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Alzheimer’s Disease Causes Metabolic Uncoupling of Associative Brain Regions Beyond that Seen in the Healthy Elderly

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Modification of Cell to Cell Signals During Normal and Pathological Aging

Part of the book series: NATO ASI Series ((ASIH,volume 9))

Abstract

Alzheimer’s disease (AD) is a progressive degenerative brain disorder that has no agreed-upon cause. The earliest and most prominent neuropsychological deficit is recent memory impairment, which usually is attributed to pathological and neurochemical changes in the hippocampus, amygdala and neocortex (3, 5, 32). The first cognitive deficits to appear that are related to neocortical dysfunction are impairments of attention, abstract reasoning, language and visuospatial construction (18, 20, 21).

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Author information

Authors and Affiliations

  1. Laboratory of Neurosciences National Institute on Aging, National Institutes of Health, Bethesda, Md., 20892, USA

    Stanley I. Rapoport, Barry Horwitz, C. L. Grady & J. V. Haxby

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  1. Stanley I. Rapoport
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  2. Barry Horwitz
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  3. C. L. Grady
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  4. J. V. Haxby
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Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milano, Via A. del Sarto, 21, 20129, Milano, Italy

    Stefano Govoni  & Fiorenzo Battaini  & 

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Rapoport, S.I., Horwitz, B., Grady, C.L., Haxby, J.V. (1987). Alzheimer’s Disease Causes Metabolic Uncoupling of Associative Brain Regions Beyond that Seen in the Healthy Elderly. In: Govoni, S., Battaini, F. (eds) Modification of Cell to Cell Signals During Normal and Pathological Aging. NATO ASI Series, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72729-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-72729-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72731-3

  • Online ISBN: 978-3-642-72729-0

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