Abstract
The pathophysiological mechanism by which asphyxia causes the brain injury associated with cerebral palsy is not totally clear. Myers et al. 1981 think that the damage to neuronal tissues is caused by a critically high level of lactic acid, an end product of anaerobic metabolism which the tissues employ for energy in the absence of oxygen. Animal work confirms the clinical observation that severe fetal hypoxia results in brain injury. It also suggests an explanation for the confusing clinical observation that most fetal hypoxia does not result in brain injury.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barnett HL, Einhorn AH (1972) Pediatrics, 15th edn. Appleton Century Crofts, New York.
Dweck H, Huggings W, Dorman L et al. (1974) Development sequelae in infants having suffered severe perinatal asphyxia. Am J Obstet Gynecol 119: 811.
Hagberg B (1975) Pre-, peri-and postnatal prevention of major neuropediatric handicaps. Neuropediatrics 6: 331.
Ingemarsson E, Ingemarsson I, Niels W (1981) Impact of routine fetal monitoring during labor on fetal outcome with long-term follow-up. Am J Obstet Gynecol 141: 29–38.
Low J, Galbraith R, Muir D et al. (1978) Intrapartum fetal asphyxia: a preliminary report in regard to longterm morbidity. Am J Obstet Gynecol 130: 525.
Low J, Galbraith R, Muir D et al. (1983) Intrapartum fetal hypoxia: a study of long-term morbidity. Am J Obstet Gynecol 145: 129.
Myers RE, Wagner KR, de Courten GM (1981) Lactic acid accumulation in tissues as cause of brain injury and death in cardiogenic shock from asphyxia. In: Lauerser NH, Hochberg HM (eds) Perinatal biochemical monitoring. William and Wilkins, Baltimore.
Saling E (1966) Das Kind im Bereich der Geburtshilfe. Thieme, Stuttgart
Sykes G, Johnson P, Ashworth E et al. (1982) Do Apgar scores indicate asphyxia? Lancet 1: 494.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hochuli, E., Vogt, H.P. (1988). Available Evidence Relating Abnormal Intrapartum Fetal Acid Base Balance (pH) to Neuromotor Dysfunction and Mental Handicap. In: Kubli, F., Patel, N., Schmidt, W., Linderkamp, O. (eds) Perinatal Events and Brain Damage in Surviving Children. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72850-1_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-72850-1_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-72852-5
Online ISBN: 978-3-642-72850-1
eBook Packages: Springer Book Archive