Abstract
An understanding of the way interferons (IFNs) can exert their anticancer effects is vital to optimal clinical use of these agents. Animal tumour models can provide this. From the data obtained from such models, it is not clear whether in any given host/tumour situation a therapeutic effect of an IFN is due to a unique combination of its regulatory effects on the tumour and the host, or whether there is one novel, as yet unidentified, mechanism by which IFNs exert anticancer activity in all situations (1,2).
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References
Balkwill FR: Antitumour effects of interferons in animals. In: Finter ND and Oldham RK (eds) Interferon 4, In vivo and clinical studies. Amsterdam: Elseviers Publishers BV 1985:23–45
Grosser I: How does Interferon inhibit tumor growth? Interferon 1985 (6):93–126
Balkwill FR, Moodie EM, Freedman V, Fantes KH: Human interferon inhibits the growth of established human breast tumours in the nude mouse. Int J Cancer 1982 (30):231–235
Balkwill FR, Proietti E, Bodmer J, Hart I and Ramani P: Mechanisms of antitumour action of interferons on human tumour xenografts and in mouse metastases models. UCLA Symposium on Interferons as growth inhibitors and antitumour agents (1986, in press)
Balkwill FR, Goldstein L and Stebbing N: Differential action of six human interferons against two human carcinomas growing in nude mice. Int J Cancer 1985 (35):613–617
Freireich EJ, Gehan RA, Rail DA, Schmidt LH and Skipper HE: Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother Rep 1966 (50):219–244
Balkwill FR and Moodie EM: Positive interactions between human interferon and cyclophosphamide or adriamycin in a human tumour model system. Cancer Res 1984 (44): 904–908
Balkwill FR, Stevens MH, Griffin DB, Thomas JA and Bodmer JG: Interferon gamma regulates HLA-D expression on solid tumours in vivo. Eur J Cancer 1986, in press
Skoskiewicz MJ, Colvin RB, Schneborger EE and Russell PS: Widespread and selective induction of major histocompatibility complex-determined antigen in vivo by gamma interferon. J Exp Med 1985 (162):1645–1664
Balkwill FR and Proietti E: The effects of mouse interferon on human tumour xenografts in the nude mouse host. Int J Cancer 1986, in press
Ramani P, Hart IR and Balkwill FR: The effect of interferon on experimental metastases in immunocompetent and immunodeficient mice. Int J Cancer 1986 (37):563–568
Ormerod EJ, Everett CA, Hart IR: Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-Azacytidine. Cancer Res 1986 (46):884–890
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© 1987 Springer-Verlag Berlin Heidelberg
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Balkwill, F.R., Ramani, P. (1987). Animal Models for Studying Antitumour and Antimetastatic Activities of Interferons. In: Smyth, J.F. (eds) Interferons in Oncology. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72805-1_6
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DOI: https://doi.org/10.1007/978-3-642-72805-1_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-72807-5
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