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Cholinergic Mechanisms in Mood: Neuroendocrine Aspects

  • Conference paper
Neuroendocrinology of Mood

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 8))

Abstract

Central cholinergic mechanisms are thought to play key roles in such critical and diverse brain functions as motor tone and coordination, sleep and dreaming, analgesia, cognition and memory, and neuroendocrine regulation (Risch and Janowsky 1984). In addition, acetylcholine has been implicated in the regulation of mood and in the pathogenesis of affective illness (Janowsky et al. 1972 a). Data derived from both animal and human studies suggest that the relative balance between central cholinergic and adrenergic tone may play a role in the modulation of mood. Further, preliminary evidence suggests that patients suffering from affective disorders may be hypersensitive, both in terms of behavioral and neuroendocrine responses, to the pharmacologic effects of centrally acting cholinomi- metic agents. Such hypersensitivity may be a reflection of central cholinergic receptor hypersensitivity.

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Authors and Affiliations

  1. Psychiatry Department, University of North Carolina, School of Medicine, Chapel Hill, NC, 27514, USA

    D. S. Janowsky & R. N. Golden

  2. Psychiatry Department, School of Medicine, University of California at San Diego, La Jolla, CA, 92093, USA

    S. C. Risch

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  1. D. S. Janowsky
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  2. R. N. Golden
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  3. S. C. Risch
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  1. Pharmakologisches Institut, Universität Heidelberg, 1m Neuenheimer Feld 366, 6900, Heidelberg, Germany

    Detlev Ganten M.D., Ph.D.

  2. Rockefeller University, York Avenue, and 66th Street, New York, NY, 10021, USA

    Donald Pfaff Ph.D.

  3. Karolinska Institute, P.O. Box 60400, 10401, Stockholm, Sweden

    Kjell Fuxe M.D.

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Janowsky, D.S., Golden, R.N., Risch, S.C. (1988). Cholinergic Mechanisms in Mood: Neuroendocrine Aspects. In: Ganten, D., Pfaff, D., Fuxe, K. (eds) Neuroendocrinology of Mood. Current Topics in Neuroendocrinology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72738-2_8

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