Hormonal Control of Fetal Breathing

  • G. S. Dawes
Conference paper


After birth breathing movements are linked closely to metabolism, and there is small scope for hormonal control. Before birth, however, the situation is different. Fetal breathing movements are normally associated with episodes of low voltage electrocortical activity and rapid eye movements in sheep. In man they are also episodic in character, and are modulated by episodic sleep rhythms as identified by external ultrasound measurements. The natural history of fetal breathing suggests that there may be three circumstances in which hormones influence the control of breathing, directly or indirectly. These are during diurnal variation, shortly after food ingestion by the mother and immediately preceding parturition.


Diurnal Variation Corticotrophin Release Factor Fetal Heart Rate Maternal Plasma Breathing Movement 
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  1. Arduini D, Rizzo G, Giorlandino G, Valensise H, Dell’Acqua S, Romanini C (1986 a) Modifications of ultradian and circadian rhythms of fetal heart rate after fetal-maternal adrenal gland suppression: a double blind study. Prenat Diagn 6: 409–417PubMedCrossRefGoogle Scholar
  2. Arduini D, Rizzo G, Parlati E, Dell’Acqua S, Romanini R, Mancuso S (1986b) Loss of circadian rhythms of fetal behaviour in a totally adrenalectomized pregnant woman. Gynecol Obst Invest 23: 226–229CrossRefGoogle Scholar
  3. Arduini D, Rizzo G, Parlati E, Dell’Acqua S, Mancuso S, Romanini R (1987) Are the fetal heart rate patterns related to fetal maternal-endocrine rhythms at term of pregnancy? J Fetal Med 6: 53–57Google Scholar
  4. Bamford OS, Dawes GS, Ward RA (1986 a) Effects of apomorphine and haloperidol in fetal lambs. J Physiol 377: 37–47PubMedGoogle Scholar
  5. Bamford OS, Dawes GS, Denny R, Ward RA (1986b) Effects of the α 2-adrenergic agonist Clonidine and its antagonist idazoxan on the fetal lamb. J Physiol 381: 29–37PubMedGoogle Scholar
  6. Bennett L, Gluckmann PD, Johnston BM (1986) The central effects of thyrotrophin-releasing hormone (TRH) on fetal breathing movements and electrocortical activity. International Union of Physiological Sciences Satellite Symposium: Fetal physiology — cellular and systems approaches, p 55Google Scholar
  7. Bennett L, Johnston BM, Vale W, Gluckman PD (1987) Corticotrophin releasing factor (CRF) is a potent stimulus to fetal breathing. Society for the Study of Fetal Physiology, 14th annual meeting, poster 1Google Scholar
  8. Boddy K, Dawes GS, Robinson J (1973) A 24-hour rhythm in the foetus. In: Cross KW, Dawes GS, Comline R, Nathanielsz P (eds) Foetal and neonatal physiology: Proceedings of the Sir Joseph Barcroft Centenary Symposium. Cambridge University Press, Cambridge, pp 63–66Google Scholar
  9. Boddy K, Dawes GS, Robinson JS (1975) Intrauterine fetal breathing movements. In: Gluck L (ed) Modern perinatal medicine. Year Book Publishers, Chicago, p 381Google Scholar
  10. Carmichael LK, Campbell K, Natale R, Patrick J, Richardson B (1984) Decrease in human fetal breathing movements prior to spontaneous labour at term. Am J Obstet Gynecol 148: 675–682PubMedGoogle Scholar
  11. Castle BM, Turnbull AC (1983) The presence or absence of fetal breathing movements predicts the outcome of preterm labour. Lancet ii: 471–473CrossRefGoogle Scholar
  12. Dawes GS (1973a) Revolutions and cyclical rhythms in prenatal life: fetal respiratory movements rediscovered. Pediatrics 51: 965–971PubMedGoogle Scholar
  13. Dawes GS (1973 b) Foetal physiology and the onset of labour. Mem Soc Endocrinol 25–36Google Scholar
  14. Dawes GS, Robinson JS (1976) Rhythmic phenomena in prenatal life. Prog Brain Res 45: 383–390PubMedCrossRefGoogle Scholar
  15. Dawes GS, Gardener WN, Johnston BM, Walker DW (1983) Breathing in fetal lambs: the effects of brain stem section. J Physiol 335: 535–553PubMedGoogle Scholar
  16. Johnston BM, Gluckman PD (1983) GABA-mediated inhibition of breathing in the late gestation sheep fetus. J Dev Physiol 5: 353–360PubMedGoogle Scholar
  17. Jones CT, Ritchie JWK (1978 a) The cardiovascular effects of circulating catecholamines in fetal sheep. J Physiol 285: 381–393PubMedGoogle Scholar
  18. Jones CT, Ritchie JWK (1978b) The metabolic and endocrine effects of circulating catecholamines in fetal sheep. J Physiol 285: 395–408PubMedGoogle Scholar
  19. Kitterman JA, Liggins GC, Clements JA, Tooley WH (1979) Stimulation of breathing movements in fetal sheep by inhibitors of prostaglandin synthesis. J Dev Physiol 1: 453–466PubMedGoogle Scholar
  20. Kitterman JA, Liggins GC, Fewell JE, Tooley WH (1983) Inhibition of breathing movements in fetal sheep by prostaglandins. J Appl Physiol 54: 687–692PubMedGoogle Scholar
  21. Koos BJ (1985) Central stimulation of breathing movements by prostaglandin synthetase inhibitors. J Physiol 362: 455–466PubMedGoogle Scholar
  22. Natale R, Patrick J, Richardson B (1978) Effects of human maternal venous plasma glucose concentrations on fetal breathing movements. Am J Obstet Gynecol 132: 36–41PubMedGoogle Scholar
  23. Nijhuis JG, Jongsma HW, Crijns IJMJ, de Valk IMGM, van der Valden JWHJ (1985) Incidence of fetal breathing movements after glucose intake by the mother at 24 and 28 weeks gestation. Society for the Study of Fetal Physiology, 12th annual meeting, Haifa, July 1985, communication 34Google Scholar
  24. Olsen GD, Dawes GS (1985) Morphine-induced depression and stimulation of breathing movements in the fetal lamb. Jones C, Nathanielsz P (ed) The physiological development of the fetus and newborn. Academic, London, pp 633–638Google Scholar
  25. Patrick J, Dalton KJ, Dawes GS (1976) Breathing patterns before death in fetal lambs. Am J Obstet Gynecol 125: 73–78PubMedGoogle Scholar
  26. Patrick J, Fetherston W, Vick H, Voegelin R (1978 a) Human fetal breathing movements and gross fetal body movements at weeks 34–35 of gestation. Am J Obstet Gynecol 130: 693–699PubMedGoogle Scholar
  27. Patrick J, Natale R, Richardson B (1978 b) Patterns of human fetal breathing activity at 34–35 weeks gestational age. Am J Obstet Gynecol 132: 507–513PubMedGoogle Scholar
  28. Patrick J, Challis J, Natale R, Richardson B (1979) Circadian rhythms in maternal plasma Cortisol, estrone, estradiol and estriol at 34–35 weeks gestation. Am J Obstet Gynecol 135: 791–798PubMedGoogle Scholar
  29. Patrick J, Challis J, Campbell K, Carmichael L, Richardson B, Tevaarwerk G (1981) Effects of synthetic glucocorticoid administration on human fetal breathing movements at 34–35 weeks gestational age. Am J Obstet Gynecol 139: 324–328PubMedGoogle Scholar
  30. Quilligan EJ, Clewlow F, Johnston BM, Walker DW (1981) Effect of 5-hydroxytrytophane on electrocortical activity and breathing movements of fetal sheep. Am J Obstet Gynecol 141: 271–275PubMedGoogle Scholar
  31. Richardson B, Natale R, Patrick J (1979) Human fetal breathing activity during induced labour at term. Am J Obstet Gynecol 133: 247–255PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. S. Dawes
    • 1
  1. 1.Charing Cross Sunley Research CentreLondonUK

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