Available Evidence Relating Abnormal Intrapartum Fetal Acid Base Balance (pH) to Neuromotor Dysfunction and Mental Handicap

  • E. Hochuli
  • H. P. Vogt
Conference paper

Abstract

The pathophysiological mechanism by which asphyxia causes the brain injury associated with cerebral palsy is not totally clear. Myers et al. 1981 think that the damage to neuronal tissues is caused by a critically high level of lactic acid, an end product of anaerobic metabolism which the tissues employ for energy in the absence of oxygen. Animal work confirms the clinical observation that severe fetal hypoxia results in brain injury. It also suggests an explanation for the confusing clinical observation that most fetal hypoxia does not result in brain injury.

Keywords

Dementia Peri Hypothyroidism Phenylketonuria 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barnett HL, Einhorn AH (1972) Pediatrics, 15th edn. Appleton Century Crofts, New York.Google Scholar
  2. Dweck H, Huggings W, Dorman L et al. (1974) Development sequelae in infants having suffered severe perinatal asphyxia. Am J Obstet Gynecol 119: 811.PubMedGoogle Scholar
  3. Hagberg B (1975) Pre-, peri-and postnatal prevention of major neuropediatric handicaps. Neuropediatrics 6: 331.CrossRefGoogle Scholar
  4. Ingemarsson E, Ingemarsson I, Niels W (1981) Impact of routine fetal monitoring during labor on fetal outcome with long-term follow-up. Am J Obstet Gynecol 141: 29–38.PubMedGoogle Scholar
  5. Low J, Galbraith R, Muir D et al. (1978) Intrapartum fetal asphyxia: a preliminary report in regard to longterm morbidity. Am J Obstet Gynecol 130: 525.PubMedGoogle Scholar
  6. Low J, Galbraith R, Muir D et al. (1983) Intrapartum fetal hypoxia: a study of long-term morbidity. Am J Obstet Gynecol 145: 129.PubMedGoogle Scholar
  7. Myers RE, Wagner KR, de Courten GM (1981) Lactic acid accumulation in tissues as cause of brain injury and death in cardiogenic shock from asphyxia. In: Lauerser NH, Hochberg HM (eds) Perinatal biochemical monitoring. William and Wilkins, Baltimore.Google Scholar
  8. Saling E (1966) Das Kind im Bereich der Geburtshilfe. Thieme, StuttgartGoogle Scholar
  9. Sykes G, Johnson P, Ashworth E et al. (1982) Do Apgar scores indicate asphyxia? Lancet 1: 494.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • E. Hochuli
  • H. P. Vogt

There are no affiliations available

Personalised recommendations