Role of Catecholamines in Thermoregulation of Cold-Adapted and Newborn Guinea Pigs
The strain of birth — particularly that caused by hypoxia and pressure on the head — produce in the fetus an unusually high release in catecholamines. The levels of these ‘stress’ hormones in the human fetus are probably increased as early as several days before delivery. Catecholamine concentrations in human fetal scalp samples taken at the beginning of normal delivery, when the mother’s cervix was barely dilated (2–3 cm), were about 5 times as high as the concentrations in a resting adult. After birth the catecholamine levels were found to have doubled or tripled again; thus, levels in umbilical samples of neonates were found to be about 15–20 times higher on average than levels in the venous blood of resting adults. Neonates thus had catecholamine levels more than 5–8 times higher than stressed adults such as women during delivery or men during heavy exercise. Their levels were even higher than in patients with pheochromocytoma.
KeywordsBrown Adipose Tissue Catecholamine Level Cold Adaptation Sympathetic System Postnatal Development
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- Brück K (1970) Nonshivering thermogenesis and brown adipose tissue in relation to age, and their integration in the thermoregulatory system. In: Lindberg O (ed) Brown adipose tissue. Elsevier, New York, pp 117–154Google Scholar
- Brück K (1978) Heat production and temperature regulation. In: Stave U (ed) Perinatal physiology. Plenum, New York, pp 455–498Google Scholar
- Brück K, Zeisberger E (1978) Significance and possible central mechanisms of thermoregulatory threshold deviations in thermal adaptation. In: Wang LCH, Hudson JW (eds) Strategies in cold: natural torpidity and thermogenesis. Academic, New York, pp 654–694Google Scholar
- Cannon B, Nedergaard J (1984) The biochemistry of an inefficient tissue. Essays Biochem 20: 110–164Google Scholar
- Lagercrantz H, Slotkin TA (1986) The “stress” of being born. Sci Am 54: 92–102Google Scholar
- Rothwell NJ, Stock MJ (1984) Brown adipose tissue. In: Baker PF (ed) Recent advances in physiology, vol 11. Churchill Livingstone, Edinburgh, pp 349–384Google Scholar
- Zeisberger E (1982) The role of noradrenergic systems in thermal adaptation. In: Hildebrandt G, Hensel H (eds) Biological adaptation. Thieme/Stratton, Stuttgart-New York, pp 140–147Google Scholar