Control of Spasticity with Intrathecal Morphine Sulfate

  • D. L. Erickson
  • P. Moreno
  • J. Lo
  • J. Cameron
  • M. Michaelson


Spasticity due to spinal cord insult, can be controlled effectively in many patients with intrathecal morphine sulfate (M.S.). M.S. is known to produce analgesia by blocking A delta and C fiber synapses in the dorsal horn of the spinal cord. Morphine also interrupts the multisynaptic reflexes associated with stimulation of those same small fiber afferents, with no effect on the monosynaptic reflex and no direct effect on the lower motor neuron [1, 3, 4, 6, 8, 9, 11, 12]. It therefore seemed possible that intraspinal morphine might favorably effect spasticity at segmental levels without increasing paresis.


Lower Motor Neuron Test Injection Intrathecal Morphine Fiber Synapse Spastic Quadriparesis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. L. Erickson
  • P. Moreno
  • J. Lo
  • J. Cameron
  • M. Michaelson

There are no affiliations available

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