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The Psychobiology of Neurotensin

  • Conference paper
Neuroendocrinology of Mood

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 8))

Abstract

The tridecapeptide neurotensin (NT) was first identified in bovine hypothalamic extracts and characterized by Carraway and Leeman (1973, 1975,1976) and has subsequently been found in all classes of vertebrates (Carraway and Leeman 1976; Kitabgi et al. 1976; Kataoka et al. 1979; Langer et al. 1979; Reinecke et al. 1980 a; Cooper et al. 1981; Grant et al. 1982; Carraway et al. 1982; Eldred and Karten 1983), many invertebrates (Reinecke et al. 1980 b; Grimmelikhuijzen et al. 1981; Price et al. 1982), and certain bacteria (Bhatnagar and Carraway 1981). It is distributed throughout the mammalian central nervous system (CNS) (Uhl and Snyder 1977 a, b), gastrointestinal tract (Sundler et al. 1977; Schultzberg et al. 1980), cerebrospinal fluid (CSF), adrenals, pancreas, and plasma (Fernstrom et al. 1980). When administered systemically, the peptide has a variety of effects such as hypotension, hyperglycemia, decreased gastric acid secretion, decreased gut motility, and altered secretion of anterior pituitary hormones (Leeman and Carraway 1982). NT apparently does not cross the blood-brain barrier in appreciable quantities; however, when administered directly into the CNS, it produces a number of physiological and behavioral effects. A burgeoning body of evidence supports the role of NT as a neurotransmitter or neuromodulator. Thus far, heterogeneous CNS distribution, release of NT upon neuronal depolarization, satu- rable and specific binding of NT to receptors, and degradation by peptidases have all been demonstrated.

The authors are supported by NIMH MH-39415, MH-40159, MH-42088, MH-40524, and a Nanaline Duke Scholars Award to Charles B. Nemeroff

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  1. Department of Pharmacology, Duke University Medical Center, Durham, NC, 27710, USA

    B. Levant

  2. Departments of Psychiatry and Pharmacology, Duke University Medical Center, Durham, NC, 27710, USA

    C. B. Nemeroff

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  1. Pharmakologisches Institut, Universität Heidelberg, 1m Neuenheimer Feld 366, 6900, Heidelberg, Germany

    Detlev Ganten M.D., Ph.D.

  2. Rockefeller University, York Avenue, and 66th Street, New York, NY, 10021, USA

    Donald Pfaff Ph.D.

  3. Karolinska Institute, P.O. Box 60400, 10401, Stockholm, Sweden

    Kjell Fuxe M.D.

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Levant, B., Nemeroff, C.B. (1988). The Psychobiology of Neurotensin. In: Ganten, D., Pfaff, D., Fuxe, K. (eds) Neuroendocrinology of Mood. Current Topics in Neuroendocrinology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72738-2_9

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