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Neural Transplants and Recovery of Function after Brain Damage

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Functional Morphology of Neuroendocrine Systems

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Abstract

During the last few years evidence has accumulated that fetal neurons, implanted into the depth of the brain in adult rats, can reestablish damaged connections in the host brain and substitute functionally for elements lost or damaged as a result of an experimental lesion. This research has led to the realization that, contrary to traditional views, the adult mammalian CNS has the potential to incorporate new neuronal elements into already established neuronal circuitry and that such implanted neurons can modify the function and behavior of the recipient. For a long time it was thought that the remarkable regenerative potential of CNS tissue in cold-blooded vertebrates reflected a fundamental difference in the regenerative properties of central nervous tissue between cold-blooded vertebrates and mammals. During the last few years it has become evident, however, that at least certain types of intracerebral neural grafts can perform just as well in developing and adult mammals as in developing or adult submammalian vertebrates.

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Authors and Affiliations

  1. Department of Histology, University of Lund, Lund, Sweden

    A. Björklund & F. H. Gage

Authors
  1. A. Björklund
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  2. F. H. Gage
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Editors and Affiliations

  1. Department of Anatomy, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA

    Berta Scharrer

  2. Department of Anatomy and Cytobiology, Justus Liebig University Giessen, Aulweg 123, D-6300, Giessen, Deutschland

    Horst-Werner Korf

  3. Department of Anatomy II, Moorenstraße 5, D-4000, Düsseldorf 1, Deutschland

    Hans-Georg Hartwig

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© 1987 Springer-Verlag Berlin Heidelberg

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Björklund, A., Gage, F.H. (1987). Neural Transplants and Recovery of Function after Brain Damage. In: Scharrer, B., Korf, HW., Hartwig, HG. (eds) Functional Morphology of Neuroendocrine Systems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72886-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-72886-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72888-4

  • Online ISBN: 978-3-642-72886-0

  • eBook Packages: Springer Book Archive

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