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Effects of Peripheral Thyroid Hormones on the Central Nervous System: Relevance to Disorders of Mood

  • Conference paper
Neuroendocrinology of Mood

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 8))

Abstract

The association of mood symptoms with disorders of the thyroid has been evident since the earliest clinical descriptions of such disorders. From Caleb Parry’s mention of “nervous affectations” (1825) and Graves’ delineation of “symptoms which were supposed to be hysterical” (1940), to more recent longitudinal studies such as that of Hermann and Quarton (1965), thyroid hyperfunction has been shown to play an etiologic role in the production of many and varied mental symptoms. Similarly, since the early study of hypothyroidism by the Clinical Society of London (1888) and Asher’s classic longitudinal study (1949), thyroid hy- pofunction has been identified as a causative agent in various sorts of psycho- pathology. This close relationship between thyroid economy and mental function has interested psychiatric researchers with diverse interests over at least the last 40 years (e.g., Gjessing et al. 1976; Lidz and Whitehorn 1949). More recently, this interest in the role of the thyroid axis in psychiatric disorders, particularly disorders of mood, has grown. Impetus for recent research stems from such clinical observations as the high prevalence of abnormal thyrotroph responsiveness to thyrotropin-releasing hormone (TRH) in unipolar and bipolar depression, and the efficacy of thyroid hormones as adjuvants in the treatment of unipolar and bipolar affective disorders.

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  1. Affective Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    P. C. Whybrow & M. S. Bauer

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  1. Pharmakologisches Institut, Universität Heidelberg, 1m Neuenheimer Feld 366, 6900, Heidelberg, Germany

    Detlev Ganten M.D., Ph.D.

  2. Rockefeller University, York Avenue, and 66th Street, New York, NY, 10021, USA

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  3. Karolinska Institute, P.O. Box 60400, 10401, Stockholm, Sweden

    Kjell Fuxe M.D.

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Whybrow, P.C., Bauer, M.S. (1988). Effects of Peripheral Thyroid Hormones on the Central Nervous System: Relevance to Disorders of Mood. In: Ganten, D., Pfaff, D., Fuxe, K. (eds) Neuroendocrinology of Mood. Current Topics in Neuroendocrinology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72738-2_13

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