Abstract
Due to its polarity and water solubility, GABA (γ-aminobutyric acid), an inhibitory transmitter within the central nervous system, does not cross the blood-brain barrier and, therefore, is ineffective after oral or parenteral application [2]. Baclofen (β-(p-chlorphenyl)-γ-aminobutyric acid) was synthesised in 1965 as a GABA derivative with lipophilic substitution in order to overcome this disadvantage [3]. Due to the assymmetric substitution, baclofen exists in two optical active isomers, D- and L-baclo-fen. The commercially available preparation contains the racemate, but central nervous activity (as well as toxicity) of the drug is only related to the L-isomer [11].
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© 1988 Springer-Verlag Berlin Heidelberg
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Müller, H., Zierski, J., Dralle, D., Krauß, D., Mutschler, E. (1988). Pharmacokinetics of Intrathecal Baclofen. In: Müller, H., Zierski, J., Penn, R.D. (eds) Local-spinal Therapy of Spasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72954-6_17
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DOI: https://doi.org/10.1007/978-3-642-72954-6_17
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