Interaction of Leishmania and Membrane-Stabilizing Drugs with Human Phagocytic Cells
Leishmaniasis inflicts more than one million people in the world and causes over 1000 deaths per year. Therapy of these patients poses a serious problem. Pentavalent antimonials at higher doses exhibit considerable toxicity, some patients with visceral leishmaniasis become unresponsive to conventional doses of antimonials, and the usual second line drugs such as pentamidine and amphotericin B are also toxic and difficult to administer. In order to devise more effective ways to control the disease, there is a great need for better understanding of the host-parasite interactions. Identification and characterization of the parasite products which are involved in attraction of the parasite by the host cells, and in binding to and ingestion of the parasite by these cells will be of particular interest in this context.
KeywordsVisceral Leishmaniasis Chemotactic Activity Leishmania Species Leishmania Parasite Lipid Fluidity
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