Abstract
During the last few years a new method of medication has experienced wide-spread use, for which so far no generic term has been established. Its outstanding characteristic is the application of drug solutions with the use of technical aids, especially pump systems. This method has raised hopes that certain problems of pharmacotherapy, which until now seemed to be unsolvable, may be overcome in the near future. Definitions of this pharmacological regimen as well as the technical devices necessary to realize it are given in Table 1.
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Aigner KR, Walther H, Link KH, Muhrer KH, Filler RD, Schwemmle K, Seuffer R, Schoch P, Petrege C, Tonn JC, Müller H (1983) Die intraarterielle Zytostatikainfusion bei Lebertumoren. Med Klin 78:774–778
Andersen MB, Kjærgård J, Eriksen J (1986) Subcutaneously implanted injection system for epidural administration. Acta Anaesthesiol Scand 30:473–476
Arzbaecher R, Bump T, Brown J, Yurkonis C (1986) Optimal control of antiarrhythmic drug infusion. Clin Prog Electrophysiol and Pacing 4[Suppl]: A349
Balch CU, Urist UU (1984) Intraarterielle Chemotherapie mit einer implantierbaren Infusionspumpe bei Lebermetastasen colorektaler Tumoren und Hepatomen. Chirurg 55:485–493
Ballantine P (1984) Intraventricular lithium infusion and potential applications in psychiatry. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, p 113
Baker SR, Wheeler RH, Ensminger WD, Niederhuber JE (1981) Intraarterial infusion chemotherapy for head and neck cancer using a totally implantable infusion pump. Head Neck Surg 4:118–124
Barone RM, Byfield JE, Goldfarb BP, Frankel S, Ginn C, Green S (1982) Intraarterial chemotherapy using an implantable infusion pump and liver irradiation for treatment of hepatic metastases. Cancer 50:850–862
Beck DO (1984) Continuous infusion of methotrexate therapy of meningeal carcinomatosis. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, p 35
Blachowicz J, Wojtala M, Wojciechowski D, Pryzchodzen J, Bielawski S, Stopczyk M (1986) Automatic system for nitroglycerine therapy in acute myocardial infarction. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A350
Blackshear PJ, Dorman FD, Blackshear PL, Varco RL, Buchwald H (1970) A permanently implantable self-recycling low flow constant rate multipurpose infusion pump of simple design. Surg Forum 21:136
Blackshear PJ, Rohde TD, Varco RL, Buchwald H (1975) One year of continuous heparinization in a dog using a totally implantable infusion pump. Surg Gynecol Obstet 141:176–186
Bland KI, Woodcock T (1984) Totally implantable venous access system for cyclic administration of cytotoxic chemotherapy. Am J Surg 147:815–816
Bleyer WA, Poplack DG, Simon RM (1978) Methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms. Blood 50:835–842
Bringer J (1986) GnRH pulsatile infusion and methods of desensitisation-stimulation versus conventional treatment of anovulations. RBM (Revue Europénne de Technologie Biomédicale) 8:178
Bruera ED, Chadwick S, Bacovsky R, Macdonald N (1985) Continuous subcutaneous infusion of narcotics using a portable disposable pump. J Pall Care 1:46–47
Campell C, Mason J, Weicer J (1983) Continuous subcutaneous infusion of morphine for the pain of terminal malignancy. Ann Intern Med 98:51–52
Caputi CA, Busca G, Fogliardi A, Giugliano F (1983) Evaluation of tolerance in long-term treatment of cancer pain with epidural morphine. Int J Clin Pharmacol Ther Toxicol 21:587–590
Chrubasik J, Kapsch A, Bonath K, Gerlach K, Cramer H, Scholler KL, Wünsch E (1985) Zur Durapermeabilität peridural applizierten Somatostatins. Schmerz 6:13–17
Chrubasik J, Meynadier J, Blond S, Scherpereel P, Ackerman E, Weinstock M, Bonath K, Cramer H, Wünsch E (1984) Somatostatin, a potent analgesic. Lancet II:1208–1209
Citron M, Johnston A, Fossiek B (1984) Safety and efficacy of continuous intravenous morphine for severe cancer pain. Am J Med 77:199–204
Coombs DW, Maurer LH, Saunders RL, Gaylor M (1984) Outcomes and complications of continuous intraspinal narcotic analgesia for cancer pain control. J Clin Oncol 2:1414–1426
Coombs DW, Savage S, Lachange D, Saunders RL (1984) Intrathecal Clonidine control of cancer pain when spinal morphine tolerance develops. Pain [Suppl]: S21
Coombs DW, Saunders RL, Gaylor MS, Pageau MG (1982) Epidural narcotic infusion reservoir: implantation technique and efficacy. Anesthesiology 56:469–473
Crawford ME, Andersen HB, Augustenborg G, Bay J, Beck O, Benveniste D, Larsen LB, Carl P, Djernes M, Eriksen J, Grell AM, Henriksen H, Johansen SH, Jörgensen HOK, Möller IW, Pedersen JEP, Ravlo O (1983) Pain treatment on outpatients basis utilizing extradural opiates. A Danish multicenter study comprising 105 patients. Pain 16:41–47
Dakhil S, Ensminger WD, Kindt G, Niederhuber J, Chandler W, Greenberg H, Wheeler R (1981) Implanted system for intraventricular drug infusion in central nervous system tumors. Cancer Treat Rep 65:401–411
Delemarre-van de Waal HA, Schoemaker J (1983) Induction of puberty by prolonged pulsatile LRH administration. Acta Endocrinol 102:603–611
Dralle D, Müller H, Zierski J, Klug N (1985) Intrathecal baclofen for spasticity. Lancet II: 1003
Erickson DL (1984) Treatment of spasticity with intrathecal morphine. In: Coombs DW, Enegren BJ, Harbaugh RE, Nieder-huber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 143–145
Findler G, Olshwang D, Hadani M (1982) Continuous epidural morphine treatment of intractable pain in terminal cancer patients. Pain 14:311–315
Fiore CE, Castorina F, Malatino LS, Tamburino C (1983) Analgetic activity of calcitonin: Effectiveness of the epidural and subarachnoid routes in man. Int J Clin Pharmacol Res 3:257–260
Flüchtner ST, Bichler KH, Walter E, Laberke HG, Müller-Schauenburg W, Nelde HJ, Rothe KF (1985) Intraarterielle synchrone Mikrosphären-Zytostatikainfusion urologischer Tumoren. In: Nagel GA (ed) Mitomycin 85. Zuckschwerdt, München Bern Wien, p 172
Fraser D (1980) Intravenous morphine infusion for chronic pain. Ann Intern Med 93:781–782
Greenberg HS (1982) Potential application of the Infusaid System in the treatment of Parkinson’s disease. In: Robertson JT, Enegren BJ, Youel DB, Noble AP (eds) Totally implantable pumps: morphine, heparin, CNS chemotherapy and other uses. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 143–146
Greenberg HS, Ensminger WD, Seeger JF (1981) Intra-arterial BCNU chemotherapy for the treatment of malignant gliomas of the central nervous system: a preliminary report. Cancer Treat Rep 65:803–810
Greenberg HS, Taren J, Ensminger WD, Doan K (1982) Benefit from and tolerance to continuous intrathecal infusion of morphine for intractable cancer pain. J Neurosurg 57:360–364
Gutin PH, Levi JA, Wiernick PH (1977) Treatment of malignant meningeal disease with intrathecal thiotepa. Cancer Treat Rep 61:885–887
Gyves J, Ensminger WD, Niederhuber JE, Liepmann M, Cozzi E, Doan K, Dakhil S, Wheeler R (1982) Totally implanted system for intravenous chemotherapy in patients with cancer. Am J Med 73:841–845
Halberg F (1986) Chronobiologic prevention, screening, diagnosis, prognosis and therapy of high blood pressure. RBM (Revue Europénne de Technologie Biomédicale) 8:175
Harbaugh RE (1984) Intracranial bethanechol infusion in patients with Alzheimer’s disease. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 89–110
Harbaugh R (1986) Drug delivery to the brain by central infusion: rational and clinical application in Alzheimer’s disease. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A375
Harbaugh RE, Roberts DW, Coombs DW, Saunders RL, Reeder TM (1984) Preliminary report: Intracranial cholineric drug infusion in patients with Alzheimer’s disease. Neurosurgery 15:514–518
Harter M, Fenichel P (1986) Hyperpro-lactinaemia and gonadic insufficiency. Physiopathological contribution of pulsatile gonadorelin administration by means of a portable pump. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A 378
Hetzel WD, Castillo O, Aberle L, Pfeiffer EF (1983) Einsatz der pulsatilen Gn-RH-Substitution beim hypythalamo-hypogonadotropen Mann in Diagnostik und Therapie. Verh Dtsch Ges Inn Med 89:1089–1095
Hoffmann AR, Crowley Jr WF (1982) Induction of puberty in man by long-term pulsatile administration of low-dose gonadotropin-releasing hormone. N Engl J Med 307:1237–1242
Jaffé RB (1986) How recent knowledge in neuroendocrinology has influenced therapy in reproductive medicine. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A376
Kim EE, Bledin AG, Kavanagh J, Haynie T, Chuang VP (1984) Chemotherapy of cervical carcinoma: Use of Tc-99m-MAA infusion to predict drug distribution. Radiology 150:677–681
Kirby I, Bland MD (1984) Totally implantable venous access system for cyclic administration of cytotoxic chemotherapy. Am J Surg 147:815–816
Kirchner H (1985) Das Interferonsystem unter besonderer Berücksichtigung des Gamma-Interferons. Dtsch Med Wochenschr 111:64–70
Klopp CT, Sailer D, Wolf N, Hohenberger W (1984) Erfahrungen mit total implantierbaren Kathetersystemen in der parenteralen Heimernährung. Dtsch Med Wochenschr 109:1053–1058
Kolb S, Sailer D, Wolf N, Hohenberger W (1985) Erfahrungen mit total implantierbaren Kathetersystemen in der parenteralen Heimernährung. Infusionstherapie 12:54–57
Krause J (1987) Intraarterielle Therapie mit Prostaglandine AE 1. Congress “Intraarterielle Therapie heute-morgen”, Sion/Switzerland, 16.-17. 1. 1987
Laron Z, Prager Lewin R, Dickerman Z (1986) Therapeutic induction of puberty. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A381
Leavens M, Stratton-Hill C, Cech D, Weyland J, Weston J (1982) Intrathecal and intraventricular morphine for pain in cancer patients. J Neurosurg 56:241–245
Lenzi A, Galli G, Gandolfini M, Marini G (1985) Intraventricular morphine in paraneoplastic painful syndrome of the cervicofacial region: experience in thirty-eight cases. Neurosurgery 17:6–11
Leyendecker G, Wildt L (1982) Die pulsatile Therapie mit Gonadotropin-Releasing hormon (Gn-RH). Geburtshilfe Frauenheilkd 42:645–652
Lo JN, Erickson DL (1984) Relief of post-spinal trauma spasticity with intrathecal morphine. Anesthesiology 61: A220
Lobato R, Madrid J, Fatela LV, Rivas JJ, Reig E, Lamas E (1983) Intraventricular morphine for control of pain in terminal cancer patients. J Neurosurg 59:627–633
Mecklenburg RS, Benson JW, Becker NM (1982) Clinical use of the insulin infusion pump in 100 patients with Type I diabetes. N Engl J Med 307:513–518
Mellet M, Bringer J, Fedou C, Orsetti A (1986) Stability of isotonic solutions of GRF. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A380
Müller H (1984) Epidural application of benzodiazepines for treatment of spinal spasticity. In: Coombs DW, Enegren BJ, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 149–160
Müller H, Aigner K, Worm I, Lobisch M, Brähler A, Hempelmann G (1984) Langzeit-Erfahrungen mit der kontinuierlichen periduralen Opiatanalgesie mittels implantierter Pumpe. Anaesthesist 33:433–439
Müller H, Boldt J, Gerlach H (1983) Lokale Aufhebung von spinaler Spastik durch intrathekale Benzodiazepin-Supplikation: eine tierexperimentelle Studie. Anaesthesist 32: S259
Müller H, Börner U, Zierski J, Hempelmann G (1986) Intrathecal baclofen in tetanus. Lancet I:317–318
Müller H, Gerlach H, Boldt J, Börner U, Hild P, Oehler KU, Zierski J, Hempelmann G (1986) Spastik-Behandlung mit rückenmarksnaher Gabe von Morphin und Midazolam. In vitro-Experimente, Tierversuche und klinische Untersuchungen zur Verträglichkeit und Effektivität. Anaesthesist 35:306–316
Müller H, Gerlach H, Boldt J, Hild P, Oehler KU, Hempelmann G (1985) Local medication of spinal spasticity. Schmerz-Pain-Douleur 6:123
Müller H, Gips H, Krumholz W, Zierski J, Lüben V, Hempelmann G (1986) Pharmakokinetik der kontinuierlichen periduralen Morphininfusion. Anaesthesist 35:672–678
Müller H, Vogelsberger W, Aigner K, Herget HF, Hempelmann G (1983) Kontinuierliche peridurale Opiatapplikation mit einer implantierten Pumpe. Implantations-technik und erste Ergebnisse. Reg Anaesth 6:47–51
Müller JM, Keller HW, Brenner U, Walter M (1984) Die ambulante parenterale Dauerernährung bei Kranken mit Kurzdarm-Syndrom. Internist 25:292–298
Munsat TL (1984) Intrathecal TRH in motor neuron diseases. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, p 85
Munsat TL (1986) Intrathecal administration of TRH in amyotrophic lateral sclerosis. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A347
Niederhuber JE (1984) Infusaid pump description and function: surgical considerations in placement. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 3–5
Niederhuber JE, Ensminger W, Gyves JW, Liepman M, Doan K (1982) Totally implanted venous and arterial access system to replace external catheters in cancer treatment. Surgery 92:706–712
Niederhuber JE, Ensminger W, Gyves J, Thrall J, Walter S, Cozzi E (1984) Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer 53:1336–1342
Niederle N, Kurschel E, Schmidt (1984) Biologischer Effekt von rekombiniertem Leukozyten-alpha2-Interferon bei metastasierten kolorektalen Karzinomen. Dtsch Med Wochenschr 109:779–782
Niv D, Whitwam JG, Loh L (1983) Depression of nociceptive sympathetic reflexes by the intrathecal administration of midazolam. Br J Anaesth 55:541–543
Nurchi G (1984) Use of intraventricular and intrathecal morphine in intractable pain associated with cancer. Neurosurgery 15:801–803
Ohnishi K, Tsuchiya S, Nakayama T, Hiyama Y, Iwama S, Goto N, Takashi M, Ohtsuki T, Kono K, Nakajima Y, Okuda K (1984) Arterial chemoembolization in hepatocellular carcinoma with Mitomycin C microcapsules. Radiology 152:51–55
Onofrio BM, Yaksh TL (1983) Intrathecal delta receptor ligand produces analgesia in man. Lancet I:1386–1387
Onofrio BM, Yaksh TL, Arnold PG (1981) Continuous low-dose intrathecal morphine administration in the treatment of chronic pain of malignant origin. Mayo Clin Proc 56:516–520
Oyama T, Jin T, Yamaha R, Ling N, Guillemin R (1980) Profound analgesic effects of β-endorphin in man. Lancet 1:1222–1224
Patt YZ, Peters RE, Chuang VP, Wallace S, Mavlight G (1983) Effective retreatment of patients with colorectal cancer and liver metastases. Am J Med 75:237–240
Penn RD (1986) Chronic intrathecal betanechol for Alzheimer’s disease. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A382
Penn RD, Kroin JS (1985) Continuous intrathecal baclofen for severe spasticity. Lancet II: 125–127
Penn RD, Paice JA, Gottschalk W, Ivankovich AD (1984) Cancer pain relief using chronic morphine infusion. J Neurosurg 61:302–306
Perry CR (1986) Drug delivery systems for antibiotics infusion in osteomyelitis. RBM (Revue Européenne de Technologie Biomédicale) 8:178
Pickup JC, Keen H, Viberti GC, White MC, Kohner EM, Parsons JA, Alberti KGMM (1980) Continuous subcutaneous insulin infusion in the treatment of diabetes mellitus. Diabetes Care 3:290–300
Rhode TD, Blackshear PJ, Varco RL, Buchwald H (1977) Protracted parenteral drug infusion in ambulatory subjects using an implantable infusion pump. Trans Am Soc Artif Intern Organs 23:13–16
Roberts DW (1984) Stereotactic drug administration to the central nervous system. In: Coombs DW, Enegren BJ, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, p 139
Robertson JT (1982) The use of continuous heparin infusion in the treatment of transient ischemic attacks and certain small stroke syndromes. In: Robertson JT, Enegren BJ, Youel DB, Noble AP (eds) Totally implantable pumps: morphine, heparin, CNS chemotherapy and other uses. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 97–99
Rokitansky 0 (1987) Ozontherapie bei arteriosklerotisch bedingter Durchblutungsstörung. Congress “Intraarterielle Therapie heute-morgen”, Sion/Switzerland, 16.-17. 1. 1987
Schade DS, Eaton RP, Carlson GA, Buis RE, Goana JI, Love JT, Urenda RS, Spencer WJ (1981) Future therapy of the insulin dependent diabetic patient. The implantable insulin delivery system. Diabetes Care 4:319–325
Schiffrin A, Colle E, Belmonte M (1980) Improved control in diabetes with continuous subcutaneous insulin infusion. Diabetes Care 3:643–649
Schoemaker J, Burger CW (1986) Is GnRH infusion a treatment of polycystic ovarian disease? Clin Prog Electrophysiol and Pacing 4 [Suppl]: A 377
Schousboe A (1984) Glial GABA uptake inhibitors and epilepsy. In: Coombs DW, Enegren BJ, Ensminger WD, Harbaugh RE, Niederhuber JE (eds) Totally implantable pumps: Intraspinal analgesia, CNS malignancies, Alzheimer’s disease and other neurotransmitter disorders. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 117–136
Schultheis KH (1985) Embolisation-Chemoembolisation. Zur Behandlung maligner primärer und sekundärer Lebertumoren. Beitr Onkol 21:201–228
Schulz G, Beyer J, Strack T, Krause U, Nagel J, Cordes U, Weber T (1982) Entwicklung von Insulininfusionsprofilen zur Therapie insulinpflichtiger Diabetiker mit tragbaren Insulininfusionssystemen. Biomed Tech (Berlin) 27:203
Stahl SM (1984) Constant drug delivery of dopamine agonists and antagonists: possible prevention or treatment for tardive dyskinesia and levadopa dyskinesias. In: Abstracts of panels and posters of the annual meeting of the American college of neuropsychopharmacology. Vanderbilt University, Nashville, Tennessee, p 83
Strack T, Krause U, Schulz G, Beyer J, Beutelspacher J, Nagel J (1984) Development of individual insulin infusion profiles for open loop infusion systems. Horm Metab Res 4:163–167
Teutsch SM, Herman WH, Dwyer DM, Lane JM (1984) Mortality among diabetic patients using continuous subcutaneous insulin-infusion pumps. N Engl J Med 310: 360–368
Thirlby RC (1982) The effect of cholecystokinin (CCK) on food intake and weight control. In: Robertson JT, Enegren BJ, Youel DB, Noble AP (eds) Totally implantable pumps: morphine, heparin, CNS chemotherapy and other uses. Postgraduate Medicine and Health Professions Education, University of Michigan Medical School, pp 127–139
Timmermann K, Obert HJ (1985) Aktueller Stand der Interferon-Therapie virusbedingter Erkrankungen. Klinikarzt 14:968–991
Trubstein G (1987) Periphere intraarterielle Therapie durch Fibrinolyse. Congress “Intraarterielle Therapie heute-morgen”, Sion/Switzerland, 16.-17. 1. 1987
Von Werder K, Eversmann T (1984) Therapie des männlichen hypogonadotropen Hypogonadismus durch pulsatile Gn-RH-Applikation. Dtsch Med Wochenschr 109:432–435
Waldhäusl W, Freyler H, Bratusch-Marrain P, Vierhapper H, Bruneder H (1983) Kontinuierliche subkutane Insulin-Infusion. Langzeitbehandlung bei einer ausgewählten Gruppe insulinabhängiger Diabetiker. Dtsch Med Wochenschr 108:570–577
Wallace S, Charnsangavej C, Carrasco CH, Bechtel W (1984) Infusion-Embolisation. Cancer 54:2751–2765
West CR, Yamada K, Karakousis CP (1979) Intra-arterial BCNU infusion for intracerebral metastases from malignant melanoma and lung cancer. Proc Am Assoc Cancer Res 20:332
Wildt L, Leyendecker G (1986) Die hypothalamische Kontrolle der Ovarialfunktion und ihre Störungen. In: Schölmrich P, Kleinsorge H (eds) Apparative Technik und Pharmakotherapie. Fischer, Stuttgart New York, pp 79–89
Yakoun M, Armynot du Chatelet AM (1986) Long term parenteral nutrition with totally implantable catheters. Clin Prog Electrophysiol and Pacing 4 [Suppl]: A 379
Yaksh TL, Reedy SVR (1981) Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, adrenergic agonists and baclofen. Anesthesiology 54:451–467
Yamashita J, Harda H, Tokuriki Y (1983) Intra-arterial ACNU therapy for malignant brain tumors. J Neurosurg 59:424–430
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Müller, H., Zierski, J. (1988). Pumps in Pharmacotherapy. In: Müller, H., Zierski, J., Penn, R.D. (eds) Local-spinal Therapy of Spasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72954-6_10
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