Available Evidence Relating Abnormal Intrapartum Fetal Acid Base Balance (pH) to Neuromotor Dysfunction and Mental Handicap
The pathophysiological mechanism by which asphyxia causes the brain injury associated with cerebral palsy is not totally clear. Myers et al. 1981 think that the damage to neuronal tissues is caused by a critically high level of lactic acid, an end product of anaerobic metabolism which the tissues employ for energy in the absence of oxygen. Animal work confirms the clinical observation that severe fetal hypoxia results in brain injury. It also suggests an explanation for the confusing clinical observation that most fetal hypoxia does not result in brain injury.
KeywordsApgar Score Congenital Hypothyroidism Mental Handicap Fetal Death Rate Fetal Hypoxia
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