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Long-Term Experimental Study of Intravesical Chemotherapy: Effect on the Normal Urothelium in Dogs

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Investigative Urology 2

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Abstract

In recent years intravesical chemotherapy has become accepted worldwide in the treatment of superficial bladder cancer. The main problem treating these patients is the high frequency of recurrences even after complete transurethral resection of all visible lesions (Barnes et al. 1977; Miller et al. 1969). Depending on the grade of the primary tumor recurrences are observed between 50 to 70% (Heney et al. 1982; Dalesio et al. 1983). Concerning the results of randomized studies a maximum of 10 to 20% of the patients will profit from an adjuvant intravesical chemotherapy. More than 70% of the patients are treated unnecessarily (Rübben and Giani 1986). Thus local and systemic side effects as well as late complications of topical chemotherapy have to be considered and weighed against the therapeutic benefit (Lutzeyer et al. 1982).

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References

  • Barnes R, Hadley H, Dick A, Johnston O, Dexter J (1977) Changes in grade and stage of recurrent bladder tumors. J Urol 118: 177–178

    PubMed  CAS  Google Scholar 

  • Dale GA, Smith RB (1974) Transitional cell carcinoma of the bladder associated with cyclophosphamide. J Urol 112: 603–604

    PubMed  CAS  Google Scholar 

  • Dalesio O, Schulman CC, Silvester R, Depauw M, Robinson M, Denis L, Smith P, Viggiano G (1983) Prognostic factors in superficial bladder tumors. J Urol 129: 730–733

    PubMed  CAS  Google Scholar 

  • Daskal Y, Soloway MS, De Furia MD, Crooke ST (1980) Normal mice and mice with N-(4-5-nitro-2-furyl)-2-thiazolyl formamide induced bladder neoplasms. Cancer Res 40: 261

    PubMed  CAS  Google Scholar 

  • Engelmann U, Burger R, Jacobi GH (1982) Experimental investigations on the absorption of intra-vesically instilled Mitomycin C in the urinary bladder of the rat. Eur Urol 8: 176–181

    PubMed  CAS  Google Scholar 

  • Frith CH, Wiley LD, Shinohara Y (1982) Sequential morphogenesis of urinary bladder tumors in balb/c mice given 2-acetylaminofluorene. J Urol 128: 1071–1076

    PubMed  CAS  Google Scholar 

  • Heney NM, Nocks BN, Daly JJ, Prout GR Jr, Newall JB, Griffin PP, Perrone TL, Szyfelbein WA (1982) Ta und T1 bladder cancer: Location, recurrence and progression. Br J Urol 54: 152–157

    Article  PubMed  CAS  Google Scholar 

  • Hoover R, Fraumeni JF Jr (1981) Drug-induced cancer. Cancer 47: 1071–1080

    Article  PubMed  CAS  Google Scholar 

  • Jacobi GH, Kurth KH (1980) Topical adriamycin for prophylaxis and treatment of superficial bladder cancer: studies on plasma and tumor uptake. J Urol 124: 34–37

    PubMed  CAS  Google Scholar 

  • Lutzeyer W, Rubben H, Dahm HH (1982) Prognostic parameters in superficial bladder cancer: an analysis of 315 cases. J Urol 127: 250–252

    PubMed  CAS  Google Scholar 

  • Miller A, Mitchel JP, Brown NJ (1969) The bristol bladder tumors registry. Br J Urol 41 (Suppl 1): 5–6

    Google Scholar 

  • Murphy WM, Solo way MS (1980) The effect of thiotepa on developing and established mammalian bladder tumors. Am Can Soc 45: 870

    CAS  Google Scholar 

  • Murphy WM, Soloway MS, Crabtree WN (1981a) The morphologic effects of MMC in mammalian urinary bladder. Cancer 47: 2567–2574

    Article  PubMed  CAS  Google Scholar 

  • Murphy WM, Soloway MS, Finebaum PJ (1981b) Pathological changes associated with topical chemotherapy for superficial bladder cancer. J Urol 126: 461–464

    PubMed  CAS  Google Scholar 

  • Okajima E, Hiramatsu T, Hirao K, Ijuin M, Hirao H, Babaya K (1981) Urinary bladder tumors induced by BBN in dogs. Cancer Res 41: 1958

    PubMed  CAS  Google Scholar 

  • Pavone-Macaluso M, Gebbia N, Biondo S, Caramia G, Rizzo FP (1976) Permeability of the bladder mucosa to thiotepa, adriamycin and daunomycin in mice and rabbits. Urol Res 4: 9–13

    PubMed  CAS  Google Scholar 

  • Plötz PH, Klippel JH, Decker JL, Grauman D, Wolf B, Brown BC, Rutt G (1979) Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosis or rheumatoid arthritis. Ann Intern Med 91: 221

    PubMed  Google Scholar 

  • Pott P (1775) Cancer scroti. In: Hawes, Clark, Collins (eds) Chirurgical observations. London, p 63

    Google Scholar 

  • Rasmussen K, Peterson BL, Jacobo E, Penick GD, Sal JS (1980) Cytologic effects of thiotepa and adriamycin on normal canine urothelium. Acta cytol 24: 237

    PubMed  CAS  Google Scholar 

  • Rübben H (1983) Die intravesikale Chemotherapie des Blasenkarzinoms. Experiment und Klinik. Habilitationsschrift vor der Medizinischen Fakultät der RWTH Aachen

    Google Scholar 

  • Rübben H, Giani G (1986) Experimentelle und klinische Grundlagen der topischen Chemotherapie des Blasenkarzinoms. Manz’scher Buchverlag, Wien

    Google Scholar 

  • Rübben H, Lutzeyer W (1982) Klinische und experimentelle Gesichtspunkte der intravesikalen Behandlung superfizialer Blasenkarzinome mit Adriamycin. Urologe A 21: 20–23

    PubMed  Google Scholar 

  • Wall RL, Clausen KP (1975) Carcinoma of the urinary bladder in patients receiving cyclophosphamide. N Engl J Med 293: 271

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Urology, Medical Faculty, RWTH Aachen, Pauwelsstr., D-5100, Aachen, Germany

    F.-J. Deutz, F. Moll, R. Friedrichs, H. Rübben & W. Lutzeyer

  2. Department of Pathology, Medical Faculty, RWTH Aachen, Pauwelsstr., D-5100, Aachen, Germany

    R. Knüchel

Authors
  1. F.-J. Deutz
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  2. F. Moll
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  3. R. Friedrichs
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  4. H. Rübben
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  5. R. Knüchel
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  6. W. Lutzeyer
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Editor information

Editors and Affiliations

  1. Urologische Klinik und Poliklinik, im Klinikum der Johannes-Gutenberg-Universität, Langenbeckstraße 1, D-6500, Mainz, Germany

    Günther H. Jacobi

  2. Abteilung Urologie, Knappschaftskrankenhaus Bardenberg, Dr.-Hans-Böckler-Platz 1, D-5102, Würselen 1, Germany

    Herbert Rübben

  3. Urologische Klinik, Zentralklinikum, Stenglinstraße, D-8900, Augsburg, Germany

    Rolf Harzmann

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© 1987 Springer-Verlag Berlin Heidelberg

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Deutz, FJ., Moll, F., Friedrichs, R., Rübben, H., Knüchel, R., Lutzeyer, W. (1987). Long-Term Experimental Study of Intravesical Chemotherapy: Effect on the Normal Urothelium in Dogs. In: Jacobi, G.H., Rübben, H., Harzmann, R. (eds) Investigative Urology 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72735-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-72735-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72737-5

  • Online ISBN: 978-3-642-72735-1

  • eBook Packages: Springer Book Archive

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