Studies on the Plasmodium Falciparum 195,000 Molecular Mass Merozoite Surface Antigen Precursor

  • A. A. Holder
  • Y. Hillman
  • S. C. Nicholls
  • L. S. Davey
Conference paper
Part of the NATO ASI Series book series (volume 11)


One of the proteins synthesized by the asexual blood stage of malaria which has been studied in some detail is the precursor to the major merozoite surface antigens (PMMSA), a glycoprotein that is synthesized throughout schizogony and present on the merozoite surface in processed form (Holder & Freeman, 1982, 1984; Howard et al., 1985). Complete or partial nucleotide sequences of the gene for this protein from a number of Plasmodium falciparum strains have been reported (Holder, et al., 1985; Mackay et al., 1985; Cheung et al., 1985; Weber et al,1986). Some features of the protein and its gene will be discussed here, in particular studies we have performed with a West African (Wellcome) strain of the parasite.


Plasmodium Falciparum Variant Surface Glycoprotein Asexual Blood Stage Merozoite Surface Antigen Plasmodium Falciparum Strain 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. A. Holder
    • 1
  • Y. Hillman
    • 1
  • S. C. Nicholls
    • 1
  • L. S. Davey
    • 1
  1. 1.Department of Molecular BiologyWellcome BiotechBeckenham, KentUK

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