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Local-spinal Therapy of Spasticity pp 143–150Cite as

Clinical Experience with Spinal Morphine, Midazolam and Tizanidine in Spasticity

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Abstract

The starting point for systemic pharmacological treatment of spasticity was mephenesin, introduced in 1946. Although often stated to depress reflex activity by blocking spinal interneurons without affecting muscular function, mephenesin had a paralyzing effect in experimental animals and in man [2]. It was more or less by chance that mephenesin was also the first non-neurolytic drug to be administered intrathecally in patients with spasticity. According to these investigations intrathecal mephenesin was considered to be a potential alternative to intrathecal phenol or alcohol [10].

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Authors
  1. H. Müller
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  2. J. Zierski
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Editor information

Editors and Affiliations

  1. Dept. Anesthesiology and Intensive Care Medicine, Justus-Liebig-University, Klinikstr. 29, D-6300, Gießen, Germany

    Hermann Müller MD

  2. Dept. Neurosurgery, Justus-Liebig-University, Klinikstr. 29, D-6300, Gießen, Germany

    Jan Zierski MD

  3. Dept. Neurosurgery, Rush-Presbyterian-St. Luke’s Medical Center Rush Medical College, 1753 West Congress Parkway, Chicago, Illinois, 60612, USA

    Richard D. Penn MD

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© 1988 Springer-Verlag Berlin Heidelberg

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Müller, H., Zierski, J. (1988). Clinical Experience with Spinal Morphine, Midazolam and Tizanidine in Spasticity. In: Müller, H., Zierski, J., Penn, R.D. (eds) Local-spinal Therapy of Spasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72954-6_13

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  • DOI: https://doi.org/10.1007/978-3-642-72954-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18295-5

  • Online ISBN: 978-3-642-72954-6

  • eBook Packages: Springer Book Archive

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