Initiation of Human Parturition

  • G. C. Liggins
  • T. Wilson
Conference paper


Several thorough reviews of human parturition, each emphasising a particular viewpoint, have been published recently (Fuchs and Fuchs 1984; Liggins 1984; Thor-burn 1985; Casey and MacDonald 1986) and it is not the present intention to attempt a further comprehensive review. Rather, consideration will be given to new developments that may bring together seemingly unrelated previous observations into a coherent hypothesis.


Arachidonic Acid Amniotic Fluid Oxytocin Receptor Human Amniotic Fluid Human Parturition 
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  1. Alexandrova M, Soloff MS (1980) Oxytocin receptors and parturition. III. Increases in oestrogen receptor and oxytocin receptor concentrations in the rat myometrium at term. Endocrinology 106: 739–743PubMedCrossRefGoogle Scholar
  2. Barnford DS, Jogea M, Williams KI (1980) Prostaglandin formation by the pregnant human myometrium. Br J Obstet Gynaecol 87: 215–218CrossRefGoogle Scholar
  3. Bazer FW, Vallet JL, Roberts RM, Sharp DC, Thatcher WW (1986) Role of conceptus secretory products in establishment of pregnancy. J Reprod Fertil 76: 841–840PubMedCrossRefGoogle Scholar
  4. Billah MM, Johnston JM (1983) Identification of phospholipid platelet-activating factor (1–0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine. Bio-chem Biophys Res Commun 113: 51–58CrossRefGoogle Scholar
  5. Blackwell GJ, Carnuccio R, DiRosa M, Flower RJ, Parente L, Persico L (1980) Macrocortin: a polypeptide causing the antiphospholipase effect of glucocorticoids. Nature 287:147–149PubMedCrossRefGoogle Scholar
  6. Casey ML, MacDonald PC (1986) Initiation of labor in women. In: Huszar G (ed) The physiology and biochemistry of the uterus in pregnancy and labor. CRC Press, Boca Raton, p155Google Scholar
  7. Casey ML, MacDonald PC, Mitchell MD (1983) Stimulation of prostaglandin E2 production in amnion cells in culture by a substance(s) in human fetal and adult urine. Biochem Biophys Res Commun 114:1056–1063PubMedCrossRefGoogle Scholar
  8. Casey ML, MacDonald PC, Mitchell MD (1985) Despite a massive increase in Cortisol secretion in women during parturition, there is an equally massive increase in prostaglandin synthesis: a paradox? J Clin Invest 75:1852–1857PubMedCrossRefGoogle Scholar
  9. Dawood MY, Khan-Dawood FS (1986) Human ovarian oxytocin: its source and relationship to steroid hormones. Am J Obstet Gynecol 154: 756–763PubMedGoogle Scholar
  10. Dawood MY, Ylikorkala O, Trivedi D, Fuchs F (1979) Oxytocin in maternal circulation and amniotic fluid during pregnancy. J Clin Endocrinol Metab 49: 429–434PubMedCrossRefGoogle Scholar
  11. Di Renzo GC, Anceschi MM, Bleasdale JE (1984) Beta-adrenergic stimulation of prostaglandin production by human amnion tissue. Prostaglandins 27: 37–49PubMedGoogle Scholar
  12. Forman A, Andersson KE, Persson CGA, Ulmsten U (1979) Relaxant effects of nifedipine on isolated human myometrium. Acta Pharmacol Toxicol 45: 81–87CrossRefGoogle Scholar
  13. Fuchs A-R, Fuchs F (1984) Endocrinology of human parturition: a review. Br J Obstet Gynaecol 91: 948–967PubMedCrossRefGoogle Scholar
  14. Fuchs A-R, Fuchs F, Husslein P, Soloff MS, Fernstrom MJ (1982 a) Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science 215: 1396–1398PubMedCrossRefGoogle Scholar
  15. Fuchs A-R, Husslein P, Sumulong L, Fuchs F (1982 b) The origin of circulating 13, 14-dihydro-15-keto-PGF during delivery. Prostaglandins 24: 715–722PubMedCrossRefGoogle Scholar
  16. Fuchs A-R, Fuchs F, Husslein P, Fernstrom MJ, Soloff MS (1984) Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol 150: 734–741PubMedGoogle Scholar
  17. Hirata F, Schiffman E, Venkatasubramanian K, Salomon D, Axelrod J (1980) A phospholi-pase A2 inhibitory protein in rabbit neurophils induced by glucocorticosteroids. Proc Natl Acad Sci USA 77: 2533–2536PubMedCrossRefGoogle Scholar
  18. Hirata F, Matsuda K, Notsu Y, Hattori T, Del Carmine R (1984) Phosphorylation of a tyrosine residue of lipomodulin in nitrogen stimulated murine thyrocytes. Proe Natl Acad Sci USA 81: 4717–4721CrossRefGoogle Scholar
  19. Irvine RF (1982) How is the level of free arachidonic acid controlled in mammalian cells? Biochem J 204: 3–16PubMedGoogle Scholar
  20. Keirse MJNC, Hicks BR, Mitchell MD, Turnbull AC (1977) Increase of the prostaglandin precursor, arachidonic acid, in amniotic fluid during spontaneous labour. Br J Obstet Gynaecol 84: 937–940PubMedCrossRefGoogle Scholar
  21. Khanna NC, Masaaki T, Waisman DM (1986) Biochem Biophys Res Commun 547–554Google Scholar
  22. Kuno M, Gardner P (1987) Ion channels activated by inositol 1,4,5-triphosphate in plasma membrane of human T-lymphocytes. Nature 326: 301–304PubMedCrossRefGoogle Scholar
  23. Liggins GC, Fairclough RJ, Grieves SA, Forster CS, Knox BS (1977) Parturition in the sheep. In: Knight J, O’Connor M (eds) The fetus and birth. Ciba Found Symp 47: 5Google Scholar
  24. Liggins GC (1984) The paracrine system controlling human parturition. In: Jaffe RB, Dell’Aqua S (eds) The endocrine physiology of pregnancy and the peripartal period. Raven, New York, p 205Google Scholar
  25. MacDonald PC, Parker JC, Schwarz BE, Johnston JM (1974) Initiation of parturition I. Mechanism of action of arachidonic acid. Obstet Gynecol 44: 629–636PubMedGoogle Scholar
  26. Manzai M, Liggins GC (1984) Inhibitory effects of dispersed amnion cells on production rates of prostaglandin E and F by endometrial cells. Prostaglandins 28: 297–307Google Scholar
  27. Mitchell MD, Casey ML (1984) Role of growth factors in PGE2 formation in human amnion cells in monolayer culture. Proc Soc Gynecol Invest, p 33Google Scholar
  28. Mitchell MD, Bibby JG, Hicks BR, Turnbull AC (1978) Specific production of prostaglandin E by human amnion in vitro. Prostaglandins 15: 377–382PubMedCrossRefGoogle Scholar
  29. Mitchell MD, Ebenhack K, Kraemer DL, Cox K, Cutter S, Strickland DM (1982) A sensitive radioimmunoassay for ll-deoxy-13,14-dihydro-15-keto-ll,16-cyclo-prostaglandin E2. Prostaglandins Leukotrienes Med 9: 549–557CrossRefGoogle Scholar
  30. Mitchell MD, MacDonald PC, Casey ML (1984) Stimulation of prostaglandin E2 synthesis in human amnion cells maintained in monolayer culture by a substance(s) in amniotic fluid. Prostaglandins Leukotrienes Med 15: 399–407CrossRefGoogle Scholar
  31. Mitchell MD, Craig DA, Saeed SA, Strickland DM (1985) Endogenous stimulant of prostaglandin endoperoxide synthase activity in human amniotic fluid. Biochim Biophys Acta 833:379–385PubMedGoogle Scholar
  32. Niesert S, Christopherson W, Korte K (1987) Prostaglandin E2 9-keto-reductase activity in human decidua vera tissue. Am J Obstet Gynecol (in press)Google Scholar
  33. Okazaki T, Casey ML, Okita JR, MacDonald PC, Johnston JM (1981) Initiation of human parturition XII. Biosynthesis and metabolism of prostaglandin in human fetal membranes and uterine decidua. Am J Obstet Gynecol 139: 373–381PubMedGoogle Scholar
  34. Okazaki T, Sagawa N, Okita JR, Bleasdale JE, MacDonald PC, Johnston JM (1981) Diacyl-glycerol metabolism and arachidonic acid release in human fetal membranes and decidua vera. J Biol Chem 256: 7316–7321PubMedGoogle Scholar
  35. Olson DM, Skinner K, Challis JRG (1983) Prostaglandin production in relation to parturition by cells dispersed from human intrauterine tissues. J Clin Endocrinol Metab 57: 694–699PubMedCrossRefGoogle Scholar
  36. Reimer RK, Goldfien AC, Goldfien A, Roberts JM (1986) Rabbit uterine oxytocin receptors and in vitro contractile response: abrupt changes at term and the role of ecosanoids. Endocrinology 119: 699–709CrossRefGoogle Scholar
  37. Robinson JS, Mitchell MD, Challis JRG (1979) Parturition in the rhesus monkey. In: Keirse MJNC, Anderson ABM, Gravenhorst JB (eds) Human parturition. Nijhoff, The Hague, p25CrossRefGoogle Scholar
  38. Saeed SA, Mitchell MD (1982) Formation of arachidonate lipoxygenasae metabolites by human fetal membranes, uterine decidua vera and placenta. Prostaglandins Leukotrienes Med 8:635–640CrossRefGoogle Scholar
  39. Schrey MP, Read AM, Steer PJ (1986) Oxytocin and vasopressin stimulate inositol phosphate production in human gestational myometrium and decidua cells. Biosci Rep 6: 613–619PubMedCrossRefGoogle Scholar
  40. Skinner SJM, Liggins GC, Wilson T, Neale G (1984) Synthesis of prostaglandin F by cultured human endometrial cells. Prostaglandins 27: 821–838PubMedCrossRefGoogle Scholar
  41. Soloff MS, Fernstrom MA, Periyasamy S, Soloff S, Baldwin S, Wieder M (1983) Regulation of oxytocin receptor concentration in rat uterine expiants by oestrogen and progesterone. Can J Biochem Cell Biol 61: 625–630PubMedCrossRefGoogle Scholar
  42. Soloff MS (1985) Oxytocin receptors and mechanisms of oxytocin action. In: Amico JA and Robinson AG (eds) Oxytocin: clinical and laboratory studies. Excerpta Medica, Amsterdam, p 259Google Scholar
  43. Thorburn GD (1985) Prostaglandins and the regulation of myometrial activity: a working model. In: Jones CT and Nathanielsz PW (eds) The physiological development of the fetus and newborn. Academic, London, p 381Google Scholar
  44. Ulmsten U, Andersson KE, Wingerup L (1980) Treatment of premature labor with the calcium antagonist nifedipine. Arch Gynecol 229:1–6PubMedCrossRefGoogle Scholar
  45. Wilson T, Liggins GC, Aimer GP, Skinner SJM (1985) Partial purification and characterization of two compounds from amniotic fluid which inhibit phospholipase activity in human endometrial cells. Biochem Biophys Res Comm 131: 22–29PubMedCrossRefGoogle Scholar
  46. Wilson T, Liggins GC, Joe L (1987) Purification from incubated chorion of a phospholipase A2 inhibitor active before but not after the onset of labor. Biochem Biophys Acta (submitted)Google Scholar
  47. Wilson T, Liggins GC, Aimer GP, Watkins EJ (1986) The effect of progesterone on the release of arachidonic acid from human endometrial cells stimulated by histamine. Prostaglandins 31:343–360PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. C. Liggins
    • 1
  • T. Wilson
  1. 1.Postgraduate School of Obstetrics and GynaecologyUniversity of AucklandAucklandNew Zealand

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