Control of Spasticity with Intrathecal Morphine Sulfate
Spasticity due to spinal cord insult, can be controlled effectively in many patients with intrathecal morphine sulfate (M.S.). M.S. is known to produce analgesia by blocking A delta and C fiber synapses in the dorsal horn of the spinal cord. Morphine also interrupts the multisynaptic reflexes associated with stimulation of those same small fiber afferents, with no effect on the monosynaptic reflex and no direct effect on the lower motor neuron [1, 3, 4, 6, 8, 9, 11, 12]. It therefore seemed possible that intraspinal morphine might favorably effect spasticity at segmental levels without increasing paresis.
KeywordsLower Motor Neuron Test Injection Intrathecal Morphine Fiber Synapse Spastic Quadriparesis
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- 1.Bodo RC, Brooks C (1937) The effect of morphine on blood sugar and reflex activity in the chronic spinal cat. J Pharmacol Exp Ther 61:82–88Google Scholar
- 3.Irwin S, Houde RW, Bennett DR, Hendershot LC, Seevers MH (1950) The effects of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation. J Pharmacol Exp Ther 101:132–143Google Scholar
- 8.Wikler A (1950) Sites and mechanisms of action of morphine and related drugs in the central nervous system. Pharmacol Rev 2:435–506Google Scholar