Abstract
The anti-tuberculosis agents are, chemically, a very heterogeneous group exhibiting a wide spectrum of pharmacological and toxicological effects on the various organ systems. These range from the very early recognized ototoxicity and nephrotoxicity of the aminoglycosides, to the question of neurotoxicity, carcinogenicity and mutagenicity of INH, to the oculotoxicity of ethambutol and to effects on neuro-muscular transmission of the aminoglycosides. Whilst for some substances there are enormous numbers of publications, there are other substances where there is a noticeable lack of published pharmacological and toxicological data. With regard to the latter substances it was possible, in some cases, to include in this review previously unpublished results of studies carried out by the manufacturing companies. Since most of the anti-tuberculosis agents were introduced 20 years–30 years ago, it is practically impossible to assess the old publications on the basis of modern standards. It would be misguided, however, to ignore the results of the early studies since they provided important basic data.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bavin EM, James B (1952) Further aspects of the pharmacology of para-aminosalicylic acid. J Pharm Pharmacol 4: 856–870
Beattie J, Chambers RD (1953) The anti-thyroid action of para-aminosalicylic acid. J Endocrinol 10: 65–72
Cauwenberge H van (1951) The effect of salicylates on the pituitary and suprarenal glands. Lancet 2: 686–687
Cronheim G, King JS, Hyder N (1952) Effect of salicylic acid and similar compounds on the adrenal-pituitary system. Proc Soc Exp Biol Med 80: 51–55
Hetzel BS, Hine DC (1951) The effect of salicylates on the pituitary and suprarenal glands. Lancet 2: 94–97
Kjerulf-Jensen K, Wolffbrandt G (1951) Antithyroid effect of p-aminosalicylic acid and maminophenol. Acta Pharmacol Toxicol (Copenh) 7: 376–380
Koelzer PP, Giesen J (1951) Untersuchungen zur Toxizität der p-Aminosalicylsäure und ihrer Derivate. Z Naturforsch 6 B: 183–190
Mehrotra RML, Chandra S, Singh MP, Gupta NN (1959) Changes in the liver of albino rats after administration of para-aminosalicylic acid. Indian J Med Res 47: 500–506
Schonholzer G (1951) Comments on the toxicity of P.A.S. preparations. Aust J Pharm 32: 1359–1363
Tettenborn D (1970) Unpublished investigations
Thoma F (1962) Stabilität von PAS-Infusionslösungen und ihre Prüfung durch Papier-und Dünnschichtchromatographie. Tuberk Arzt 16: 362–368
Adams HR, Goodman FR, Lupean VA, Weiss GB (1973) Effects of neomycin on tension and 45Ca movements in rabbit aortic smooth muscle. Life Sci Part I Physiol Pharmacol 12: 279–287
Akiyoshi M, Sato K (1970) Reevaluation of the pinna reflex test as screening for ototoxicity of antibiotics. In: Progress in Antimicrobiol and Anticancer Chemotherapy; Proc 6th Intern Congr Chemotherapy, Vol 1: 621–627
Alleva FR, Balazs T, Morris SO, Crowley WR, O’Donohue TL, Jacobowitz DM (1979) Reversal of streptomycin-induced dyskinesia in rats by dopaminergic agonists. Toxicol Appl Pharmacol 48:A 36
Amann R, Radenbach KL (1961) Akute Kanamycin-Nebenwirkungen und Histaminfreisetzung. Beitr Klin Tuberk 123: 208–210
André T (1956) Studies on the distribution of tritium-labelled dihydrostreptomycin and tetracyclin in the body. Acta Radiol Suppl 142: 1–89
Bacharach AL, Clark BJ, McCulloch M, Tomich EG (1959) Comparative toxicity studies on ten antibiotics in current use. J Pharm Pharmacol 11: 737–741
Beck Ch, Krahl P (1962) Experimentelle und feingewebliche Untersuchungen über die Ototoxizität von Kanamycin. Arch Otorhinolaryngol 179: 594–610
Berg K (1951) The toxic effect of streptomycin on the vestibular and cochlear apparatus. Acta Otolaryng Suppl 97: 5–77
Bezzi G, Gessa GL (1959) Neuromuscular blocking action of some antibiotics. Nature 184: 905–906
Bezzi G, Gessa GL (1961) Influence of antibiotics on the neuromuscular transmission in mammals. Antibiot Chemotherap 11: 710–714
Boucher D, Delost P (1964) Développement post-natal des descendants issus de mères traitées par la streptomycine au cours de la gestation chez la souris. CR Soc Biol (Paris) 158: 2065–2069
Brigham RS, Nielsen JK (1958) The effect of calcium pantothenate on the acute and chronic toxicity of streptomycin and dihydrostreptomycin in mice. Anbiot Chemother 8: 122–129
Catalano GB, Madonia T (1956) Ulteriore contributo sperimentale sulle lesioni istologiche labyrinthiche da streptomicina. Clin Otorinolaryng 8:51
Caussé R, Gondet I, Vallancien B (1949) Action de la streptomycine sur les cellules ciliées des organes vestibulaires de la souris. CR Soc Biol 144: 619–620
Child KJ, Davis B, Sharpe HM, Tomich EG (1957) Toxicologic studies on the sulfates and pantothenates of streptomycin and dihydrostreptomycin. Antibiot Annu 1956–1957: 574–580
Christensen E, Hertz H, Riskaer N, Vraa-Jensen G (1950) Experiments on the neurotoxic effect of streptomycin. Acta Otolaryng Suppl 95: 165–176
Cohen LS, Wechsler AS, Mitchell JH, Glick G (1970) Depression of cardiac function by streptomycin and other antimicrobial agents. Am J Cardiol 26: 505–511
Corrado AP (1958) Ganglioplegic action of streptomycin. Arch Int Pharmacodyn 114: 166–178
Corrado AP (1963) Respiratory depression due to antibiotics: calcium in treatment. Anesth Analg 42: 1–5
Corrado AP, Ramos AO, De Escobar CT (1959) Neuro-muscular blockade by neomycin potentiation by ether anesthesia and d-tubocurarine and antagonism by calcium and prostigmine Arch Int Pharmacodyn Ther 121: 380–394
Courvoisier S, Leau O (1956) Study of the onset of deafness in rats treated with streptomycin, dihydrostreptomycin and neomycin. Antibiot Chemother 6: 411–419
DeSalva SJ, Evans RA, Marcussen HW (1969) Lethal effects of antibiotics in hamsters. Toxicol Appl Pharmacol 14: 510–514
Dretchen KL, Sokoll MD, Gergis SD, Long JP (1973) Relative effects of streptomycin on motor nerve terminal and endplate. Eur J Pharmacol 22: 10–16
Ducrot R, Leau O, Cosar C (1956) Protective action of pantothenic acid against toxic effects of streptomycin and dihydrostreptomycin. Antibiot Chemother 6: 404–410
Duvall AJ, Wersäll J (1964) Site of action of streptomycin upon inner ear sensory cells. Acta Otolaryng 57: 581–598
Dzoljié M, Babié M (1967) Action of streptomycin on the uterus. Eur J Pharmacol 2: 123–126
Edison AO, Frost BM, Graessle OE, Hawkins JE Jr, Kuna S, Mushett CW, Silber RH, Solotorovsky M (1948) An experimental evaluation of dihydrostreptomycin. Am Rev Tuberc 58: 487–493
Engström H (1967) The pathological sensory cell in the cochlea. Acta Otolaryng Appendix to Vol 63: 20–26
Ericson-Strandvik B, Gyllenstein L (1963) The central nervous system of foetal mice after administration of streptomycin. Acta Pathol Microbiol Scand 59: 292–300
Escher F (1949) Das Streptomycin in der Otolaryngologie unter besonderer Berücksichtigung der Vestibularisstörungen. Praxis: 141–146
Farkashidy J, Black RG, Briant TDR (1963) The effect of kanamycin on the internal ear: an electrophysiological and electron microscopic study. Laryngoscope 73: 713–727
Flohberg C, Hamberger CA, Hyden H (1949) Inhibition of nucleic acid production in vestibular nerve cells by streptomycin. Acta Otolaryng Suppl 75: 36
Garcia-Quiroga J, Norris CH, Glade L, Bryant GM, Tachibana M, Guth PS (1978) The relationship between kanamycin ototoxicity and glucose transport. Res Commun Chem Pathol Pharmacol 22: 535–547
Goodman FR, Weiss GB, Adams HR (1974) Alterations by neomycin of 45Ca movements and contractile responses in vascular smooth muscle. J Pharmacol Exp Ther 188: 472–480
Gray JE, Purmalis A (1958) The acute toxicity of procaine penicilline G and of dihydro-streptomycin sulfate in the pigeon and the chicken. Avian Dis 2: 187–196
Greven H (1953) Die toxische Wirkung von Streptomycin auf den Cochlear-und Vestibu-larapparat. Z Laryng Rhinol 32: 109–117
Gross A, Legait E, Delabroise AM (1969) Etude de la néphrotoxicité de la streptomycine et de la dihydrostreptomycine chez le rat blanc porteur d’une insufficance rénale expérimentale. Thérapie 24: 327–341
Hawkins JE Jr (1959) The ototoxicity of kanamycin. Ann Otol 68: 698–715
Hawkins JE Jr (1970) Biochemical aspects of ototoxicity. In: Paparella MM (ed) Biochemical mechanisms in hearing and deafness. Thomas Publ, pp 323–339
Hawkins JE Jr (1973) Ototoxic mechanisms. A working hypothesis. Audiology 12: 383–393
Hawkins JE Jr, Wolcott H, O’Shanny WJ (1957) Ototoxic effects of streptomycin and di- hydrostreptomycin pantothenates in the cat. Antibiot Annu 1956–1957: 554–563
Hinshaw HC, Feldman WH (1945) Streptomycin in treatment of clinical tuberculosis: A preliminary report. Mayo Clin Proc 20: 313
Hoffmann K (1970) unpublished investigations
Holz E, Hoffmann M, Beck Ch (1967) Morphologische und bakteriologische Befunde zur Minderung der Ototoxicität basischer Streptomycesantibiotika. Arch Otorhinolaryngol 188: 236–242
Linuma T, Mizukoshi O, Daly JF (1976) Possible effects of various ototoxic drugs upon the ATP-hydrolyzing system in the stria vascularis and spiral ligament of the guinea pig. Laryngoscope 77: 159–169
Iwatsuki K, Ueda T, Yamada A, Nishimura S, Kanemura K (1958) Effects of certain antibiotics on the action of muscle relaxants. Far East J Anesth 2:106–115; cited from Ber Ges Physiol 213 (1960): 121
Jindal MN, Desphande VR (1960) Neuromuscular blockade by streptomycin and dihydrostreptomycin. Brit J Pharmacol 15: 506–509
Johnsson L-G, Wright CG, Preston RE, Henry PJ (1980) Streptomycin-induced efects of the otoconial membrane. Acta Otolaryngol (Stockh) 89: 401–406
Keller H, Krüpe W, Sous H, Mückter H (1955) Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotika. 1. Mitt. Arzneimittelforsch 5: 170–176
Keller H, Krüpe W, Sous H, Mückter H (1956a) Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotika 2 Mitt. Arzneimittelforsch 6: 61–66
Keller H, Krüpe W, Sous H, Mückter H (1956b) Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotika. 3. Mitt. Arzneimittelforsch 6: 585–591
Kellerhals B, Engström H, Ades HW (1967) Die Morphologie des Ganglion spirale cochleae. Acta Otolaryng (Stockh) Suppl 226: 1–78
Kellerhals B (1973) Zur Ototoxizität der Aminoglykosid-Antibiotika. MMW 115: 1667–1672
Kimmerle G, Gösswald R (1956) Versuche zur Entgiftung von Streptomycin und Dihydrostreptomycin. Arzneimittelforsch 6: 379–383
Kohonen A (1965) Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig. Acta Otolaryngol (Stockh) Suppl 208: 1–70
Kohonen A, Tarkkanen JV (1966) Dihydrostreptomycin and kanamycin ototoxicity. An experimental study by surface preparation technique. Laryngoscope 76: 1671–1680
Kraus H, Doenning G (1969) Cytophotometrische RNA- und Eiweißbestimmungen am häutigen Innenohr des Meerschweinchens als Grundlage zur Beurteilung des Eiweißstoffwechsels und der Streptomycinototoxizität. Arch Otorhinolaryngol 194: 1551
Kubikowski P, Srzeniawski Z (1963) The mechanism of the neuromuscular blockade by antibiotics. Arch Int Pharmacodyn Ther 146: 549–560
Kuschinsky G, Lüllmann H, Pracht W (1959) Über den Einfluß von Pantothensäure auf die vestibularisschädigende Wirkung von Streptomycin. Dtsch Med Wochenschr 84: 363–366
Kuschinsky G, Lüllmann H (1963) Tierexperimentelle Untersuchungen zur Abhängigkeit der Ototoxicität von der Dosierung des Kanamycin und zur Schutzwirkung durch Vitamine Klin Wochenschr 41: 230–233
Lagler F, Osterloh G, Mückter H (1960) Studies on the pharmacology of kanamycin. Antibiot Annu 1959–1960: 862–867
Lange G (1968) Die quantitative Auswertung von Streptomycinschäden des vestibulären Sinnesepithels beim Meerschweinchen mit Hilfe des Cytovestibulogramms und der calorischen Erregbarkeitsprüfung. Arch Otorhinolaryngol 192: 249–257
Leaders F, Pittinger CB, Long JP (1960) Some pharmacological properties of selected antibiotics. Antibiot Chemotherap 10: 503–507
Lindeman HH (1969) Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics. Acta Otolaryngol (Stockh) 67: 177–189
Lodhi S, Weiner ND, Mechigian J, Schacht J (1980) Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides. Biochem Pharmacol 29: 597–601
Lüllmann H, Reuter H (1960a) Über die Hemmung der neuromuskulären Übertragung durch einige Antibiotika. Chemotherapia 1: 375–383
Lüllmann H, Reuter H (1960b) Die curare-artigen Nebenwirkungen einiger Antibiotika. Klin Wochenschr 38: 771–772
Lundquist P-G, Wersäll J (1966) Kanamycin-induced changes in cochlear hair cells of the guinea pig. Z Zellforsch 72: 543–561
Mascitelli-Coriandoli E (1962) Der Einfluß basischer Antibiotica auf das Coenzym A-System. Arzneimittelforsch 12: 597–601
Mahady SCF, Armstrong FL, Monroe J (1956) Purified dihydrostreptomycin. Am Rev Tuberc 73: 776–778
Marquardt P, Ziegler E (1956) Zur Pharmakologie von Streptomycinsulfat und -pantothenat. Arzneimittelforsch 6: 213–214
McGee TM, Olszewski J (1962) Streptomycin sulfate and dihydrostreptomycin toxicity. Arch Otolaryngol 75: 295–311
Mendelsohn M, Katzenberg I (1972) The effect of kanamycin on the cation content of the endolymph. Laryngoscope 82: 397–403
Merkle U, Plattig KH, Keidel UO (1968) Histologische Untersuchungen zur ototoxischen Wirkung des Kanamycins am Cortischen Organ der Katze. Zschr Mikrosk Anat Forsch 78: 441–460
Meyer zum Gottesberge A, Stupp HF (1969) Streptomycinspiegel in der Perilymphe des Menschen. Acta Otolaryngol 67: 171–176
Michael AF, Sutherland JM (1961) Antibiotic testing in newborn and adult rats. Am J Dis Child 101: 442–446
MolgĂł J, Lemeignan M, Uchiyama T, Lechat P (1979) Inhibitory effect of kanamycin on evoked transmitter release. Reversal by 3,4-diaminopyridine. Eur J Pharmacol 57: 9397
Molitor H, Graessle OE, Kuna S, Mushett ChW, Silber RH (1946) Some toxicological and pharmacological properties of streptomycin. J Pharmacol Exp Ther 86: 151–173
Molitor H, Kuna S (1949) Pharmacologic studies of the neurotoxic properties of streptomycin. Arch Int Pharmacodyn Ther 76: 197–202
Mosonyi L, Pollak L, Zulik R, Kârolyhâzi G (1956) Streptomycin and endocrine system. Experientia 12: 311–313
Mückter H (1961) Zur Pharmakologie der basischen Streptomyces-Antibiotika. Antibiotica et Chemotherapia Separatum Vol 9: 83–144
Müsebeck K, Schätzle W (1962) Experimentelle Studien zur Ototoxicität des Dihydrostreptomycins. Arch Otorhinolaryngol 181: 41–48
Mushett ChW, Maitland HS (1946) Pathologic changes resulting from the administration of streptomycin. Arch Pathol 42: 619–629
Mushett ChW, Stebbins RB (1949) Renal cytoplasmic inclusions following the administration of large doses of streptomycin. Fed Proc 8: 363
Nagaba M (1968) Electron microscopic study of semicircular canal organs and otolith organs of squirrel monkeys after administration of streptomycin sulfate. Acta Otolaryngol (Stockh) 66: 541–552
Neumann G, Neubert K (1958) Die Sensularien des Innenohres unter der Einwirkung von Streptomycin — Experimentelle Untersuchungen am Corti’schen Organ and an der Macula utricula des Meerschweinchens. Arzneimittelforsch 8: 63–72
Osterberg AC, Oleson JJ, Yuda NN, Rauh CE, Parr HG, Will LW (1957) Cochlear, vestibular and acute toxicity studies of streptomycin and dihydrostreptomycin pantothenate salts. Antibiot Annu 1956–1957: 564–573
Pfaltz CR, Piffko P (1972) Central compensation of retrolabyrinthine vestibular lesions. Acta Otolaryngol (Stockh) 73: 183–189
Pittinger CB (1970) pH and streptomycin influences upon ionic calcium in serum. Anesth Analg 49:540–545
Pittinger CB, Long JP (1958) Neuromuscular blocking action of neomycin sulfate. Antibiot Chemother 8: 198–203
Pittinger CB, Long JP, Miller JR (1958) The neuromuscular blocking action of neomycin. Anesth Analg 37: 276–282
Pittinger C, Adamson R (1972) Antibiotic blockade of neuromuscular function. Annu Rev Pharmacol 12: 169–184
Plattig KH, Keidel UO, David E (1967) Minderung der Ototoxizität des Kanamycins durch Pantothensäure. Dtsch Med Wochenschr 92: 1391–1397
Plester D (1963) Discussion remark. Arch otorhinolaryngol 182: 587
Popovici GG, Moisä L, Negoitä M, Manoilâ V, Botez E, Hafner R, Gumeni N (1965) The influence of certain antibiotics on intestinal motor activity. Arch Int Pharmacodyn Ther 154: 374–381
Popovici GG, Negoitâ M, Moisä L, Manoilä V, Hafner R, Botez E (1967) The influence of some antibiotics on uterine motor activity in the guinea pig. Arch Int Pharmacodyn Ther 166: 20–25
Popovici GG, Mungiu C, Filip M, Botez E, Ababei L (1970) Influence of some antibiotics on stationary NAD and NADP concentrations in rat liver and kidney. Arch Int Pharmacodyn Ther 188: 73–78
Prado WA, Corrado AP, Marseillan RF (1978) Competitive antagonism between calcium and antibiotics at the neuromuscular junction. Arch Int Pharmacodyn Ther 231: 297307
Prescott B, Kauffmann G, James WD, Stone HJ (1959) Means of increasing the tolerated dose of streptomycin in mice. Antibiot Chemother 9: 369–375
Raab WP (1970) Renal effects of streptomycin in rats. Clin Chim Acta 29: 451–454
Ritter R, Chou J, v Ilberg C, Wagner WH (1971) Eine neue Möglichkeit zur Verhinderung der Ototoxizität des Streptomycins. Arch Otorhinolaryngol 199: 573–577
Robson JM, Sullivan FM (1963) Antituberculous drugs. Pharmacol Rev 15: 169–223
Rudnick MD (1979) A quantitative and qualitative study of aminoglycoside antibiotic ototoxicity in the vestibulo-cochlear apparatus following intratympanic administration in guinea pig (Cavia cobaya). Dissertation Abstr Intern B 39: 4145–4146
Saito H, Daly JF (1971) Quantitative analysis of acid mucopolysaccharides in the normal and kanamycin intoxicated cochlea. Acta Otolaryngol (Stockh) 71: 22–26
Secondi U (1954) Ancora sull’effetto neurotossico della streptomicina. L’importanza del fattore dose-tempo. Arch Ital Otol 65: 165
Singh YN, Harvey AL, Marshall IG (1978) Antibiotic-induced paralysis of the mouse phrenic nerve-hemidiaphragm preparation, and reversibility by calcium and by neostigmine. Anesthesiology 48: 418–424
Sokoll MD, Diecke FPJ (1969) Some effects of streptomycin on frog nerve in vitro. Arch Int Pharmacodyn Ther 177: 332–339
Spoendlin H (1966) Zur Ototoxizität des Streptomycins. Pract Oto-Rhino-Laryng (Basel) 28:305–322; 374–375
Spoendlin H (1967) Acute streptomycin intoxication of the labyrinth. Acta Otolaryngol (Stockh) 63: 26–38
Stange G (1969) Minderung bzw. Verhütung der Ototoxizität basischer Streptomyzes-Antibiotika. Therapiewoche 19: 106–117
Stange G, Soda T, Beck Ch (1967) Elektrophysiologische Ergebnisse bei Ototoxizitätsmin- derung basischer Streptomyces-Antibiotika. Arch Otorhinolaryngol 188: 242–249
Stupp HF (1970) Untersuchung der Antibiotikaspiegel in den Innenohrflüssigkeiten und ihre Bedeutung für die spezifische Ototoxizität der Aminoglykosidantibiotika. Acta Otolaryngol (Stockh) Suppl 262
Stupp H, Rauch S, Sous H, Lagler F (1966) Untersuchungen über die Ursache der spezifisch ototoxischen Wirkung der basischen Streptomycesantibiotika unter besonderer Berücksichtigung des Kanamycins. Acta Otolaryngol (Stockh) 61: 435–444
Stupp H, Rauch S, Sous H, Brun JP, Lagler F (1967) Kanamycin dosage and levels in ear and other organs. Arch Otolaryngol 86: 515–521
Stupp H, Küpper K, Lagler F, Sous H, Quante M (1973) Inner ear concentrations and ototoxicity of different antibiotics in local and systemic application. Audiology 12: 350–363
Suzuki Y, Takeuchi S (1961) Etude expérimentale sur l’influence de la streptomycine sur l’appareil auditif du foetus après administration de doses variées a la mère enceinte. Keio. J Med 10: 31–41
Swain HH, Kiplinger GF, Brody TM (1956) Action of certain antibiotics on the isolated dog heart. J Pharmacol Exp Ther 117: 151–159
Tettenborn D (1971) Unpublished investigations
Thalmann R, Miyoshi T, Kusakari J, Thalmann J (1973) Quantitative approaches to the ototoxicity problem. Audiology 12: 364–382
Timmerman JC, Long JP, Pittinger CB (1959) Neuromuscular blocking properties of various antibiotic agents. Toxicol Appl Pharmacol 1: 299–304
Tisch DE, Huftalen JB, Dickison HL (1958) Pharmacological studies with kanamycin. Ann NY Acad Sci 76: 44–65
Tyberghein J (1962) Influence of some streptomyces antibiotics on the cochlear micro-phonics in the guinea pig. Acta Otolaryngol (Stockh) Suppl 171
Tyberghein J (1967) Einfluß der Pantothensäure auf die Ototoxizität des Kanamycins beim Meerschweinchen. Med Welt: 2017–2020
Tyberghein J, Ostjin F (1961) L’ototoxicité de la streptomycine. Acta Tuberc Pneumol Belg 52: 139–146
Vernier VG, Alleva FR (1968) The bioassay of kanamycin auditory toxicity. Arch Int Pharmacodyn Ther 176: 59–73
Vital Brazil O (1961) Streptomycin effect on the skeletal muscle stimulation produced by acetylcholine. Arch Int Pharmacodyn Ther 130: 136–140
Vital Brazil O, Corrado AP (1957) The curariform action of streptomycin. J Pharmacol Exp Ther 120: 452–459
Vital Brazil O, Corrado AP, Berti FA (1959) Neuromuscular block produced by streptomycin and some of its degradation products. In: Bovet D, Bovet-Nitti F, Marini-Bettolo (eds) Curare and curare-like agents. Elsevier, Amsterdam
Vital Brazil O, Prado-Franceschi J (1969) The nature of neuromuscular block produced by neomycin and gentamicin. Arch Int Pharmacodyn Ther 179: 78–85
Voldhch L (1965) The kinetics of streptomycin, kanamycin and neomycin in the inner ear. Acta Otolaryngol (Stockh) 60: 243–248
Vrabec DP, Cody DT, Ulrich JA (1965) A study of the relative concentrations of antibiotics in the blood, spinal fluid, and perilymph in animals. Ann Otol Rhinol Laryngol 74: 688–703
Wagner WH, Chou JTY, Ilberg v. C, Ritter R, Vosteen KH (1971) Untersuchungen zur Pharmakokinetik von Streptomycin. Arzneimittelforsch 21: 2006–2016
Watanuki K, Meyer zum Gottesberge A (1971) Toxic effect of streptomycin and kanamycin upon the sensory epithelium of the crista ampullaris. Acta Otolaryngol (Stockh) 72: 59–67
Watanuki K, Stupp H (1971) Haarzellenschädigungsmuster an Crista and Maculae bei Ototoxikose durch Antibiotika. Arch Otorhinolaryngol 199: 569–573
Watanuki K, Stupp H-F, Meyer zum Gottesberge A (1972) Toxic effects of gentamycin upon the peripheral vestibular sensory organs. Laryngoscope 82: 363–371
Wersäll J, Hawkins JE Jr (1962) The vestibular sensory epithelia in the labyrinth and their reactions in chronic streptomycin intoxication. Acta Otolaryngol (Stockh) 54: 1–23
Winston J, Lewey FH, Parentease A, Marden PA, Cramer FB (1948) An experimental study of the toxic effects of streptomycin on the vestibular apparatus of the cat. Ann Otol Rhinol Laryngol 57: 738–753
Wolf GL, Wigton RS (1971) Vasodilatation induced by streptomycin in the perfused canine kidney. Arch Int Pharmacodyn Ther 194: 285–289
Domagk G (1948) Die experimentellen Grundlagen einer Chemotherapie der Tuberkulose. Beitr KIM Tuberk 101: 372–394
Emmrich R, Petzold H (1952) Experimentelle Untersuchungen zur Frage der Leberschädigung durch TB I. Z Ges Inn Med 7: 625–628
Ginoulhiac E (1950) Toxicity of certain chemotherapeutics. Boll Soc Ital Biol Sper 26: 574–577
Gülzow M (1950) Experimentelles zur TB I-Wirkung. I. Mitteilung: Intoxikationserscheinungen. Z Ges Exp Med 116: 26–39
Gülzow M, Schlicht A (1950) Experimentelles zur TB I-Wirkung. II. Mitteilung: Aminosäure-Untersuchungen des Serum-und Organeiweiß im Verlauf von TB I (Conteben)Intoxikationen. Z Ges Exp Med 116: 40–55
Hecht G (1950) Unpublished Investigations
Moyer JH, Perkins RB (1951) Experimental studies on the toxicity of amithiozone in dogs. Am Rev Tuberc 64: 659–668
Râvnay TH, Forró L, Szegö L (1954) Untersuchungen über den Wirkungsmechanismus der Thiosemikarbazone. Z Tuberk 104: 249–255
Savini E (1950) Recherches expérimentales sur la toxicité du thiosemicarbazone. CR Soc Biol 144: 1310–1313
Bonati F, Bertoni L (1962) Derivati basici dell’acido pirazin-2-carbonico ad azione antimicobatterica. Minerva Med 53: 1704–1708
Celikovskâ G, Stastnâ J, Zitkovâ L, Brezinovâ H, Kürti V (1970) Leberschädigung nach Verabreichung von Pyrazinamid im Tierversuch. III. Biochemische Veränderungen im Lebergewebe und im Blutserum. Arzneimittelforsch 20: 155–157
Gruss JD, Nickling HG (1967) Vergleichende funktionelle und bioptische Untersuchungen der normalen Kaninchenleber während der Applikation von Pyrazincarbonsäureamid. Arzneimittelforsch 17: 1565–1568
Mori K, Yasuno A, Matsumoto K (1960) Induction of pulmonary tumors in mice with isonicotinic acid hydrazid. Gann 51: 83–89
Robinson HJ, Siegel H, Pietrowski JJ (1954) Toxicity of pyrazinamide. Am Rev Tuberc 70: 423–429
Stastnâ J, Celikovskâ G, Zitkovâ L, Viklickÿ J (1970) Leberschädigung nach Verabreichung von Pyrazinamid im Tierversuch. II. Untersuchungen über die zeitlichen Veränderungen der Konzentrationen von Pyrazinamid im Blut und der Aktivität der SerumTransaminasen. Arzneimittelforsch 20: 153–155
Zitkovâ L, Stastnâ J, Celikovskâ G, Kürti V (1970) Leberschädigung nach Verabreichung von Pyrazinamid im Tierversuch I. Änderungen des Körpergewichtes von Ratten unter Einwirkung von Pyrazinamid. Arzneimittelforsch 20: 151–153
Allmark MG, Lu FC, Carmichael E, Lavallee A (1953) Some pharmacological observations on isoniazid and iproniazid. Am Rev Tuberc 68: 199–206
Ashby J, Purchase IFH (1977) The selection of appropriate chemical class controls for use with short term tests for potential carcinogenicity. Ann Occup Hyg 20: 297–301
Ata S, Tanaka K (1952) Vitamin B12 and isoniazid. Lancet II: 589
Balzer H, Holtz P, Palm D (1960) Untersuchungen über die biochemischen Grundlagen der konvulsiven Wirkung von Hydraziden. Naunyn Schmiedebergs Arch Pharmacol 239: 520–552
Barreto RCR, Mano DB (1961) Prevention of the convulsant and lethal effects of isonicotinic acid hydrazide by pyruvic acid. Biochem Pharmacol 8: 409–412
Benson WM, Stefko PL, Roe MD (1952) Pharmacologic and toxicologic observations on hydrazine derivatives of isonicotinic acid (Rimifon, Marsilid). Am Rev Tuberc 65: 376–391
Berencsi G, Entz A, Vajkóczy A (1957) Kongreß der Ungarischen Phthisiolog Gesellsch, Szeged 1952, cited from Juhâsz J, Baló J, Kendrey G. Z Krebsforsch 62: 188–196
Beyer E, Braun R, Schöneich J (1979) Genetic activity of isoniazid in the mammalian spot test. Mutat Res 64: 152
Bhide SV, Marti GB, Sawai MM, Ranadive KJ (1978) Isoniazid tumorigenicity in mice under different experimental conditions. Int J Cancer 21: 381–386
Biancifiori C, Ribacchi R (1962) Pulmonary tumors in mice induced by oral isoniazid and its metabolites. Nature 194: 488–489
Biancifiori C, Severi L (1966) The relation of isoniazid (INH) and allied compounds to carcinogenesis in some species of small laboratory animals. A review. Br J Cancer 20: 528–538
Black SLD (1977) Hepatic triglyceride metabolism and aminoacid pools in isonicotinic acid hydrazide treated rats. Dissertation Abstr Intern B 38: 1668–1669
Blakemore WF, Palmer AC, Noel PRB (1972) Ultrastructural changes in isoniazid-induced brain oedema in the dog. J Neurocytol 1: 263–278
Botta JA Jr, Carlton WW (1967a) Studies of the toxicity of isonicotinic acid hydrazide (Isoniazid) to ducklings. Toxicol Appl Pharmacol 11: 35–48
Botta JA Jr, Carlton WW (1967b) Isoniazid toxicosis in ducklings-studies on pyridoxine, niacin, glutamic acid, and arginine supplementation. Avian Dis 11: 621–633
Brambilla G, Baldini L (1959) Azione inibitrice dell’acido isonicotinico sullo sviluppo del sarcoma Galliera del ratto. Boll Soc Ital Biol Sper 35: 1169–1171
Braun R, Schubert J, Schöneich J (1976) On the mutagenicity of isoniazid. Biol Zbl 95: 423–436
Bucher O (1953) Zur Frage der cytotoxischen Wirkung von Rimifon. Schweiz Med Wochenschr 83: 1206–1208
Bürgin H, Schmid B, Zbinden G (1979) Assessment of DNA damage in germ cells of male rabbits treated with isoniazid and procarbazine Toxicology 12: 251–257
Carlton WW (1967) Neural toxicity of isonicotinic acid hydrazide (isoniazid) for chickens. Avian Dis 11: 241–254
Carlton WW, Hunt CE, Newberne PM (1965) Neural lesions induced by isonicotinic acid hydrazide and semicarbazide hydrochloride. Exp Mol Pathol 4: 438–448
Carlton WW, Kreutzberg G (1966) Isonicotinic acid hydrazide-induced spongy degeneration of the white matter in the brains of peking ducks. Am J Pathol 48: 91–105
Casey RE, Wood JD (1973) Isonicotinic acid hydrazide-induced changes in the metabolism of y-aminobutyric acid in the brain of four species. Comp Biochem Physiol B 45: 741–748
Cavanagh JB (1967) On the pattern of change in peripheral nerves produced by isoniazid intoxication in rats. J Neurol Neurosurg Psychiat 30: 26–33
Cavanagh JB (1973) Peripheral neuropathy caused by chemical agents. CRC Crit Rev Toxicol 2: 365–417
Cedrangolo F, Gioia A, Bagnulo R (1953) Un meccanismo enzimatico, per il quale si puo’abbassare in vivo la tossicità dell’ idrazide dell’ac. isonicotinico. Enzymologia 16: 41–50
Ceriotti G, Franceschini J (1953) Dati biologici e microbiologici su un nuvo derivato della idrazide dell’acido isonicotinico a bassa tossicatà e ad alta attività (metansulfonato dell’ idrazide isonicotinica). Arch Int Pharmacodyn Ther 93: 105–117
Chin L, Sievers ML, Laird HE, Herrier RN, Picchioni AL (1978) Evaluation of diazepam and pyridoxine as antidotes to isoniazid intoxication in rats and dogs. Toxicol Appl Pharmacol 45: 713–722
Chin L, Sievers M, Herrier RN, Picchioni AL (1979) Convulsions as the etiology of lactic acidosis in acute isoniazide toxicity in dogs. Toxicol Appl Pharmacol 49: 377–384
Cirnu-Georgian L, Lenghel V (1971) Isoniazid-induced chromosome aberrations. Lancet 2: 93
Crema A, Fabris L (1954) Sulla tossicatà per il vestibolo dell’idrazide dell’ acido isonicotinico. Boll Soc Ital Biol Sper 30: 120–121
Dauphinee KR, Paynters S, Russell DW (1975) Failure of pyruvate to counteract isonazid toxicity in rabbits. J Pharm Pharmacol 27: 884–886
Dienemann G, Simon K (1953) Mitteilung eines Todesfalles nach kombinierter Verabreichung von Irgapyrin und Neoteben (INH). MMW 95: 221–222
Dixon RH, Williams HL (1962) The toxicity of pyridoxal and pyridoxal phosphate hydra-zones in mice. Fed Proc 21: 338
Dubnick B, Leeson GA, Scott CC (1960) Effect of forms of vitamin B6 on acute toxicity of hydrazines. Toxicol Appl Pharmacol 2: 403–409
Emmrich R, Petzold H (1952) Tierexperimentelle Untersuchungen zur Frage einer Leber-schädigung durch Rimifon (Isonicotinylhydrazin) Klin Wochenschr 30: 1081–1083
Engbaek HC, Bentzon H, Heegârd H, Christensen O (1965) Har isoniazid en tumorfrem-kaldende virkning? Nord Med 74: 13–26
Földi M, Zoltan ÖT, Maurer M (1970) Die Wirkung von Isonicotinsäurehydrazid (INH) auf das Zentralnervensystem und der Antagonismus zwischen dieser Substanz und Pyridoxin, Pantothensäure sowie Cumarin aus Melilotus officinalis bei Ratten. Arzneimittelforsch 20: 1620–1623
Frei H-H (1976) Elevation of central y-aminobutyric acid levels by isoniazid in mice and convulsant thresholds. Biochem Pharmacol 25: 1216–1219
Fust B, Studer A, Böhni E (1952) Experimentelle Erfahrungen mit dem Antituberculotikum „Rimifon“. Schweiz Z Tuberk 9: 226–242
Glass F, Gossow H, Mallach HJ (1964) Beobachtungen und Untersuchungen über die gemeinsame Wirkung von Alkohol und Isonicotinsäurehydrazid. Arzneimittelforsch 14: 1203–1208
Glass F, Mallach HJ (1965) Tierexperimentelle Untersuchungen über die Alkoholwirkung nach längerer Belastung mit Isonicotinsäurehydrazid. Arzneimittelforsch 15: 1069–1070
Goldin A, Dennis D, Venditti JM, Humphreys SR (1955) Potentiation of pentobarbital anesthesia by isonicotinic acid hydrazide and related compounds. Science 121: 364–365
Grasso P, Crampton RF (1972) The value of the mouse in carcinogenicity testing. Fd Cosmet Toxicol 10: 418–426
Gross W (1956) Ein Beitrag zur cytostatischen Wirkung des Isonicotinsäurehydrazids (INH). Klin Wochenschr 34: 495
Hackmann CH (1957) Unpublished data
Hammond EC, Selikoff IJ, Robitzek EK (1967) Isoniazid therapy in relation to later occurence of cancer in adults and infants. Br Med J 2: 792–795
Harper KH, Worden AN (1966) Comparative toxicity of isonicotinic acid hydrazide and its methanosulfonate derivative. Toxicol Appl Pharmacol 8: 325–333
Hecht G (1953) Unpublished data
Hellriegel W, Kraus R (1955) Über die zytostatische Wirkung des Isonikotinsäurehydrazins. Tuberk Arzt 9: 653–660
Herbold B, Buselmaier W (1976) Induction of point mutations by different chemical mechanisms in the liver microsomal assay. Mutat Res 40: 73–84
Hess M (1954) Über den Einfluß von Isonicotinsäurehydrazid (Neoteben) auf die Genitalfunktion und die Gestation. Arch Gynäkol 185: 315–324
Holtz P, Palm D (1964) Pharmacological aspects of Vitamin B6. Pharmacol Rev 16: 113–178
IARC (1974) Monographs on the evaluation of carcinogenic risk of chemicals to man, vol 4. International Agency for Research on Cancer, Lyon
Jansen JD, Clemmesen J, Sundaram K (1980) Isoniazid–an attempt at retrospective prediction. Mutat Res 76: 85–112
Jones LD, Fairchild DG, Morse WC (1971) The induction of pulmonary neoplasms in mice by isonicotinic acid hydrazide. Am Rev Respir Dis 103: 612–617
Juhâsz J, Baló J, Kendrey G (1957) Über die geschwulsterzeugende Wirkung des Isonicotinsäurehydrazid (INH). Z Krebsforsch 62: 188–196
Juhâsz J, Baló J, Szende B (1963) Neue experimentelle Angaben zur geschwulsterzeugenden Wirkung des Isonicotinsäurehydrazid (INH). Z Krebsforsch 65: 434–438
Kelly MG, O’Gara RW, Yancey ST, Gadekar K, Botkin C, Oliviero VT (1969) Comparative carcinogenicity of N-isopropyl-a-(2-methylhydrazino)-p-toluamide HC1 (procarbazine hydrochloride), its degradation products, other hydrazines, and isonicotinic acid hydrazide. J Natl Cancer Inst 42: 337–344
Kimball RF (1977) The mutagenicity of hydrazine and some of its derivatives. Mutation Res 39: 111–126
Klinghardt GW (1954) Experimentelle Nervenfaserschädigung durch Isonicotinsäurehydrazid und ihre Bedeutung für die Klinik. Verh Dtsch Ges Inn Med 60: 764–768 (Kongress München)
Krnjevic K (1971) Synaptic transmission in the brain. Klin Wochenschr 49: 519–523
Lechat P, Deleau D, Devillechabrolle A (1963) Etude expérimentale du pouvoir protecteur de la pyridoxine vis-à -vis des effets toxique de l’isoniazide. Thérapie 18: 63–67
Leopold D, Röthig W, Wehran H-J, Wolf P (1966) Verteilung und Wirkung des Isoniazid nach Applikation therapeutischer und toxischer Dosen im Tierversuch. Arch Toxicol 22: 80–91
Levene CJ (1961) The lathyrogenic effect of isonicotinic acid hydrazide (INAH) on the chick embryo and its reversal by pyridoxal. J Exp Med 113: 795–811
Loscalzo B (1964) Hydrazide de l’acide isonicotinique et neoplasies. Arch Int Pharmacodyn Ther 152: 249–251
LĂĽers H, Obe G (1971) Action of isoniazid on human chromosomes in vitro. EMS Newsletter: 36
Manthei RW (1957) Effect of calcium pantothenate on isoniazid toxicity in the guinea pig. Proc Soc Exp Biol Med 95: 402–404
Manthei RW (1960) Vitamin B6 and isoniazid toxicity. Fed Proc 19: 414
Matsumoto K, Mori K, Yasuno A (1960) Effect of isonicotinic acid hydrazide on hepatocarcinogenesis. Gann 51: 91–95
McCormick DB, Snell EE (1961) Pyridoxal phosphokinases. J Biol Chem 236: 2085–2088
Miller CT, Stoltz DR (1978) Mutagenicity induced by lyophilization or storage of urine from isoniazid-treated rats. Mutat Res 56: 289–293
Mori K, Yasuno A (1959) Preliminary note on the induction of pulmonary tumors in mice by isonicotinic acid hydrazide feeding. Gann 50: 107–110
Mori K, Yasuno A, Matsumoto K (1960) Induction of pulmonary tumors in mice with isonicotinic acid hydrazide. Gann 51: 83–89
Nelson SD, Snodgrass WR, Mitchell JR (1976) Chemical reaction mechanisms responsible for the tissue injury caused by monosubstituted hydrazines and their hydrazide drug precursors. In: De Serres, Fouts, Bend and Philpot (eds) In vitro metabolic activation in mutagenesis testing. Elsevier, Amsterdam, pp 257–276
Noda A, Goromaru T, Matsuyama K, Sogabe K, Hsu KY, Iguchi S (1978) Quantitative determination of hydrazines derived from isoniazid in patients. J Pharmacol Dyn 1: 132–141
Noel PRB, Worden AN, Palmer AC (1967) Neuropathologic effects and comparative toxicity for dogs of isonicotinic acid hydrazide and its methanosulfonate derivative. Toxicol Appl Pharmacol 10: 183–198
Orlowski EH, Rosenfeld M, Wolter H, Schunk R (1976) Experimentelle vergleichende Untersuchung der tuberkulostatischen Wirksamkeit und Toxizität von INH, INHG und INHG-Na. Arzneimittelforsch 26: 409–416
Palmer AC, Noel PRB (1965) Neuropathological effects of dosing dogs with isonicotinic hydrazide and with its methanosulphonate derivative. Nature 205: 506–507
P’an SY, Markaroglu L, Reilly J (1952) The effects of barbiturates on the toxicity of isoniazid (isonicotinic acid hydrazide). Am Rev Tuberc 66: 100–103
Pansa E, Bikfalvi A (1960) Ober die Wirkung hoher Dosen Isonikotinsäure-Hydrazid (INH) auf die Bronchusschleimhaut der Kaninchen. Thoraxchirurgie 8: 451–457
Pansa E, Picco A, Gnavi M (1962) Sul problema del supposto effecto carcinogenetico dell’idrazide dell’acido isonicotinico (IAI). Richerchi sperimentali sul ratto. Minerva Med 53: 3162–3168
Peacock A, Peacock PR (1966) The results of prolonged administration of isoniazid to mice, rats and hamsters. Br J Canc 20: 307–325
Prescott B, Kauffmann G, James WD (1954) A means of increasing the tolerated dose of isoniazid in mice. Proc Soc Exp Biol Med 86: 682–685
Prescott B, Kauffmann G, James WD (1957a) Increase in tolerated dose of isoniazid in mice by use of cycloserine. Proc Soc Exp Biol Med 94: 94–96
Prescott B, Kauffmann G, James WD (1957b) Effect of glycerine on toxicity of isoniazid in mice. Proc Soc Exp Biol Med 94: 272–276
Prescott B, Kauffmann G, James WD (1957c) Means of increasing the tolerated dose of isoniazid in mice. II. Certain amino acids. Proc Soc Exp Biol Med 95: 687–690
Prescott B, Kauffmann G, James WD (1957d) Means of increasing the tolerated dose of isoniazid in mice. III. Certain vitamins. Proc Soc Exp Biol Med 95: 705–708
Prescott B, Stone HJ (1969) Glycerol formol as a solvent for detoxification of isoniazid. Chemotherapy 14: 227–231
Quadbeck G, Sartori GD (1957) Über den Einfluß von Pyridoxin und Pyridoxal-5-Phosphat auf den Thiosemicarbazid-Krampf der Ratte. Naunyn Schmiedebergs Arch Pharmacol 230: 457–461
Raisfeld IH (1975) Drug-induced liver disease: guinea pig model for isoniazid (INH) hepatitis — the predictive value of urinary d-glucaric acid excretion. Gastroenterology 69: A54 /854
Reilly RH, Killam KF, Jenney EH, Marshall WH, Tausig T, Apter NS, Pfeiffer CC (1953) Convulsant effect of isoniazid. JAMA 152: 1317–1321
Reinhardt JF, Kimura ET, Schachter RJ (1952) Some pharmacologic characteristics of isonicotinyl hydrazide (Pyricidin®), a new antituberculosis drug. Science 116: 166–167
Roberts E (1974) y-Aminobutyric acid and nervous system function a perspective. Biochem Pharmacol 23:2637–2649
Röhrborn G, Propping P, Buselmaier W (1972) Mutagenic activity of isoniazid and hydrazine in mammalian test systems. Mutat Res 16: 189–194
Röhrborn G et al. (1978) A correlated study of the cytogenetic effect of isoniazid (INH) on cell systems of mammals and man conducted by thirteen laboratories. Hum Genet 42: 1–60
Rosen F (1955) Effect of isonicotinic acid hydrazide on niacin and pyridoxine metabolism in rats. Proc Soc Exp Biol Med 88: 243–246
Rosenkranz HS, Carr HS (1971) Hydrazine antidepressants and isoniazid: potential carcinogens. Lancet I: 1354–1355
Rubin B, Hassert GL, Jr, Thomas BGH, Burke JC (1952) Pharmacology of isonicotinic acid hydrazide (Nydrazid). Am Rev Tuberc 65: 392–401
Rubin B, Burke JC (1952) Vitamin B12 and isoniazid. Lancet II: 937
Rubin B, Burke JC (1953) Further observations on the pharmacology of isoniazid. Am Rev Tuberc 67: 644–651
Said AH, Ahmed AAS (1967) Connective tissue changes induced in the chick embryo by isonicotinic acid hydrazide and vitamin K. Zbl Veterinarmed (A) 14: 78–84
Schlaepfer WW, Hager H (1964a) Ultrastructural studies of INH-induced neuropathy in rats. I. Early axonal changes. Am J Pathol 45: 209–219
Schlaepfer WW, Hager H (1964b) Ultrastructural studies of INH-induced neuropathy in rats. II. Alteration and decomposition of the myelin sheath. Am J Pathol 45: 423–433
Schlaepfer WW, Hager H (1964c) Ultrastructural studies of INH-induced neuropathy in rats. III. Repair and Regeneration. Am J Pathol 45: 679–689
Schmidt LH, Hoffmann R, Hughes HB (1953) The toxicity of isoniazid for the rhesus monkey. Am Rev Tuberc 67: 798–807
Schöneich J (1976) Safety evaluation based on microbial assay procedures. Mutat Res 41: 89–94
Schröder JM (1970a) Zur Pathogenese der Isoniazid-Neuropathie. I. Eine feinstrukturelle Differenzierung gegenüber der Wallerschen Degeneration. Acta Neuropath 16: 301–323
Schröder JM (1970b) Zur Pathogenese der Isoniazid-Neuropathie. II. Phasenkontrast-und elektronenmikroskopische Untersuchungen am Rückenmark, an Spinalganglien und Muskelspindeln. Acta Neuropathol 16: 324–341
Seifert S (1966) Die teratogene Wirkung von Isonikotinséurehydrazid (INH) auf den Héhnerembryo. Diss Freiburg i Br
Severi L, Biancifiori C (1968) Hepatic carcinogenesis in CBA/Cb/Se mice and Cb/Se rats by isonicotinic acid hydrazide and hydrazine sulfate. J Natn Cancer Inst 41: 331–340
Siegel D, Iwainsky H (1960) Über den Einfluß von Iso-Nicotinsäure-Hydrazid (INH) auf die Metastasierungsquote des Ehrlichschen Ascitescarcinom der Maus. Klin Wochenschr 38: 769
Siegel D (1960) Beitrag zur Frage der cytostatischen Wirkung des Iso-Nicotinsäure-Hydrazids (INH). Naturwissenschaften 47: 307–308
Siegel D (1961) Veränderungen des Nucleinsäuregehaltes tumorösen Gewebes durch IsoNikotinsäure-Hydrazid (INH). Naturwissenschaften 48: 55–56
Siegel D, Berschneider F (1960) Untersuchungen zum Nucleinsäurestoffwechsel der regenerierenden Leber nach Isonicotinsäurehydrazid (INH). Z Gesamte Exp Med 134: 59–64
Simon K (1952) Untersuchungen von Derivaten des Hydrazins auf ihre cytostatische Wirkung am Ascitestumor der Maus. Z Naturforsch 7 b: 531–536
Steinbrück P (1959) Der Einfluß über lange Zeit fortgeführter INH-Gaben auf die Fruchtbarkeit der weißen Maus. Z Tuberk 113: 281–284
Tiboldi T, David M, Kovacs K, Molnar P (1955) Die Wirkung des Isonikotinsäurehydrazid auf das Brown-Pearce-Karzinom des Kaninchens. Z Tuberk 106: 257–260
Timbrell JA, Mitchell JR, Snodgrass WR, Nelson SD (1980) Isoniazid hepatotoxicity: the relationship between covalent binding and metabolism in vivo. J Pharmacol Exp Ther 213: 364–369
Tirunarayanan MO, Vischer WA (1956) Effect of vitamines on the acute toxicity of hydrazine derivatives. Experientia 12: 291–292
Tosk J, Schmeltz I, Hoffmann D (1979) Hydrazines as mutagenes in a histidine — requiring auxotroph of Salmonella typhimurium. Mutat Res 66: 247–252
Toth B, Shubik P (1966a) Inhibition of tumor development and carcinogenesis by isonicotinic acid hydrazide (INH) in C3H und AKR mice. Abstract, p 124. Presented at the IX International Cancer Congress, Tokyo
Toth B, Shubik P (1966b) Mammary tumor inhibition and lung adenoma induction by isonicotinic acid hydrazide. Science 152: 1376–1377
Toth B, Shubik P (1966c) Carcinogenesis in swiss mice by isonicotinic acid hydrazide. Cancer Res 26: 1473–1475
Toth B, Rustja A (1967) The effect of isonicotinic acid hydrazide on the development of tumors. Int J Cancer 2: 413–420
Toth B, Shubik P (1969) Lack of carcinogenic effects of isonicotinic acid hydrazide in the syrian golden hamster. Tumori 55: 127–135
Toth B, Boreisha J (1969) Tumorigenesis with isonicotinic acid hydrazide and urethan in the syrian golden hamsters. Eur J Cancer 5: 165–171
Toth B, Toth T (1970) Investigation on the tumor producing effect of isonicotinic acid hydrazide in ASW/Sn mice and MCR rats. Tumori 56: 315–324
Toth B, Shimizu H (1973) Lung carcinogenesis with 1-Acetyl-2-Isonicotinoylhydrazine, the major metabolite of isoniazid. Eur J Cancer 9: 285–289
Viallier J, Casanova F (1960) L’isoniazide a-t-il des propriétés cancérigènes? Essai sur l’animal. CR Soc Biol 154: 985–987
Wade DR, Lohman PHM, Mattem IE, Berends F (1980) The mutagenicity of isoniazid in Salmonella and its effects on DNA repair and synthesis in human fibroblasts. Mutat Res 89: 9–20
Wagner H, Moritz R (1962) Beeinflussung des Tumorwachstums durch INH in Tierversuch und Gewebekultur. Arch Geschwulstforsch 19: 123–129
Weinstein HJ, Kinosita R (1963) Isoniazid induction of pulmonary tumors in mice. Am Rev Respir Dis 88: 124–125
Weiss P, Gâti T, Forrai G (1954) Die Wirkung von Isonikotinsäurehydrazid auf das Hypophysen-Nebennierenrindensystem bei weißen Ratten. Z Inn Med 9: 808–809
Whitehouse LW, Tryphonas L, Thomas BH, Paul CP, Zeitz W (1978) Isoniazid toxicity alone and in combination with ethanol in the rabbit. I. Pathologic and biochemical factors. Toxicol Appl Pharmacol 45: 351
Wiezorek WD, Kermes U, Wolf P (1977) Experimentelle Untersuchungen über die Wirkung von Barbituraten, Methaqualon und Benzodiazepinen bei der akuten Isoniazidintoxikation. Pharmazie 32: 37–39
Williams HL, Wiegand RG (1960) Xanthurenic acid excretion and possible pyridoxine deficiency produced by isonicotinic acid hydrazide and other convulsant hydrazides. J Pharmacol Exp Ther 128: 344–348
Williams HL, Bain JA (1961) Convulsive effects of hydrazides: relationship to pyridoxine. Int Rev Neurobiol 3: 319–348
Wolf P, Ellert T, Gröger H (1965) Zur Frage der Beeinflußbarkeit der Isoniazid-Intoxikation durch einige Barbiturate, Chloralhydrat und Methylpentinol im Tierexperiment. Acta Biol Med German 15: 184–186
Worden AN, Palmer AC, Noel PRB, Mawdesley-Thomas LE (1967) Lesions in the brain of the dog induced by prolonged administration of mono-amine oxidase inhibitors and isoniazid. Proc Eur Soc Study Drug Tox 8: 149–161
Yamamoto RS, Weisburger JH (1970) Failure of arginine glutamate to inhibit lung tumour formation by isoniazid and hydrazine in mice. Life Sci 9 (II): 285–289
Zbinden G, Studer A (1955a) Zur Wirkung von Vitaminen der B-Gruppe auf die experimentelle Isoniazid-„Neuritis“. Schweiz Z Path Bakt 18: 1198–1211
Zbinden G, Studer A (1955b) Experimenteller Beitrag zur Frage der Isoniazid-Neuritis und ihrer Beeinflussung durch Pyridoxin. Z Tuberk 107: 97–107
Zbinden G, Studer A (1955c) Vergleichende Untersuchungen über die Wirkung von Pyridoxin, Pyridoxal-5’-phosphat und Pyridoxal-isonicotinylhydrazon auf die experimentelle Isoniazid-„Neuritis” der Ratte. Int Z Vitaminforsch 26: 130–137
Zbinden G, Studer A (1956) Wirkung der Glutaminsäure auf die experimentelle IsoniazidSchädigung peripherer Nerven bei Ratten. Experientia 12: 442–443
Zeller EA, Barsky J, Fouts JR, Kirchheimer WF, Van Orden LS (1952) Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinyl-2-isopropyl hydrazide (IIH) on bacterial and mammalian enzymes. Experientia 8: 349–350
André T (1956) Studies on the distribution of tritium-labeled dihydrostreptomycin and tetracycline in the body. Acta Radiol Suppl 142: 52–73
Bacharach AL, Clark BJ, McCulloch M, Tomich EG (1959) Comparative toxicity studies on ten antibiotics in current use. J Pharm Pharmacol 11: 737–741
Barkalaya AJ (1964), Transplacental effect of antibiotics of tetracycline group on kidneys of fetuses of pregnant rats. Fed Proc 23: T753–754
Benitz K-F, Diermeier HF (1964) Renal toxicity of tetracycline degradation products. Proc Soc Exp Biol 115: 930–935
Bevelander G (1963) Effect of tetracycline on crystal growth. Nature 198: 1103
Bevelander G, Nakahara H, Rolle GK (1960) The effect of tetracycline on the development of the skeletal system of the chick embryo. Dev Biol 2: 298–312
Bevelander G, Rolle GK, Cohlan SQ (1961) The effect of the administration of tetracycline on the development of teeth. J Dent Res 40: 1020–1024
Bevelander G, Cohlan SQ (1962) The effect on the rat fetus of transplacentally acquired tetracycline. Biol Neonat 4: 365–370
Bevelander G, Goss RJ (1962) Influence of tetracycline on calcification in normal and regenerating teleost scales. Nature 193: 1098–1099
Bezzi G, Gessa GL (1961) Influence of antibiotics on the neuromuscular transmission in mammals. Antibiot Chemotherap 11: 710–714
Breen KJ, Schenker S, Heimberg M (1972a) Pathogenesis of tetracycline fatty liver. Clin Res 20: 74
Breen K, Schenker S, Heimberg M (1972b) The effect of tetracycline on the hepatic secretion of triglyceride. Biochem Biophys Acta 270: 74–80
Breen KJ, Schenker S, Heimberg M (1975) Fatty liver induced by tetracycline in the rat. Dose-response relationship and effect of sex. Gastroenterology 69: 717–723
Brown DM, Harper KH, Palmer AK, Tesh SA (1968) Effects of antibiotics upon pregnancy in the rabbit. Toxicol Appl Pharmacol 12: 295
Du Buy HG, Showacre JL (1961) Selective localization of tetracycline in mitochondria of living cells. Science 133: 196–197
Clausen G, Nagy Z, Szalay L, Aukland K (1975) Mechanism in acute oliguric renal failure induced by tetracycline infusion. Scand J Clin Lab Invest 35: 625–633
Cohen LS, Wechsler AS, Mitchell JH, Glick G (1970) Depression of cardiac function by streptomycin and other antimicrobial agents. Am J Cardiol 26: 505–511
Cohlan SQ, Bevelander G, Tiamsic T (1963) Growth inhibition of prematures receiving tetracycline. Am J Dis Child 105: 453–461
Cullen SJ, Catalano PM, Helfman RJ (1966) Tetracycline sun sensitivity. Arch Derm 93: 77
Cunningham RW, Hines LR, Stokey EH, Vessey RE, Yuda NN (1953) Pharmacology of tetracycline. Antibiot Annu 1953–1954: 63–69
Damjanov J, Solter D (1971) Ultrastructure of acute tetracycline induced liver change. Experientia 27: 1204–1205
Detyuk ES, Vdovichenko IA, Kartysh GA (1971) Tetracycline effect on embryogenesis of albino rats. Antibiotiki (Moskau) 16: 923–926
Eger W, Ilbagian K (1962) Untersuchungen über die Wirkung von Tetracyclinen auf die Leber. Arzneimittelforsch 12: 285–289
English AR, P’an SY, McBride TJ, Gardocki JF, Van Halsema G, Wright WA (1953) Tetracycline-microbiologic, pharmacologic and clinical evaluation. Antibiot Annu 19531954: 70–80
Farhat SM, Schelhart DL, Musselman MM (1958) Clinical toxicity of antibiotics correlated with animal studies. AMA Arch Surg 76: 762–765
Fillippi B, Mela V (1957) Malformazioni congenite facciali e degli arti da tetraciclina. Minerva Chir 12: 1–15
Fillippi B (1967) Antibiotics and congenital malformations: Evaluation of the teratogenicity of antibiotics. Adv Teratol 2: 239–256
Franklin TJ (1963) The inhibition of incorporation of leucine into protein of cell-free systems from rat liver and Escherichia coli by chlortetracycline. Biochem J 87: 449–453
Franklin TJ (1964) The effect of chlortetracycline on the transfer of leucine and “transfer” ribonucleic acid to rat-liver ribosomes in vitro. Biochem J 90: 624–628
Giovannini M (1962) Toxizität (der Tetracycline). In: Brunner R, Machek G (eds) Die Antibiotika, Band I, Teil 2. Carl, Nürnberg, pp 506–510
Gray JE, Weaver RN, Skinner P, Mathews J, Day CE, Stern K (1974) Effects of tetracycline on ultrastructure and lipoprotein secretion in the rat hepatocyte. Toxicol Appl Pharmacol 30: 317–322
Greenberger NJ, Perkins RL, Cuppage FE, Ruppert RD (1967) Severe metabolic acidosis in the rat induced by toxic doses of tetracycline. Proc Soc Exp Biol Med 125: 11941197
Greenberger NJ (1967) Inhibition of protein synthesis in rat intestinal slices by tetracycline. Nature 214: 702–703
Hahn KJ, Morgenstern E, von Puttkamer K, Weber E (1970) Schädigungen der Mitochondrien von Darmepithelzellen bei oraler Therapie mit Tetrazyklinen. Naunyn Schmiedebergs Arch Pharmacol 266: 347
Hakkinen JPT (1958) The fluorescence of tetracycline in rats treated with dihydrotachysterol, AT 10. Acta Physiol Scand 42: 282–287
Halme J, Aer J (1968) Inhibition of collagen synthesis and bone calcification in the foetal rat by tetracycline. Scand J Clin Lab Invest 21, Suppl 101: 4
Halme J, Kivirikko KJ, Kaitila J, Saxen L (1969) Effect of tetracycline on collagen biosynthesis in cultured embryonic bones. Biochem Pharmacol 18: 827–836
Hansen CH, Pearson LH, Schenker S, Combes B (1968) Impaired secretion of triglycerides by the liver; a cause of tetracycline-induced fatty liver. Proc Soc Exp Biol Med 128: 143–146
Hanson DJ (1961) Local toxic effects of broad-spectrum antibiotics following injection. Antibiot Chemotherap 11: 390–404
Harcourt JK, Johnson NW, Storey E (1962) Incorporation of tetracycline antibiotics in bone, teeth, and egg shells. J Dent Res 41: 511
Hash JH (1963) Effects of tetracyclines on the incorporation of C14-alanine into staphylococcus aureus. Fed Proc 22: 301
Helander S, Böttiger L (1953) On the distribution of terramycin in different tissues. Acta Med Scand 147: 71–75
Hughes WH, Lee WR, Flood DJ (1965) A comparative study of the actions of six tetracy-clines on the development of the chick embryo. Br J Pharmacol 25: 317–323
Hurley LS, Tuchmann-Duplessis H (1963) Influence de la tétracycline sur le développement pré-et post-natal du rat. CR Acad Sci 257: 302–304
Ibsen KH, Urist MR (1963) Complexes of calcium and magnesium with oxytetracycline. Proc Soc Exp Biol Med 109: 797–801
Ison A, Blank H (1967) Testing drug phototoxicity in mice. J Invest Dermatol 49: 508–511
Kämmerer H, Eger W (1956) Tetracycline and Knochenstoffwechsel. Med Welt 1: 986–991
Kelly RG, Buyske D (1960) Metabolism of tetracycline in the rat and the dog. J Pharmacol Exp Ther 130: 144–149
Kohonen J, Guile EE, Plosila A (1968) Effects of tetracycline on osteogenesis in embryos of mice. Scand J Clin Lab Invest 21, Suppl 101: 4
Kubikowski P, Szreniawski Z (1963) The mechanism of the neuromuscular blockade by antibiotics. Arch Int Pharmacodyn Ther 146: 549–560
Kuck NA, Redin GS (1960) Comparison of demethylchlortetracycline with tetracycline in the control of experimental infections in mice. J Pharmacol Exp Ther 129: 350–355
Küpper K, Stupp H, Orsulakova A, Quante M (1970) Vergleichende Untersuchungen der Ototoxizität verschiedener antibiotischer Substanzen bei lokaler Applikation am Innenohr des Meerschweinchens. Arch Otorhinolaryngol 196: 169–172
Leaders F, Pittinger CB, Long JP (1960) Some pharmacological properties of selected antibiotics. Antibiot Chemotherap 10: 503–507
Lewis M, Schenker S (1966) Studies on the pathogenesis of tetracycline-induced fatty liver. Clin Res 14: 48
Lewis M, Schenker S, Combee B (1967) Studies on the pathogenesis of tetracycline-induced fatty liver. Am J Digest Dis 12: 429–438
Lindquist RR, Fellers FX (1966) Degraded tetracycline nephropathy. Lab Invest 15: 864–876
Lowe MB, Tapp E (1966) Renal damage caused by anhydro-4-epitetracycline. Arch Pathol 81: 362–364
Maffii G, Semenza F, Soncin E (1957) Saline solutions as a factor affecting the toxicity of intravenously injected tetracyclines in mice. J Pharm Pharmacol 9:105–112
McColl JD, Globus M, Robinson S (1965) Effect of some therapeutic agents on the developing rat fetus. Toxicol Appl Pharmacol 7: 409–417
McIntosh HA, Storey E (1970) Tetracycline-induced tooth changes, Part 4. Discoloration and hypoplasia induced by tetracycline analogues. Med J Aust 1: 114–119
Mennie AT (1962) Tetracycline and congenital limb abnormalities. Br Med J II: 480
Mikaelyan NP, Ulyanov MI (1971) On some shifts in thrombocytopoiesis systems in rabbits treated with tetracyclin. Antibiotiki 16: 624–626
Mikaelyan NP, Eingorn AG, Ulyanov MI (1973) Morphological changes induced by tetracycline in rabbits. Antibiotiki 18: 906–910
Milch RA, Rall DP, Tobie JE (1957) Bone localization of the tetracyclines. J Natl Cancer Inst 19: 87–93
Milch RA, Rall DP, Tobie JE (1958) Fluorescence of tetracycline antibiotics in bone. J Bone Joint Surg 40 A: 897–910
Milch RA, Tobie JE, Robinson J (1961) A microscopic study of tetracycline localization in skeletal neoplasms. J Histochem Cytochem 9: 261–270
Miller SEP, MacSween RNM, Glen ACA, Tribedi K, Moore FML (1967) Experimental studies on the hepatic effects of tetracycline. Br J Exp Pathol 48: 51–57
Mukherjee D, Mukherjee S (1969) Studies on the effect of tetracycline on triglyceride synthesis in experimental rats. J Antibiotics 22: 45–48
Mukherjee D, Ghosh H, Mukherjee S (1969) Studies on the effect of administration of tetracycline on free fatty acid metabolism in adrenalectomised and control rats. J Antibiotics 22: 480–483
Mukherjee D, Ghosh HN, Mukherjee S (1971) The effect of tetracycline on synthesis of fatty acid and cholesterol in the liver of control and experimental rats. J Antibiotics 24: 263–265
Nelson AA, Radomski JL (1954) Comparative pathological study in dogs of feeding of six broadspectrum antibiotics. Antibiotics Chemother 4: 1174
Owen LN (1961) Fluorescence of tetracyclines in bone tumors, normal bone teeth. Nature 190: 500–502
P’an SY, Scaduto L, Cullen M (1950) Pharmacology of terramycin in experimental animals. Ann New York Acad Sci 53: 238–244
Parker FL, James GWL (1978) The effect of various topical antibiotics and antibacterial agents on the middle and inner ear of the guinea-pig. J Pharm Pharmacol 30: 236–239
Pittinger Ch, Adamson R (1972) Antibiotic blockade of neuromuscular function. Annu Rev Pharmacol 12: 169–184
Polec RB, Yeh SDJ, Shils ME (1971) Protective effect of ascorbic acid, isoascorbic acid and mannitol against tetracycline-induced nephrotoxicity. J Pharmacol Exp Ther 178: 152–158
Rall DP, Loo TL, Lane M, Kelly MG (1957) Appearance and persistence of fluorescent material in tumor tissue after tetracycline administration. J Natl Cancer Inst 19: 79–85
Rendi R, Ochoa S (1961) Enzyme specificity in activation and transfer of amino acids to ribonucleoprotein particles. Science 133: 1367
Savini EC, Moulin MA, Herrou MFJ (1968) Effets tératogènes de l’oxytetracycline. Thérapie 23: 1247–1260
Saxén L (1966) Effect of tetracycline on osteogenesis in vitro. J Exp Zool 162: 269–294
Schenker S, Hansen C, Combes B (1968) Impaired secretion of hepatic triglycerides - a cause of tetracycline-induced fatty liver. Gastroenterology 54: 1268
Schoenbach EM, Bryer MS, Long PH (1950–1951) The pharmacology of terramycin in animals and man with reference to its clinical trial. Ann NY Acad Sci 53:245–252
Shauer BA, Lukacs L, Zimmerman HJ (1974) Biochemical indices of tetracycline hepatic injury in rats. Proc Soc Exp Biol Med 147: 868–872
Schorr WF, Monash S (1963) Photo-irradiation studies of two tetracyclines. Arch. Dermatol 88: 440–444
Smith H, Chapman IV (1963) Use of the living chick embryo as a biological indicator of the effectiveness of chelating agents. Nature 198: 32–33
Steiner G, Bradford W, Craig JM (1965) Tetracycline-induced abortion in the rat. Lab Invest 14: 1456–1463
Suarez G, Nathans D (1965) Inhibition of aminoacyl-sRNA binding to ribosomes by tetracycline. Biochem Biophys Res Comm 18: 743–750
Surgen RC, Nielsen JK (1960) Some factors influencing the toxicity (safety) test for antibiotics. Antibiot Chemotherap 10: 169–173
Swain HH, Kiplinger GF, Brody TM (1956) Actions of certain antibiotics on the isolated dog heart. J Pharmacol Exp Ther 117: 151–159
Tubaro E (1964) Possible relationship between tetracycline stability and effect on foetal skeleton. Br J Pharmacol 23: 445–448
Tubaro E, Barletta M, Banci F (1964) Some pharmacological aspects of a new water-soluble tetracycline. J Pharm Pharmacol 16: 33–37
Urist MR, Ibsen KH (1963) Chemical reactivity of mineralized tissue with oxytetracycline. Arch Pathol 76: 484–496
Verret MJ, Mutchier MK (1964) Teratogenic effects of antibiotics in the chick embryo. Fed Proc 23: 104
Wivagg RT, Jaffe JM, Colaizzi JL (1976) Influence of pH and route of injection on acute toxicity of tetracycline in mice. J Pharm Sci 65: 916–918
Yeh SDJ, Shils ME (1966) Tetracycline and incorporation of amino acids into proteins of rat tissues. Proc Soc Exp Biol Med 121: 729–734
Zolotukhin SI (1958) The effect of the tetracycline group of antibiotics on the coagulation of the blood. Antibiotics 4: 324–327
Adamson RH, Marshall FN, Long JP (1960) Neuromuscular blocking properties of various polypeptide antibiotics. Proc Soc Exp Biol Med 105: 494–497
Caesar R (1965) Die Bedeutung der Lysosomen für die formale Genese der Viomycin-Nephrose. Verh Dtsch Ges Pathol 49: 157–161
Gössner W (1963) Nebenwirkungen der modernen Chemotherapeutika vom Standpunkt des Pathologen. Antibiot Chemother 11: 285–300
Kanda T, Igarashi M (1969) Ultra-structural changes in vestibular sensory and organs after viomycin sulfate intoxication. Acta Otolaryngol 68: 474–488
Keller H, Krüpe W, Sous H, Mückter H (1956) Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotica. 2. Mitteilung. Arzneimittelforsch 6: 61–66
Klein HJ, Steinbach E, Schümmelfeder N (1966) Ultrastrukturelle und histochemische Untersuchungen zur Entstehung der Viomycin-Nephrose. Frankfurter Z Pathol 75: 432–445
Kubikowski P, Szreniawski Z (1963) The mechanism of the neuromuscular blockade by antibiotics. Arch Int Pharmacodyn Ther 146: 549–560
Moyer JH, Handley CA (1953) Renal function during viomycin administration to dogs. Proc Soc Exp Biol Med 82: 761–763
Mückter H (1961) Zur Pharmakologie der basischen Streptomyces-Antibiotika. Antibiot Chemother 9 Sep: 83–144
P’an SY, Halley TV, Reilly JC, Pekich AM (1951) Viomycin. Acute and chronic toxicity in experimental animals. Am Rev Tuberc 63: 44–48
Staemmler M, Karhoff B (1956) Die akuten Nephrosen. II. Mitteilung. Nierenschäden durch Antibiotica. Virchows Arch 328: 481–502
Staemmler M (1957) Die akuten Nephrosen. IV. Mitteilung. Tubuläre Schädigung und Wiederherstellung. Virchows Arch 330: 139–155
Vital Brazil O, Ramos AO, Sperandio LG, Martinez AL (1961) Viomycin. Pharmacological actions on myoneural junction, ganglionic synapse and smooth muscle. Chemotherapia 3: 521–531
Anderson RC, Worth HM, Welles JS, Harris PN, Chen KK (1956) Pharmacology and toxicology of cycloserine. Antibiot Chemother 6: 360–368
Bonati F, Bertoni L, Rosati G, Zanichelli V (1963) Caratteristiche biologiche ed attività antibatterica del teridizone. Il Farmaco Prat 20: 381–395
Bonavita V, Lettieri M, Monaco P (1964) Behavioural studies on rats injected with L-cycloserine and other compounds. Psychopharmacologia 5: 234–238
Bykova MA, Storozhev IA, Berezin EA (1965) Zur Pharmakologie des D-Cycloserin. Antibiotiki 10: 626–629
Dengler HJ (1962) Zur Hemmung der L-Glutaminsäure-und L-Dopadecarboxylase durch D-Cycloserin und andere Isoxazolidone. Naunyn Schmiedebergs Arch Pharmacol 243: 366–381
Epstein IG, Nair KGS, Mulinos MG, Haber A (1959) Pyridoxine and its relation to cycloserin neurotoxicity. Antibiot Annu 1958–1959: 472–481
Fust B, Böhni E, Pellmont B, Zbinden G, Studer A (1958) Experimentelle Untersuchungen mit D-Cycloserin. Schweiz Z Tuberk 15: 129–157
Glass F, Mallach HJ, Simsch A (1965) Beobachtungen und Untersuchungen über die gemeinsame Wirkung von Alkohol und D-Cycloserin. Arzneimittelforsch 15: 684–688
Lange P, Oehme P (1964) Zentralnervöse Wirkungen von D- und D,L-Cycloserin. Arch Int Pharmacodyn Ther 152: 466–473
Mayer O, Jankü I, Krsiak M (1971) Die zentralen Wirkungen des Cycloserins im Tierexperiment. Arzneimittelforsch 21: 298–303
Prescott B, Kauffmann G, James WD (1957) Increase in tolerated dose of isoniazid in mice by use of cycloserine. Proc Soc Exp Biol Med 94: 94–96
Robinson HJ, Mason RC, Siegel H (1956) Toxicity and pharmacology of cycloserine. Am Rev Tuberc 74: 972–976
Spencer JN, Payne HG (1956) Cycloserine. Experimental Studies. Antibiot Chemother 6: 708–716
Baeder DH, Ledaux G, Marier G (1962) The pharmacology and toxicology of ethionamide. Fed Proc 21: 452
Bargeton D (1964) Etude toxicologique du 1321 TH. Unpublished investigations Biancifiori C, Milia U, Di Leo FP (1964) Lay Ist Anat Istol patol Univ Perugia 24:145
Biancifiori C, Severi C (1966) The relationship of isoniazid (INH) and allied compounds to carcinogenesis in some species of small laboratory animals: A review. Br J Cancer 20: 528–538
Dubost P, Fournel J, Ganter P, Julou L, Laville J, Myon J, Pascal S (1964) Produits 1314 TH (8.545 R.P.) ou ethionamide (Trecator, N.D. Theraplix) et 1321 TH (9.778 R.P.). Toxicité aigue et toxicité terme (3 mois). Unpublished investigations
Iliin AM (1975) Pharmaco-toxicogical study of the antituberculous preparation prothionamide Farmakol Toksikol 38: 471–472
Ingham B (1963) Personal communication
Khan J, Azam A (1969) Study of teratogenic activity of trifluorperazine, amitriptyline, ethionamide and thalidomide in pregnant rabbits and mice. Proc Eur Soc Study Drug Tox 10: 235–241
Lorke D (1963/64) Bericht ĂĽber die PrĂĽfung der embryotoxischen Wirkung von Iridocin (1314 TH). Unpublished investigations
Maral R, Ganter P (1967) Etude de l’activité cancerogène de: l’isoniazide (5.015 R.P.), du prothionamide (9.778 R.P. =1321 TH), de l’urethane (10.506 R.P.) et de l’hydrazine (14.377 R.P.). Unpublished investigations
Roux CH (1962) Rapport sur l’ètude du pouvoir teratogène du 1314 TH et du 2162 TH. Unpublished investigations
Roux CH (1963) Rapport sur l’ètude du pouvoir teratogène du 1314 TH et du 2162 TH. Unpublished investigations
Roux CH (1965) Rapport sur l’ètude du pouvoir teratogène du 1314 TH et du 2162 TH. Unpublished investigations
Roux CH (1965) Rapport sur l’ètude de l’effect teratogène du 1321 TH. Unpublished investigations
Woodard G (1960) Toxicity of TH-1314 following single and repeated daily doses in rats and dogs. Unpublished investigations
Akiyoshi M, Sato K (1970) Reevaluation of the pinna reflex test as screening for otoxicity of antibiotics. In: Progress in antimicrobial and anticancer chemotherapy. Proc 6th Intern Congr Chemotherapy, Vol I: 621–627
Amann R, Radenbach KL (1961) Akute Kanamycin-Nebenwirkungen und Histaminfreisetzung. Beitr Klin Tuberk 123: 208–210
Beck CHL, Krahl P (1962) Experimentelle und feingewebliche Untersuchungen über die Otoxicität von Kanamycin. Arch Otorhinolaryngol 179: 594–610
Bevelander G, Cohlan SQ (1962) The effect on the rat of transplacentally aquired tetracycline. Biol Neonate 4: 365–370
Brown JJ, Brummett RE, Fox KE (1979) Combined effects of noise and kanamycin: Cochlear pathology and pharmacokinetics in the guinea pig. Pharmacologist 21: 144
Brummett RE, Traynor J, Brown R, Himes D (1975) Cochlear damage resulting from kanamycin and furosemide. Acta Oto-Laryngol (Stockh) 80: 86–92
Cohen LS, Wechsler AS, Mitchell JH, Glick G (1970) Depression of cardiac function by streptomycin and other antimicrobial agents. Am J Cardiol 26: 505–511
Farkashidy J, Black RG, Briant TDR (1963) The effect of kanamycin on the internal ear: an electrophysiological and electron microscope study. Laryngoscope 73: 713–727
Goldberg LE (1964) Pharmakologische Prüfung des Antibiotikums Kanamycin (russ.). Antibiotiki (Moskau) 9: 414–420
Goldberg LE, Ilyushina NG (1968) Experimental investigation of kanamycin circulation between mother and fetus. Byul Eksp Biol Med 66: 994–996
Hawkins JE Jr (1959) The otoxicity of kanamycin. Ann Otol 68: 698–715
Kinoshita Y, Yamasaku F, Takeda H, Usuda Y, Kitahara K (1970) Nephrotoxicity of kanamycin with a combination of plasma expander. In: Progress in antimicrobiol and anticancer chemotherapy. Proc 6th Intern Congr Chemotherapy, Vol I: 586–590
Kohonen A (1965) Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig. Acta Otolaryng (Stockh) Suppl 208: 9–70
Lagler F, Osterloh G, Mückter H (1960) Studies on the pharmacology of kanamycin. Antibiot Annu 1959–1960: 862–867
Luft F, Bloch R, Sloan RS, Yum MN, Costello R, Maxwell DR (1978) Comparative nephrotoxicity of aminoglycoside antibiotics in rats. J Infect Dis 138: 541–545
Mückter H (1961) Zur Pharmakologie der basischen Streptomyces-Antibiotika. Antibiot Chemotherap 9 Sep: 83–114
Nakazono M, Naide Y, Ohkoshi M (1970) Biochemical studies on nephrotoxicity of kanamycin. In: Progress in antimicrobial Chemotherapy. Vol I: 591–595
Orr JL (1980) Behavioral toxicology of kanamycin. Dissertation Abstr Intern B 40: 50–68
Osaka S, Tokimoto T, Matsuura S (1979) Effects of kanamycin on the auditory evoked responses during postnatal development of the hearing of the rat. Acta Oto-Laryngol (Stockh) 88: 359–368
Owada K (1962) Experimental studies on the toxicity of kanamycin, its hydrolyzed products and neomycin. Chemotherapia 5: 277–293
Pindell MH, Lein J (1964) Comparison of biological and toxicological properties of meth- ane sulfonate and sulfonate derivatives of antibiotics Chemotherapia 8: 163–174
Plattig KH, Keidel UO, David E (1967) Minderung der Otoxizität des Kanamycin durch Panthothensäure. Elektrophysiologische Untersuchungen an der Katze. Dtsch Med Wochenschr 92: 1391–1397
Raphael Y, Fein A (1980) Kanamycin otoxicity in utero. Isr J Med Sci 16: 554–555
Renaud S (1960) The toxicity of kanamycin and bacitracin as influenced by stress and sodium chloride. Toxicol Appl Pharmacol 2: 708–714
Sack K, Züllich B (1978) Differenzierung der nephrotoxischen Potenzen von Aminoglykosiden und Cephalosporinen im Tierexperiment. Therapiewoche 28: 2107–2114
Singh YN, Harvey AL, Marshall IG (1978) Antibiotic-induced paralysis of the mouse phrenic nerve-hemidiaphragm preparation, and reversibility by calcium and by neostigmine. Anesthesiology 48: 418–424
Staemmler M, Dudkowiak V (1961) Über Wirkungen des Kanamycin auf die Nieren. Med Welt: 1296–1299
Stebbins WC, Miller JM, Johnsson L-G, Hawkins JE Jr (1969) Ototoxic hearing loss and cochlear pathology in the monkey. Ann Otol 78: 1007–1025
Tisch DE, Huftalen JB, Dickison HL (1958) Pharmacological studies with kanamycin. Ann NY Acad Sci 76: 44–65
Toyada Y, Saito H, Matsuoka H, Takenaka H, Oshima W, Mizukoshi O (1978) Quanti- tative analysis of kanamycin ototoxicosis. Acta Oto-Laryngol (Stockh) 84: 202–212
Russel NJ, Fox KE, Brummett RE (1979) Ototoxic effects of the interaction between kanamycin and ethacrynic acid. Cochlear ultrastructure correlated with cochlear potentials and kanamycin levels. Acta Oto-Laryngol (Stockh) 88: 369–381
Tyberghein J (1962) Influence of some streptomyces antibiotics on the cochlear microphonics in the guinea pig. Acta Otolaryng (Stockh) Suppl 171
West BA, Brummett RE, Himes DL (1973) Interaction of kanamycin and ethacrynic acid. Arch Otolaryngol 98: 32–37
Lambelin G (1970) Pharmacology and toxicology of Isoxyl. Antibiotica et Chemotherapia 16: 84–95
Lambelin G, Parmentier R (1963) Etude toxicologique de l’Isoxyl sur l’animal. Acta Tuberc Pneumol Be1g 54: 476–493
Lambelin G, Parmentier R (1966) Study of the toxicity of isoxyl. Arzneimittelforsch 16: 881–886
Akiyoshi M, Sato Y, Shoji T, Sugahiro K, Tamura H (1971) Histological changes in the stria vascularis of the inner ear in the case of auricular toxicosis by antibiotics (in Japanese). J Otolaryngol (Jap) 74: 476–477
Muraoka Y, Hayashi Y, Minesita T (1968) Studies of capreomycin nephrotoxicity. Toxicol Appl Pharmacol 12: 350–359
Welles JS, Harris PN, Small RM, Worth HM, Anderson RC (1966) The toxicity of capreomycin in laboratory animals. Ann NY Acad Sci 135: 960–973
Asole A, Panu R, Palmieri G (1976) Effetti dell’etambutolo sull’epitelio seminale di ratto e pollo. Boll Soc Ital Biol Sper 52: 846–848
Borchard U (1974) Untersuchungen über den Einfluß von Ethambutol auf peripheres and zentralnervöses Gewebe. Thesis, University of Cologne
Botticelli A, Trentini GP, Barbolini G (1971) Lesioni testicolari nel ratto trattato con etambutolo. Boll Soc Ital Biol Sper 47: 72–75
Bruckschen EG (1970) Myambutol. Experimentelle and klinische Ergebnisse. Arzneimittelforsch, 20. Beiheft 2. Aufl.
Buyske DA, Sterling W, Peets E (1966) Pharmacological and biochemical studies on ethambutol in laboratory animals. Ann NY Acad Sci 135: 711–725
Cappiello VP, Layton WM Jr (1965) A one-year study of the toxicity of ethambutol in dogs: results of gross and histopathologic examinations. Toxicol Appl Pharmacol 7: 844–849
Diermeier HF, Kaiser JA, Yuda N (1966) Safety evaluation of ethambutol. Ann NY Acad Sci 135: 732–746
Fantoli U, Sebastiani M, Cattaneo C, Sbampato M (1968) Comportamento dell’ attività colinesterasica sierica in soggeti trattati con Etambutolo. Ann Inst C Forlanini 28: 164
Figueroa R, Weiss H, Smith JC Jr, Hackley BM, McBean LD, Swassing ChR, Halsted JA (1971) Effect of ethambutol on the ocular zinc concentrations in dogs. Am Rev Resp Dis 104: 592–594
Grifa P, Jotti D, Benatti G (1967) Ricereche sperimentali sulla tossicità dell’ Etambutolo sul sistema nervoso centrale di alcuni animali. Giorn It Chemiother 14: 65
Hara T, Baba H (1970) Incorporation and metabolism of ethambutol in rat organs. Kekkaku 45: 129
Kaiser JA (1964) A one-year study of the toxicity of ethambutol in dogs: results during life. Toxicol Appl Pharmacol 6: 557–567
Schmidt J, Schmidt LH (1964) Neurotoxicity of ethambutol, an anti-tuberculosis drug. Anat Rec 148: 333
Schmidt JG (1966) Central nervous system effects of ethambutol in monkeys. Ann NY Acad Sci 135: 759–774
Thomas JP, Baughn CO, Wilkinson RG, Sheperd RG (1961) A new synthetic compound with antituberculous activity in mice: ethambutol (dextro-2,2’-(ethylenediimino)-di-lbutanol). Am Rev Respir Dis 83: 891–893
Vogel AW, Kaiser JA (1963) Ethambutol-induced transient change and reconstitution (in vivo) of the tapetum lucidum color in the dog. Exp Mol Pathol Suppl 2: 136–149
Anufrieva RG, Zeltser IZ, Svinogeeva TP (1980a) Placenta permeability by rifampicin (Russ.). Antibiotiki 25: 199–201
Anufrieva RG, Zeltser IZ, Balabanova EL, Lapchinskaya AV, Baru RV, Svinogeeva TP (1980b) Experimental study of rifampicin effect on albino rat embryo genesis (Russ.). Antibiotiki 25: 280–284
Balea T, Marche C, Marche J (1970) Effets hépato-biliaires de l’association rifarnpicineisoniazide. II. Etude histologique chez la souris tuberculisée. Thérapie 25: 125–130
Bichl J (1973) Rifampicin in a carcinogenic experiment. Lancet 2: 1209
Della Porta G, Cabral JR, Rossi L (1978) Carcinogenicity study of rifampicin in mice and rats. Toxicol Appl Pharmacol 43: 293–302
Epstein SS, Arnold E, Andrea J, Bass W, Bishop Y (1972) Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol Appl Pharmacol 23: 288–325
Felgenhauer F, Lagler F (1970) Experimental animal investigations with rifampicin on the question of its influence on the vestibular system and its period of retention in the peri-lymph of the inner ear. Antibiot Chemother 16: 361–368
Furesz S (1970) Chemical and biological properties of rifampicin. Antibiot Chemother 16: 316–351
Hugues F-C, Marche C, Marche J (1969) Effets hépato-biliaires de l’association rifampicine-isoniazide. I. Etude histologique chez le rat. Thérapie 24: 899–906
Hugues F-C, Marche C, Marche J (1970) Effets hépato-biliaires de l’association rifampicine-prothionamide. I. Etude histologique chez le rat. Thérapie 25: 131–136
Jaeger E, Merker HJ, Bass R (1974) Investigations on the mode of teratogenic action of high doses of rifampicin. Teratology 10: 312
Jezequel AM, Orlandi F, Tenconi LT (1971) Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes. Gut 12: 984–987
Kluyskens P (1969) Recherches expérimentales de toxicité otovestibulaire des rifamycines. Acta Tuberc Pneumol Belg 60: 323–326
Piriou A, Warnet JM, Jacqueson A, Claude JR, Truhaut R (1979) Fatty liver induced by high doses of rifampicin in the rat: possible relation with an inhibition of RNA polymerase in eukaryotic cells. Arch Toxicol Suppl 2: 333–337
Schiatti P, Maggi N, Sensi P, Maffei G (1967) Biliary excretion rate of semisynthetic rifamycins in the rat. Chemotherapia 12: 155–171
Sensi P, Maggi N, Füresz S, Maffei G (1967) Chemical modifications and biological properties of rifamycins. Antimicrob Agents Chemother 1966: 699–714
Srb V, Puza V, Spurna V, Kerptova J (1974) The action of rifampicin on stabilized cell lines HEp-2 and HeLa. Experientia 30: 484–486
Tuchmann-Duplessis H, Mercier-Parot L (1969) Influence d’un antibiotique, la rifampicine, sur le développement prénatal des rongeurs. CR Acad Sc (Paris) Série D 269: 2147–2149
Vogel E, Obe G (1973) Testing of rifampicin on possible genetic effects on Drosophila melanogaster and human leukocyte chromosomes in vitro. Experientia 29: 124–125
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Tettenborn, D. (1988). Experimental Pharmacology and Toxicology of Antituberculosis Drugs. In: Bartmann, K. (eds) Antituberculosis Drugs. Handbook of Experimental Pharmacology, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72873-0_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-72873-0_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-72875-4
Online ISBN: 978-3-642-72873-0
eBook Packages: Springer Book Archive