Analysis of the Secretory Products of the Subcommissural Organ

  • E. M. Rodríguez
  • S. Hein
  • S. Rodríguez
  • H. Herrera
  • B. Peruzzo
  • F. Nualart
  • A. Oksche


The subcommissural organ (SCO) can be regarded as an area of highly differentiated ependyma located in the dorso-caudal region of the third ventricle, at the entrance of the Sylvian aqueduct. Dendy (1902) was the first to describe the SCO as a specialized region of the ventricular wall. Later on, Dendy and Nicholls (1910) introduced the term “subcommissural organ”. Previously, in 1899, Studnička had suggested that this structure may be capable of secretory activity, and Bauer-Jokl (1917) provided some evidence for such a secretory role. The analysis of the secretory function of the SCO was improved when, in 1950, Stutinsky demonstrated for the first time a selectively stainable (“Gomori-positive”) secretory material in its ependymal cells. This finding in the frog was confirmed and extended to several vertebrate species (Bargmann and Schiebler 1952; Mazzi 1952; Wislocki and Leduc 1952; Wingstrand 1953; Oksche 1954, 1956).


Sialic Acid Rough Endoplasmic Reticulum Ependymal Cell Secretory Product Central Canal 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • E. M. Rodríguez
    • 1
    • 2
  • S. Hein
    • 1
    • 2
  • S. Rodríguez
    • 1
    • 2
  • H. Herrera
    • 1
    • 2
  • B. Peruzzo
    • 1
    • 2
  • F. Nualart
    • 1
    • 2
  • A. Oksche
    • 1
    • 2
  1. 1.Instituto de Histología y PatologíaUniversidad Austral de ChileValdiviaChile
  2. 2.Department of Anatomy and CytobiologyJustus Liebig UniversityGiessenGermany

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