The Neuropharmacology of Baclofen

  • W. Zieglgänsberger
  • J. R. Howe
  • B. Sutor


Gamma-aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the mammalian central nervous system [see: 36, 69, 92, 98]. GABAergic neurons have been identified throughout the central nervous system with histochemical techniques [see: 75]. GABA is, however, of no therapeutical value because the amino acid does not pass the blood-brain barrier in sufficient amounts to affect neuronal excitability [9, 64].


Synaptic Transmission GABAB Receptor Excitatory Synaptic Transmission Neocortical Neuron Pocampal Slice 
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© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • W. Zieglgänsberger
  • J. R. Howe
  • B. Sutor

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