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Ungeklärte HIV Serokonversionen nach Substitution mit hitzeinaktivierten Faktorenkonzentraten

Probleme der Kausalitätsabklärung

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Zusammenfassung

Über Faktor VIII- und Faktor IX-Substitution sind seit 1980, auch in Deutschland, eine zunächst steigende Zahl von Hämophilie-Patienten mit dem „human immunodeficiency virus“ HIV (früher LAV/HTLV-III) infiziert worden (Tab. 1) (1, 2, 3, 4, 5).

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Literatur

  1. Mathez, D., J. Leibovitch, Y. Sultan, P. Maisonneuve: LAV/HTLY III seroconversion and disease in hemophiliacs treated in France. New Engl. J. Med. 314, 118–119 (1986)

    PubMed  CAS  Google Scholar 

  2. Gürtler, L.G., D. Wernicke, J. Eberle, G. Zoulek, F. Deinhardt, W. Schramm: Increase in prevalence of anti-HTLV III in hemophiliacs. Lancet II, 1275–1276 (1984)

    Article  Google Scholar 

  3. Evatt, B.L., E.D. Gomperts, J.S. McDougal, R.B. Ramsey: Coincidental appearance of LAV/HTLV III antibodies in hemophiliacs and the onset of the AIDS epidemic New Engl. J. Med. 312, 483–486 (1985)

    Article  PubMed  CAS  Google Scholar 

  4. Machin, S.J., B.A. McVerry, R. Cheingsong-Popov, R.S. Tedder: Serokonversion for HTLV III since 1980 in British hemophiliacs. Lancet i, 336 (1985)

    Article  Google Scholar 

  5. Ludlam, C.A., J. Tucker, C.M. Steel, R.S. Tedder, R. Cheingsong-Popov, R.A. Weiss, D.B.L. McClelland, I. Philip, R.J. Prescott: Human T-Lymphotropic virus Typ III (HTLV III) infection in seronegative hemophiliacs after transfusion of factor VIII. Lancet ii, 233–236 (1985)

    Article  Google Scholar 

  6. White, G.C., T.J. Matthews, K.J. Weinhold, B.F. Haynes, H. Le Roy Cromartie, C.W. McMillan, D.P. Bolognesi: HTLV III seroconversion associated with heat-treated Factor VIII concentrate. Lancet i, 611–612 (1986)

    Article  Google Scholar 

  7. van den Berg, W., J.W. ten Cate, C. Breederveld, J. Goudsmit: Seroconversion to HTLV III in a hemophiliac given heat-treated factor VIII concentrate. Lancet i, 803–804 (1986)

    Article  Google Scholar 

  8. Mdsseler, J., Kl. Schimpf, G. Auerswald, H. Bayer, J. Schneider, G. Hunsmann: Inability of pasteurized factor VIII preparations to induce antibodies to HTLV III after long term treatment Lancet i, 1111 (1985)

    Article  Google Scholar 

  9. Felding, P., I.M. Nilsson, B.G. Hansson, G. Biberfeld: Absence of antibodies to LAV/HTLV III in haemophiliacs treated with heat-treated factor VIII concentrate of American origin. Lancet ii, 832–833 (1985)

    Article  Google Scholar 

  10. Rouzioux, C., S. Chamaret, L. Montagnier, V. Carnelli, G. Rolland, P. Mannuci: Absence of antibodies to AIDS virus in haemophiliacs treated with heat-treated factor VIII concentrate. Lancet i, 271–272 (1985)

    Article  Google Scholar 

  11. Anonymous: Needlestick transmission of HTLV III from a patient infected in Africa Lancet ii, 1376–1377

    Google Scholar 

  12. Mayer, K.H., A.M. Stoddard, J. McCuster, D. Ayotte, R. Feriani, J. Groopman: Human T-lymphotropic virus type III in high risk, antibody negative homosexual men Ann. Int. Med. 104, 194–196 (1986)

    PubMed  CAS  Google Scholar 

  13. Cavel, F., D. Guetard, F. Brun-Vezinet, S. Chamaret, M.A. Rey, M.O. Santos-Ferreira, A.G. Laurent, C. Dauguet, C. Katlama, C. Rouzioux, D. Klatzmann, J.L. Champalimaud, L. Montagnier: Isolation of a new human retrovirus from West African patients with AIDS Science 233, 343–346 (1986)

    Article  Google Scholar 

  14. McDouga1, J.S., L.S. Martin, S.P. Cort, M. Mozert, C.M. Heldebandt, B.L. Evatt: Thermal inactivation of the Acquired Immunodeficiency Syndrome Virus, Human T-lymphotropic v irus-111/Lymphadenopathy-associ ated virus, with special reference to antihemophilic factor J. Clin. Invest. 76, 875–877 (1985)

    Article  PubMed  CAS  Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Gürtler, L., Schramm, W., Weisser, J., Krauss-Dietz, B. (1987). Ungeklärte HIV Serokonversionen nach Substitution mit hitzeinaktivierten Faktorenkonzentraten. In: Landbeck, G., Schimpf, K. (eds) 3. Rundtischgespräch über aktuelle Probleme der Substitutionstherapie Hämophiler. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72825-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-72825-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18059-3

  • Online ISBN: 978-3-642-72825-9

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