Skip to main content
SpringerLink
Log in

Experimental Pharmacology and Toxicology of Antituberculosis Drugs

  • Chapter
Antituberculosis Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 84))

Abstract

The anti-tuberculosis agents are, chemically, a very heterogeneous group exhibiting a wide spectrum of pharmacological and toxicological effects on the various organ systems. These range from the very early recognized ototoxicity and nephrotoxicity of the aminoglycosides, to the question of neurotoxicity, carcinogenicity and mutagenicity of INH, to the oculotoxicity of ethambutol and to effects on neuro-muscular transmission of the aminoglycosides. Whilst for some substances there are enormous numbers of publications, there are other substances where there is a noticeable lack of published pharmacological and toxicological data. With regard to the latter substances it was possible, in some cases, to include in this review previously unpublished results of studies carried out by the manufacturing companies. Since most of the anti-tuberculosis agents were introduced 20 years–30 years ago, it is practically impossible to assess the old publications on the basis of modern standards. It would be misguided, however, to ignore the results of the early studies since they provided important basic data.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bavin EM, James B (1952) Further aspects of the pharmacology of para-aminosalicylic acid. J Pharm Pharmacol 4: 856–870

    PubMed  CAS  Google Scholar 

  • Beattie J, Chambers RD (1953) The anti-thyroid action of para-aminosalicylic acid. J Endocrinol 10: 65–72

    PubMed  CAS  Google Scholar 

  • Cauwenberge H van (1951) The effect of salicylates on the pituitary and suprarenal glands. Lancet 2: 686–687

    Google Scholar 

  • Cronheim G, King JS, Hyder N (1952) Effect of salicylic acid and similar compounds on the adrenal-pituitary system. Proc Soc Exp Biol Med 80: 51–55

    PubMed  CAS  Google Scholar 

  • Hetzel BS, Hine DC (1951) The effect of salicylates on the pituitary and suprarenal glands. Lancet 2: 94–97

    PubMed  CAS  Google Scholar 

  • Kjerulf-Jensen K, Wolffbrandt G (1951) Antithyroid effect of p-aminosalicylic acid and maminophenol. Acta Pharmacol Toxicol (Copenh) 7: 376–380

    CAS  Google Scholar 

  • Koelzer PP, Giesen J (1951) Untersuchungen zur Toxizität der p-Aminosalicylsäure und ihrer Derivate. Z Naturforsch 6 B: 183–190

    Google Scholar 

  • Mehrotra RML, Chandra S, Singh MP, Gupta NN (1959) Changes in the liver of albino rats after administration of para-aminosalicylic acid. Indian J Med Res 47: 500–506

    CAS  Google Scholar 

  • Schonholzer G (1951) Comments on the toxicity of P.A.S. preparations. Aust J Pharm 32: 1359–1363

    CAS  Google Scholar 

  • Tettenborn D (1970) Unpublished investigations

    Google Scholar 

  • Thoma F (1962) Stabilität von PAS-Infusionslösungen und ihre Prüfung durch Papier-und Dünnschichtchromatographie. Tuberk Arzt 16: 362–368

    CAS  Google Scholar 

  • Adams HR, Goodman FR, Lupean VA, Weiss GB (1973) Effects of neomycin on tension and 45Ca movements in rabbit aortic smooth muscle. Life Sci Part I Physiol Pharmacol 12: 279–287

    CAS  Google Scholar 

  • Akiyoshi M, Sato K (1970) Reevaluation of the pinna reflex test as screening for ototoxicity of antibiotics. In: Progress in Antimicrobiol and Anticancer Chemotherapy; Proc 6th Intern Congr Chemotherapy, Vol 1: 621–627

    Google Scholar 

  • Alleva FR, Balazs T, Morris SO, Crowley WR, O’Donohue TL, Jacobowitz DM (1979) Reversal of streptomycin-induced dyskinesia in rats by dopaminergic agonists. Toxicol Appl Pharmacol 48:A 36

    Google Scholar 

  • Amann R, Radenbach KL (1961) Akute Kanamycin-Nebenwirkungen und Histaminfreisetzung. Beitr Klin Tuberk 123: 208–210

    CAS  Google Scholar 

  • André T (1956) Studies on the distribution of tritium-labelled dihydrostreptomycin and tetracyclin in the body. Acta Radiol Suppl 142: 1–89

    PubMed  Google Scholar 

  • Bacharach AL, Clark BJ, McCulloch M, Tomich EG (1959) Comparative toxicity studies on ten antibiotics in current use. J Pharm Pharmacol 11: 737–741

    PubMed  CAS  Google Scholar 

  • Beck Ch, Krahl P (1962) Experimentelle und feingewebliche Untersuchungen über die Ototoxizität von Kanamycin. Arch Otorhinolaryngol 179: 594–610

    CAS  Google Scholar 

  • Berg K (1951) The toxic effect of streptomycin on the vestibular and cochlear apparatus. Acta Otolaryng Suppl 97: 5–77

    Google Scholar 

  • Bezzi G, Gessa GL (1959) Neuromuscular blocking action of some antibiotics. Nature 184: 905–906

    PubMed  CAS  Google Scholar 

  • Bezzi G, Gessa GL (1961) Influence of antibiotics on the neuromuscular transmission in mammals. Antibiot Chemotherap 11: 710–714

    CAS  Google Scholar 

  • Boucher D, Delost P (1964) Développement post-natal des descendants issus de mères traitées par la streptomycine au cours de la gestation chez la souris. CR Soc Biol (Paris) 158: 2065–2069

    CAS  Google Scholar 

  • Brigham RS, Nielsen JK (1958) The effect of calcium pantothenate on the acute and chronic toxicity of streptomycin and dihydrostreptomycin in mice. Anbiot Chemother 8: 122–129

    CAS  Google Scholar 

  • Catalano GB, Madonia T (1956) Ulteriore contributo sperimentale sulle lesioni istologiche labyrinthiche da streptomicina. Clin Otorinolaryng 8:51

    CAS  Google Scholar 

  • Caussé R, Gondet I, Vallancien B (1949) Action de la streptomycine sur les cellules ciliées des organes vestibulaires de la souris. CR Soc Biol 144: 619–620

    Google Scholar 

  • Child KJ, Davis B, Sharpe HM, Tomich EG (1957) Toxicologic studies on the sulfates and pantothenates of streptomycin and dihydrostreptomycin. Antibiot Annu 1956–1957: 574–580

    Google Scholar 

  • Christensen E, Hertz H, Riskaer N, Vraa-Jensen G (1950) Experiments on the neurotoxic effect of streptomycin. Acta Otolaryng Suppl 95: 165–176

    Google Scholar 

  • Cohen LS, Wechsler AS, Mitchell JH, Glick G (1970) Depression of cardiac function by streptomycin and other antimicrobial agents. Am J Cardiol 26: 505–511

    PubMed  CAS  Google Scholar 

  • Corrado AP (1958) Ganglioplegic action of streptomycin. Arch Int Pharmacodyn 114: 166–178

    PubMed  CAS  Google Scholar 

  • Corrado AP (1963) Respiratory depression due to antibiotics: calcium in treatment. Anesth Analg 42: 1–5

    PubMed  CAS  Google Scholar 

  • Corrado AP, Ramos AO, De Escobar CT (1959) Neuro-muscular blockade by neomycin potentiation by ether anesthesia and d-tubocurarine and antagonism by calcium and prostigmine Arch Int Pharmacodyn Ther 121: 380–394

    CAS  Google Scholar 

  • Courvoisier S, Leau O (1956) Study of the onset of deafness in rats treated with streptomycin, dihydrostreptomycin and neomycin. Antibiot Chemother 6: 411–419

    CAS  Google Scholar 

  • DeSalva SJ, Evans RA, Marcussen HW (1969) Lethal effects of antibiotics in hamsters. Toxicol Appl Pharmacol 14: 510–514

    PubMed  CAS  Google Scholar 

  • Dretchen KL, Sokoll MD, Gergis SD, Long JP (1973) Relative effects of streptomycin on motor nerve terminal and endplate. Eur J Pharmacol 22: 10–16

    PubMed  CAS  Google Scholar 

  • Ducrot R, Leau O, Cosar C (1956) Protective action of pantothenic acid against toxic effects of streptomycin and dihydrostreptomycin. Antibiot Chemother 6: 404–410

    CAS  Google Scholar 

  • Duvall AJ, Wersäll J (1964) Site of action of streptomycin upon inner ear sensory cells. Acta Otolaryng 57: 581–598

    PubMed  CAS  Google Scholar 

  • Dzoljié M, Babié M (1967) Action of streptomycin on the uterus. Eur J Pharmacol 2: 123–126

    Google Scholar 

  • Edison AO, Frost BM, Graessle OE, Hawkins JE Jr, Kuna S, Mushett CW, Silber RH, Solotorovsky M (1948) An experimental evaluation of dihydrostreptomycin. Am Rev Tuberc 58: 487–493

    PubMed  CAS  Google Scholar 

  • Engström H (1967) The pathological sensory cell in the cochlea. Acta Otolaryng Appendix to Vol 63: 20–26

    Google Scholar 

  • Ericson-Strandvik B, Gyllenstein L (1963) The central nervous system of foetal mice after administration of streptomycin. Acta Pathol Microbiol Scand 59: 292–300

    PubMed  CAS  Google Scholar 

  • Escher F (1949) Das Streptomycin in der Otolaryngologie unter besonderer Berücksichtigung der Vestibularisstörungen. Praxis: 141–146

    Google Scholar 

  • Farkashidy J, Black RG, Briant TDR (1963) The effect of kanamycin on the internal ear: an electrophysiological and electron microscopic study. Laryngoscope 73: 713–727

    PubMed  CAS  Google Scholar 

  • Flohberg C, Hamberger CA, Hyden H (1949) Inhibition of nucleic acid production in vestibular nerve cells by streptomycin. Acta Otolaryng Suppl 75: 36

    Google Scholar 

  • Garcia-Quiroga J, Norris CH, Glade L, Bryant GM, Tachibana M, Guth PS (1978) The relationship between kanamycin ototoxicity and glucose transport. Res Commun Chem Pathol Pharmacol 22: 535–547

    PubMed  CAS  Google Scholar 

  • Goodman FR, Weiss GB, Adams HR (1974) Alterations by neomycin of 45Ca movements and contractile responses in vascular smooth muscle. J Pharmacol Exp Ther 188: 472–480

    PubMed  CAS  Google Scholar 

  • Gray JE, Purmalis A (1958) The acute toxicity of procaine penicilline G and of dihydro-streptomycin sulfate in the pigeon and the chicken. Avian Dis 2: 187–196

    CAS  Google Scholar 

  • Greven H (1953) Die toxische Wirkung von Streptomycin auf den Cochlear-und Vestibu-larapparat. Z Laryng Rhinol 32: 109–117

    CAS  Google Scholar 

  • Gross A, Legait E, Delabroise AM (1969) Etude de la néphrotoxicité de la streptomycine et de la dihydrostreptomycine chez le rat blanc porteur d’une insufficance rénale expérimentale. Thérapie 24: 327–341

    PubMed  CAS  Google Scholar 

  • Hawkins JE Jr (1959) The ototoxicity of kanamycin. Ann Otol 68: 698–715

    Google Scholar 

  • Hawkins JE Jr (1970) Biochemical aspects of ototoxicity. In: Paparella MM (ed) Biochemical mechanisms in hearing and deafness. Thomas Publ, pp 323–339

    Google Scholar 

  • Hawkins JE Jr (1973) Ototoxic mechanisms. A working hypothesis. Audiology 12: 383–393

    PubMed  Google Scholar 

  • Hawkins JE Jr, Wolcott H, O’Shanny WJ (1957) Ototoxic effects of streptomycin and di- hydrostreptomycin pantothenates in the cat. Antibiot Annu 1956–1957: 554–563

    Google Scholar 

  • Hinshaw HC, Feldman WH (1945) Streptomycin in treatment of clinical tuberculosis: A preliminary report. Mayo Clin Proc 20: 313

    Google Scholar 

  • Hoffmann K (1970) unpublished investigations

    Google Scholar 

  • Holz E, Hoffmann M, Beck Ch (1967) Morphologische und bakteriologische Befunde zur Minderung der Ototoxicität basischer Streptomycesantibiotika. Arch Otorhinolaryngol 188: 236–242

    CAS  Google Scholar 

  • Linuma T, Mizukoshi O, Daly JF (1976) Possible effects of various ototoxic drugs upon the ATP-hydrolyzing system in the stria vascularis and spiral ligament of the guinea pig. Laryngoscope 77: 159–169

    Google Scholar 

  • Iwatsuki K, Ueda T, Yamada A, Nishimura S, Kanemura K (1958) Effects of certain antibiotics on the action of muscle relaxants. Far East J Anesth 2:106–115; cited from Ber Ges Physiol 213 (1960): 121

    Google Scholar 

  • Jindal MN, Desphande VR (1960) Neuromuscular blockade by streptomycin and dihydrostreptomycin. Brit J Pharmacol 15: 506–509

    PubMed  CAS  Google Scholar 

  • Johnsson L-G, Wright CG, Preston RE, Henry PJ (1980) Streptomycin-induced efects of the otoconial membrane. Acta Otolaryngol (Stockh) 89: 401–406

    CAS  Google Scholar 

  • Keller H, Krüpe W, Sous H, Mückter H (1955) Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotika. 1. Mitt. Arzneimittelforsch 5: 170–176

    PubMed  CAS  Google Scholar 

  • Keller H, Krüpe W, Sous H, Mückter H (1956a) Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotika 2 Mitt. Arzneimittelforsch 6: 61–66

    CAS  Google Scholar 

  • Keller H, Krüpe W, Sous H, Mückter H (1956b) Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotika. 3. Mitt. Arzneimittelforsch 6: 585–591

    CAS  Google Scholar 

  • Kellerhals B, Engström H, Ades HW (1967) Die Morphologie des Ganglion spirale cochleae. Acta Otolaryng (Stockh) Suppl 226: 1–78

    Google Scholar 

  • Kellerhals B (1973) Zur Ototoxizität der Aminoglykosid-Antibiotika. MMW 115: 1667–1672

    CAS  Google Scholar 

  • Kimmerle G, Gösswald R (1956) Versuche zur Entgiftung von Streptomycin und Dihydrostreptomycin. Arzneimittelforsch 6: 379–383

    PubMed  CAS  Google Scholar 

  • Kohonen A (1965) Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig. Acta Otolaryngol (Stockh) Suppl 208: 1–70

    Google Scholar 

  • Kohonen A, Tarkkanen JV (1966) Dihydrostreptomycin and kanamycin ototoxicity. An experimental study by surface preparation technique. Laryngoscope 76: 1671–1680

    PubMed  CAS  Google Scholar 

  • Kraus H, Doenning G (1969) Cytophotometrische RNA- und Eiweißbestimmungen am häutigen Innenohr des Meerschweinchens als Grundlage zur Beurteilung des Eiweißstoffwechsels und der Streptomycinototoxizität. Arch Otorhinolaryngol 194: 1551

    Google Scholar 

  • Kubikowski P, Srzeniawski Z (1963) The mechanism of the neuromuscular blockade by antibiotics. Arch Int Pharmacodyn Ther 146: 549–560

    PubMed  CAS  Google Scholar 

  • Kuschinsky G, Lüllmann H, Pracht W (1959) Über den Einfluß von Pantothensäure auf die vestibularisschädigende Wirkung von Streptomycin. Dtsch Med Wochenschr 84: 363–366

    Google Scholar 

  • Kuschinsky G, Lüllmann H (1963) Tierexperimentelle Untersuchungen zur Abhängigkeit der Ototoxicität von der Dosierung des Kanamycin und zur Schutzwirkung durch Vitamine Klin Wochenschr 41: 230–233

    CAS  Google Scholar 

  • Lagler F, Osterloh G, Mückter H (1960) Studies on the pharmacology of kanamycin. Antibiot Annu 1959–1960: 862–867

    Google Scholar 

  • Lange G (1968) Die quantitative Auswertung von Streptomycinschäden des vestibulären Sinnesepithels beim Meerschweinchen mit Hilfe des Cytovestibulogramms und der calorischen Erregbarkeitsprüfung. Arch Otorhinolaryngol 192: 249–257

    CAS  Google Scholar 

  • Leaders F, Pittinger CB, Long JP (1960) Some pharmacological properties of selected antibiotics. Antibiot Chemotherap 10: 503–507

    CAS  Google Scholar 

  • Lindeman HH (1969) Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics. Acta Otolaryngol (Stockh) 67: 177–189

    CAS  Google Scholar 

  • Lodhi S, Weiner ND, Mechigian J, Schacht J (1980) Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides. Biochem Pharmacol 29: 597–601

    PubMed  CAS  Google Scholar 

  • Lüllmann H, Reuter H (1960a) Über die Hemmung der neuromuskulären Übertragung durch einige Antibiotika. Chemotherapia 1: 375–383

    Google Scholar 

  • Lüllmann H, Reuter H (1960b) Die curare-artigen Nebenwirkungen einiger Antibiotika. Klin Wochenschr 38: 771–772

    Google Scholar 

  • Lundquist P-G, Wersäll J (1966) Kanamycin-induced changes in cochlear hair cells of the guinea pig. Z Zellforsch 72: 543–561

    PubMed  CAS  Google Scholar 

  • Mascitelli-Coriandoli E (1962) Der Einfluß basischer Antibiotica auf das Coenzym A-System. Arzneimittelforsch 12: 597–601

    PubMed  CAS  Google Scholar 

  • Mahady SCF, Armstrong FL, Monroe J (1956) Purified dihydrostreptomycin. Am Rev Tuberc 73: 776–778

    PubMed  CAS  Google Scholar 

  • Marquardt P, Ziegler E (1956) Zur Pharmakologie von Streptomycinsulfat und -pantothenat. Arzneimittelforsch 6: 213–214

    PubMed  CAS  Google Scholar 

  • McGee TM, Olszewski J (1962) Streptomycin sulfate and dihydrostreptomycin toxicity. Arch Otolaryngol 75: 295–311

    Google Scholar 

  • Mendelsohn M, Katzenberg I (1972) The effect of kanamycin on the cation content of the endolymph. Laryngoscope 82: 397–403

    PubMed  CAS  Google Scholar 

  • Merkle U, Plattig KH, Keidel UO (1968) Histologische Untersuchungen zur ototoxischen Wirkung des Kanamycins am Cortischen Organ der Katze. Zschr Mikrosk Anat Forsch 78: 441–460

    CAS  Google Scholar 

  • Meyer zum Gottesberge A, Stupp HF (1969) Streptomycinspiegel in der Perilymphe des Menschen. Acta Otolaryngol 67: 171–176

    PubMed  CAS  Google Scholar 

  • Michael AF, Sutherland JM (1961) Antibiotic testing in newborn and adult rats. Am J Dis Child 101: 442–446

    Google Scholar 

  • Molgó J, Lemeignan M, Uchiyama T, Lechat P (1979) Inhibitory effect of kanamycin on evoked transmitter release. Reversal by 3,4-diaminopyridine. Eur J Pharmacol 57: 9397

    Google Scholar 

  • Molitor H, Graessle OE, Kuna S, Mushett ChW, Silber RH (1946) Some toxicological and pharmacological properties of streptomycin. J Pharmacol Exp Ther 86: 151–173

    PubMed  CAS  Google Scholar 

  • Molitor H, Kuna S (1949) Pharmacologic studies of the neurotoxic properties of streptomycin. Arch Int Pharmacodyn Ther 76: 197–202

    Google Scholar 

  • Mosonyi L, Pollak L, Zulik R, Kârolyhâzi G (1956) Streptomycin and endocrine system. Experientia 12: 311–313

    PubMed  CAS  Google Scholar 

  • Mückter H (1961) Zur Pharmakologie der basischen Streptomyces-Antibiotika. Antibiotica et Chemotherapia Separatum Vol 9: 83–144

    Google Scholar 

  • Müsebeck K, Schätzle W (1962) Experimentelle Studien zur Ototoxicität des Dihydrostreptomycins. Arch Otorhinolaryngol 181: 41–48

    Google Scholar 

  • Mushett ChW, Maitland HS (1946) Pathologic changes resulting from the administration of streptomycin. Arch Pathol 42: 619–629

    CAS  Google Scholar 

  • Mushett ChW, Stebbins RB (1949) Renal cytoplasmic inclusions following the administration of large doses of streptomycin. Fed Proc 8: 363

    Google Scholar 

  • Nagaba M (1968) Electron microscopic study of semicircular canal organs and otolith organs of squirrel monkeys after administration of streptomycin sulfate. Acta Otolaryngol (Stockh) 66: 541–552

    CAS  Google Scholar 

  • Neumann G, Neubert K (1958) Die Sensularien des Innenohres unter der Einwirkung von Streptomycin — Experimentelle Untersuchungen am Corti’schen Organ and an der Macula utricula des Meerschweinchens. Arzneimittelforsch 8: 63–72

    PubMed  CAS  Google Scholar 

  • Osterberg AC, Oleson JJ, Yuda NN, Rauh CE, Parr HG, Will LW (1957) Cochlear, vestibular and acute toxicity studies of streptomycin and dihydrostreptomycin pantothenate salts. Antibiot Annu 1956–1957: 564–573

    Google Scholar 

  • Pfaltz CR, Piffko P (1972) Central compensation of retrolabyrinthine vestibular lesions. Acta Otolaryngol (Stockh) 73: 183–189

    CAS  Google Scholar 

  • Pittinger CB (1970) pH and streptomycin influences upon ionic calcium in serum. Anesth Analg 49:540–545

    PubMed  CAS  Google Scholar 

  • Pittinger CB, Long JP (1958) Neuromuscular blocking action of neomycin sulfate. Antibiot Chemother 8: 198–203

    CAS  Google Scholar 

  • Pittinger CB, Long JP, Miller JR (1958) The neuromuscular blocking action of neomycin. Anesth Analg 37: 276–282

    PubMed  CAS  Google Scholar 

  • Pittinger C, Adamson R (1972) Antibiotic blockade of neuromuscular function. Annu Rev Pharmacol 12: 169–184

    PubMed  CAS  Google Scholar 

  • Plattig KH, Keidel UO, David E (1967) Minderung der Ototoxizität des Kanamycins durch Pantothensäure. Dtsch Med Wochenschr 92: 1391–1397

    CAS  Google Scholar 

  • Plester D (1963) Discussion remark. Arch otorhinolaryngol 182: 587

    Google Scholar 

  • Popovici GG, Moisä L, Negoitä M, Manoilâ V, Botez E, Hafner R, Gumeni N (1965) The influence of certain antibiotics on intestinal motor activity. Arch Int Pharmacodyn Ther 154: 374–381

    PubMed  CAS  Google Scholar 

  • Popovici GG, Negoitâ M, Moisä L, Manoilä V, Hafner R, Botez E (1967) The influence of some antibiotics on uterine motor activity in the guinea pig. Arch Int Pharmacodyn Ther 166: 20–25

    PubMed  CAS  Google Scholar 

  • Popovici GG, Mungiu C, Filip M, Botez E, Ababei L (1970) Influence of some antibiotics on stationary NAD and NADP concentrations in rat liver and kidney. Arch Int Pharmacodyn Ther 188: 73–78

    PubMed  CAS  Google Scholar 

  • Prado WA, Corrado AP, Marseillan RF (1978) Competitive antagonism between calcium and antibiotics at the neuromuscular junction. Arch Int Pharmacodyn Ther 231: 297307

    Google Scholar 

  • Prescott B, Kauffmann G, James WD, Stone HJ (1959) Means of increasing the tolerated dose of streptomycin in mice. Antibiot Chemother 9: 369–375

    CAS  Google Scholar 

  • Raab WP (1970) Renal effects of streptomycin in rats. Clin Chim Acta 29: 451–454

    PubMed  CAS  Google Scholar 

  • Ritter R, Chou J, v Ilberg C, Wagner WH (1971) Eine neue Möglichkeit zur Verhinderung der Ototoxizität des Streptomycins. Arch Otorhinolaryngol 199: 573–577

    CAS  Google Scholar 

  • Robson JM, Sullivan FM (1963) Antituberculous drugs. Pharmacol Rev 15: 169–223

    PubMed  CAS  Google Scholar 

  • Rudnick MD (1979) A quantitative and qualitative study of aminoglycoside antibiotic ototoxicity in the vestibulo-cochlear apparatus following intratympanic administration in guinea pig (Cavia cobaya). Dissertation Abstr Intern B 39: 4145–4146

    Google Scholar 

  • Saito H, Daly JF (1971) Quantitative analysis of acid mucopolysaccharides in the normal and kanamycin intoxicated cochlea. Acta Otolaryngol (Stockh) 71: 22–26

    CAS  Google Scholar 

  • Secondi U (1954) Ancora sull’effetto neurotossico della streptomicina. L’importanza del fattore dose-tempo. Arch Ital Otol 65: 165

    PubMed  CAS  Google Scholar 

  • Singh YN, Harvey AL, Marshall IG (1978) Antibiotic-induced paralysis of the mouse phrenic nerve-hemidiaphragm preparation, and reversibility by calcium and by neostigmine. Anesthesiology 48: 418–424

    PubMed  CAS  Google Scholar 

  • Sokoll MD, Diecke FPJ (1969) Some effects of streptomycin on frog nerve in vitro. Arch Int Pharmacodyn Ther 177: 332–339

    PubMed  CAS  Google Scholar 

  • Spoendlin H (1966) Zur Ototoxizität des Streptomycins. Pract Oto-Rhino-Laryng (Basel) 28:305–322; 374–375

    Google Scholar 

  • Spoendlin H (1967) Acute streptomycin intoxication of the labyrinth. Acta Otolaryngol (Stockh) 63: 26–38

    Google Scholar 

  • Stange G (1969) Minderung bzw. Verhütung der Ototoxizität basischer Streptomyzes-Antibiotika. Therapiewoche 19: 106–117

    Google Scholar 

  • Stange G, Soda T, Beck Ch (1967) Elektrophysiologische Ergebnisse bei Ototoxizitätsmin- derung basischer Streptomyces-Antibiotika. Arch Otorhinolaryngol 188: 242–249

    CAS  Google Scholar 

  • Stupp HF (1970) Untersuchung der Antibiotikaspiegel in den Innenohrflüssigkeiten und ihre Bedeutung für die spezifische Ototoxizität der Aminoglykosidantibiotika. Acta Otolaryngol (Stockh) Suppl 262

    Google Scholar 

  • Stupp H, Rauch S, Sous H, Lagler F (1966) Untersuchungen über die Ursache der spezifisch ototoxischen Wirkung der basischen Streptomycesantibiotika unter besonderer Berücksichtigung des Kanamycins. Acta Otolaryngol (Stockh) 61: 435–444

    Google Scholar 

  • Stupp H, Rauch S, Sous H, Brun JP, Lagler F (1967) Kanamycin dosage and levels in ear and other organs. Arch Otolaryngol 86: 515–521

    PubMed  CAS  Google Scholar 

  • Stupp H, Küpper K, Lagler F, Sous H, Quante M (1973) Inner ear concentrations and ototoxicity of different antibiotics in local and systemic application. Audiology 12: 350–363

    PubMed  CAS  Google Scholar 

  • Suzuki Y, Takeuchi S (1961) Etude expérimentale sur l’influence de la streptomycine sur l’appareil auditif du foetus après administration de doses variées a la mère enceinte. Keio. J Med 10: 31–41

    Google Scholar 

  • Swain HH, Kiplinger GF, Brody TM (1956) Action of certain antibiotics on the isolated dog heart. J Pharmacol Exp Ther 117: 151–159

    PubMed  CAS  Google Scholar 

  • Tettenborn D (1971) Unpublished investigations

    Google Scholar 

  • Thalmann R, Miyoshi T, Kusakari J, Thalmann J (1973) Quantitative approaches to the ototoxicity problem. Audiology 12: 364–382

    PubMed  CAS  Google Scholar 

  • Timmerman JC, Long JP, Pittinger CB (1959) Neuromuscular blocking properties of various antibiotic agents. Toxicol Appl Pharmacol 1: 299–304

    CAS  Google Scholar 

  • Tisch DE, Huftalen JB, Dickison HL (1958) Pharmacological studies with kanamycin. Ann NY Acad Sci 76: 44–65

    PubMed  CAS  Google Scholar 

  • Tyberghein J (1962) Influence of some streptomyces antibiotics on the cochlear micro-phonics in the guinea pig. Acta Otolaryngol (Stockh) Suppl 171

    Google Scholar 

  • Tyberghein J (1967) Einfluß der Pantothensäure auf die Ototoxizität des Kanamycins beim Meerschweinchen. Med Welt: 2017–2020

    Google Scholar 

  • Tyberghein J, Ostjin F (1961) L’ototoxicité de la streptomycine. Acta Tuberc Pneumol Belg 52: 139–146

    PubMed  CAS  Google Scholar 

  • Vernier VG, Alleva FR (1968) The bioassay of kanamycin auditory toxicity. Arch Int Pharmacodyn Ther 176: 59–73

    PubMed  CAS  Google Scholar 

  • Vital Brazil O (1961) Streptomycin effect on the skeletal muscle stimulation produced by acetylcholine. Arch Int Pharmacodyn Ther 130: 136–140

    Google Scholar 

  • Vital Brazil O, Corrado AP (1957) The curariform action of streptomycin. J Pharmacol Exp Ther 120: 452–459

    Google Scholar 

  • Vital Brazil O, Corrado AP, Berti FA (1959) Neuromuscular block produced by streptomycin and some of its degradation products. In: Bovet D, Bovet-Nitti F, Marini-Bettolo (eds) Curare and curare-like agents. Elsevier, Amsterdam

    Google Scholar 

  • Vital Brazil O, Prado-Franceschi J (1969) The nature of neuromuscular block produced by neomycin and gentamicin. Arch Int Pharmacodyn Ther 179: 78–85

    Google Scholar 

  • Voldhch L (1965) The kinetics of streptomycin, kanamycin and neomycin in the inner ear. Acta Otolaryngol (Stockh) 60: 243–248

    Google Scholar 

  • Vrabec DP, Cody DT, Ulrich JA (1965) A study of the relative concentrations of antibiotics in the blood, spinal fluid, and perilymph in animals. Ann Otol Rhinol Laryngol 74: 688–703

    Google Scholar 

  • Wagner WH, Chou JTY, Ilberg v. C, Ritter R, Vosteen KH (1971) Untersuchungen zur Pharmakokinetik von Streptomycin. Arzneimittelforsch 21: 2006–2016

    PubMed  CAS  Google Scholar 

  • Watanuki K, Meyer zum Gottesberge A (1971) Toxic effect of streptomycin and kanamycin upon the sensory epithelium of the crista ampullaris. Acta Otolaryngol (Stockh) 72: 59–67

    CAS  Google Scholar 

  • Watanuki K, Stupp H (1971) Haarzellenschädigungsmuster an Crista and Maculae bei Ototoxikose durch Antibiotika. Arch Otorhinolaryngol 199: 569–573

    CAS  Google Scholar 

  • Watanuki K, Stupp H-F, Meyer zum Gottesberge A (1972) Toxic effects of gentamycin upon the peripheral vestibular sensory organs. Laryngoscope 82: 363–371

    PubMed  CAS  Google Scholar 

  • Wersäll J, Hawkins JE Jr (1962) The vestibular sensory epithelia in the labyrinth and their reactions in chronic streptomycin intoxication. Acta Otolaryngol (Stockh) 54: 1–23

    Google Scholar 

  • Winston J, Lewey FH, Parentease A, Marden PA, Cramer FB (1948) An experimental study of the toxic effects of streptomycin on the vestibular apparatus of the cat. Ann Otol Rhinol Laryngol 57: 738–753

    PubMed  CAS  Google Scholar 

  • Wolf GL, Wigton RS (1971) Vasodilatation induced by streptomycin in the perfused canine kidney. Arch Int Pharmacodyn Ther 194: 285–289

    PubMed  CAS  Google Scholar 

  • Domagk G (1948) Die experimentellen Grundlagen einer Chemotherapie der Tuberkulose. Beitr KIM Tuberk 101: 372–394

    Google Scholar 

  • Emmrich R, Petzold H (1952) Experimentelle Untersuchungen zur Frage der Leberschädigung durch TB I. Z Ges Inn Med 7: 625–628

    PubMed  CAS  Google Scholar 

  • Ginoulhiac E (1950) Toxicity of certain chemotherapeutics. Boll Soc Ital Biol Sper 26: 574–577

    PubMed  CAS  Google Scholar 

  • Gülzow M (1950) Experimentelles zur TB I-Wirkung. I. Mitteilung: Intoxikationserscheinungen. Z Ges Exp Med 116: 26–39

    PubMed  Google Scholar 

  • Gülzow M, Schlicht A (1950) Experimentelles zur TB I-Wirkung. II. Mitteilung: Aminosäure-Untersuchungen des Serum-und Organeiweiß im Verlauf von TB I (Conteben)Intoxikationen. Z Ges Exp Med 116: 40–55

    PubMed  Google Scholar 

  • Hecht G (1950) Unpublished Investigations

    Google Scholar 

  • Moyer JH, Perkins RB (1951) Experimental studies on the toxicity of amithiozone in dogs. Am Rev Tuberc 64: 659–668

    PubMed  CAS  Google Scholar 

  • Râvnay TH, Forró L, Szegö L (1954) Untersuchungen über den Wirkungsmechanismus der Thiosemikarbazone. Z Tuberk 104: 249–255

    PubMed  Google Scholar 

  • Savini E (1950) Recherches expérimentales sur la toxicité du thiosemicarbazone. CR Soc Biol 144: 1310–1313

    CAS  Google Scholar 

  • Bonati F, Bertoni L (1962) Derivati basici dell’acido pirazin-2-carbonico ad azione antimicobatterica. Minerva Med 53: 1704–1708

    PubMed  CAS  Google Scholar 

  • Celikovskâ G, Stastnâ J, Zitkovâ L, Brezinovâ H, Kürti V (1970) Leberschädigung nach Verabreichung von Pyrazinamid im Tierversuch. III. Biochemische Veränderungen im Lebergewebe und im Blutserum. Arzneimittelforsch 20: 155–157

    PubMed  Google Scholar 

  • Gruss JD, Nickling HG (1967) Vergleichende funktionelle und bioptische Untersuchungen der normalen Kaninchenleber während der Applikation von Pyrazincarbonsäureamid. Arzneimittelforsch 17: 1565–1568

    CAS  Google Scholar 

  • Mori K, Yasuno A, Matsumoto K (1960) Induction of pulmonary tumors in mice with isonicotinic acid hydrazid. Gann 51: 83–89

    PubMed  CAS  Google Scholar 

  • Robinson HJ, Siegel H, Pietrowski JJ (1954) Toxicity of pyrazinamide. Am Rev Tuberc 70: 423–429

    PubMed  CAS  Google Scholar 

  • Stastnâ J, Celikovskâ G, Zitkovâ L, Viklickÿ J (1970) Leberschädigung nach Verabreichung von Pyrazinamid im Tierversuch. II. Untersuchungen über die zeitlichen Veränderungen der Konzentrationen von Pyrazinamid im Blut und der Aktivität der SerumTransaminasen. Arzneimittelforsch 20: 153–155

    PubMed  Google Scholar 

  • Zitkovâ L, Stastnâ J, Celikovskâ G, Kürti V (1970) Leberschädigung nach Verabreichung von Pyrazinamid im Tierversuch I. Änderungen des Körpergewichtes von Ratten unter Einwirkung von Pyrazinamid. Arzneimittelforsch 20: 151–153

    PubMed  Google Scholar 

  • Allmark MG, Lu FC, Carmichael E, Lavallee A (1953) Some pharmacological observations on isoniazid and iproniazid. Am Rev Tuberc 68: 199–206

    PubMed  CAS  Google Scholar 

  • Ashby J, Purchase IFH (1977) The selection of appropriate chemical class controls for use with short term tests for potential carcinogenicity. Ann Occup Hyg 20: 297–301

    PubMed  CAS  Google Scholar 

  • Ata S, Tanaka K (1952) Vitamin B12 and isoniazid. Lancet II: 589

    Google Scholar 

  • Balzer H, Holtz P, Palm D (1960) Untersuchungen über die biochemischen Grundlagen der konvulsiven Wirkung von Hydraziden. Naunyn Schmiedebergs Arch Pharmacol 239: 520–552

    CAS  Google Scholar 

  • Barreto RCR, Mano DB (1961) Prevention of the convulsant and lethal effects of isonicotinic acid hydrazide by pyruvic acid. Biochem Pharmacol 8: 409–412

    PubMed  CAS  Google Scholar 

  • Benson WM, Stefko PL, Roe MD (1952) Pharmacologic and toxicologic observations on hydrazine derivatives of isonicotinic acid (Rimifon, Marsilid). Am Rev Tuberc 65: 376–391

    PubMed  CAS  Google Scholar 

  • Berencsi G, Entz A, Vajkóczy A (1957) Kongreß der Ungarischen Phthisiolog Gesellsch, Szeged 1952, cited from Juhâsz J, Baló J, Kendrey G. Z Krebsforsch 62: 188–196

    Google Scholar 

  • Beyer E, Braun R, Schöneich J (1979) Genetic activity of isoniazid in the mammalian spot test. Mutat Res 64: 152

    Google Scholar 

  • Bhide SV, Marti GB, Sawai MM, Ranadive KJ (1978) Isoniazid tumorigenicity in mice under different experimental conditions. Int J Cancer 21: 381–386

    PubMed  CAS  Google Scholar 

  • Biancifiori C, Ribacchi R (1962) Pulmonary tumors in mice induced by oral isoniazid and its metabolites. Nature 194: 488–489

    PubMed  CAS  Google Scholar 

  • Biancifiori C, Severi L (1966) The relation of isoniazid (INH) and allied compounds to carcinogenesis in some species of small laboratory animals. A review. Br J Cancer 20: 528–538

    PubMed  CAS  Google Scholar 

  • Black SLD (1977) Hepatic triglyceride metabolism and aminoacid pools in isonicotinic acid hydrazide treated rats. Dissertation Abstr Intern B 38: 1668–1669

    Google Scholar 

  • Blakemore WF, Palmer AC, Noel PRB (1972) Ultrastructural changes in isoniazid-induced brain oedema in the dog. J Neurocytol 1: 263–278

    PubMed  CAS  Google Scholar 

  • Botta JA Jr, Carlton WW (1967a) Studies of the toxicity of isonicotinic acid hydrazide (Isoniazid) to ducklings. Toxicol Appl Pharmacol 11: 35–48

    CAS  Google Scholar 

  • Botta JA Jr, Carlton WW (1967b) Isoniazid toxicosis in ducklings-studies on pyridoxine, niacin, glutamic acid, and arginine supplementation. Avian Dis 11: 621–633

    CAS  Google Scholar 

  • Brambilla G, Baldini L (1959) Azione inibitrice dell’acido isonicotinico sullo sviluppo del sarcoma Galliera del ratto. Boll Soc Ital Biol Sper 35: 1169–1171

    PubMed  CAS  Google Scholar 

  • Braun R, Schubert J, Schöneich J (1976) On the mutagenicity of isoniazid. Biol Zbl 95: 423–436

    CAS  Google Scholar 

  • Bucher O (1953) Zur Frage der cytotoxischen Wirkung von Rimifon. Schweiz Med Wochenschr 83: 1206–1208

    PubMed  CAS  Google Scholar 

  • Bürgin H, Schmid B, Zbinden G (1979) Assessment of DNA damage in germ cells of male rabbits treated with isoniazid and procarbazine Toxicology 12: 251–257

    Google Scholar 

  • Carlton WW (1967) Neural toxicity of isonicotinic acid hydrazide (isoniazid) for chickens. Avian Dis 11: 241–254

    PubMed  CAS  Google Scholar 

  • Carlton WW, Hunt CE, Newberne PM (1965) Neural lesions induced by isonicotinic acid hydrazide and semicarbazide hydrochloride. Exp Mol Pathol 4: 438–448

    CAS  Google Scholar 

  • Carlton WW, Kreutzberg G (1966) Isonicotinic acid hydrazide-induced spongy degeneration of the white matter in the brains of peking ducks. Am J Pathol 48: 91–105

    PubMed  CAS  Google Scholar 

  • Casey RE, Wood JD (1973) Isonicotinic acid hydrazide-induced changes in the metabolism of y-aminobutyric acid in the brain of four species. Comp Biochem Physiol B 45: 741–748

    PubMed  CAS  Google Scholar 

  • Cavanagh JB (1967) On the pattern of change in peripheral nerves produced by isoniazid intoxication in rats. J Neurol Neurosurg Psychiat 30: 26–33

    CAS  Google Scholar 

  • Cavanagh JB (1973) Peripheral neuropathy caused by chemical agents. CRC Crit Rev Toxicol 2: 365–417

    PubMed  CAS  Google Scholar 

  • Cedrangolo F, Gioia A, Bagnulo R (1953) Un meccanismo enzimatico, per il quale si puo’abbassare in vivo la tossicità dell’ idrazide dell’ac. isonicotinico. Enzymologia 16: 41–50

    PubMed  CAS  Google Scholar 

  • Ceriotti G, Franceschini J (1953) Dati biologici e microbiologici su un nuvo derivato della idrazide dell’acido isonicotinico a bassa tossicatà e ad alta attività (metansulfonato dell’ idrazide isonicotinica). Arch Int Pharmacodyn Ther 93: 105–117

    PubMed  CAS  Google Scholar 

  • Chin L, Sievers ML, Laird HE, Herrier RN, Picchioni AL (1978) Evaluation of diazepam and pyridoxine as antidotes to isoniazid intoxication in rats and dogs. Toxicol Appl Pharmacol 45: 713–722

    PubMed  CAS  Google Scholar 

  • Chin L, Sievers M, Herrier RN, Picchioni AL (1979) Convulsions as the etiology of lactic acidosis in acute isoniazide toxicity in dogs. Toxicol Appl Pharmacol 49: 377–384

    PubMed  CAS  Google Scholar 

  • Cirnu-Georgian L, Lenghel V (1971) Isoniazid-induced chromosome aberrations. Lancet 2: 93

    PubMed  CAS  Google Scholar 

  • Crema A, Fabris L (1954) Sulla tossicatà per il vestibolo dell’idrazide dell’ acido isonicotinico. Boll Soc Ital Biol Sper 30: 120–121

    PubMed  CAS  Google Scholar 

  • Dauphinee KR, Paynters S, Russell DW (1975) Failure of pyruvate to counteract isonazid toxicity in rabbits. J Pharm Pharmacol 27: 884–886

    PubMed  CAS  Google Scholar 

  • Dienemann G, Simon K (1953) Mitteilung eines Todesfalles nach kombinierter Verabreichung von Irgapyrin und Neoteben (INH). MMW 95: 221–222

    CAS  Google Scholar 

  • Dixon RH, Williams HL (1962) The toxicity of pyridoxal and pyridoxal phosphate hydra-zones in mice. Fed Proc 21: 338

    Google Scholar 

  • Dubnick B, Leeson GA, Scott CC (1960) Effect of forms of vitamin B6 on acute toxicity of hydrazines. Toxicol Appl Pharmacol 2: 403–409

    PubMed  CAS  Google Scholar 

  • Emmrich R, Petzold H (1952) Tierexperimentelle Untersuchungen zur Frage einer Leber-schädigung durch Rimifon (Isonicotinylhydrazin) Klin Wochenschr 30: 1081–1083

    CAS  Google Scholar 

  • Engbaek HC, Bentzon H, Heegârd H, Christensen O (1965) Har isoniazid en tumorfrem-kaldende virkning? Nord Med 74: 13–26

    Google Scholar 

  • Földi M, Zoltan ÖT, Maurer M (1970) Die Wirkung von Isonicotinsäurehydrazid (INH) auf das Zentralnervensystem und der Antagonismus zwischen dieser Substanz und Pyridoxin, Pantothensäure sowie Cumarin aus Melilotus officinalis bei Ratten. Arzneimittelforsch 20: 1620–1623

    PubMed  Google Scholar 

  • Frei H-H (1976) Elevation of central y-aminobutyric acid levels by isoniazid in mice and convulsant thresholds. Biochem Pharmacol 25: 1216–1219

    Google Scholar 

  • Fust B, Studer A, Böhni E (1952) Experimentelle Erfahrungen mit dem Antituberculotikum „Rimifon“. Schweiz Z Tuberk 9: 226–242

    Google Scholar 

  • Glass F, Gossow H, Mallach HJ (1964) Beobachtungen und Untersuchungen über die gemeinsame Wirkung von Alkohol und Isonicotinsäurehydrazid. Arzneimittelforsch 14: 1203–1208

    PubMed  CAS  Google Scholar 

  • Glass F, Mallach HJ (1965) Tierexperimentelle Untersuchungen über die Alkoholwirkung nach längerer Belastung mit Isonicotinsäurehydrazid. Arzneimittelforsch 15: 1069–1070

    PubMed  CAS  Google Scholar 

  • Goldin A, Dennis D, Venditti JM, Humphreys SR (1955) Potentiation of pentobarbital anesthesia by isonicotinic acid hydrazide and related compounds. Science 121: 364–365

    PubMed  CAS  Google Scholar 

  • Grasso P, Crampton RF (1972) The value of the mouse in carcinogenicity testing. Fd Cosmet Toxicol 10: 418–426

    CAS  Google Scholar 

  • Gross W (1956) Ein Beitrag zur cytostatischen Wirkung des Isonicotinsäurehydrazids (INH). Klin Wochenschr 34: 495

    CAS  Google Scholar 

  • Hackmann CH (1957) Unpublished data

    Google Scholar 

  • Hammond EC, Selikoff IJ, Robitzek EK (1967) Isoniazid therapy in relation to later occurence of cancer in adults and infants. Br Med J 2: 792–795

    PubMed  CAS  Google Scholar 

  • Harper KH, Worden AN (1966) Comparative toxicity of isonicotinic acid hydrazide and its methanosulfonate derivative. Toxicol Appl Pharmacol 8: 325–333

    PubMed  CAS  Google Scholar 

  • Hecht G (1953) Unpublished data

    Google Scholar 

  • Hellriegel W, Kraus R (1955) Über die zytostatische Wirkung des Isonikotinsäurehydrazins. Tuberk Arzt 9: 653–660

    CAS  Google Scholar 

  • Herbold B, Buselmaier W (1976) Induction of point mutations by different chemical mechanisms in the liver microsomal assay. Mutat Res 40: 73–84

    PubMed  CAS  Google Scholar 

  • Hess M (1954) Über den Einfluß von Isonicotinsäurehydrazid (Neoteben) auf die Genitalfunktion und die Gestation. Arch Gynäkol 185: 315–324

    PubMed  CAS  Google Scholar 

  • Holtz P, Palm D (1964) Pharmacological aspects of Vitamin B6. Pharmacol Rev 16: 113–178

    PubMed  CAS  Google Scholar 

  • IARC (1974) Monographs on the evaluation of carcinogenic risk of chemicals to man, vol 4. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • Jansen JD, Clemmesen J, Sundaram K (1980) Isoniazid–an attempt at retrospective prediction. Mutat Res 76: 85–112

    CAS  Google Scholar 

  • Jones LD, Fairchild DG, Morse WC (1971) The induction of pulmonary neoplasms in mice by isonicotinic acid hydrazide. Am Rev Respir Dis 103: 612–617

    PubMed  CAS  Google Scholar 

  • Juhâsz J, Baló J, Kendrey G (1957) Über die geschwulsterzeugende Wirkung des Isonicotinsäurehydrazid (INH). Z Krebsforsch 62: 188–196

    PubMed  Google Scholar 

  • Juhâsz J, Baló J, Szende B (1963) Neue experimentelle Angaben zur geschwulsterzeugenden Wirkung des Isonicotinsäurehydrazid (INH). Z Krebsforsch 65: 434–438

    PubMed  Google Scholar 

  • Kelly MG, O’Gara RW, Yancey ST, Gadekar K, Botkin C, Oliviero VT (1969) Comparative carcinogenicity of N-isopropyl-a-(2-methylhydrazino)-p-toluamide HC1 (procarbazine hydrochloride), its degradation products, other hydrazines, and isonicotinic acid hydrazide. J Natl Cancer Inst 42: 337–344

    PubMed  CAS  Google Scholar 

  • Kimball RF (1977) The mutagenicity of hydrazine and some of its derivatives. Mutation Res 39: 111–126

    PubMed  CAS  Google Scholar 

  • Klinghardt GW (1954) Experimentelle Nervenfaserschädigung durch Isonicotinsäurehydrazid und ihre Bedeutung für die Klinik. Verh Dtsch Ges Inn Med 60: 764–768 (Kongress München)

    Google Scholar 

  • Krnjevic K (1971) Synaptic transmission in the brain. Klin Wochenschr 49: 519–523

    PubMed  CAS  Google Scholar 

  • Lechat P, Deleau D, Devillechabrolle A (1963) Etude expérimentale du pouvoir protecteur de la pyridoxine vis-à-vis des effets toxique de l’isoniazide. Thérapie 18: 63–67

    PubMed  CAS  Google Scholar 

  • Leopold D, Röthig W, Wehran H-J, Wolf P (1966) Verteilung und Wirkung des Isoniazid nach Applikation therapeutischer und toxischer Dosen im Tierversuch. Arch Toxicol 22: 80–91

    CAS  Google Scholar 

  • Levene CJ (1961) The lathyrogenic effect of isonicotinic acid hydrazide (INAH) on the chick embryo and its reversal by pyridoxal. J Exp Med 113: 795–811

    PubMed  CAS  Google Scholar 

  • Loscalzo B (1964) Hydrazide de l’acide isonicotinique et neoplasies. Arch Int Pharmacodyn Ther 152: 249–251

    PubMed  CAS  Google Scholar 

  • Lüers H, Obe G (1971) Action of isoniazid on human chromosomes in vitro. EMS Newsletter: 36

    Google Scholar 

  • Manthei RW (1957) Effect of calcium pantothenate on isoniazid toxicity in the guinea pig. Proc Soc Exp Biol Med 95: 402–404

    PubMed  CAS  Google Scholar 

  • Manthei RW (1960) Vitamin B6 and isoniazid toxicity. Fed Proc 19: 414

    Google Scholar 

  • Matsumoto K, Mori K, Yasuno A (1960) Effect of isonicotinic acid hydrazide on hepatocarcinogenesis. Gann 51: 91–95

    CAS  Google Scholar 

  • McCormick DB, Snell EE (1961) Pyridoxal phosphokinases. J Biol Chem 236: 2085–2088

    PubMed  CAS  Google Scholar 

  • Miller CT, Stoltz DR (1978) Mutagenicity induced by lyophilization or storage of urine from isoniazid-treated rats. Mutat Res 56: 289–293

    PubMed  CAS  Google Scholar 

  • Mori K, Yasuno A (1959) Preliminary note on the induction of pulmonary tumors in mice by isonicotinic acid hydrazide feeding. Gann 50: 107–110

    CAS  Google Scholar 

  • Mori K, Yasuno A, Matsumoto K (1960) Induction of pulmonary tumors in mice with isonicotinic acid hydrazide. Gann 51: 83–89

    PubMed  CAS  Google Scholar 

  • Nelson SD, Snodgrass WR, Mitchell JR (1976) Chemical reaction mechanisms responsible for the tissue injury caused by monosubstituted hydrazines and their hydrazide drug precursors. In: De Serres, Fouts, Bend and Philpot (eds) In vitro metabolic activation in mutagenesis testing. Elsevier, Amsterdam, pp 257–276

    Google Scholar 

  • Noda A, Goromaru T, Matsuyama K, Sogabe K, Hsu KY, Iguchi S (1978) Quantitative determination of hydrazines derived from isoniazid in patients. J Pharmacol Dyn 1: 132–141

    CAS  Google Scholar 

  • Noel PRB, Worden AN, Palmer AC (1967) Neuropathologic effects and comparative toxicity for dogs of isonicotinic acid hydrazide and its methanosulfonate derivative. Toxicol Appl Pharmacol 10: 183–198

    CAS  Google Scholar 

  • Orlowski EH, Rosenfeld M, Wolter H, Schunk R (1976) Experimentelle vergleichende Untersuchung der tuberkulostatischen Wirksamkeit und Toxizität von INH, INHG und INHG-Na. Arzneimittelforsch 26: 409–416

    PubMed  CAS  Google Scholar 

  • Palmer AC, Noel PRB (1965) Neuropathological effects of dosing dogs with isonicotinic hydrazide and with its methanosulphonate derivative. Nature 205: 506–507

    PubMed  CAS  Google Scholar 

  • P’an SY, Markaroglu L, Reilly J (1952) The effects of barbiturates on the toxicity of isoniazid (isonicotinic acid hydrazide). Am Rev Tuberc 66: 100–103

    PubMed  Google Scholar 

  • Pansa E, Bikfalvi A (1960) Ober die Wirkung hoher Dosen Isonikotinsäure-Hydrazid (INH) auf die Bronchusschleimhaut der Kaninchen. Thoraxchirurgie 8: 451–457

    PubMed  CAS  Google Scholar 

  • Pansa E, Picco A, Gnavi M (1962) Sul problema del supposto effecto carcinogenetico dell’idrazide dell’acido isonicotinico (IAI). Richerchi sperimentali sul ratto. Minerva Med 53: 3162–3168

    CAS  Google Scholar 

  • Peacock A, Peacock PR (1966) The results of prolonged administration of isoniazid to mice, rats and hamsters. Br J Canc 20: 307–325

    CAS  Google Scholar 

  • Prescott B, Kauffmann G, James WD (1954) A means of increasing the tolerated dose of isoniazid in mice. Proc Soc Exp Biol Med 86: 682–685

    PubMed  CAS  Google Scholar 

  • Prescott B, Kauffmann G, James WD (1957a) Increase in tolerated dose of isoniazid in mice by use of cycloserine. Proc Soc Exp Biol Med 94: 94–96

    CAS  Google Scholar 

  • Prescott B, Kauffmann G, James WD (1957b) Effect of glycerine on toxicity of isoniazid in mice. Proc Soc Exp Biol Med 94: 272–276

    CAS  Google Scholar 

  • Prescott B, Kauffmann G, James WD (1957c) Means of increasing the tolerated dose of isoniazid in mice. II. Certain amino acids. Proc Soc Exp Biol Med 95: 687–690

    CAS  Google Scholar 

  • Prescott B, Kauffmann G, James WD (1957d) Means of increasing the tolerated dose of isoniazid in mice. III. Certain vitamins. Proc Soc Exp Biol Med 95: 705–708

    CAS  Google Scholar 

  • Prescott B, Stone HJ (1969) Glycerol formol as a solvent for detoxification of isoniazid. Chemotherapy 14: 227–231

    PubMed  CAS  Google Scholar 

  • Quadbeck G, Sartori GD (1957) Über den Einfluß von Pyridoxin und Pyridoxal-5-Phosphat auf den Thiosemicarbazid-Krampf der Ratte. Naunyn Schmiedebergs Arch Pharmacol 230: 457–461

    CAS  Google Scholar 

  • Raisfeld IH (1975) Drug-induced liver disease: guinea pig model for isoniazid (INH) hepatitis — the predictive value of urinary d-glucaric acid excretion. Gastroenterology 69: A54 /854

    Google Scholar 

  • Reilly RH, Killam KF, Jenney EH, Marshall WH, Tausig T, Apter NS, Pfeiffer CC (1953) Convulsant effect of isoniazid. JAMA 152: 1317–1321

    CAS  Google Scholar 

  • Reinhardt JF, Kimura ET, Schachter RJ (1952) Some pharmacologic characteristics of isonicotinyl hydrazide (Pyricidin®), a new antituberculosis drug. Science 116: 166–167

    Google Scholar 

  • Roberts E (1974) y-Aminobutyric acid and nervous system function a perspective. Biochem Pharmacol 23:2637–2649

    PubMed  CAS  Google Scholar 

  • Röhrborn G, Propping P, Buselmaier W (1972) Mutagenic activity of isoniazid and hydrazine in mammalian test systems. Mutat Res 16: 189–194

    PubMed  Google Scholar 

  • Röhrborn G et al. (1978) A correlated study of the cytogenetic effect of isoniazid (INH) on cell systems of mammals and man conducted by thirteen laboratories. Hum Genet 42: 1–60

    Google Scholar 

  • Rosen F (1955) Effect of isonicotinic acid hydrazide on niacin and pyridoxine metabolism in rats. Proc Soc Exp Biol Med 88: 243–246

    PubMed  CAS  Google Scholar 

  • Rosenkranz HS, Carr HS (1971) Hydrazine antidepressants and isoniazid: potential carcinogens. Lancet I: 1354–1355

    Google Scholar 

  • Rubin B, Hassert GL, Jr, Thomas BGH, Burke JC (1952) Pharmacology of isonicotinic acid hydrazide (Nydrazid). Am Rev Tuberc 65: 392–401

    PubMed  CAS  Google Scholar 

  • Rubin B, Burke JC (1952) Vitamin B12 and isoniazid. Lancet II: 937

    Google Scholar 

  • Rubin B, Burke JC (1953) Further observations on the pharmacology of isoniazid. Am Rev Tuberc 67: 644–651

    PubMed  CAS  Google Scholar 

  • Said AH, Ahmed AAS (1967) Connective tissue changes induced in the chick embryo by isonicotinic acid hydrazide and vitamin K. Zbl Veterinarmed (A) 14: 78–84

    CAS  Google Scholar 

  • Schlaepfer WW, Hager H (1964a) Ultrastructural studies of INH-induced neuropathy in rats. I. Early axonal changes. Am J Pathol 45: 209–219

    Google Scholar 

  • Schlaepfer WW, Hager H (1964b) Ultrastructural studies of INH-induced neuropathy in rats. II. Alteration and decomposition of the myelin sheath. Am J Pathol 45: 423–433

    CAS  Google Scholar 

  • Schlaepfer WW, Hager H (1964c) Ultrastructural studies of INH-induced neuropathy in rats. III. Repair and Regeneration. Am J Pathol 45: 679–689

    CAS  Google Scholar 

  • Schmidt LH, Hoffmann R, Hughes HB (1953) The toxicity of isoniazid for the rhesus monkey. Am Rev Tuberc 67: 798–807

    PubMed  CAS  Google Scholar 

  • Schöneich J (1976) Safety evaluation based on microbial assay procedures. Mutat Res 41: 89–94

    PubMed  Google Scholar 

  • Schröder JM (1970a) Zur Pathogenese der Isoniazid-Neuropathie. I. Eine feinstrukturelle Differenzierung gegenüber der Wallerschen Degeneration. Acta Neuropath 16: 301–323

    Google Scholar 

  • Schröder JM (1970b) Zur Pathogenese der Isoniazid-Neuropathie. II. Phasenkontrast-und elektronenmikroskopische Untersuchungen am Rückenmark, an Spinalganglien und Muskelspindeln. Acta Neuropathol 16: 324–341

    Google Scholar 

  • Seifert S (1966) Die teratogene Wirkung von Isonikotinséurehydrazid (INH) auf den Héhnerembryo. Diss Freiburg i Br

    Google Scholar 

  • Severi L, Biancifiori C (1968) Hepatic carcinogenesis in CBA/Cb/Se mice and Cb/Se rats by isonicotinic acid hydrazide and hydrazine sulfate. J Natn Cancer Inst 41: 331–340

    CAS  Google Scholar 

  • Siegel D, Iwainsky H (1960) Über den Einfluß von Iso-Nicotinsäure-Hydrazid (INH) auf die Metastasierungsquote des Ehrlichschen Ascitescarcinom der Maus. Klin Wochenschr 38: 769

    CAS  Google Scholar 

  • Siegel D (1960) Beitrag zur Frage der cytostatischen Wirkung des Iso-Nicotinsäure-Hydrazids (INH). Naturwissenschaften 47: 307–308

    Google Scholar 

  • Siegel D (1961) Veränderungen des Nucleinsäuregehaltes tumorösen Gewebes durch IsoNikotinsäure-Hydrazid (INH). Naturwissenschaften 48: 55–56

    CAS  Google Scholar 

  • Siegel D, Berschneider F (1960) Untersuchungen zum Nucleinsäurestoffwechsel der regenerierenden Leber nach Isonicotinsäurehydrazid (INH). Z Gesamte Exp Med 134: 59–64

    CAS  Google Scholar 

  • Simon K (1952) Untersuchungen von Derivaten des Hydrazins auf ihre cytostatische Wirkung am Ascitestumor der Maus. Z Naturforsch 7 b: 531–536

    Google Scholar 

  • Steinbrück P (1959) Der Einfluß über lange Zeit fortgeführter INH-Gaben auf die Fruchtbarkeit der weißen Maus. Z Tuberk 113: 281–284

    Google Scholar 

  • Tiboldi T, David M, Kovacs K, Molnar P (1955) Die Wirkung des Isonikotinsäurehydrazid auf das Brown-Pearce-Karzinom des Kaninchens. Z Tuberk 106: 257–260

    PubMed  CAS  Google Scholar 

  • Timbrell JA, Mitchell JR, Snodgrass WR, Nelson SD (1980) Isoniazid hepatotoxicity: the relationship between covalent binding and metabolism in vivo. J Pharmacol Exp Ther 213: 364–369

    PubMed  CAS  Google Scholar 

  • Tirunarayanan MO, Vischer WA (1956) Effect of vitamines on the acute toxicity of hydrazine derivatives. Experientia 12: 291–292

    PubMed  CAS  Google Scholar 

  • Tosk J, Schmeltz I, Hoffmann D (1979) Hydrazines as mutagenes in a histidine — requiring auxotroph of Salmonella typhimurium. Mutat Res 66: 247–252

    PubMed  CAS  Google Scholar 

  • Toth B, Shubik P (1966a) Inhibition of tumor development and carcinogenesis by isonicotinic acid hydrazide (INH) in C3H und AKR mice. Abstract, p 124. Presented at the IX International Cancer Congress, Tokyo

    Google Scholar 

  • Toth B, Shubik P (1966b) Mammary tumor inhibition and lung adenoma induction by isonicotinic acid hydrazide. Science 152: 1376–1377

    CAS  Google Scholar 

  • Toth B, Shubik P (1966c) Carcinogenesis in swiss mice by isonicotinic acid hydrazide. Cancer Res 26: 1473–1475

    CAS  Google Scholar 

  • Toth B, Rustja A (1967) The effect of isonicotinic acid hydrazide on the development of tumors. Int J Cancer 2: 413–420

    PubMed  CAS  Google Scholar 

  • Toth B, Shubik P (1969) Lack of carcinogenic effects of isonicotinic acid hydrazide in the syrian golden hamster. Tumori 55: 127–135

    PubMed  CAS  Google Scholar 

  • Toth B, Boreisha J (1969) Tumorigenesis with isonicotinic acid hydrazide and urethan in the syrian golden hamsters. Eur J Cancer 5: 165–171

    CAS  Google Scholar 

  • Toth B, Toth T (1970) Investigation on the tumor producing effect of isonicotinic acid hydrazide in ASW/Sn mice and MCR rats. Tumori 56: 315–324

    PubMed  CAS  Google Scholar 

  • Toth B, Shimizu H (1973) Lung carcinogenesis with 1-Acetyl-2-Isonicotinoylhydrazine, the major metabolite of isoniazid. Eur J Cancer 9: 285–289

    PubMed  CAS  Google Scholar 

  • Viallier J, Casanova F (1960) L’isoniazide a-t-il des propriétés cancérigènes? Essai sur l’animal. CR Soc Biol 154: 985–987

    CAS  Google Scholar 

  • Wade DR, Lohman PHM, Mattem IE, Berends F (1980) The mutagenicity of isoniazid in Salmonella and its effects on DNA repair and synthesis in human fibroblasts. Mutat Res 89: 9–20

    Google Scholar 

  • Wagner H, Moritz R (1962) Beeinflussung des Tumorwachstums durch INH in Tierversuch und Gewebekultur. Arch Geschwulstforsch 19: 123–129

    CAS  Google Scholar 

  • Weinstein HJ, Kinosita R (1963) Isoniazid induction of pulmonary tumors in mice. Am Rev Respir Dis 88: 124–125

    Google Scholar 

  • Weiss P, Gâti T, Forrai G (1954) Die Wirkung von Isonikotinsäurehydrazid auf das Hypophysen-Nebennierenrindensystem bei weißen Ratten. Z Inn Med 9: 808–809

    CAS  Google Scholar 

  • Whitehouse LW, Tryphonas L, Thomas BH, Paul CP, Zeitz W (1978) Isoniazid toxicity alone and in combination with ethanol in the rabbit. I. Pathologic and biochemical factors. Toxicol Appl Pharmacol 45: 351

    Google Scholar 

  • Wiezorek WD, Kermes U, Wolf P (1977) Experimentelle Untersuchungen über die Wirkung von Barbituraten, Methaqualon und Benzodiazepinen bei der akuten Isoniazidintoxikation. Pharmazie 32: 37–39

    PubMed  CAS  Google Scholar 

  • Williams HL, Wiegand RG (1960) Xanthurenic acid excretion and possible pyridoxine deficiency produced by isonicotinic acid hydrazide and other convulsant hydrazides. J Pharmacol Exp Ther 128: 344–348

    PubMed  CAS  Google Scholar 

  • Williams HL, Bain JA (1961) Convulsive effects of hydrazides: relationship to pyridoxine. Int Rev Neurobiol 3: 319–348

    Google Scholar 

  • Wolf P, Ellert T, Gröger H (1965) Zur Frage der Beeinflußbarkeit der Isoniazid-Intoxikation durch einige Barbiturate, Chloralhydrat und Methylpentinol im Tierexperiment. Acta Biol Med German 15: 184–186

    PubMed  CAS  Google Scholar 

  • Worden AN, Palmer AC, Noel PRB, Mawdesley-Thomas LE (1967) Lesions in the brain of the dog induced by prolonged administration of mono-amine oxidase inhibitors and isoniazid. Proc Eur Soc Study Drug Tox 8: 149–161

    CAS  Google Scholar 

  • Yamamoto RS, Weisburger JH (1970) Failure of arginine glutamate to inhibit lung tumour formation by isoniazid and hydrazine in mice. Life Sci 9 (II): 285–289

    CAS  Google Scholar 

  • Zbinden G, Studer A (1955a) Zur Wirkung von Vitaminen der B-Gruppe auf die experimentelle Isoniazid-„Neuritis“. Schweiz Z Path Bakt 18: 1198–1211

    CAS  Google Scholar 

  • Zbinden G, Studer A (1955b) Experimenteller Beitrag zur Frage der Isoniazid-Neuritis und ihrer Beeinflussung durch Pyridoxin. Z Tuberk 107: 97–107

    CAS  Google Scholar 

  • Zbinden G, Studer A (1955c) Vergleichende Untersuchungen über die Wirkung von Pyridoxin, Pyridoxal-5’-phosphat und Pyridoxal-isonicotinylhydrazon auf die experimentelle Isoniazid-„Neuritis” der Ratte. Int Z Vitaminforsch 26: 130–137

    CAS  Google Scholar 

  • Zbinden G, Studer A (1956) Wirkung der Glutaminsäure auf die experimentelle IsoniazidSchädigung peripherer Nerven bei Ratten. Experientia 12: 442–443

    PubMed  Google Scholar 

  • Zeller EA, Barsky J, Fouts JR, Kirchheimer WF, Van Orden LS (1952) Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinyl-2-isopropyl hydrazide (IIH) on bacterial and mammalian enzymes. Experientia 8: 349–350

    CAS  Google Scholar 

  • André T (1956) Studies on the distribution of tritium-labeled dihydrostreptomycin and tetracycline in the body. Acta Radiol Suppl 142: 52–73

    Google Scholar 

  • Bacharach AL, Clark BJ, McCulloch M, Tomich EG (1959) Comparative toxicity studies on ten antibiotics in current use. J Pharm Pharmacol 11: 737–741

    PubMed  CAS  Google Scholar 

  • Barkalaya AJ (1964), Transplacental effect of antibiotics of tetracycline group on kidneys of fetuses of pregnant rats. Fed Proc 23: T753–754

    Google Scholar 

  • Benitz K-F, Diermeier HF (1964) Renal toxicity of tetracycline degradation products. Proc Soc Exp Biol 115: 930–935

    PubMed  CAS  Google Scholar 

  • Bevelander G (1963) Effect of tetracycline on crystal growth. Nature 198: 1103

    CAS  Google Scholar 

  • Bevelander G, Nakahara H, Rolle GK (1960) The effect of tetracycline on the development of the skeletal system of the chick embryo. Dev Biol 2: 298–312

    PubMed  CAS  Google Scholar 

  • Bevelander G, Rolle GK, Cohlan SQ (1961) The effect of the administration of tetracycline on the development of teeth. J Dent Res 40: 1020–1024

    Google Scholar 

  • Bevelander G, Cohlan SQ (1962) The effect on the rat fetus of transplacentally acquired tetracycline. Biol Neonat 4: 365–370

    PubMed  CAS  Google Scholar 

  • Bevelander G, Goss RJ (1962) Influence of tetracycline on calcification in normal and regenerating teleost scales. Nature 193: 1098–1099

    PubMed  CAS  Google Scholar 

  • Bezzi G, Gessa GL (1961) Influence of antibiotics on the neuromuscular transmission in mammals. Antibiot Chemotherap 11: 710–714

    CAS  Google Scholar 

  • Breen KJ, Schenker S, Heimberg M (1972a) Pathogenesis of tetracycline fatty liver. Clin Res 20: 74

    Google Scholar 

  • Breen K, Schenker S, Heimberg M (1972b) The effect of tetracycline on the hepatic secretion of triglyceride. Biochem Biophys Acta 270: 74–80

    CAS  Google Scholar 

  • Breen KJ, Schenker S, Heimberg M (1975) Fatty liver induced by tetracycline in the rat. Dose-response relationship and effect of sex. Gastroenterology 69: 717–723

    Google Scholar 

  • Brown DM, Harper KH, Palmer AK, Tesh SA (1968) Effects of antibiotics upon pregnancy in the rabbit. Toxicol Appl Pharmacol 12: 295

    Google Scholar 

  • Du Buy HG, Showacre JL (1961) Selective localization of tetracycline in mitochondria of living cells. Science 133: 196–197

    Google Scholar 

  • Clausen G, Nagy Z, Szalay L, Aukland K (1975) Mechanism in acute oliguric renal failure induced by tetracycline infusion. Scand J Clin Lab Invest 35: 625–633

    PubMed  CAS  Google Scholar 

  • Cohen LS, Wechsler AS, Mitchell JH, Glick G (1970) Depression of cardiac function by streptomycin and other antimicrobial agents. Am J Cardiol 26: 505–511

    PubMed  CAS  Google Scholar 

  • Cohlan SQ, Bevelander G, Tiamsic T (1963) Growth inhibition of prematures receiving tetracycline. Am J Dis Child 105: 453–461

    Google Scholar 

  • Cullen SJ, Catalano PM, Helfman RJ (1966) Tetracycline sun sensitivity. Arch Derm 93: 77

    PubMed  CAS  Google Scholar 

  • Cunningham RW, Hines LR, Stokey EH, Vessey RE, Yuda NN (1953) Pharmacology of tetracycline. Antibiot Annu 1953–1954: 63–69

    Google Scholar 

  • Damjanov J, Solter D (1971) Ultrastructure of acute tetracycline induced liver change. Experientia 27: 1204–1205

    PubMed  CAS  Google Scholar 

  • Detyuk ES, Vdovichenko IA, Kartysh GA (1971) Tetracycline effect on embryogenesis of albino rats. Antibiotiki (Moskau) 16: 923–926

    CAS  Google Scholar 

  • Eger W, Ilbagian K (1962) Untersuchungen über die Wirkung von Tetracyclinen auf die Leber. Arzneimittelforsch 12: 285–289

    PubMed  CAS  Google Scholar 

  • English AR, P’an SY, McBride TJ, Gardocki JF, Van Halsema G, Wright WA (1953) Tetracycline-microbiologic, pharmacologic and clinical evaluation. Antibiot Annu 19531954: 70–80

    Google Scholar 

  • Farhat SM, Schelhart DL, Musselman MM (1958) Clinical toxicity of antibiotics correlated with animal studies. AMA Arch Surg 76: 762–765

    PubMed  CAS  Google Scholar 

  • Fillippi B, Mela V (1957) Malformazioni congenite facciali e degli arti da tetraciclina. Minerva Chir 12: 1–15

    Google Scholar 

  • Fillippi B (1967) Antibiotics and congenital malformations: Evaluation of the teratogenicity of antibiotics. Adv Teratol 2: 239–256

    Google Scholar 

  • Franklin TJ (1963) The inhibition of incorporation of leucine into protein of cell-free systems from rat liver and Escherichia coli by chlortetracycline. Biochem J 87: 449–453

    PubMed  CAS  Google Scholar 

  • Franklin TJ (1964) The effect of chlortetracycline on the transfer of leucine and “transfer” ribonucleic acid to rat-liver ribosomes in vitro. Biochem J 90: 624–628

    PubMed  CAS  Google Scholar 

  • Giovannini M (1962) Toxizität (der Tetracycline). In: Brunner R, Machek G (eds) Die Antibiotika, Band I, Teil 2. Carl, Nürnberg, pp 506–510

    Google Scholar 

  • Gray JE, Weaver RN, Skinner P, Mathews J, Day CE, Stern K (1974) Effects of tetracycline on ultrastructure and lipoprotein secretion in the rat hepatocyte. Toxicol Appl Pharmacol 30: 317–322

    CAS  Google Scholar 

  • Greenberger NJ, Perkins RL, Cuppage FE, Ruppert RD (1967) Severe metabolic acidosis in the rat induced by toxic doses of tetracycline. Proc Soc Exp Biol Med 125: 11941197

    Google Scholar 

  • Greenberger NJ (1967) Inhibition of protein synthesis in rat intestinal slices by tetracycline. Nature 214: 702–703

    PubMed  CAS  Google Scholar 

  • Hahn KJ, Morgenstern E, von Puttkamer K, Weber E (1970) Schädigungen der Mitochondrien von Darmepithelzellen bei oraler Therapie mit Tetrazyklinen. Naunyn Schmiedebergs Arch Pharmacol 266: 347

    PubMed  CAS  Google Scholar 

  • Hakkinen JPT (1958) The fluorescence of tetracycline in rats treated with dihydrotachysterol, AT 10. Acta Physiol Scand 42: 282–287

    PubMed  CAS  Google Scholar 

  • Halme J, Aer J (1968) Inhibition of collagen synthesis and bone calcification in the foetal rat by tetracycline. Scand J Clin Lab Invest 21, Suppl 101: 4

    Google Scholar 

  • Halme J, Kivirikko KJ, Kaitila J, Saxen L (1969) Effect of tetracycline on collagen biosynthesis in cultured embryonic bones. Biochem Pharmacol 18: 827–836

    PubMed  CAS  Google Scholar 

  • Hansen CH, Pearson LH, Schenker S, Combes B (1968) Impaired secretion of triglycerides by the liver; a cause of tetracycline-induced fatty liver. Proc Soc Exp Biol Med 128: 143–146

    PubMed  CAS  Google Scholar 

  • Hanson DJ (1961) Local toxic effects of broad-spectrum antibiotics following injection. Antibiot Chemotherap 11: 390–404

    CAS  Google Scholar 

  • Harcourt JK, Johnson NW, Storey E (1962) Incorporation of tetracycline antibiotics in bone, teeth, and egg shells. J Dent Res 41: 511

    Google Scholar 

  • Hash JH (1963) Effects of tetracyclines on the incorporation of C14-alanine into staphylococcus aureus. Fed Proc 22: 301

    Google Scholar 

  • Helander S, Böttiger L (1953) On the distribution of terramycin in different tissues. Acta Med Scand 147: 71–75

    PubMed  CAS  Google Scholar 

  • Hughes WH, Lee WR, Flood DJ (1965) A comparative study of the actions of six tetracy-clines on the development of the chick embryo. Br J Pharmacol 25: 317–323

    CAS  Google Scholar 

  • Hurley LS, Tuchmann-Duplessis H (1963) Influence de la tétracycline sur le développement pré-et post-natal du rat. CR Acad Sci 257: 302–304

    CAS  Google Scholar 

  • Ibsen KH, Urist MR (1963) Complexes of calcium and magnesium with oxytetracycline. Proc Soc Exp Biol Med 109: 797–801

    Google Scholar 

  • Ison A, Blank H (1967) Testing drug phototoxicity in mice. J Invest Dermatol 49: 508–511

    PubMed  CAS  Google Scholar 

  • Kämmerer H, Eger W (1956) Tetracycline and Knochenstoffwechsel. Med Welt 1: 986–991

    Google Scholar 

  • Kelly RG, Buyske D (1960) Metabolism of tetracycline in the rat and the dog. J Pharmacol Exp Ther 130: 144–149

    PubMed  CAS  Google Scholar 

  • Kohonen J, Guile EE, Plosila A (1968) Effects of tetracycline on osteogenesis in embryos of mice. Scand J Clin Lab Invest 21, Suppl 101: 4

    Google Scholar 

  • Kubikowski P, Szreniawski Z (1963) The mechanism of the neuromuscular blockade by antibiotics. Arch Int Pharmacodyn Ther 146: 549–560

    PubMed  CAS  Google Scholar 

  • Kuck NA, Redin GS (1960) Comparison of demethylchlortetracycline with tetracycline in the control of experimental infections in mice. J Pharmacol Exp Ther 129: 350–355

    PubMed  CAS  Google Scholar 

  • Küpper K, Stupp H, Orsulakova A, Quante M (1970) Vergleichende Untersuchungen der Ototoxizität verschiedener antibiotischer Substanzen bei lokaler Applikation am Innenohr des Meerschweinchens. Arch Otorhinolaryngol 196: 169–172

    Google Scholar 

  • Leaders F, Pittinger CB, Long JP (1960) Some pharmacological properties of selected antibiotics. Antibiot Chemotherap 10: 503–507

    CAS  Google Scholar 

  • Lewis M, Schenker S (1966) Studies on the pathogenesis of tetracycline-induced fatty liver. Clin Res 14: 48

    Google Scholar 

  • Lewis M, Schenker S, Combee B (1967) Studies on the pathogenesis of tetracycline-induced fatty liver. Am J Digest Dis 12: 429–438

    PubMed  CAS  Google Scholar 

  • Lindquist RR, Fellers FX (1966) Degraded tetracycline nephropathy. Lab Invest 15: 864–876

    PubMed  CAS  Google Scholar 

  • Lowe MB, Tapp E (1966) Renal damage caused by anhydro-4-epitetracycline. Arch Pathol 81: 362–364

    PubMed  CAS  Google Scholar 

  • Maffii G, Semenza F, Soncin E (1957) Saline solutions as a factor affecting the toxicity of intravenously injected tetracyclines in mice. J Pharm Pharmacol 9:105–112

    PubMed  CAS  Google Scholar 

  • McColl JD, Globus M, Robinson S (1965) Effect of some therapeutic agents on the developing rat fetus. Toxicol Appl Pharmacol 7: 409–417

    PubMed  CAS  Google Scholar 

  • McIntosh HA, Storey E (1970) Tetracycline-induced tooth changes, Part 4. Discoloration and hypoplasia induced by tetracycline analogues. Med J Aust 1: 114–119

    PubMed  CAS  Google Scholar 

  • Mennie AT (1962) Tetracycline and congenital limb abnormalities. Br Med J II: 480

    Google Scholar 

  • Mikaelyan NP, Ulyanov MI (1971) On some shifts in thrombocytopoiesis systems in rabbits treated with tetracyclin. Antibiotiki 16: 624–626

    CAS  Google Scholar 

  • Mikaelyan NP, Eingorn AG, Ulyanov MI (1973) Morphological changes induced by tetracycline in rabbits. Antibiotiki 18: 906–910

    CAS  Google Scholar 

  • Milch RA, Rall DP, Tobie JE (1957) Bone localization of the tetracyclines. J Natl Cancer Inst 19: 87–93

    PubMed  CAS  Google Scholar 

  • Milch RA, Rall DP, Tobie JE (1958) Fluorescence of tetracycline antibiotics in bone. J Bone Joint Surg 40 A: 897–910

    PubMed  Google Scholar 

  • Milch RA, Tobie JE, Robinson J (1961) A microscopic study of tetracycline localization in skeletal neoplasms. J Histochem Cytochem 9: 261–270

    PubMed  CAS  Google Scholar 

  • Miller SEP, MacSween RNM, Glen ACA, Tribedi K, Moore FML (1967) Experimental studies on the hepatic effects of tetracycline. Br J Exp Pathol 48: 51–57

    PubMed  CAS  Google Scholar 

  • Mukherjee D, Mukherjee S (1969) Studies on the effect of tetracycline on triglyceride synthesis in experimental rats. J Antibiotics 22: 45–48

    CAS  Google Scholar 

  • Mukherjee D, Ghosh H, Mukherjee S (1969) Studies on the effect of administration of tetracycline on free fatty acid metabolism in adrenalectomised and control rats. J Antibiotics 22: 480–483

    CAS  Google Scholar 

  • Mukherjee D, Ghosh HN, Mukherjee S (1971) The effect of tetracycline on synthesis of fatty acid and cholesterol in the liver of control and experimental rats. J Antibiotics 24: 263–265

    CAS  Google Scholar 

  • Nelson AA, Radomski JL (1954) Comparative pathological study in dogs of feeding of six broadspectrum antibiotics. Antibiotics Chemother 4: 1174

    CAS  Google Scholar 

  • Owen LN (1961) Fluorescence of tetracyclines in bone tumors, normal bone teeth. Nature 190: 500–502

    PubMed  CAS  Google Scholar 

  • P’an SY, Scaduto L, Cullen M (1950) Pharmacology of terramycin in experimental animals. Ann New York Acad Sci 53: 238–244

    Google Scholar 

  • Parker FL, James GWL (1978) The effect of various topical antibiotics and antibacterial agents on the middle and inner ear of the guinea-pig. J Pharm Pharmacol 30: 236–239

    PubMed  CAS  Google Scholar 

  • Pittinger Ch, Adamson R (1972) Antibiotic blockade of neuromuscular function. Annu Rev Pharmacol 12: 169–184

    PubMed  CAS  Google Scholar 

  • Polec RB, Yeh SDJ, Shils ME (1971) Protective effect of ascorbic acid, isoascorbic acid and mannitol against tetracycline-induced nephrotoxicity. J Pharmacol Exp Ther 178: 152–158

    PubMed  CAS  Google Scholar 

  • Rall DP, Loo TL, Lane M, Kelly MG (1957) Appearance and persistence of fluorescent material in tumor tissue after tetracycline administration. J Natl Cancer Inst 19: 79–85

    PubMed  CAS  Google Scholar 

  • Rendi R, Ochoa S (1961) Enzyme specificity in activation and transfer of amino acids to ribonucleoprotein particles. Science 133: 1367

    Google Scholar 

  • Savini EC, Moulin MA, Herrou MFJ (1968) Effets tératogènes de l’oxytetracycline. Thérapie 23: 1247–1260

    PubMed  CAS  Google Scholar 

  • Saxén L (1966) Effect of tetracycline on osteogenesis in vitro. J Exp Zool 162: 269–294

    Google Scholar 

  • Schenker S, Hansen C, Combes B (1968) Impaired secretion of hepatic triglycerides - a cause of tetracycline-induced fatty liver. Gastroenterology 54: 1268

    Google Scholar 

  • Schoenbach EM, Bryer MS, Long PH (1950–1951) The pharmacology of terramycin in animals and man with reference to its clinical trial. Ann NY Acad Sci 53:245–252

    Google Scholar 

  • Shauer BA, Lukacs L, Zimmerman HJ (1974) Biochemical indices of tetracycline hepatic injury in rats. Proc Soc Exp Biol Med 147: 868–872

    PubMed  CAS  Google Scholar 

  • Schorr WF, Monash S (1963) Photo-irradiation studies of two tetracyclines. Arch. Dermatol 88: 440–444

    PubMed  CAS  Google Scholar 

  • Smith H, Chapman IV (1963) Use of the living chick embryo as a biological indicator of the effectiveness of chelating agents. Nature 198: 32–33

    PubMed  CAS  Google Scholar 

  • Steiner G, Bradford W, Craig JM (1965) Tetracycline-induced abortion in the rat. Lab Invest 14: 1456–1463

    PubMed  CAS  Google Scholar 

  • Suarez G, Nathans D (1965) Inhibition of aminoacyl-sRNA binding to ribosomes by tetracycline. Biochem Biophys Res Comm 18: 743–750

    CAS  Google Scholar 

  • Surgen RC, Nielsen JK (1960) Some factors influencing the toxicity (safety) test for antibiotics. Antibiot Chemotherap 10: 169–173

    CAS  Google Scholar 

  • Swain HH, Kiplinger GF, Brody TM (1956) Actions of certain antibiotics on the isolated dog heart. J Pharmacol Exp Ther 117: 151–159

    PubMed  CAS  Google Scholar 

  • Tubaro E (1964) Possible relationship between tetracycline stability and effect on foetal skeleton. Br J Pharmacol 23: 445–448

    CAS  Google Scholar 

  • Tubaro E, Barletta M, Banci F (1964) Some pharmacological aspects of a new water-soluble tetracycline. J Pharm Pharmacol 16: 33–37

    PubMed  CAS  Google Scholar 

  • Urist MR, Ibsen KH (1963) Chemical reactivity of mineralized tissue with oxytetracycline. Arch Pathol 76: 484–496

    PubMed  CAS  Google Scholar 

  • Verret MJ, Mutchier MK (1964) Teratogenic effects of antibiotics in the chick embryo. Fed Proc 23: 104

    Google Scholar 

  • Wivagg RT, Jaffe JM, Colaizzi JL (1976) Influence of pH and route of injection on acute toxicity of tetracycline in mice. J Pharm Sci 65: 916–918

    PubMed  CAS  Google Scholar 

  • Yeh SDJ, Shils ME (1966) Tetracycline and incorporation of amino acids into proteins of rat tissues. Proc Soc Exp Biol Med 121: 729–734

    PubMed  CAS  Google Scholar 

  • Zolotukhin SI (1958) The effect of the tetracycline group of antibiotics on the coagulation of the blood. Antibiotics 4: 324–327

    Google Scholar 

  • Adamson RH, Marshall FN, Long JP (1960) Neuromuscular blocking properties of various polypeptide antibiotics. Proc Soc Exp Biol Med 105: 494–497

    PubMed  CAS  Google Scholar 

  • Caesar R (1965) Die Bedeutung der Lysosomen für die formale Genese der Viomycin-Nephrose. Verh Dtsch Ges Pathol 49: 157–161

    PubMed  CAS  Google Scholar 

  • Gössner W (1963) Nebenwirkungen der modernen Chemotherapeutika vom Standpunkt des Pathologen. Antibiot Chemother 11: 285–300

    Google Scholar 

  • Kanda T, Igarashi M (1969) Ultra-structural changes in vestibular sensory and organs after viomycin sulfate intoxication. Acta Otolaryngol 68: 474–488

    PubMed  CAS  Google Scholar 

  • Keller H, Krüpe W, Sous H, Mückter H (1956) Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotica. 2. Mitteilung. Arzneimittelforsch 6: 61–66

    PubMed  CAS  Google Scholar 

  • Klein HJ, Steinbach E, Schümmelfeder N (1966) Ultrastrukturelle und histochemische Untersuchungen zur Entstehung der Viomycin-Nephrose. Frankfurter Z Pathol 75: 432–445

    CAS  Google Scholar 

  • Kubikowski P, Szreniawski Z (1963) The mechanism of the neuromuscular blockade by antibiotics. Arch Int Pharmacodyn Ther 146: 549–560

    PubMed  CAS  Google Scholar 

  • Moyer JH, Handley CA (1953) Renal function during viomycin administration to dogs. Proc Soc Exp Biol Med 82: 761–763

    PubMed  CAS  Google Scholar 

  • Mückter H (1961) Zur Pharmakologie der basischen Streptomyces-Antibiotika. Antibiot Chemother 9 Sep: 83–144

    Google Scholar 

  • P’an SY, Halley TV, Reilly JC, Pekich AM (1951) Viomycin. Acute and chronic toxicity in experimental animals. Am Rev Tuberc 63: 44–48

    PubMed  Google Scholar 

  • Staemmler M, Karhoff B (1956) Die akuten Nephrosen. II. Mitteilung. Nierenschäden durch Antibiotica. Virchows Arch 328: 481–502

    PubMed  CAS  Google Scholar 

  • Staemmler M (1957) Die akuten Nephrosen. IV. Mitteilung. Tubuläre Schädigung und Wiederherstellung. Virchows Arch 330: 139–155

    PubMed  CAS  Google Scholar 

  • Vital Brazil O, Ramos AO, Sperandio LG, Martinez AL (1961) Viomycin. Pharmacological actions on myoneural junction, ganglionic synapse and smooth muscle. Chemotherapia 3: 521–531

    Google Scholar 

  • Anderson RC, Worth HM, Welles JS, Harris PN, Chen KK (1956) Pharmacology and toxicology of cycloserine. Antibiot Chemother 6: 360–368

    CAS  Google Scholar 

  • Bonati F, Bertoni L, Rosati G, Zanichelli V (1963) Caratteristiche biologiche ed attività antibatterica del teridizone. Il Farmaco Prat 20: 381–395

    Google Scholar 

  • Bonavita V, Lettieri M, Monaco P (1964) Behavioural studies on rats injected with L-cycloserine and other compounds. Psychopharmacologia 5: 234–238

    PubMed  CAS  Google Scholar 

  • Bykova MA, Storozhev IA, Berezin EA (1965) Zur Pharmakologie des D-Cycloserin. Antibiotiki 10: 626–629

    PubMed  CAS  Google Scholar 

  • Dengler HJ (1962) Zur Hemmung der L-Glutaminsäure-und L-Dopadecarboxylase durch D-Cycloserin und andere Isoxazolidone. Naunyn Schmiedebergs Arch Pharmacol 243: 366–381

    CAS  Google Scholar 

  • Epstein IG, Nair KGS, Mulinos MG, Haber A (1959) Pyridoxine and its relation to cycloserin neurotoxicity. Antibiot Annu 1958–1959: 472–481

    Google Scholar 

  • Fust B, Böhni E, Pellmont B, Zbinden G, Studer A (1958) Experimentelle Untersuchungen mit D-Cycloserin. Schweiz Z Tuberk 15: 129–157

    PubMed  CAS  Google Scholar 

  • Glass F, Mallach HJ, Simsch A (1965) Beobachtungen und Untersuchungen über die gemeinsame Wirkung von Alkohol und D-Cycloserin. Arzneimittelforsch 15: 684–688

    PubMed  CAS  Google Scholar 

  • Lange P, Oehme P (1964) Zentralnervöse Wirkungen von D- und D,L-Cycloserin. Arch Int Pharmacodyn Ther 152: 466–473

    PubMed  CAS  Google Scholar 

  • Mayer O, Jankü I, Krsiak M (1971) Die zentralen Wirkungen des Cycloserins im Tierexperiment. Arzneimittelforsch 21: 298–303

    CAS  Google Scholar 

  • Prescott B, Kauffmann G, James WD (1957) Increase in tolerated dose of isoniazid in mice by use of cycloserine. Proc Soc Exp Biol Med 94: 94–96

    PubMed  CAS  Google Scholar 

  • Robinson HJ, Mason RC, Siegel H (1956) Toxicity and pharmacology of cycloserine. Am Rev Tuberc 74: 972–976

    PubMed  CAS  Google Scholar 

  • Spencer JN, Payne HG (1956) Cycloserine. Experimental Studies. Antibiot Chemother 6: 708–716

    CAS  Google Scholar 

  • Baeder DH, Ledaux G, Marier G (1962) The pharmacology and toxicology of ethionamide. Fed Proc 21: 452

    Google Scholar 

  • Bargeton D (1964) Etude toxicologique du 1321 TH. Unpublished investigations Biancifiori C, Milia U, Di Leo FP (1964) Lay Ist Anat Istol patol Univ Perugia 24:145

    Google Scholar 

  • Biancifiori C, Severi C (1966) The relationship of isoniazid (INH) and allied compounds to carcinogenesis in some species of small laboratory animals: A review. Br J Cancer 20: 528–538

    PubMed  CAS  Google Scholar 

  • Dubost P, Fournel J, Ganter P, Julou L, Laville J, Myon J, Pascal S (1964) Produits 1314 TH (8.545 R.P.) ou ethionamide (Trecator, N.D. Theraplix) et 1321 TH (9.778 R.P.). Toxicité aigue et toxicité terme (3 mois). Unpublished investigations

    Google Scholar 

  • Iliin AM (1975) Pharmaco-toxicogical study of the antituberculous preparation prothionamide Farmakol Toksikol 38: 471–472

    Google Scholar 

  • Ingham B (1963) Personal communication

    Google Scholar 

  • Khan J, Azam A (1969) Study of teratogenic activity of trifluorperazine, amitriptyline, ethionamide and thalidomide in pregnant rabbits and mice. Proc Eur Soc Study Drug Tox 10: 235–241

    CAS  Google Scholar 

  • Lorke D (1963/64) Bericht über die Prüfung der embryotoxischen Wirkung von Iridocin (1314 TH). Unpublished investigations

    Google Scholar 

  • Maral R, Ganter P (1967) Etude de l’activité cancerogène de: l’isoniazide (5.015 R.P.), du prothionamide (9.778 R.P. =1321 TH), de l’urethane (10.506 R.P.) et de l’hydrazine (14.377 R.P.). Unpublished investigations

    Google Scholar 

  • Roux CH (1962) Rapport sur l’ètude du pouvoir teratogène du 1314 TH et du 2162 TH. Unpublished investigations

    Google Scholar 

  • Roux CH (1963) Rapport sur l’ètude du pouvoir teratogène du 1314 TH et du 2162 TH. Unpublished investigations

    Google Scholar 

  • Roux CH (1965) Rapport sur l’ètude du pouvoir teratogène du 1314 TH et du 2162 TH. Unpublished investigations

    Google Scholar 

  • Roux CH (1965) Rapport sur l’ètude de l’effect teratogène du 1321 TH. Unpublished investigations

    Google Scholar 

  • Woodard G (1960) Toxicity of TH-1314 following single and repeated daily doses in rats and dogs. Unpublished investigations

    Google Scholar 

  • Akiyoshi M, Sato K (1970) Reevaluation of the pinna reflex test as screening for otoxicity of antibiotics. In: Progress in antimicrobial and anticancer chemotherapy. Proc 6th Intern Congr Chemotherapy, Vol I: 621–627

    Google Scholar 

  • Amann R, Radenbach KL (1961) Akute Kanamycin-Nebenwirkungen und Histaminfreisetzung. Beitr Klin Tuberk 123: 208–210

    CAS  Google Scholar 

  • Beck CHL, Krahl P (1962) Experimentelle und feingewebliche Untersuchungen über die Otoxicität von Kanamycin. Arch Otorhinolaryngol 179: 594–610

    CAS  Google Scholar 

  • Bevelander G, Cohlan SQ (1962) The effect on the rat of transplacentally aquired tetracycline. Biol Neonate 4: 365–370

    CAS  Google Scholar 

  • Brown JJ, Brummett RE, Fox KE (1979) Combined effects of noise and kanamycin: Cochlear pathology and pharmacokinetics in the guinea pig. Pharmacologist 21: 144

    Google Scholar 

  • Brummett RE, Traynor J, Brown R, Himes D (1975) Cochlear damage resulting from kanamycin and furosemide. Acta Oto-Laryngol (Stockh) 80: 86–92

    CAS  Google Scholar 

  • Cohen LS, Wechsler AS, Mitchell JH, Glick G (1970) Depression of cardiac function by streptomycin and other antimicrobial agents. Am J Cardiol 26: 505–511

    PubMed  CAS  Google Scholar 

  • Farkashidy J, Black RG, Briant TDR (1963) The effect of kanamycin on the internal ear: an electrophysiological and electron microscope study. Laryngoscope 73: 713–727

    PubMed  CAS  Google Scholar 

  • Goldberg LE (1964) Pharmakologische Prüfung des Antibiotikums Kanamycin (russ.). Antibiotiki (Moskau) 9: 414–420

    CAS  Google Scholar 

  • Goldberg LE, Ilyushina NG (1968) Experimental investigation of kanamycin circulation between mother and fetus. Byul Eksp Biol Med 66: 994–996

    Google Scholar 

  • Hawkins JE Jr (1959) The otoxicity of kanamycin. Ann Otol 68: 698–715

    Google Scholar 

  • Kinoshita Y, Yamasaku F, Takeda H, Usuda Y, Kitahara K (1970) Nephrotoxicity of kanamycin with a combination of plasma expander. In: Progress in antimicrobiol and anticancer chemotherapy. Proc 6th Intern Congr Chemotherapy, Vol I: 586–590

    Google Scholar 

  • Kohonen A (1965) Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig. Acta Otolaryng (Stockh) Suppl 208: 9–70

    Google Scholar 

  • Lagler F, Osterloh G, Mückter H (1960) Studies on the pharmacology of kanamycin. Antibiot Annu 1959–1960: 862–867

    Google Scholar 

  • Luft F, Bloch R, Sloan RS, Yum MN, Costello R, Maxwell DR (1978) Comparative nephrotoxicity of aminoglycoside antibiotics in rats. J Infect Dis 138: 541–545

    PubMed  CAS  Google Scholar 

  • Mückter H (1961) Zur Pharmakologie der basischen Streptomyces-Antibiotika. Antibiot Chemotherap 9 Sep: 83–114

    Google Scholar 

  • Nakazono M, Naide Y, Ohkoshi M (1970) Biochemical studies on nephrotoxicity of kanamycin. In: Progress in antimicrobial Chemotherapy. Vol I: 591–595

    Google Scholar 

  • Orr JL (1980) Behavioral toxicology of kanamycin. Dissertation Abstr Intern B 40: 50–68

    Google Scholar 

  • Osaka S, Tokimoto T, Matsuura S (1979) Effects of kanamycin on the auditory evoked responses during postnatal development of the hearing of the rat. Acta Oto-Laryngol (Stockh) 88: 359–368

    Google Scholar 

  • Owada K (1962) Experimental studies on the toxicity of kanamycin, its hydrolyzed products and neomycin. Chemotherapia 5: 277–293

    PubMed  CAS  Google Scholar 

  • Pindell MH, Lein J (1964) Comparison of biological and toxicological properties of meth- ane sulfonate and sulfonate derivatives of antibiotics Chemotherapia 8: 163–174

    CAS  Google Scholar 

  • Plattig KH, Keidel UO, David E (1967) Minderung der Otoxizität des Kanamycin durch Panthothensäure. Elektrophysiologische Untersuchungen an der Katze. Dtsch Med Wochenschr 92: 1391–1397

    CAS  Google Scholar 

  • Raphael Y, Fein A (1980) Kanamycin otoxicity in utero. Isr J Med Sci 16: 554–555

    Google Scholar 

  • Renaud S (1960) The toxicity of kanamycin and bacitracin as influenced by stress and sodium chloride. Toxicol Appl Pharmacol 2: 708–714

    PubMed  CAS  Google Scholar 

  • Sack K, Züllich B (1978) Differenzierung der nephrotoxischen Potenzen von Aminoglykosiden und Cephalosporinen im Tierexperiment. Therapiewoche 28: 2107–2114

    Google Scholar 

  • Singh YN, Harvey AL, Marshall IG (1978) Antibiotic-induced paralysis of the mouse phrenic nerve-hemidiaphragm preparation, and reversibility by calcium and by neostigmine. Anesthesiology 48: 418–424

    PubMed  CAS  Google Scholar 

  • Staemmler M, Dudkowiak V (1961) Über Wirkungen des Kanamycin auf die Nieren. Med Welt: 1296–1299

    Google Scholar 

  • Stebbins WC, Miller JM, Johnsson L-G, Hawkins JE Jr (1969) Ototoxic hearing loss and cochlear pathology in the monkey. Ann Otol 78: 1007–1025

    CAS  Google Scholar 

  • Tisch DE, Huftalen JB, Dickison HL (1958) Pharmacological studies with kanamycin. Ann NY Acad Sci 76: 44–65

    PubMed  CAS  Google Scholar 

  • Toyada Y, Saito H, Matsuoka H, Takenaka H, Oshima W, Mizukoshi O (1978) Quanti- tative analysis of kanamycin ototoxicosis. Acta Oto-Laryngol (Stockh) 84: 202–212

    Google Scholar 

  • Russel NJ, Fox KE, Brummett RE (1979) Ototoxic effects of the interaction between kanamycin and ethacrynic acid. Cochlear ultrastructure correlated with cochlear potentials and kanamycin levels. Acta Oto-Laryngol (Stockh) 88: 369–381

    Google Scholar 

  • Tyberghein J (1962) Influence of some streptomyces antibiotics on the cochlear microphonics in the guinea pig. Acta Otolaryng (Stockh) Suppl 171

    Google Scholar 

  • West BA, Brummett RE, Himes DL (1973) Interaction of kanamycin and ethacrynic acid. Arch Otolaryngol 98: 32–37

    PubMed  CAS  Google Scholar 

  • Lambelin G (1970) Pharmacology and toxicology of Isoxyl. Antibiotica et Chemotherapia 16: 84–95

    CAS  Google Scholar 

  • Lambelin G, Parmentier R (1963) Etude toxicologique de l’Isoxyl sur l’animal. Acta Tuberc Pneumol Be1g 54: 476–493

    CAS  Google Scholar 

  • Lambelin G, Parmentier R (1966) Study of the toxicity of isoxyl. Arzneimittelforsch 16: 881–886

    PubMed  CAS  Google Scholar 

  • Akiyoshi M, Sato Y, Shoji T, Sugahiro K, Tamura H (1971) Histological changes in the stria vascularis of the inner ear in the case of auricular toxicosis by antibiotics (in Japanese). J Otolaryngol (Jap) 74: 476–477

    CAS  Google Scholar 

  • Muraoka Y, Hayashi Y, Minesita T (1968) Studies of capreomycin nephrotoxicity. Toxicol Appl Pharmacol 12: 350–359

    CAS  Google Scholar 

  • Welles JS, Harris PN, Small RM, Worth HM, Anderson RC (1966) The toxicity of capreomycin in laboratory animals. Ann NY Acad Sci 135: 960–973

    PubMed  CAS  Google Scholar 

  • Asole A, Panu R, Palmieri G (1976) Effetti dell’etambutolo sull’epitelio seminale di ratto e pollo. Boll Soc Ital Biol Sper 52: 846–848

    PubMed  CAS  Google Scholar 

  • Borchard U (1974) Untersuchungen über den Einfluß von Ethambutol auf peripheres and zentralnervöses Gewebe. Thesis, University of Cologne

    Google Scholar 

  • Botticelli A, Trentini GP, Barbolini G (1971) Lesioni testicolari nel ratto trattato con etambutolo. Boll Soc Ital Biol Sper 47: 72–75

    PubMed  CAS  Google Scholar 

  • Bruckschen EG (1970) Myambutol. Experimentelle and klinische Ergebnisse. Arzneimittelforsch, 20. Beiheft 2. Aufl.

    Google Scholar 

  • Buyske DA, Sterling W, Peets E (1966) Pharmacological and biochemical studies on ethambutol in laboratory animals. Ann NY Acad Sci 135: 711–725

    PubMed  CAS  Google Scholar 

  • Cappiello VP, Layton WM Jr (1965) A one-year study of the toxicity of ethambutol in dogs: results of gross and histopathologic examinations. Toxicol Appl Pharmacol 7: 844–849

    PubMed  CAS  Google Scholar 

  • Diermeier HF, Kaiser JA, Yuda N (1966) Safety evaluation of ethambutol. Ann NY Acad Sci 135: 732–746

    PubMed  CAS  Google Scholar 

  • Fantoli U, Sebastiani M, Cattaneo C, Sbampato M (1968) Comportamento dell’ attività colinesterasica sierica in soggeti trattati con Etambutolo. Ann Inst C Forlanini 28: 164

    CAS  Google Scholar 

  • Figueroa R, Weiss H, Smith JC Jr, Hackley BM, McBean LD, Swassing ChR, Halsted JA (1971) Effect of ethambutol on the ocular zinc concentrations in dogs. Am Rev Resp Dis 104: 592–594

    PubMed  CAS  Google Scholar 

  • Grifa P, Jotti D, Benatti G (1967) Ricereche sperimentali sulla tossicità dell’ Etambutolo sul sistema nervoso centrale di alcuni animali. Giorn It Chemiother 14: 65

    CAS  Google Scholar 

  • Hara T, Baba H (1970) Incorporation and metabolism of ethambutol in rat organs. Kekkaku 45: 129

    PubMed  CAS  Google Scholar 

  • Kaiser JA (1964) A one-year study of the toxicity of ethambutol in dogs: results during life. Toxicol Appl Pharmacol 6: 557–567

    PubMed  CAS  Google Scholar 

  • Schmidt J, Schmidt LH (1964) Neurotoxicity of ethambutol, an anti-tuberculosis drug. Anat Rec 148: 333

    Google Scholar 

  • Schmidt JG (1966) Central nervous system effects of ethambutol in monkeys. Ann NY Acad Sci 135: 759–774

    PubMed  CAS  Google Scholar 

  • Thomas JP, Baughn CO, Wilkinson RG, Sheperd RG (1961) A new synthetic compound with antituberculous activity in mice: ethambutol (dextro-2,2’-(ethylenediimino)-di-lbutanol). Am Rev Respir Dis 83: 891–893

    PubMed  CAS  Google Scholar 

  • Vogel AW, Kaiser JA (1963) Ethambutol-induced transient change and reconstitution (in vivo) of the tapetum lucidum color in the dog. Exp Mol Pathol Suppl 2: 136–149

    CAS  Google Scholar 

  • Anufrieva RG, Zeltser IZ, Svinogeeva TP (1980a) Placenta permeability by rifampicin (Russ.). Antibiotiki 25: 199–201

    CAS  Google Scholar 

  • Anufrieva RG, Zeltser IZ, Balabanova EL, Lapchinskaya AV, Baru RV, Svinogeeva TP (1980b) Experimental study of rifampicin effect on albino rat embryo genesis (Russ.). Antibiotiki 25: 280–284

    CAS  Google Scholar 

  • Balea T, Marche C, Marche J (1970) Effets hépato-biliaires de l’association rifarnpicineisoniazide. II. Etude histologique chez la souris tuberculisée. Thérapie 25: 125–130

    PubMed  CAS  Google Scholar 

  • Bichl J (1973) Rifampicin in a carcinogenic experiment. Lancet 2: 1209

    Google Scholar 

  • Della Porta G, Cabral JR, Rossi L (1978) Carcinogenicity study of rifampicin in mice and rats. Toxicol Appl Pharmacol 43: 293–302

    Google Scholar 

  • Epstein SS, Arnold E, Andrea J, Bass W, Bishop Y (1972) Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol Appl Pharmacol 23: 288–325

    PubMed  CAS  Google Scholar 

  • Felgenhauer F, Lagler F (1970) Experimental animal investigations with rifampicin on the question of its influence on the vestibular system and its period of retention in the peri-lymph of the inner ear. Antibiot Chemother 16: 361–368

    PubMed  CAS  Google Scholar 

  • Furesz S (1970) Chemical and biological properties of rifampicin. Antibiot Chemother 16: 316–351

    PubMed  CAS  Google Scholar 

  • Hugues F-C, Marche C, Marche J (1969) Effets hépato-biliaires de l’association rifampicine-isoniazide. I. Etude histologique chez le rat. Thérapie 24: 899–906

    PubMed  CAS  Google Scholar 

  • Hugues F-C, Marche C, Marche J (1970) Effets hépato-biliaires de l’association rifampicine-prothionamide. I. Etude histologique chez le rat. Thérapie 25: 131–136

    PubMed  CAS  Google Scholar 

  • Jaeger E, Merker HJ, Bass R (1974) Investigations on the mode of teratogenic action of high doses of rifampicin. Teratology 10: 312

    Google Scholar 

  • Jezequel AM, Orlandi F, Tenconi LT (1971) Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes. Gut 12: 984–987

    PubMed  CAS  Google Scholar 

  • Kluyskens P (1969) Recherches expérimentales de toxicité otovestibulaire des rifamycines. Acta Tuberc Pneumol Belg 60: 323–326

    PubMed  CAS  Google Scholar 

  • Piriou A, Warnet JM, Jacqueson A, Claude JR, Truhaut R (1979) Fatty liver induced by high doses of rifampicin in the rat: possible relation with an inhibition of RNA polymerase in eukaryotic cells. Arch Toxicol Suppl 2: 333–337

    PubMed  Google Scholar 

  • Schiatti P, Maggi N, Sensi P, Maffei G (1967) Biliary excretion rate of semisynthetic rifamycins in the rat. Chemotherapia 12: 155–171

    CAS  Google Scholar 

  • Sensi P, Maggi N, Füresz S, Maffei G (1967) Chemical modifications and biological properties of rifamycins. Antimicrob Agents Chemother 1966: 699–714

    Google Scholar 

  • Srb V, Puza V, Spurna V, Kerptova J (1974) The action of rifampicin on stabilized cell lines HEp-2 and HeLa. Experientia 30: 484–486

    PubMed  CAS  Google Scholar 

  • Tuchmann-Duplessis H, Mercier-Parot L (1969) Influence d’un antibiotique, la rifampicine, sur le développement prénatal des rongeurs. CR Acad Sc (Paris) Série D 269: 2147–2149

    CAS  Google Scholar 

  • Vogel E, Obe G (1973) Testing of rifampicin on possible genetic effects on Drosophila melanogaster and human leukocyte chromosomes in vitro. Experientia 29: 124–125

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. D. Tettenborn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Julius-Lucas-Weg 67, D-5600, Wuppertal 1, Germany

    Karl Bartmann

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Tettenborn, D. (1988). Experimental Pharmacology and Toxicology of Antituberculosis Drugs. In: Bartmann, K. (eds) Antituberculosis Drugs. Handbook of Experimental Pharmacology, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72873-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72873-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72875-4

  • Online ISBN: 978-3-642-72873-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation