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An Evaluation of Prostaglandin Activity and Pathologic Changes Following Carbon Dioxide Laser Endarterectomy

  • Francis W. GamacheJr.
  • Babette Weksler
  • Daniel Alonso
Conference paper

Abstract

Laser endarterectomy has been proposed as a method to recanalize narrowed or occluded arteries, especially coronarles. Since a substantial number of patients with anterior cerebral circulation ischemic symptoms have evidence of obstructive carotid lesions, laser angioplasty may perhaps be a useful technigue for the treatment of cerebrovascular disease. Most of the endarterectomy studies performed to date have been performed using argon lasers (1). Alterations in clotting have been associated with argon laser angioplasty (2,3). Such alterations would have considerable impact on cerebro-vascular circulation where thrombosis and embolism are poorly tolerated. Very little basic science data has been published regarding carbon dioxide laser irradiation of vessel surfaces. CO2 lasers generally induce more superficial lesions in tissue than argon or YAG so as to make them perhaps more useful in the performance of laser angioplasty. McVicker et al have recently published results from CO2 laser treatments of canine carotid and femoral vessels studying the acute thrombotic conseguences of laser irradiation (4). The current study set out to attempt to reproduce those data as well as to evaluate the delayed effects, observed after several hours of recirculation of CO2 laser endarterectomy.

Keywords

Common Carotid Artery Femoral Vessel Carbon Dioxide Laser Superficial Lesion Laser Angioplasty 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    Abola G, Normann S, Cohen D, et al: Effects of carbon dioxide, Nd-YAG, and argon laser radiation on coronary artheroraatous plaques. Am J Cardiol 50:1199–1205, 1982.CrossRefGoogle Scholar
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    Weichert W, Pauliks V, Breddin H: Laser induced thrombi in rat mesenteric vessels and antithrombotic drugs. Haemostasis 13: 61–71, 1983.Google Scholar
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    Treat M, Weld F, White J: Effect of CO2 laser on the luminal surface of blood vessels in-vivo. Lasers Surg Med 31:247–254,1983.CrossRefGoogle Scholar
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    McVicker J, Day A, Savage D, et al: Laser endarterectomy: A comparison of thrombotic potential following CO2 laser versus surgical endarterectomy. Stroke 17:266–270, 1986.CrossRefGoogle Scholar
  5. 5).
    Weksler, B, Pett S, Alonso D, et al. Differential inhibition by aspirin of vascular & Platelet prostaglandin synthesis in atherosclerotic patients. N Engl J Med 308:800–805, 1983.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1988

Authors and Affiliations

  • Francis W. GamacheJr.
    • 1
  • Babette Weksler
    • 1
  • Daniel Alonso
    • 1
  1. 1.Departments of Neurological Surgery, Hematology & PathologyCornell University Medical CollegeNew YorkUSA

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