new modalities of treatment in Phase I and Phase II trials

  2. b)

    The development of new drug combinations or schedules which may eventually produce long-term survival and cure

  3. c)

    The selection of optimal treatments in terms of palliation (quality of life) and time (quantity of life).

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References

  1. Mouridsen HT: Value and limitation of current criteria for assessing response. In: Cavalli F (ed) Endocrine Treatment of Breast Cancer II: Current Developments and New Methodologies. European School of Oncology Monograph Series, Springer Verlag, Berlin, Heidelberg, New York 1987

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  4. Carter SK: The role of clinical trials. In: Veronesi U and Bonadonni G (eds) Clinical Trials in Cancer Medicine. Academic Press 1986 pp 1–24

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  5. Gelber RD, Goldhirsch A for the Ludwig Breast Cancer Study Group: A new endpoint for the measurement of adjuvant therapy in postmenopausal women with operable breast cancer. J Clin Oncol 1986 (4):1772–1779

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Author information

Authors and Affiliations

  1. Institute of Medical Oncology, Inselspital, Bern, Switzerland

    K. W. Brunner

Authors
  1. K. W. Brunner
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Editor information

Editors and Affiliations

  1. Division of Oncology, Ospedale San Giovanni, 6500, Bellinzona, Switzerland

    Franco Cavalli

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© 1987 Springer-Verlag Berlin Heidelberg

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Brunner, K.W. (1987). Evaluation Criteria in Comparative Clinical Trials in Advanced Breast Cancer: A Proposal for Improvement. In: Cavalli, F. (eds) Endocrine Therapy of Breast Cancer. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72983-6_7

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  • DOI: https://doi.org/10.1007/978-3-642-72983-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72985-0

  • Online ISBN: 978-3-642-72983-6

  • eBook Packages: Springer Book Archive

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