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The Mechanism by which Interferon Gamma Blocks the Growth of Toxoplasma Gondii in Cultured Fibroblasts

  • E. R. Pfefferkorn
Conference paper
Part of the NATO ASI Series book series (volume 11)

Abstract

Toxoplasma gondii is an obligate intracellular protozoan parasite. Overt disease, except in the context of transplacental infection or of immunosuppression, is rare. The immunological basis for the prevention of symptomatic infection is not completely understood. Experiments with passive transfer of immunity in mice suggest that the cellular component is more important than the humoral. To explore the role of T-cells, we concentrated on the activity of interferon gamma (IFN-γ).

Keywords

Human Fibroblast Toxic Metabolite Toxoplasma Gondii Tryptophan Metabolism Tryptophan Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Kaufman HE, Melton ML, Remington JS, Jacobs L (1959) Strain differences of Toxoplasma gondii. J Parasitol 45: 189–190PubMedCrossRefGoogle Scholar
  2. McCabe RE, Luft BJ, Remington JS (1984) Effect of murine interferon gamma on murine toxoplasmosis. J Infect Dis 150: 961–962PubMedCrossRefGoogle Scholar
  3. Nathan CF, Murray HW, Wiebe ME, Rubin BY (1983) Identification of interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 158: 670–689PubMedCrossRefGoogle Scholar
  4. Oxender DL, Lee M, Moore PA, Cecchini G (1977) Neutral amino acid transport systems of tissue culture cells. J Biol Chem 252: 2675–2679PubMedGoogle Scholar
  5. Pfefferkorn ER (1984) Interferon y blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Nat Acad Sci USA 81: 908–912PubMedCrossRefGoogle Scholar
  6. Pfefferkorn ER (1986) Interferon-y and the growth of Toxoplasma gondii in fibroblasts. Ann Inst Pasteur/Microbiol 137A: 348–352CrossRefGoogle Scholar
  7. Pfefferkorn ER, Eckel M, Rebhun S (1986) Interferon-γ suppresses the growth of Toxoplasma gondii in human fibroblasts through starvation for tryptophan. Molec Biochem Parasitol, in pressGoogle Scholar
  8. Pfefferkorn ER, Guyre PM (1984) Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon. Infect and Immun 44: 211–216Google Scholar
  9. Pfefferkorn ER, Rebhun S, Eckel M (1986) Characterization of an indoleamine 2, 3-dioxygenase induced by IFN-γ in cultured human fibroblasts. J Interferon Res 6: 267–279PubMedCrossRefGoogle Scholar
  10. Trinchieri G, Perussia B (1985) Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 6: 131–136CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • E. R. Pfefferkorn
    • 1
  1. 1.Department of MicrobiologyDartmouth Medical SchoolHanoverUSA

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