Interaction of Leishmania and Membrane-Stabilizing Drugs with Human Phagocytic Cells

  • Arsalan Kharazmi
Conference paper
Part of the NATO ASI Series book series (volume 11)

Abstract

Leishmaniasis inflicts more than one million people in the world and causes over 1000 deaths per year. Therapy of these patients poses a serious problem. Pentavalent antimonials at higher doses exhibit considerable toxicity, some patients with visceral leishmaniasis become unresponsive to conventional doses of antimonials, and the usual second line drugs such as pentamidine and amphotericin B are also toxic and difficult to administer. In order to devise more effective ways to control the disease, there is a great need for better understanding of the host-parasite interactions. Identification and characterization of the parasite products which are involved in attraction of the parasite by the host cells, and in binding to and ingestion of the parasite by these cells will be of particular interest in this context.

Keywords

Toxicity Serotonin Stein Dine Amphotericin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Arsalan Kharazmi
    • 1
  1. 1.State Serum Institute, Department of Clinical MicrobiologyRigshospitaletCopenhagen NDenmark

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