Skip to main content

Animal Models for Studying Antitumour and Antimetastatic Activities of Interferons

  • Conference paper
Interferons in Oncology

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

  • 24 Accesses

Abstract

An understanding of the way interferons (IFNs) can exert their anticancer effects is vital to optimal clinical use of these agents. Animal tumour models can provide this. From the data obtained from such models, it is not clear whether in any given host/tumour situation a therapeutic effect of an IFN is due to a unique combination of its regulatory effects on the tumour and the host, or whether there is one novel, as yet unidentified, mechanism by which IFNs exert anticancer activity in all situations (1,2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Balkwill FR: Antitumour effects of interferons in animals. In: Finter ND and Oldham RK (eds) Interferon 4, In vivo and clinical studies. Amsterdam: Elseviers Publishers BV 1985:23–45

    Google Scholar 

  2. Grosser I: How does Interferon inhibit tumor growth? Interferon 1985 (6):93–126

    Google Scholar 

  3. Balkwill FR, Moodie EM, Freedman V, Fantes KH: Human interferon inhibits the growth of established human breast tumours in the nude mouse. Int J Cancer 1982 (30):231–235

    Article  PubMed  CAS  Google Scholar 

  4. Balkwill FR, Proietti E, Bodmer J, Hart I and Ramani P: Mechanisms of antitumour action of interferons on human tumour xenografts and in mouse metastases models. UCLA Symposium on Interferons as growth inhibitors and antitumour agents (1986, in press)

    Google Scholar 

  5. Balkwill FR, Goldstein L and Stebbing N: Differential action of six human interferons against two human carcinomas growing in nude mice. Int J Cancer 1985 (35):613–617

    Article  PubMed  CAS  Google Scholar 

  6. Freireich EJ, Gehan RA, Rail DA, Schmidt LH and Skipper HE: Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother Rep 1966 (50):219–244

    PubMed  CAS  Google Scholar 

  7. Balkwill FR and Moodie EM: Positive interactions between human interferon and cyclophosphamide or adriamycin in a human tumour model system. Cancer Res 1984 (44): 904–908

    PubMed  CAS  Google Scholar 

  8. Balkwill FR, Stevens MH, Griffin DB, Thomas JA and Bodmer JG: Interferon gamma regulates HLA-D expression on solid tumours in vivo. Eur J Cancer 1986, in press

    Google Scholar 

  9. Skoskiewicz MJ, Colvin RB, Schneborger EE and Russell PS: Widespread and selective induction of major histocompatibility complex-determined antigen in vivo by gamma interferon. J Exp Med 1985 (162):1645–1664

    Article  PubMed  CAS  Google Scholar 

  10. Balkwill FR and Proietti E: The effects of mouse interferon on human tumour xenografts in the nude mouse host. Int J Cancer 1986, in press

    Google Scholar 

  11. Ramani P, Hart IR and Balkwill FR: The effect of interferon on experimental metastases in immunocompetent and immunodeficient mice. Int J Cancer 1986 (37):563–568

    Article  PubMed  CAS  Google Scholar 

  12. Ormerod EJ, Everett CA, Hart IR: Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-Azacytidine. Cancer Res 1986 (46):884–890

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Balkwill, F.R., Ramani, P. (1987). Animal Models for Studying Antitumour and Antimetastatic Activities of Interferons. In: Smyth, J.F. (eds) Interferons in Oncology. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72805-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72805-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72807-5

  • Online ISBN: 978-3-642-72805-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics