Antidiuretic Action of Vasoactive Intestinal Peptide in the Canine Kidney
Vascoactive Intestinal Peptide [VIP] is a highly basic octacosapeptide (molecular weight 3809) originally extracted from porcine lung tissue by Said and Mutt (Said et al. 1968), but later isolated and purified from porcine upper intestine (Said and Mutt (1970). Immunhistochemical studies have revealed a widespread occurrence of VIP containing neurons and nerve fibers in the brain, the peripheral nerves, salivary glands, trachea, lung, upper and lower digestive tract, urogenital tract, and around peripheral blood vessels (Said et al. 1968; Said and Mutt 1970; Said and Rosenberg 1976; Lundberg et al. 1984; Polak and Bloom 1982; Larsson et al. 1976; Larsson 1977; Ottesen 1983; Hokfelt et al. 1978; Uddman et al. 1981). A broad spectrum of actions has been ascribed to VIP, of which the most important are vasodilation and hypotension (Said et al. 1968) relaxation of smooth muscle (Polak and Bloom 1982; Ottesen 1983), excretion of water and bicarbonate by the pancreas (Maklouf et al. 1978), intestinal secretion (Krejs et al. 1978) and release of insulin and glucagon (Schebalin et al. 1977). A recent study showed that VIP can stimulate renin relase and increase renal blood flow (Porter et al. 1982). The following experiments were conducted to investigate the effects of VIP on renal function in connection with hemodynamic responses.
KeywordsVasoactive Intestinal Peptide Renal Blood Flow Vasoactive Intestinal Polypeptide Pulsatile Flow Urine Production
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