The Mechanism by which Interferon Gamma Blocks the Growth of Toxoplasma Gondii in Cultured Fibroblasts

  • E. R. Pfefferkorn
Conference paper
Part of the NATO ASI Series book series (volume 11)


Toxoplasma gondii is an obligate intracellular protozoan parasite. Overt disease, except in the context of transplacental infection or of immunosuppression, is rare. The immunological basis for the prevention of symptomatic infection is not completely understood. Experiments with passive transfer of immunity in mice suggest that the cellular component is more important than the humoral. To explore the role of T-cells, we concentrated on the activity of interferon gamma (IFN-γ).


Human Fibroblast Toxic Metabolite Toxoplasma Gondii Tryptophan Metabolism Tryptophan Concentration 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • E. R. Pfefferkorn
    • 1
  1. 1.Department of MicrobiologyDartmouth Medical SchoolHanoverUSA

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