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Pumps in Pharmacotherapy

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Local-spinal Therapy of Spasticity

Abstract

During the last few years a new method of medication has experienced wide-spread use, for which so far no generic term has been established. Its outstanding characteristic is the application of drug solutions with the use of technical aids, especially pump systems. This method has raised hopes that certain problems of pharmacotherapy, which until now seemed to be unsolvable, may be overcome in the near future. Definitions of this pharmacological regimen as well as the technical devices necessary to realize it are given in Table 1.

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References

  1. Aigner KR, Walther H, Link KH, Muhrer KH, Filler RD, Schwemmle K, Seuffer R, Schoch P, Petrege C, Tonn JC, Müller H (1983) Die intraarterielle Zytostatikainfusion bei Lebertumoren. Med Klin 78:774–778

    Google Scholar 

  2. Andersen MB, Kjærgård J, Eriksen J (1986) Subcutaneously implanted injection system for epidural administration. Acta Anaesthesiol Scand 30:473–476

    Article  PubMed  CAS  Google Scholar 

  3. Arzbaecher R, Bump T, Brown J, Yurkonis C (1986) Optimal control of antiarrhythmic drug infusion. Clin Prog Electrophysiol and Pacing 4[Suppl]: A349

    Google Scholar 

  4. Balch CU, Urist UU (1984) Intraarterielle Chemotherapie mit einer implantierbaren Infusionspumpe bei Lebermetastasen colorektaler Tumoren und Hepatomen. Chirurg 55:485–493

    PubMed  CAS  Google Scholar 

  5. Ballantine P (1984) Intraventricular lithium infusion and potential applications in psychiatry. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, p 113

    Google Scholar 

  6. Baker SR, Wheeler RH, Ensminger WD, Niederhuber JE (1981) Intraarterial infusion chemotherapy for head and neck cancer using a totally implantable infusion pump. Head Neck Surg 4:118–124

    Article  PubMed  CAS  Google Scholar 

  7. Barone RM, Byfield JE, Goldfarb BP, Frankel S, Ginn C, Green S (1982) Intraarterial chemotherapy using an implantable infusion pump and liver irradiation for treatment of hepatic metastases. Cancer 50:850–862

    Article  PubMed  CAS  Google Scholar 

  8. Beck DO (1984) Continuous infusion of methotrexate therapy of meningeal carcinomatosis. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, p 35

    Google Scholar 

  9. Blachowicz J, Wojtala M, Wojciechowski D, Pryzchodzen J, Bielawski S, Stopczyk M (1986) Automatic system for nitroglycerine therapy in acute myocardial infarction. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A350

    Google Scholar 

  10. Blackshear PJ, Dorman FD, Blackshear PL, Varco RL, Buchwald H (1970) A permanently implantable self-recycling low flow constant rate multipurpose infusion pump of simple design. Surg Forum 21:136

    PubMed  CAS  Google Scholar 

  11. Blackshear PJ, Rohde TD, Varco RL, Buchwald H (1975) One year of continuous heparinization in a dog using a totally implantable infusion pump. Surg Gynecol Obstet 141:176–186

    PubMed  CAS  Google Scholar 

  12. Bland KI, Woodcock T (1984) Totally implantable venous access system for cyclic administration of cytotoxic chemotherapy. Am J Surg 147:815–816

    Article  PubMed  CAS  Google Scholar 

  13. Bleyer WA, Poplack DG, Simon RM (1978) Methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms. Blood 50:835–842

    Google Scholar 

  14. Bringer J (1986) GnRH pulsatile infusion and methods of desensitisation-stimulation versus conventional treatment of anovulations. RBM (Revue Europénne de Technologie Biomédicale) 8:178

    Google Scholar 

  15. Bruera ED, Chadwick S, Bacovsky R, Macdonald N (1985) Continuous subcutaneous infusion of narcotics using a portable disposable pump. J Pall Care 1:46–47

    CAS  Google Scholar 

  16. Campell C, Mason J, Weicer J (1983) Continuous subcutaneous infusion of morphine for the pain of terminal malignancy. Ann Intern Med 98:51–52

    Google Scholar 

  17. Caputi CA, Busca G, Fogliardi A, Giugliano F (1983) Evaluation of tolerance in long-term treatment of cancer pain with epidural morphine. Int J Clin Pharmacol Ther Toxicol 21:587–590

    PubMed  CAS  Google Scholar 

  18. Chrubasik J, Kapsch A, Bonath K, Gerlach K, Cramer H, Scholler KL, Wünsch E (1985) Zur Durapermeabilität peridural applizierten Somatostatins. Schmerz 6:13–17

    Google Scholar 

  19. Chrubasik J, Meynadier J, Blond S, Scherpereel P, Ackerman E, Weinstock M, Bonath K, Cramer H, Wünsch E (1984) Somatostatin, a potent analgesic. Lancet II:1208–1209

    Article  Google Scholar 

  20. Citron M, Johnston A, Fossiek B (1984) Safety and efficacy of continuous intravenous morphine for severe cancer pain. Am J Med 77:199–204

    Article  PubMed  CAS  Google Scholar 

  21. Coombs DW, Maurer LH, Saunders RL, Gaylor M (1984) Outcomes and complications of continuous intraspinal narcotic analgesia for cancer pain control. J Clin Oncol 2:1414–1426

    PubMed  CAS  Google Scholar 

  22. Coombs DW, Savage S, Lachange D, Saunders RL (1984) Intrathecal Clonidine control of cancer pain when spinal morphine tolerance develops. Pain [Suppl]: S21

    Google Scholar 

  23. Coombs DW, Saunders RL, Gaylor MS, Pageau MG (1982) Epidural narcotic infusion reservoir: implantation technique and efficacy. Anesthesiology 56:469–473

    Article  PubMed  CAS  Google Scholar 

  24. Crawford ME, Andersen HB, Augustenborg G, Bay J, Beck O, Benveniste D, Larsen LB, Carl P, Djernes M, Eriksen J, Grell AM, Henriksen H, Johansen SH, Jörgensen HOK, Möller IW, Pedersen JEP, Ravlo O (1983) Pain treatment on outpatients basis utilizing extradural opiates. A Danish multicenter study comprising 105 patients. Pain 16:41–47

    Article  PubMed  CAS  Google Scholar 

  25. Dakhil S, Ensminger WD, Kindt G, Niederhuber J, Chandler W, Greenberg H, Wheeler R (1981) Implanted system for intraventricular drug infusion in central nervous system tumors. Cancer Treat Rep 65:401–411

    PubMed  CAS  Google Scholar 

  26. Delemarre-van de Waal HA, Schoemaker J (1983) Induction of puberty by prolonged pulsatile LRH administration. Acta Endocrinol 102:603–611

    PubMed  CAS  Google Scholar 

  27. Dralle D, Müller H, Zierski J, Klug N (1985) Intrathecal baclofen for spasticity. Lancet II: 1003

    Article  Google Scholar 

  28. Erickson DL (1984) Treatment of spasticity with intrathecal morphine. In: Coombs DW, Enegren BJ, Harbaugh RE, Nieder-huber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 143–145

    Google Scholar 

  29. Findler G, Olshwang D, Hadani M (1982) Continuous epidural morphine treatment of intractable pain in terminal cancer patients. Pain 14:311–315

    Article  PubMed  CAS  Google Scholar 

  30. Fiore CE, Castorina F, Malatino LS, Tamburino C (1983) Analgetic activity of calcitonin: Effectiveness of the epidural and subarachnoid routes in man. Int J Clin Pharmacol Res 3:257–260

    PubMed  CAS  Google Scholar 

  31. Flüchtner ST, Bichler KH, Walter E, Laberke HG, Müller-Schauenburg W, Nelde HJ, Rothe KF (1985) Intraarterielle synchrone Mikrosphären-Zytostatikainfusion urologischer Tumoren. In: Nagel GA (ed) Mitomycin 85. Zuckschwerdt, München Bern Wien, p 172

    Google Scholar 

  32. Fraser D (1980) Intravenous morphine infusion for chronic pain. Ann Intern Med 93:781–782

    PubMed  CAS  Google Scholar 

  33. Greenberg HS (1982) Potential application of the Infusaid System in the treatment of Parkinson’s disease. In: Robertson JT, Enegren BJ, Youel DB, Noble AP (eds) Totally implantable pumps: morphine, heparin, CNS chemotherapy and other uses. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 143–146

    Google Scholar 

  34. Greenberg HS, Ensminger WD, Seeger JF (1981) Intra-arterial BCNU chemotherapy for the treatment of malignant gliomas of the central nervous system: a preliminary report. Cancer Treat Rep 65:803–810

    PubMed  CAS  Google Scholar 

  35. Greenberg HS, Taren J, Ensminger WD, Doan K (1982) Benefit from and tolerance to continuous intrathecal infusion of morphine for intractable cancer pain. J Neurosurg 57:360–364

    Article  PubMed  CAS  Google Scholar 

  36. Gutin PH, Levi JA, Wiernick PH (1977) Treatment of malignant meningeal disease with intrathecal thiotepa. Cancer Treat Rep 61:885–887

    PubMed  CAS  Google Scholar 

  37. Gyves J, Ensminger WD, Niederhuber JE, Liepmann M, Cozzi E, Doan K, Dakhil S, Wheeler R (1982) Totally implanted system for intravenous chemotherapy in patients with cancer. Am J Med 73:841–845

    Article  PubMed  CAS  Google Scholar 

  38. Halberg F (1986) Chronobiologic prevention, screening, diagnosis, prognosis and therapy of high blood pressure. RBM (Revue Europénne de Technologie Biomédicale) 8:175

    Google Scholar 

  39. Harbaugh RE (1984) Intracranial bethanechol infusion in patients with Alzheimer’s disease. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 89–110

    Google Scholar 

  40. Harbaugh R (1986) Drug delivery to the brain by central infusion: rational and clinical application in Alzheimer’s disease. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A375

    Google Scholar 

  41. Harbaugh RE, Roberts DW, Coombs DW, Saunders RL, Reeder TM (1984) Preliminary report: Intracranial cholineric drug infusion in patients with Alzheimer’s disease. Neurosurgery 15:514–518

    Article  PubMed  CAS  Google Scholar 

  42. Harter M, Fenichel P (1986) Hyperpro-lactinaemia and gonadic insufficiency. Physiopathological contribution of pulsatile gonadorelin administration by means of a portable pump. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A 378

    Google Scholar 

  43. Hetzel WD, Castillo O, Aberle L, Pfeiffer EF (1983) Einsatz der pulsatilen Gn-RH-Substitution beim hypythalamo-hypogonadotropen Mann in Diagnostik und Therapie. Verh Dtsch Ges Inn Med 89:1089–1095

    Google Scholar 

  44. Hoffmann AR, Crowley Jr WF (1982) Induction of puberty in man by long-term pulsatile administration of low-dose gonadotropin-releasing hormone. N Engl J Med 307:1237–1242

    Article  Google Scholar 

  45. Jaffé RB (1986) How recent knowledge in neuroendocrinology has influenced therapy in reproductive medicine. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A376

    Google Scholar 

  46. Kim EE, Bledin AG, Kavanagh J, Haynie T, Chuang VP (1984) Chemotherapy of cervical carcinoma: Use of Tc-99m-MAA infusion to predict drug distribution. Radiology 150:677–681

    PubMed  CAS  Google Scholar 

  47. Kirby I, Bland MD (1984) Totally implantable venous access system for cyclic administration of cytotoxic chemotherapy. Am J Surg 147:815–816

    Article  Google Scholar 

  48. Kirchner H (1985) Das Interferonsystem unter besonderer Berücksichtigung des Gamma-Interferons. Dtsch Med Wochenschr 111:64–70

    Article  Google Scholar 

  49. Klopp CT, Sailer D, Wolf N, Hohenberger W (1984) Erfahrungen mit total implantierbaren Kathetersystemen in der parenteralen Heimernährung. Dtsch Med Wochenschr 109:1053–1058

    Article  Google Scholar 

  50. Kolb S, Sailer D, Wolf N, Hohenberger W (1985) Erfahrungen mit total implantierbaren Kathetersystemen in der parenteralen Heimernährung. Infusionstherapie 12:54–57

    CAS  Google Scholar 

  51. Krause J (1987) Intraarterielle Therapie mit Prostaglandine AE 1. Congress “Intraarterielle Therapie heute-morgen”, Sion/Switzerland, 16.-17. 1. 1987

    Google Scholar 

  52. Laron Z, Prager Lewin R, Dickerman Z (1986) Therapeutic induction of puberty. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A381

    Google Scholar 

  53. Leavens M, Stratton-Hill C, Cech D, Weyland J, Weston J (1982) Intrathecal and intraventricular morphine for pain in cancer patients. J Neurosurg 56:241–245

    Article  PubMed  CAS  Google Scholar 

  54. Lenzi A, Galli G, Gandolfini M, Marini G (1985) Intraventricular morphine in paraneoplastic painful syndrome of the cervicofacial region: experience in thirty-eight cases. Neurosurgery 17:6–11

    Article  PubMed  CAS  Google Scholar 

  55. Leyendecker G, Wildt L (1982) Die pulsatile Therapie mit Gonadotropin-Releasing hormon (Gn-RH). Geburtshilfe Frauenheilkd 42:645–652

    Article  Google Scholar 

  56. Lo JN, Erickson DL (1984) Relief of post-spinal trauma spasticity with intrathecal morphine. Anesthesiology 61: A220

    Article  Google Scholar 

  57. Lobato R, Madrid J, Fatela LV, Rivas JJ, Reig E, Lamas E (1983) Intraventricular morphine for control of pain in terminal cancer patients. J Neurosurg 59:627–633

    Article  PubMed  CAS  Google Scholar 

  58. Mecklenburg RS, Benson JW, Becker NM (1982) Clinical use of the insulin infusion pump in 100 patients with Type I diabetes. N Engl J Med 307:513–518

    Article  PubMed  CAS  Google Scholar 

  59. Mellet M, Bringer J, Fedou C, Orsetti A (1986) Stability of isotonic solutions of GRF. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A380

    Google Scholar 

  60. Müller H (1984) Epidural application of benzodiazepines for treatment of spinal spasticity. In: Coombs DW, Enegren BJ, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 149–160

    Google Scholar 

  61. Müller H, Aigner K, Worm I, Lobisch M, Brähler A, Hempelmann G (1984) Langzeit-Erfahrungen mit der kontinuierlichen periduralen Opiatanalgesie mittels implantierter Pumpe. Anaesthesist 33:433–439

    PubMed  Google Scholar 

  62. Müller H, Boldt J, Gerlach H (1983) Lokale Aufhebung von spinaler Spastik durch intrathekale Benzodiazepin-Supplikation: eine tierexperimentelle Studie. Anaesthesist 32: S259

    Google Scholar 

  63. Müller H, Börner U, Zierski J, Hempelmann G (1986) Intrathecal baclofen in tetanus. Lancet I:317–318

    Article  Google Scholar 

  64. Müller H, Gerlach H, Boldt J, Börner U, Hild P, Oehler KU, Zierski J, Hempelmann G (1986) Spastik-Behandlung mit rückenmarksnaher Gabe von Morphin und Midazolam. In vitro-Experimente, Tierversuche und klinische Untersuchungen zur Verträglichkeit und Effektivität. Anaesthesist 35:306–316

    PubMed  Google Scholar 

  65. Müller H, Gerlach H, Boldt J, Hild P, Oehler KU, Hempelmann G (1985) Local medication of spinal spasticity. Schmerz-Pain-Douleur 6:123

    Google Scholar 

  66. Müller H, Gips H, Krumholz W, Zierski J, Lüben V, Hempelmann G (1986) Pharmakokinetik der kontinuierlichen periduralen Morphininfusion. Anaesthesist 35:672–678

    PubMed  Google Scholar 

  67. Müller H, Vogelsberger W, Aigner K, Herget HF, Hempelmann G (1983) Kontinuierliche peridurale Opiatapplikation mit einer implantierten Pumpe. Implantations-technik und erste Ergebnisse. Reg Anaesth 6:47–51

    PubMed  Google Scholar 

  68. Müller JM, Keller HW, Brenner U, Walter M (1984) Die ambulante parenterale Dauerernährung bei Kranken mit Kurzdarm-Syndrom. Internist 25:292–298

    PubMed  Google Scholar 

  69. Munsat TL (1984) Intrathecal TRH in motor neuron diseases. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, p 85

    Google Scholar 

  70. Munsat TL (1986) Intrathecal administration of TRH in amyotrophic lateral sclerosis. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A347

    Google Scholar 

  71. Niederhuber JE (1984) Infusaid pump description and function: surgical considerations in placement. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 3–5

    Google Scholar 

  72. Niederhuber JE, Ensminger W, Gyves JW, Liepman M, Doan K (1982) Totally implanted venous and arterial access system to replace external catheters in cancer treatment. Surgery 92:706–712

    PubMed  CAS  Google Scholar 

  73. Niederhuber JE, Ensminger W, Gyves J, Thrall J, Walter S, Cozzi E (1984) Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer 53:1336–1342

    Article  PubMed  CAS  Google Scholar 

  74. Niederle N, Kurschel E, Schmidt (1984) Biologischer Effekt von rekombiniertem Leukozyten-alpha2-Interferon bei metastasierten kolorektalen Karzinomen. Dtsch Med Wochenschr 109:779–782

    Article  PubMed  CAS  Google Scholar 

  75. Niv D, Whitwam JG, Loh L (1983) Depression of nociceptive sympathetic reflexes by the intrathecal administration of midazolam. Br J Anaesth 55:541–543

    Article  PubMed  CAS  Google Scholar 

  76. Nurchi G (1984) Use of intraventricular and intrathecal morphine in intractable pain associated with cancer. Neurosurgery 15:801–803

    Article  PubMed  CAS  Google Scholar 

  77. Ohnishi K, Tsuchiya S, Nakayama T, Hiyama Y, Iwama S, Goto N, Takashi M, Ohtsuki T, Kono K, Nakajima Y, Okuda K (1984) Arterial chemoembolization in hepatocellular carcinoma with Mitomycin C microcapsules. Radiology 152:51–55

    PubMed  CAS  Google Scholar 

  78. Onofrio BM, Yaksh TL (1983) Intrathecal delta receptor ligand produces analgesia in man. Lancet I:1386–1387

    Article  Google Scholar 

  79. Onofrio BM, Yaksh TL, Arnold PG (1981) Continuous low-dose intrathecal morphine administration in the treatment of chronic pain of malignant origin. Mayo Clin Proc 56:516–520

    PubMed  CAS  Google Scholar 

  80. Oyama T, Jin T, Yamaha R, Ling N, Guillemin R (1980) Profound analgesic effects of β-endorphin in man. Lancet 1:1222–1224

    Google Scholar 

  81. Patt YZ, Peters RE, Chuang VP, Wallace S, Mavlight G (1983) Effective retreatment of patients with colorectal cancer and liver metastases. Am J Med 75:237–240

    Article  PubMed  CAS  Google Scholar 

  82. Penn RD (1986) Chronic intrathecal betanechol for Alzheimer’s disease. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A382

    Google Scholar 

  83. Penn RD, Kroin JS (1985) Continuous intrathecal baclofen for severe spasticity. Lancet II: 125–127

    Article  Google Scholar 

  84. Penn RD, Paice JA, Gottschalk W, Ivankovich AD (1984) Cancer pain relief using chronic morphine infusion. J Neurosurg 61:302–306

    Article  PubMed  CAS  Google Scholar 

  85. Perry CR (1986) Drug delivery systems for antibiotics infusion in osteomyelitis. RBM (Revue Européenne de Technologie Biomédicale) 8:178

    Google Scholar 

  86. Pickup JC, Keen H, Viberti GC, White MC, Kohner EM, Parsons JA, Alberti KGMM (1980) Continuous subcutaneous insulin infusion in the treatment of diabetes mellitus. Diabetes Care 3:290–300

    PubMed  CAS  Google Scholar 

  87. Rhode TD, Blackshear PJ, Varco RL, Buchwald H (1977) Protracted parenteral drug infusion in ambulatory subjects using an implantable infusion pump. Trans Am Soc Artif Intern Organs 23:13–16

    Google Scholar 

  88. Roberts DW (1984) Stereotactic drug administration to the central nervous system. In: Coombs DW, Enegren BJ, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, p 139

    Google Scholar 

  89. Robertson JT (1982) The use of continuous heparin infusion in the treatment of transient ischemic attacks and certain small stroke syndromes. In: Robertson JT, Enegren BJ, Youel DB, Noble AP (eds) Totally implantable pumps: morphine, heparin, CNS chemotherapy and other uses. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 97–99

    Google Scholar 

  90. Rokitansky 0 (1987) Ozontherapie bei arteriosklerotisch bedingter Durchblutungsstörung. Congress “Intraarterielle Therapie heute-morgen”, Sion/Switzerland, 16.-17. 1. 1987

    Google Scholar 

  91. Schade DS, Eaton RP, Carlson GA, Buis RE, Goana JI, Love JT, Urenda RS, Spencer WJ (1981) Future therapy of the insulin dependent diabetic patient. The implantable insulin delivery system. Diabetes Care 4:319–325

    Article  PubMed  CAS  Google Scholar 

  92. Schiffrin A, Colle E, Belmonte M (1980) Improved control in diabetes with continuous subcutaneous insulin infusion. Diabetes Care 3:643–649

    Article  PubMed  CAS  Google Scholar 

  93. Schoemaker J, Burger CW (1986) Is GnRH infusion a treatment of polycystic ovarian disease? Clin Prog Electrophysiol and Pacing 4 [Suppl]: A 377

    Google Scholar 

  94. Schousboe A (1984) Glial GABA uptake inhibitors and epilepsy. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 117–136

    Google Scholar 

  95. Schultheis KH (1985) Embolisation-Chemoembolisation. Zur Behandlung maligner primärer und sekundärer Lebertumoren. Beitr Onkol 21:201–228

    Google Scholar 

  96. Schulz G, Beyer J, Strack T, Krause U, Nagel J, Cordes U, Weber T (1982) Entwicklung von Insulininfusionsprofilen zur Therapie insulinpflichtiger Diabetiker mit tragbaren Insulininfusionssystemen. Biomed Tech (Berlin) 27:203

    Article  CAS  Google Scholar 

  97. Stahl SM (1984) Constant drug delivery of dopamine agonists and antagonists: possible prevention or treatment for tardive dyskinesia and levadopa dyskinesias. In: Abstracts of panels and posters of the annual meeting of the American college of neuropsychopharmacology. Vanderbilt University, Nashville, Tennessee, p 83

    Google Scholar 

  98. Strack T, Krause U, Schulz G, Beyer J, Beutelspacher J, Nagel J (1984) Development of individual insulin infusion profiles for open loop infusion systems. Horm Metab Res 4:163–167

    Article  Google Scholar 

  99. Teutsch SM, Herman WH, Dwyer DM, Lane JM (1984) Mortality among diabetic patients using continuous subcutaneous insulin-infusion pumps. N Engl J Med 310: 360–368

    Article  Google Scholar 

  100. Thirlby RC (1982) The effect of cholecystokinin (CCK) on food intake and weight control. In: Robertson JT, Enegren BJ, Youel DB, Noble AP (eds) Totally implantable pumps: morphine, heparin, CNS chemotherapy and other uses. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 127–139

    Google Scholar 

  101. Timmermann K, Obert HJ (1985) Aktueller Stand der Interferon-Therapie virusbedingter Erkrankungen. Klinikarzt 14:968–991

    Google Scholar 

  102. Trubstein G (1987) Periphere intraarterielle Therapie durch Fibrinolyse. Congress “Intraarterielle Therapie heute-morgen”, Sion/Switzerland, 16.-17. 1. 1987

    Google Scholar 

  103. Von Werder K, Eversmann T (1984) Therapie des männlichen hypogonadotropen Hypogonadismus durch pulsatile Gn-RH-Applikation. Dtsch Med Wochenschr 109:432–435

    Article  Google Scholar 

  104. Waldhäusl W, Freyler H, Bratusch-Marrain P, Vierhapper H, Bruneder H (1983) Kontinuierliche subkutane Insulin-Infusion. Langzeitbehandlung bei einer ausgewählten Gruppe insulinabhängiger Diabetiker. Dtsch Med Wochenschr 108:570–577

    Article  PubMed  Google Scholar 

  105. Wallace S, Charnsangavej C, Carrasco CH, Bechtel W (1984) Infusion-Embolisation. Cancer 54:2751–2765

    Article  PubMed  CAS  Google Scholar 

  106. West CR, Yamada K, Karakousis CP (1979) Intra-arterial BCNU infusion for intracerebral metastases from malignant melanoma and lung cancer. Proc Am Assoc Cancer Res 20:332

    Google Scholar 

  107. Wildt L, Leyendecker G (1986) Die hypothalamische Kontrolle der Ovarialfunktion und ihre Störungen. In: Schölmrich P, Kleinsorge H (eds) Apparative Technik und Pharmakotherapie. Fischer, Stuttgart New York, pp 79–89

    Google Scholar 

  108. Yakoun M, Armynot du Chatelet AM (1986) Long term parenteral nutrition with totally implantable catheters. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A 379

    Google Scholar 

  109. Yaksh TL, Reedy SVR (1981) Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, adrenergic agonists and baclofen. Anesthesiology 54:451–467

    Article  PubMed  CAS  Google Scholar 

  110. Yamashita J, Harda H, Tokuriki Y (1983) Intra-arterial ACNU therapy for malignant brain tumors. J Neurosurg 59:424–430

    Article  PubMed  CAS  Google Scholar 

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Müller, H., Zierski, J. (1988). Pumps in Pharmacotherapy. In: Müller, H., Zierski, J., Penn, R.D. (eds) Local-spinal Therapy of Spasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72954-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-72954-6_10

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