Available Evidence Relating Abnormal Intrapartum Fetal Acid Base Balance (pH) to Neuromotor Dysfunction and Mental Handicap
The pathophysiological mechanism by which asphyxia causes the brain injury associated with cerebral palsy is not totally clear. Myers et al. 1981 think that the damage to neuronal tissues is caused by a critically high level of lactic acid, an end product of anaerobic metabolism which the tissues employ for energy in the absence of oxygen. Animal work confirms the clinical observation that severe fetal hypoxia results in brain injury. It also suggests an explanation for the confusing clinical observation that most fetal hypoxia does not result in brain injury.
KeywordsDementia Peri Hypothyroidism Phenylketonuria
Unable to display preview. Download preview PDF.
- Barnett HL, Einhorn AH (1972) Pediatrics, 15th edn. Appleton Century Crofts, New York.Google Scholar
- Myers RE, Wagner KR, de Courten GM (1981) Lactic acid accumulation in tissues as cause of brain injury and death in cardiogenic shock from asphyxia. In: Lauerser NH, Hochberg HM (eds) Perinatal biochemical monitoring. William and Wilkins, Baltimore.Google Scholar
- Saling E (1966) Das Kind im Bereich der Geburtshilfe. Thieme, StuttgartGoogle Scholar