Inhibition of Knob Formation on PlasmodiumFalciparum-Infected Erythrocytes by 2-Fluoro-L-Histidine
Knob protrusions and associated submembrane electron dense material (EDM) appear on the membrane of erythrocytes infected with Plasmodium falciparum (Aikawa et al. 1972, Luse and Miller 1971). These knobs form focal junctions with the endothelial cells of capillaries, resulting in the sequestration of infected erythrocytes along the vascular endothelium (Luse and Miller 1971, Udeinya et al. 1981, Oo et al. 1986). Parasites that do not produce knobs (K- phenotype) neither attach to endothelial cells in vitro, nor do they sequester in vivo (Barnwell et al. 1983). These findings indicate the presence of cytoadherence properties at knobs and the importance of knobs for parasite survival in vivo.
KeywordsPlasmodium Falciparum Erythrocyte Membrane Cerebral Malaria Infected Erythrocyte Plasmodium Falciparum Malaria
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