Studies on the Plasmodium Falciparum 195,000 Molecular Mass Merozoite Surface Antigen Precursor
One of the proteins synthesized by the asexual blood stage of malaria which has been studied in some detail is the precursor to the major merozoite surface antigens (PMMSA), a glycoprotein that is synthesized throughout schizogony and present on the merozoite surface in processed form (Holder & Freeman, 1982, 1984; Howard et al., 1985). Complete or partial nucleotide sequences of the gene for this protein from a number of Plasmodium falciparum strains have been reported (Holder, et al., 1985; Mackay et al., 1985; Cheung et al., 1985; Weber et al,1986). Some features of the protein and its gene will be discussed here, in particular studies we have performed with a West African (Wellcome) strain of the parasite.
KeywordsCodon Recombination Glycine Cysteine Electrophoresis
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- Holder AA, Freeman RR(1982) Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody. J exp Med 156: 1528–1538Google Scholar
- Holder AA, Sandhu JS, Hillman Y, Davey LS, Nicholls SC, Lockyer MJ (1987) Processing of the precursor to the major merozoite surface antigens of Plasmodium falciparum, (submitted)Google Scholar
- Lyon JA, Geller RH, Haynes JD, Chulay JD, Weber JL(1986) Epitope map and processing scheme for the 195,000-dalton surface glycoprotein of Plasmodium falciparum merozoites deduced from cloned overlapping segments of the gene. Proc Natl Acad Sci USA 83: 2989–2993Google Scholar
- Schwarz RT, Riveros-Moreno V, Lockyer MJ, Nicholls SC, Davey LS, Hillman Y, Sandhu JS, Freeman RR, Holder AA(1986) Structural diversity of the major antigen of Plsmodium falciparum merozoites. Mol Cell Biol 6: 964–968Google Scholar