Abstract
Knob protrusions and associated submembrane electron dense material (EDM) appear on the membrane of erythrocytes infected with Plasmodium falciparum (Aikawa et al. 1972, Luse and Miller 1971). These knobs form focal junctions with the endothelial cells of capillaries, resulting in the sequestration of infected erythrocytes along the vascular endothelium (Luse and Miller 1971, Udeinya et al. 1981, Oo et al. 1986). Parasites that do not produce knobs (K- phenotype) neither attach to endothelial cells in vitro, nor do they sequester in vivo (Barnwell et al. 1983). These findings indicate the presence of cytoadherence properties at knobs and the importance of knobs for parasite survival in vivo.
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References
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© 1987 Springer-Verlag Berlin Heidelberg
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Aikawa, M., Uni, S., Andrutis, A.T., Kirk, K.L., Cohen, L.A., Howard, R.J. (1987). Inhibition of Knob Formation on Plasmodium Falciparum-Infected Erythrocytes by 2-Fluoro-L-Histidine. In: Chang, KP., Snary, D. (eds) Host-Parasite Cellular and Molecular Interactions in Protozoal Infections. NATO ASI Series, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72840-2_34
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DOI: https://doi.org/10.1007/978-3-642-72840-2_34
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