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Inhibition of Knob Formation on PlasmodiumFalciparum-Infected Erythrocytes by 2-Fluoro-L-Histidine

  • Masamichi Aikawa
  • Shigehiko Uni
  • Annette T. Andrutis
  • Kenneth L. Kirk
  • Louis A. Cohen
  • Russell J. Howard
Conference paper
Part of the NATO ASI Series book series (volume 11)

Abstract

Knob protrusions and associated submembrane electron dense material (EDM) appear on the membrane of erythrocytes infected with Plasmodium falciparum (Aikawa et al. 1972, Luse and Miller 1971). These knobs form focal junctions with the endothelial cells of capillaries, resulting in the sequestration of infected erythrocytes along the vascular endothelium (Luse and Miller 1971, Udeinya et al. 1981, Oo et al. 1986). Parasites that do not produce knobs (K- phenotype) neither attach to endothelial cells in vitro, nor do they sequester in vivo (Barnwell et al. 1983). These findings indicate the presence of cytoadherence properties at knobs and the importance of knobs for parasite survival in vivo.

Keywords

Plasmodium Falciparum Erythrocyte Membrane Cerebral Malaria Infected Erythrocyte Plasmodium Falciparum Malaria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Masamichi Aikawa
    • 1
  • Shigehiko Uni
    • 1
  • Annette T. Andrutis
    • 2
  • Kenneth L. Kirk
    • 3
  • Louis A. Cohen
    • 3
  • Russell J. Howard
    • 2
  1. 1.Institute of PathologyCase Western Reserve UniversityClevelandUSA
  2. 2.Laboratory of Parasitic DiseasesNational Institute of Allergy & Infectious DiseasesUSA
  3. 3.Laboratory of Chemistry, National Institute of Arthritis, Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaUSA

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