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Role of Catecholamines in Thermoregulation of Cold-Adapted and Newborn Guinea Pigs

  • E. Zeisberger
  • J. Roth

Abstract

The strain of birth — particularly that caused by hypoxia and pressure on the head — produce in the fetus an unusually high release in catecholamines. The levels of these ‘stress’ hormones in the human fetus are probably increased as early as several days before delivery. Catecholamine concentrations in human fetal scalp samples taken at the beginning of normal delivery, when the mother’s cervix was barely dilated (2–3 cm), were about 5 times as high as the concentrations in a resting adult. After birth the catecholamine levels were found to have doubled or tripled again; thus, levels in umbilical samples of neonates were found to be about 15–20 times higher on average than levels in the venous blood of resting adults. Neonates thus had catecholamine levels more than 5–8 times higher than stressed adults such as women during delivery or men during heavy exercise. Their levels were even higher than in patients with pheochromocytoma.

Keywords

Brown Adipose Tissue Catecholamine Level Cold Adaptation Sympathetic System Postnatal Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abeling NG, v Gennip AH, Overmars H, Voute PA (1984) Simultaneous determination of catecholamines and metanephrines in urine by HPLC with fluorometrie detection. Clin Chim Acta 137: 211–226PubMedCrossRefGoogle Scholar
  2. Brück K (1970) Nonshivering thermogenesis and brown adipose tissue in relation to age, and their integration in the thermoregulatory system. In: Lindberg O (ed) Brown adipose tissue. Elsevier, New York, pp 117–154Google Scholar
  3. Brück K (1978) Heat production and temperature regulation. In: Stave U (ed) Perinatal physiology. Plenum, New York, pp 455–498Google Scholar
  4. Brück K, Zeisberger E (1978) Significance and possible central mechanisms of thermoregulatory threshold deviations in thermal adaptation. In: Wang LCH, Hudson JW (eds) Strategies in cold: natural torpidity and thermogenesis. Academic, New York, pp 654–694Google Scholar
  5. Brück K, Zeisberger E (1987) Adaptive changes in thermoregulation and their neuropharmacological basis. Pharmac Ther 35: 163–215CrossRefGoogle Scholar
  6. Cannon B, Nedergaard J (1984) The biochemistry of an inefficient tissue. Essays Biochem 20: 110–164Google Scholar
  7. Jansky L (1973) Nonshivering thermogenesis and its thermoregulatory significance. Biol Rev 48: 85–132PubMedGoogle Scholar
  8. Jansky L, Bartunkova R, Zeisberger E (1967) Acclimation of the white rat to cold: noradrenaline thermogenesis. Physiol Bohemoslov 16: 366–372PubMedGoogle Scholar
  9. Lagercrantz H, Slotkin TA (1986) The “stress” of being born. Sci Am 54: 92–102Google Scholar
  10. Leduc J (1961) Catecholamine production and release in exposure and acclimation to cold. Acta Physiol Scand 53: 1–101CrossRefGoogle Scholar
  11. Nicholls DG, Locke R (1984) Thermogenic mechanisms in brown fat. Physiol Rev 64: 1–64PubMedGoogle Scholar
  12. Rial E, Nicholls DG (1984) The mitochondrial uncoupling protein from guinea-pig brown adipose tissue. Biochem J 222: 685–693PubMedGoogle Scholar
  13. Roth J, Zeisberger E, Schwandt HJ (1987) Changes in peripheral metabolism of catecholamines in guinea-pig during thermal adaptation. J Therm Biol 12: 39–44CrossRefGoogle Scholar
  14. Roth J, Zeisberger E, Schwandt HJ (1988) Influence of increased catecholamine levels in blood plasma during cold-adaptation and intramuscular infusion on thresholds of thermoregulatory reactions in guinea-pigs. J Comp Physiol B 157: 855–863PubMedCrossRefGoogle Scholar
  15. Rothwell NJ, Stock MJ (1984) Brown adipose tissue. In: Baker PF (ed) Recent advances in physiology, vol 11. Churchill Livingstone, Edinburgh, pp 349–384Google Scholar
  16. Zeisberger E (1982) The role of noradrenergic systems in thermal adaptation. In: Hildebrandt G, Hensel H (eds) Biological adaptation. Thieme/Stratton, Stuttgart-New York, pp 140–147Google Scholar
  17. Zeisberger E (1987) The roles of monoaminergic neurotransmitters in thermoregulation. Can J Physiol Pharmacol 65: 1395–1401PubMedCrossRefGoogle Scholar
  18. Zeisberger E, Brück K (1976) Alterations of shivering threshold in cold- and warm-adapted guinea-pigs following intrahypothalamic injections of noradrenaline and of an adrenergic alpha-receptor blocking agent. Pflügers Arch 362: 113–119PubMedCrossRefGoogle Scholar
  19. Zeisberger E, Brück K, Wünnenberg W, Wietasch C (1967) Das Ausmaß der zitterfreien Ther-mogenese des Meerschweinchens in Abhängigkeit vom Lebensalter, Pflügers Arch 296: 276–288CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • E. Zeisberger
    • 1
  • J. Roth
  1. 1.Physiological InstituteUniversity of GiessenGiessenGermany

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