Rapid Diagnosis of the Bernard-Soulier Syndrome Using a Monoclonal Antibody Against Glycoprotein Ib
The Bernard-Soulier syndrome is an autosomal recessive trait characterized by deficient synthesis of platelet surface glycoprotein Ib (GP Ib) resulting in impaired platelet function and bleeding tendency . GP Ib is a link protein for assembly of platelet and von Willebrand factor  during haemostasis. The development of a monoclonal antibody specific for GP Ib, denoted AN51, was reported by McMichael and coworkers . The antibody is now commercially available. Employing this antibody and using a previously reported ELISA method for detection of platelet surface proteins , we developed a simple technique for direct detection of GP Ib.
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