Infectivity of Leishmania Promastigotes is Dependent on the Expression of a 65,000 Dalton Surface Antigen
Leishmania spp., a digenetic trypanosomatid protozoan, is an obligate intracellular parasite of mononuclear phagocytes transmitted by phlebotomine sandflies. The parasite cycles between a flagellated motile promastigote stage in the insect vector and a non-motile intracellular amastigote stage parasitizing the mammalian phagocytic cells. Differentiation into amastigote occurs after surface attachment and entry of promastigotes into mononuclear phagocytes.
KeywordsMononuclear Phagocyte Infective Stage Surface Antigenic Expression Obligate Intracellular Parasite Phase Parasite
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